Need Advice For Reta dosages

Coktail

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Dear Forum Members,
Hello Everyone,

my first injections were administered as follows:

Week 1 - 1 mg (my weight 110 kg)

Week 2 - 1 mg

Week 3 - 1.5 mg

Week 4 - 1.5 mg (100 kg)

Week 5 - 2 mg

Week 6 - 2 mg (97.65 kg)

Week 7 - 2.5 mg (97.50 kg)

Week 8 - 2.5 mg (97.30 kg)

Week 9 - 2.5 mg (96.30 kg)


As you can see, I lost 10 kg in 4 weeks. During this time, I also changed my diet. No sugar, no bread, no sweets, no alcohol, and no juices. My portion sizes also became smaller.

Last 4 weeks i stay on 2.5 mg weekly and nearly dont lost any kg's

My question to the experienced Members is; Should i go higher dose? What is your recommandations?

I thought i can use 2.5mg all the time.
Thank you in advance

Best Regards
 
I'm newer to this Reta thing too (one month of 1mg weekly now, titrating up to 2mg starting tomorrow) but the research I've done over the months (I tend to over analyze things a lot) can be summarized roughly as:

Month 1: 1mg weekly to make sure you're not going to have any reactions/side effects & to build it up in the system. (much of the weight loss during this step at this dose is glycogen stores as your body starts shedding it and not as much fat burning early on)

Month 2: 2mg and monitor (this is when you should start seeing the fat burning effects to a lesser degree but could also begin noticing side effects. Hydration is important throughout but especially as your body adjusts to burning fat early on)

Month 3: 3mg or 4mg depending on how your step to 2mg was and what your weight loss looks like and desired pace. (I prefer slower as I'm in no rush. I'd prefer to minimize potential risk for side effects and having a general bad time. I like having head room to build to in terms of dosage rather than maxing out at the effective range and having nowhere else to go before reaching goals. I'm also all about the lowest effective dose if things I take more than the instant gratification side of things that others seem to prefer)

....carry on like this on a personalized path that follows a similar guideline but allows for small variances based on the individual. The 1-month between titration changes gives the dose time to reach a static level within the body as it's processing it during the ramp up and needs to stabilize a bit. I saw a good video that described it as a bathtub you're filling with an open drain. Use too little and it all goes out before your body uses it. It takes time though to see what each "fill rate" does.

Some people titrate up month-by-month all the way to 12mg (seems to be the max effective dose before side effects become almost a certainty) and others find a happy spot at less than half of that. It seems that most titrate up to the 8mg "sweet spot" for best results. It's all individualistic as different people react differently. People also have different goals. I started w/needing to lose ~75lbs where as others are trying to cut the last few % of BF for a competition. Obviously their data has less weight for my personal research.

Once target weight is reached, find a maintenance dose that works based on individual goals. Some quit completely for sustained periods. Others prefer to stay on a small amount consistently. I'll probably fall into this latter category as I would like to keep the neuroprotective and anti-inflammatory benefits.

It's nice to have the clinical human studies to refer to for most likely/common outcomes across a broad range of variables but we should really take advantage of being our own guides on this path to customize it for what works best for us individually.
 
GLP-1 makes it much easier for us to lose weight, but it is not a magic pill that will do the work for us. We lose weight thanks to a calorie deficit. Observing this and similar forums, it is clear that people who also do strength training lose weight the fastest. In addition, strength training is also recommended so as not to lose muscle mass. So it is worth adding at least one strength training session per week and seeing what the results will be. It is also important to ensure that your diet contains the right amount of protein.

I find it interesting that people who do endurance training, such as running, do not tend to share their results.
 
Coktail said:
Dear Forum Members,
Hello Everyone,

my first injections were administered as follows:

Week 1 - 1 mg (my weight 110 kg)

Week 2 - 1 mg

Week 3 - 1.5 mg

Week 4 - 1.5 mg (100 kg)

Week 5 - 2 mg

Week 6 - 2 mg (97.65 kg)

Week 7 - 2.5 mg (97.50 kg)

Week 8 - 2.5 mg (97.30 kg)

Week 9 - 2.5 mg (96.30 kg)


As you can see, I lost 10 kg in 4 weeks. During this time, I also changed my diet. No sugar, no bread, no sweets, no alcohol, and no juices. My portion sizes also became smaller.

