Warning about a low probability event: adverse liver reaction to GLP-1 drug

[rsmith]

What am I missing? Why are you surprised by your lipids increasing when you stopped a lipid lowering medication?

Since starting GLPs and the like (e.g., cagri), I've been taken off of 2 hypertensives and had another one reduced by 2/3. Blood pressure has dropped and labs are improving dramatically as well. So the triple increase in LDL was somewhat of a surprise although it's likely a "rebound" effect rather than anything to worry about. The Survo I'm titrating up at present will hopefully bring that back down via the glucagon component.

 

[keangkong]

Am I correct that the blood testing results below, along with the dates of drug stops and starts, indicates that reta is likely causing liver problems? By the way, I don't plan on resuming Lipitor (atorvastatin) since I already had elevated enzymes while on it. I intend to speak with my cardiologist about pitavastatin, a statin that is less likely to cause liver problems. The rapid decline in liver enzymes after I stopped taking reta and Lipitor looks good. However, the rapid rise in liver enzymes after I resumed reta (at a tiny dose) look bad. These results are troubling since tirz alone was not getting me to a weight that I wanted to be. Still a slightly heavier me is better than a messed up liver.

 

[rsmith]

Am I correct that the blood testing results below, along with the dates of drug stops and starts, indicates that reta is likely causing liver problems? By the way, I don't plan on resuming Lipitor (atorvastatin) since I already had elevated enzymes while on it. I intend to speak with my cardiologist about pitavastatin, a statin that is less likely to cause liver problems. The rapid decline in liver enzymes after I stopped taking reta and Lipitor looks good. However, the rapid rise in liver enzymes after I resumed reta (at a tiny dose) look bad. These results are troubling since tirz alone was not getting me to a weight that I wanted to be. Still a slightly heavier me is better than a messed up liver.

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It's too early to tell if Reta is your problem. Take it for at least 3 more weeks.

Also and importantly, since you're also still taking Tirz, it might be the Tirz X Reta interaction that is causing the liver enzymes to go up. Only way to know it to stop the Tirz, continue the Reta solo and see what happens over at least 1 month. Please keep us up to date.