GLP-1 Forum

Considering Survodutide

brentm said:
Survo is a great stack. I really liked it with Tirz and Sema combined.... All three and I felt like I covered my bases.

Now I'm trying RETA out to see if I can notice any difference. I titrated up really fast on RETA. Not advice for anyone but my general approach is if I feel something isn't working, I'll do a mid-schedule bump. Usually choosing survo for that bump or sema, depending on days.

It feels very "willie nillie" but my tolerance is pretty high. I was on 20mg of tirz a week, 4mg of sema and 6mg of survo per week (split into two dose days).
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I was on 20mg of tirz a week, 4mg of sema and 6mg of survo per week (split into two dose days).

Yikes! That sounds like a pretty potent stack. How did it work for you or did it stop working, causing you to move to Reta? What dose of Reta are you on now and how is it working given the potent previous stack?
 
rsmith said:
I was on 20mg of tirz a week, 4mg of sema and 6mg of survo per week (split into two dose days).

Yikes! That sounds like a pretty potent stack. How did it work for you or did it stop working, causing you to move to Reta? What dose of Reta are you on now and how is it working given the potent previous stack?
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I lose track... I think I'm hovering around 12mg of RETA a week... I want to say I'm at 10, but I know I've bumped.

I dunno that it stopped working. I haven't really tried to lose weight. I just want it to magically fall off like it did earlier. I blame my wife for providing me desert every night. I don't care how not hungry I am, there's always room for ice cream.
 
brentm said:
I lose track... I think I'm hovering around 12mg of RETA a week... I want to say I'm at 10, but I know I've bumped.

I dunno that it stopped working. I haven't really tried to lose weight. I just want it to magically fall off like it did earlier. I blame my wife for providing me desert every night. I don't care how not hungry I am, there's always room for ice cream.
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I have a T-shirt that says “I beat Ozymp!€“ but that was due to beer and dark liquor. Also, my friends are a-holes. I’m impressed by those numbers. 5mg every 5 days is a lot for me.
 
BooneDonk said:
I have a T-shirt that says “I beat Ozymp!€“ but that was due to beer and dark liquor. Also, my friends are a-holes. I’m impressed by those numbers. 5mg every 5 days is a lot for me.
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That's pretty good! I'd probably rotate it like 3.5 to 4 mg every three days to keep things a bit smoother. I think that's the equiv of 5mg every 5
 
rsmith said:
I don’t get anything out of it just trying to help Johnny out. I like how he operates so I’d like to see him stick around so I can continue to buy off him lol

Yeah, same here. I got 5 of those Survo12 kits and have started using it already. It lives up to it's Jano results (strong stuff!).
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I'm glad you did. I picked up klow components from him a few weeks ago, and grabbed a kit of Survo from him the other night. Only one; it seems likely that I'll never even get to the point of needing it; I've lost twenty pounds since I started tirz (July 29th) and have only titrated up to 4.4mg per week, which I'm feeling like is a little high for me right now and plan to try 3.3 next week. I only have 30 pounds left to goal, so if I stay focused, I ought to get there before I titrate up too much further. But I wanted a full kit from a good seller in the freezer to keep my anxiety down.
 
keangkong said:
Does anyone have a source for the the graphic below? I searched for it and I saw that it was on Reddit too. But I wanted to know if there was a scholarly source. View attachment 9370
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As I understand, this is is from several in vitro studies, so nothing testet on humans.
But it's a summary from several studies done.
They show this in a lot of articles, as a sum up of results.

These:

Tirzepatide (Mounjaro)
Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, et al.
Lilly’s tirzepatide: dual GIP and GLP-1 receptor agonist for type 2 diabetes.
Front Endocrinol. 2022
👉 Reports Ki for GIPR = 0.135 nM and GLP-1R = 4.23 nM in HEK293 cells.

Semaglutide & Liraglutide
Knudsen LB, Lau J.
The discovery and development of liraglutide and semaglutide.
Front Endocrinol. 2019
👉 Contains binding and activation data for GLP-1R (semaglutide Ki ~0.38 nM).

Retatrutide (LY3437943)
Urva S, Coskun T, Loghin C, et al.
LY3437943 is a triple GIP, GLP-1, and glucagon receptor agonist for the treatment of type 2 diabetes.
Diabetes 2022 (Abstracts, ADA) + preclinical data from Eli Lilly
👉 Shows affinity for all three receptors (nanomolar range).

Survodutide (BI 456906)
Brandt SJ, Gotfredsen CF, et al.
Dual GLP-1/glucagon receptor agonist BI 456906: preclinical pharmacology.
Diabetes Obes Metab. 2021
👉 Affinity measured in cAMP assays for GLP-1R and GCGR.

Mazdutide (IBI362/LY3305677)
Yang J, Wang S, et al.
Mazdutide (IBI362), a novel GLP-1/glucagon receptor dual agonist: preclinical characterization.
Diabetes Obes Metab. 2022
👉 Receptor binding data for GLP-1R and GCGR.

CagriSema (cagrilintide + semaglutide)
Both components have their own in vitro profiles:
  • Cagrilintide: amylin receptor agonism (CTR/RAMP complexes) → presented in Novo Nordisk preclinical papers (Diabetes 2020 abstract).
  • Semaglutide: see above (Knudsen & Lau).
 
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keangkong said:
Does anyone have a source for the the graphic below? I searched for it and I saw that it was on Reddit too. But I wanted to know if there was a scholarly source. View attachment 9370
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we have had this pic for at least 2 years and i can confirm on my test RD that most of these numbers are correct on effects. Now how long effects and feels last vary VASTLY imo
survo starts off strong but weakens fast after a month of usage.
 
Super Trips said:
we have had this pic for at least 2 years and i can confirm on my test RD that most of these numbers are correct on effects. Now how long effects and feels last vary VASTLY imo
survo starts off strong but weakens fast after a month of usage.
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Only a month ?? that's very short.
There are a lot of individual factors, we don't know. Some people respond well to sema, some to tirz etc.
Just like some people don't respond to the drugs at all.
Did you try Maz ?
 
miss-sanne said:
Only a month ?? that's very short.
There are a lot of individual factors, we don't know. Some people respond well to sema, some to tirz etc.
Just like some people don't respond to the drugs at all.
Did you try Maz ?
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I really hope it's not true for most. I'm heading into week four on a very small dose stacked against a small dose of tirzepatide, and I REALLY like it so far.
 
randompersonrandom said:
I really hope it's not true for most. I'm heading into week four on a very small dose stacked against a small dose of tirzepatide, and I REALLY like it so far.
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What is your dose ? That's great to hear.
I think it must be individual, because the studies doesn't show that, they wouldn't go to phase 3, if the effect diminishes after 1 month.
 
miss-sanne said:
What is your dose ? That's great to hear.
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I was moving it around a bit, but I'm sort of settled on 0.3 mg of survo on Tuesday, 0.5mg of tirz on Friday. I started stacking it because the fatigue from tirz is manageable but a bit of a bummer for me, and I'd heard people say Survo helps. It does, a very little, but it also seems to make weight come off me just a little bit easier so far. Hard to tell for sure, because it's not been a full month yet, but it sure seems it.
 
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