amylynntaulbee
Recently Joined
Is Tesa worth the cost? Usually I’ll get a couple vials of something and try it out, before committing to a kit, but it seems like Tesa takes a while to get results. Is it worth getting kit?
If you are taking ridiculously high doses, it might. If you are outside of your 30s and taking 2-3iu it isn’t going to be any worse than taking a growth hormone releasing hormone.HGH is even worst, like your internal organs growing
Definitely. HGH is also cheaper than tesa.Ipa & CJC also works for lean muscle and are cheaper to run.
So the way Im reading it - Tesa Specifically targets VAT vs HGH just reducing overall BF. CJC doesnt seem to be as strong as either in the fat burning dept.Since I'm cheap, I would get CJC instead of tesa or just use HGH.
Feature Ipamorelin (Ipa) CJC-1295 (often with Ipamorelin) Tesamorelin (Tesa) Human Growth Hormone (HGH) Anavar (Oxandrolone) Testosterone Cypionate (Test-C) Type of Substance Growth Hormone Secretagogue Peptide GHRH Analog Peptide (longer acting) GHRH Analog Peptide (highly targeted) Recombinant Human Growth Hormone (exogenous) Oral Anabolic Androgenic Steroid (AAS) Injectable Anabolic Androgenic Steroid (AAS) Mechanism of Action for Fat Loss Stimulates natural GH release in pulsatile manner, leading to increased lipolysis and metabolism. Stimulates sustained natural GH release, leading to increased lipolysis and metabolism. Stimulates natural GH release, uniquely targeting and reducing visceral adipose tissue (VAT). Direct lipolytic effects; increases metabolism; in deficient individuals, restores fat metabolism. Directly promotes lipolysis; preserves/builds lean muscle mass, increasing metabolic rate. Promotes lean muscle mass, increasing metabolic rate; may directly influence fat cell metabolism; plays a role in overall body composition. Primary Fat Target General fat loss (subcutaneous and visceral) General fat loss (subcutaneous and visceral) Specifically Visceral Adipose Tissue (VAT) General fat loss (subcutaneous and visceral), especially in deficient states. General fat loss (subcutaneous and visceral), with notable effects on abdominal fat. General fat loss (subcutaneous and visceral), particularly in individuals with low testosterone. Fat Burning Efficacy (General) Moderate (as part of overall body recomposition) Moderate to Good (as part of overall body recomposition) High for VAT; less pronounced for overall subcutaneous fat. Moderate to High in GH-deficient individuals; Modest in healthy individuals. High (especially for preserving muscle during caloric deficit). Moderate to High (especially in hypogonadal men, contributes to better body composition). Targeted Fat Reduction Indirect via GH increase Indirect via sustained GH increase Highly targeted to VAT General, but can reduce VAT in deficient states. General, with strong effects on body recomposition. General, helps optimize body composition. Muscle Preservation/Gain Yes, by increasing GH and IGF-1 Yes, by increasing GH and IGF-1 Yes, due to increased GH and IGF-1 Yes, promotes muscle growth and preservation, especially in deficient states. Significant, known for preserving lean mass during cutting. Significant, primary role is muscle growth and strength. Typical Use Context Anti-aging, general wellness, body recomposition Anti-aging, general wellness, body recomposition, recovery HIV-associated lipodystrophy (FDA-approved), some off-label for VAT. GH deficiency treatment; some off-label in sports (controversial). Medical: muscle wasting conditions; Illicit: bodybuilding (cutting). Medical: Testosterone Replacement Therapy (TRT) for hypogonadism; Illicit: bodybuilding. Legal Status (USA) Prescription peptide (generally) Prescription peptide (generally) Prescription drug (FDA-approved) Prescription drug (Controlled substance for non-medical use) Prescription drug (Controlled substance) Prescription drug (Controlled substance) Potential Side Effects Mild (e.g., injection site reactions, transient flushing) Mild (e.g., injection site reactions, transient flushing) Mild (e.g., injection site reactions, headache, joint pain) Swelling, joint pain, carpal tunnel, insulin resistance, acromegaly (with abuse). Liver toxicity, cholesterol changes, virilization in females, hair loss, acne. Estrogen-related (gynecomastia, water retention), acne, hair loss, prostate issues, cardiovascular risks.
