Need Advice For Reta dosages

[Coktail]

Dear Forum Members,
Hello Everyone,

my first injections were administered as follows:

Week 1 - 1 mg (my weight 110 kg)

Week 2 - 1 mg

Week 3 - 1.5 mg

Week 4 - 1.5 mg (100 kg)

Week 5 - 2 mg

Week 6 - 2 mg (97.65 kg)

Week 7 - 2.5 mg (97.50 kg)

Week 8 - 2.5 mg (97.30 kg)

Week 9 - 2.5 mg (96.30 kg)


As you can see, I lost 10 kg in 4 weeks. During this time, I also changed my diet. No sugar, no bread, no sweets, no alcohol, and no juices. My portion sizes also became smaller.

Last 4 weeks i stay on 2.5 mg weekly and nearly dont lost any kg's

My question to the experienced Members is; Should i go higher dose? What is your recommandations?

I thought i can use 2.5mg all the time.
Thank you in advance

Best Regards

 

[ostrichsak]

I'm newer to this Reta thing too (one month of 1mg weekly now, titrating up to 2mg starting tomorrow) but the research I've done over the months (I tend to over analyze things a lot) can be summarized roughly as:

Month 1: 1mg weekly to make sure you're not going to have any reactions/side effects & to build it up in the system. (much of the weight loss during this step at this dose is glycogen stores as your body starts shedding it and not as much fat burning early on)

Month 2: 2mg and monitor (this is when you should start seeing the fat burning effects to a lesser degree but could also begin noticing side effects. Hydration is important throughout but especially as your body adjusts to burning fat early on)

Month 3: 3mg or 4mg depending on how your step to 2mg was and what your weight loss looks like and desired pace. (I prefer slower as I'm in no rush. I'd prefer to minimize potential risk for side effects and having a general bad time. I like having head room to build to in terms of dosage rather than maxing out at the effective range and having nowhere else to go before reaching goals. I'm also all about the lowest effective dose if things I take more than the instant gratification side of things that others seem to prefer)

....carry on like this on a personalized path that follows a similar guideline but allows for small variances based on the individual. The 1-month between titration changes gives the dose time to reach a static level within the body as it's processing it during the ramp up and needs to stabilize a bit. I saw a good video that described it as a bathtub you're filling with an open drain. Use too little and it all goes out before your body uses it. It takes time though to see what each "fill rate" does.

Some people titrate up month-by-month all the way to 12mg (seems to be the max effective dose before side effects become almost a certainty) and others find a happy spot at less than half of that. It seems that most titrate up to the 8mg "sweet spot" for best results. It's all individualistic as different people react differently. People also have different goals. I started w/needing to lose ~75lbs where as others are trying to cut the last few % of BF for a competition. Obviously their data has less weight for my personal research.

Once target weight is reached, find a maintenance dose that works based on individual goals. Some quit completely for sustained periods. Others prefer to stay on a small amount consistently. I'll probably fall into this latter category as I would like to keep the neuroprotective and anti-inflammatory benefits.

It's nice to have the clinical human studies to refer to for most likely/common outcomes across a broad range of variables but we should really take advantage of being our own guides on this path to customize it for what works best for us individually.

 

[ambot88]

you can for sure go up, 2.5 is still a small dose. I'm at week 12 and taking 4mg every 5 days.

 

[Vash_]

Check out this study.

https://onlinelibrary.wiley.com/doi/10.1002/hsr2.1864

 

[GeraltRedhammer]

GLP-1 makes it much easier for us to lose weight, but it is not a magic pill that will do the work for us. We lose weight thanks to a calorie deficit. Observing this and similar forums, it is clear that people who also do strength training lose weight the fastest. In addition, strength training is also recommended so as not to lose muscle mass. So it is worth adding at least one strength training session per week and seeing what the results will be. It is also important to ensure that your diet contains the right amount of protein.

I find it interesting that people who do endurance training, such as running, do not tend to share their results.

 

[miss-sanne]

Dear Forum Members,
Hello Everyone,

my first injections were administered as follows:

Week 1 - 1 mg (my weight 110 kg)

Week 2 - 1 mg

Week 3 - 1.5 mg

Week 4 - 1.5 mg (100 kg)

Week 5 - 2 mg

Week 6 - 2 mg (97.65 kg)

Week 7 - 2.5 mg (97.50 kg)

Week 8 - 2.5 mg (97.30 kg)

Week 9 - 2.5 mg (96.30 kg)


As you can see, I lost 10 kg in 4 weeks. During this time, I also changed my diet. No sugar, no bread, no sweets, no alcohol, and no juices. My portion sizes also became smaller.

Last 4 weeks i stay on 2.5 mg weekly and nearly dont lost any kg's

My question to the experienced Members is; Should i go higher dose? What is your recommandations?

I thought i can use 2.5mg all the time.
Thank you in advance

Best Regards

Your body/ brain could just be adjusting, and will pick up weight loss again.
You did loose a lot of weight in a short amount of time.
2,5 is a bit low after 9 weeks and minimal loss over 4 weeks, I would go up.
Could be from 2 to 4 to 6 to 8.
You could read up on trials dosing.
You don't mention exercise, cardio and resitstance training ? It's quite important.