Psoriasis and the Oral Peptide Icotrokinra

[patches]

Hello everyone I'd like to bring your attention to this new peptide that has gone under radar. Icotrokinra is a first-in-class oral peptide that precisely targets and blocks the IL-23 receptor. It binds to the IL-23 receptor, which effectively inhibits the IL-23 pathway and the downstream signaling that drives inflammation in conditions like plaque psoriasis and ulcerative colitis.

https://www.fiercebiotech.com/biotech/jjs-il-23-drug-defeats-reigning-champ-sotyktu-phase-3-psoriasis-trial

They have submitted for FDA approval in July 2025 and it's currently pending.

I found a user on Reddit who was part of the trial and here's his results

2 week results according to user (you can find these if you search it's old name "JNJ-2113 results reddit"

I just wanted to spread the word to other sufferers like me that there's a peptide with promise on the horizon.

 

[byefatlicia]

This is exciting🙂 i wonder how long until we might see this available in the grey?

 

[andreigl]

Watching this... Please update... I have old folks in our family with psoriasis sufferers for years.

 

[patches]

This would also work as an injectable. The oral bioavailability is roughly 0.1–0.3% so the 200mg dosage they use you're only absorbing ~0.5 mg systematically. You could inject 0.5mg per day and get the same results bringing cost way down. Maybe one day this will be a reality..

 

[byefatlicia]

This would also work as an injectable. The oral bioavailability is roughly 0.1–0.3% so the 200mg dosage they use you're only absorbing ~0.5 mg systematically. You could inject 0.5mg per day and get the same results bringing cost way down. Maybe one day this will be a reality..

But wouldn't we need vials instead of tabs for this? Or can it be done another way?

 

[patches]

But wouldn't we need vials instead of tabs for this? Or can it be done another way?

Ya it would be powder form not a tab so vial or pen