Summary of Fat Burning Strengths:
* Anavar: Generally considered the most direct and potent for overall fat loss and body recomposition among these compounds, especially for cutting cycles, due to its ability to preserve muscle while stripping fat.
* Tesamorelin: Uniquely effective and targeted for visceral fat reduction, particularly its FDA-approved use in HIV-related lipodystrophy.
* HGH: Highly effective for fat loss in GH-deficient individuals. Its efficacy for significant fat loss in otherwise healthy individuals is more modest and controversial.
* Testosterone Cypionate: Contributes to fat loss primarily by increasing lean muscle mass and improving overall body composition, especially in men with low testosterone.
* Ipamorelin & CJC-1295: These GH-releasing peptides promote fat loss indirectly by naturally increasing GH and IGF-1 levels, contributing to improved metabolism and body composition over time. They are generally milder than direct HGH or steroids.
Substance Recovery Focus Healing Power Legal Status (USA) Ipamorelin (Ipa) GH-mediated tissue repair, sleep Good Prescription Peptide CJC-1295 (w/Ipa) Sustained GH/IGF-1 for repair, sleep Very Good Prescription Peptide Tesamorelin (Tesa) Indirect GH for general tissue health (VAT focus) Moderate Prescription Drug Human Growth Hormone (HGH) Direct tissue regen., collagen, inflammation Excellent Controlled Drug Anavar Muscle preservation/repair, anabolic Good Controlled Drug Testosterone Cypionate Muscle growth/repair, anti-catabolic Very Good Controlled Drug BPC-157 Targeted tissue/GI/nerve healing, anti-inflam. Exceptional Unapproved Drug TB-500 Broad tissue repair (muscle, tendon, skin), flexibility Exceptional Unapproved Drug GHK-Cu Skin/wound healing, anti-inflam., collagen Good OTC/Unapproved Inj.
I'm on a clen cycle now, but it's hard to know what tirz vs. clen is doing. After reading the article on clen at Meso, I also bought albuterol tablets since they are less potentially risky.Before and 140 min after ingestion of 80 μg clenbuterol, resting metabolic rate and contractile function of the quadriceps muscle were measured, and blood samples as well as vastus lateralis muscle biopsies were collected. Clenbuterol increased resting energy expenditure by 21% (P < 0.001), and fat oxidation by 39% (P = 0.006), whereas carbohydrate oxidation was unchanged.
I believe that was in reference to tesofensine. But, Clenbuterol is definitely an awesome tool. As far as the GHRHs like Tesamorelin, Sermorelin, CJC-1295, Ipamorelin, I just recommend people commit and use HGH. Possible side effects are the same but they only provide a fraction of the benefits, if any at all. I understand the programming that causes people to resist the idea of HGH and some proven AAS’ (ones that have legit human medical uses) but if people do their research and start conservatively they can absolutely improve their physical and mental health.Also, as @AndyPanda once said, just use clen instead of tesa.
Gemini says clen can burn more fat than anything else mentioned in this thread, and it gave this reference:
https://pubmed.ncbi.nlm.nih.gov/31887249/
I'm on a clen cycle now, but it's hard to know what tirz vs clen is doing.
Thats kinda where Im at. I need to rabbit hole it all.I believe that was in reference to tesofensine. But, Clenbuterol is definitely an awesome tool. As far as the GHRHs like Tesamorelin, Sermorelin, CJC-1295, Ipamorelin, I just recommend people commit and use HGH. Possible side effects are the same but they only provide a fraction of the benefits, if any at all. I understand the programming that causes people to resist the idea of HGH and some proven AAS’ (ones that have legit human medical uses) but if people do their research and start conservatively they can absolutely improve their physical and mental health.
but they only provide a fraction of the benefits, if any at all.
Google Gemini said:Clinical trials [of tesamorelin] typically show significant reductions in visceral fat after 26 weeks (about 6 months) of daily treatment.