Last 4 weeks i stay on 2.5 mg weekly and nearly dont lost any kg's

My question to the experienced Members is; Should i go higher dose? What is your recommandations?

I thought i can use 2.5mg all the time.
Thank you in advance

Best Regards
Click to expand...
Your body/ brain could just be adjusting, and will pick up weight loss again.
You did loose a lot of weight in a short amount of time.
2,5 is a bit low after 9 weeks and minimal loss over 4 weeks, I would go up.
Could be from 2 to 4 to 6 to 8.
You could read up on trials dosing.
You don't mention exercise, cardio and resitstance training ? It's quite important.
 
I'm on a similar timeline with similar weight loss. Though I've hit zero plateau's and on 1mg every 3days. My daily deficit is 600-1000 (based on weekly weight loss average) . Its a little too linear for me currently but it should start to level out as I get closer to my goal weight plus the holidays in the states mean my calorie intake will probably be closer to maintenance at least for a few days.

All that said I would highly encourage you to really track daily calories. Not necessarily to hit a certain number but to build the habit of tracking. Which should really make your weight loss journey easier.

Because your calorie intake should really be in your post. Just dose and weight isnt' the whole picture.
 
My experience with weight loss always seems the same. There’s a ton of weight at first, then plateau for a bit, then lose a ton more weight, lather rinse repeat. I wish it was more like a steady one to 2 pounds a week but it’s more like nothing and then four or 5 pounds overnight. I don’t know if this is normal. if I were in your shoes I would probably titrate up. Personally, I started at 4 mg per week and just titrate up to 8 mg per week. I haven’t lost nearly as much as you this is week five
 
If titrating up doesn't work very well, tirz may offer more suppression.
 
Hello Mate,

i just want a give an update on my Reta journey. Last weeks i do not lost any kg's.
May i dose wrong? Any recommondations please?

22.09.2025 - 1 mg 110 kg
29.09.2025 - 1 mg
06.10.2025 - 1,5 mg
13.10.2025 - 1,5 mg 100 kg
20.10.2025 - 2 mg
27.10.2025 - 2 mg 97 kg
03.11.2025 - 2,5 mg 97,65 kg
10.11.2025 - 2,5 mg 96,60 kg
17.11.2025 - 2,5 mg 96,90 kg
24.11.2025 - 3 mg 95,75 kg
01.12.2025 - 3 mg 93,5 kg
08.12.2025 - 3 mg 93 kg
15.12.2025 - 3 mg 92,5 kg
22.12.2025 - 3.5 mg 92,5 kg
29.12.2025 - 3.5 mg 91,5 kg
05.01.2026 - 3.5 mg 91.4 kg
12.01.2026 - 3.5 mg 91.5 kg
19.01.2026 - 4 mg 91.5 kg
26.01.2026 - 4 mg 90.05 kg
02.02.2026 - 3.5 mg 89,50 kg
09.02.2026 - 3.5 mg 88.90 kg
16.02.2026 - 3.5 mg 87.90 kg
23.02.2026 - 4 mg 88.10 kg
02.03.2026 - 5 mg 87.20 kg
09.03.2026 - 4 mg 87.10 kg
16.03.2026 - 4 mg 88 kg
23.03.2026 - 4.5 mg 87 kg
30.03.2026 - 4.5 mg 87 kg
06.04.2026 - 5 mg 87 kg

Thank you in advance
Best Reagrds
 
Thank you for the update. So many people post about stalls or other problems, but you don't get to see what happens after some time.
 