Substance(s) Time to Start Noticing Fat Changes Primary Reason for Length / Fat Burning Mechanism Clenbuterol (Clen) As early as 1-2 weeks, more significant at 2-4 weeks Potent thermogenic; directly increases calorie expenditure and fat breakdown. Phentermine Within 1-4 weeks (primarily via appetite suppression) Appetite suppressant (sympathomimetic); reduces caloric intake. Anavar (Oxandrolone) Within 2-4 weeks (indirect via muscle preservation) Indirect fat loss by preserving/building lean muscle, raising metabolic rate. Modafinil Variable; appetite changes in 1-2 weeks for some, but fat loss is secondary Wakefulness-promoting agent; can indirectly aid fat loss by suppressing appetite or increasing physical activity. Tesofensine Appetite changes in 2 weeks; noticeable weight loss in 1-3 months Appetite suppression, increased resting energy expenditure, increased fat oxidation. Ipamorelin, CJC-1295, Tesamorelin Body composition changes in 4-8 weeks; optimal effects longer Stimulate natural GH release, leading to lipolysis. Tesamorelin specifically targets visceral fat. HGH (Human Growth Hormone) Subtle changes in 1-2 months; significant in 3-6 months Promotes lipolysis (fat breakdown). Effects are gradual and cumulative. Testosterone Replacement Therapy (TRT) Noticeable changes in 2-3 months; significant over 6-12 months Normalizes testosterone levels, leading to increased muscle and reduced body fat (systemic improvement).
A similar thing easy to forget in the peptide hype is that it takes longer with peptides, compared to traditional taboo pharma like stimulants and AAS.
Teso would fall under traditional pharma too, compared to the peptide tesa:
tesa was worthwhile for sure, but it made my CTS bad so I had to stop it. by the time I had a CT release I had done enough research to conclude that gh is a better choice for me anyway, so I never tried the tesa again post-surgery. i do think the tesa was effective for trimming down the midsection a bit, though.Everyone here who took tesa was on GLPs, all of which burn visceral fat, so it's hard to know anything by anecdotal evidence. And the clinical trials for tesa were for a specific population.
@exploitedworkerbee exploited tesa before, but it was not in the holy trinity of reta, HGH, and BPC.
Medication (Brand Names) Mechanism of Action Status (as of July 2025) Average Weight Loss (Clinical Trials) Visceral Fat Reduction Potential (Relative Order) Notes on Visceral Fat Retatrutide ("Reta") Triple GLP-1/GIP/Glucagon Receptor Agonist Phase 3 Clinical Trials ~20-25% of body weight (Phase 2 data) Highest Triple action targets fat metabolism more comprehensively; exceptional overall weight loss strongly indicates superior visceral fat reduction. Strong liver fat reduction also observed. Survodutide Dual GLP-1/Glucagon Receptor Agonist Phase 3 Clinical Trials ~15-19% of body weight (Phase 2 data) Very High Glucagon agonism directly promotes fat breakdown and energy expenditure, which is key for visceral fat. Significant liver fat reduction seen. Mazdutide ("Madz") Dual GLP-1/Glucagon Receptor Agonist Approved in China (Obesity, T2D); Phase 3 in other regions ~12-19% of body weight (Phase 2/3 data from China) Very High Similar to survodutide, its dual GLP-1/glucagon action is highly effective for fat burning and has shown significant reductions in waist circumference and liver fat. Tirzepatide (Zepbound, Mounjaro) Dual GIP/GLP-1 Receptor Agonist Approved (Obesity, T2D) ~15-22% of body weight (Zepbound) High Powerful overall weight loss, with studies specifically showing significant reductions in visceral fat mass and waist circumference. Strong evidence for liver fat reduction. Semaglutide (Wegovy, Ozempic, Rybelsus) GLP-1 Receptor Agonist Approved (Obesity, T2D) ~15% of body weight (Wegovy) High Proven to significantly reduce visceral fat and liver fat, while preserving lean muscle mass more effectively than some other weight loss methods.