I think to understand what is going on I would need to know general health, age and height and some idea of physique? If very well muscled it changes the equation a lot, and what weight you are targeting?
According to what I see, you started at 110kg and weight loss has slowed right down over the past month, but with total losses of 23kg over 7 months or so, which is quite a lot , about 20% and above the average weight loss for that dose of reta. The lack of recent progress could just be fluid balance changes, looking at a graph of the changes would be useful but it looks like it gradually slowed down, rather than suddenly stopped. So it is probably a genuine plateau for you for that dose of reta. Do you know how many calories a day you are eating? has it changed? how hungry are you? are you exercising? The loss of 23kg is enough to drop energy expenditure quite a bit more from having less fat and lean tissue using up calories, than from long term metabolic adaptation to low calorie input at this stage. So the same number of calories in will be less of a deficit than it was at the start.
Given you are asking the question, I assume you still want to lose more weight. Do you have side effects? Why did you increase to 5mg then back to 4mg then back to 5mg?
Assuming side effects are not a problem and you would prefer to lose more weight , you need to increase the dose, there are no good reasons not to, unless side effects are an issue, and higher doses are more effective at losing more weight than lower doses. I would guess that at the moment the dose you are on is enough to keep your weight down by 23kg , but not enough to drop it further. In the long term in terms of health keeping that 23kg from getting put back on is more important than anything else, and a reason to stay on reta to maintain the weight loss.
 
He seems to bounce around a bunch on the injection amounts. I'm not sure on the effect of that logic.
 
lessthanhalf said:
I think to understand what is going on I would need to know general health, age and height and some idea of physique? If very well muscled it changes the equation a lot, and what weight you are targeting?
According to what I see, you started at 110kg and weight loss has slowed right down over the past month, but with total losses of 23kg over 7 months or so, which is quite a lot , about 20% and above the average weight loss for that dose of reta. The lack of recent progress could just be fluid balance changes, looking at a graph of the changes would be useful but it looks like it gradually slowed down, rather than suddenly stopped. So it is probably a genuine plateau for you for that dose of reta. Do you know how many calories a day you are eating? has it changed? how hungry are you? are you exercising? The loss of 23kg is enough to drop energy expenditure quite a bit more from having less fat and lean tissue using up calories, than from long term metabolic adaptation to low calorie input at this stage. So the same number of calories in will be less of a deficit than it was at the start.
Given you are asking the question, I assume you still want to lose more weight. Do you have side effects? Why did you increase to 5mg then back to 4mg then back to 5mg?
Assuming side effects are not a problem and you would prefer to lose more weight , you need to increase the dose, there are no good reasons not to, unless side effects are an issue, and higher doses are more effective at losing more weight than lower doses. I would guess that at the moment the dose you are on is enough to keep your weight down by 23kg , but not enough to drop it further. In the long term in terms of health keeping that 23kg from getting put back on is more important than anything else, and a reason to stay on reta to maintain the weight loss.
Click to expand...
Hello,

thank you for your reply. I am 54 years old, my hight is 178 cm. No muscles, not doing gym.
I am targeting 76 kgs. I not just use Reta i also changed my diet, no alcohol, no sugar, no bread and so on. I really dont count the calories but eat twice a day.

i increase to 5 mg then back to 4 mg because when i inject 5mg i got low blood preasure and dizzy. Also have skin pain.(like a sunburn)
I inject reta every monday and sundays i got more hungry.

Regards
 
It does sound like you cannot easily increase the dose of reta due to side effects. It might be worth trying a smaller dose like 2.5mg twice a week and see if that helps with the skin pain and getting hungry before the next dose is due, and then trying to increase doses a tiny bit at a time, like 0.5mg twice a week to see if it causes problems. I am limited on doses for the same reason, except thankfully this happens for me at 15mg of tirz plus 5mg of reta. The skin sensitivity problem often does get better over time so you might find you can increase doses a bit after a month or 2.
Start BMI is 34.7 , currently 27.5 lost 21% of start weight. At 54 that degree of obesity is definitely a health issue, but you have actually mostly fixed that already, and realistically that is the most important part in terms of reducing chances of diabetes, heart attacks and strokes etc. Though getting blood sugars, blood pressure and lipids checked is still important.

I think combinations of GLP drugs can be justified in severe obesity bmi 40+ where the health risks are so high that any risk from experimental combinations is unlikely to be that bad, but you are not that obese, so it is not so clear, and you are only on a low dose of reta.

In my experience the skin sensitivity gets worse from tiny increases in dose of either reta or tirz, so adding tirz is fairly likely to do the same for you. You could try low dose cagri to see if it agrees with you, like start at 0.25mg a week, and very slowly increase, as it works on different receptors it should not cause skin issues, but can cause nausea, but unlikely to be a big issue at very low doses. Quite a few people have used low dose cagri with tirz or reta to lose large amounts of weight. The alternative is swapping to tirz instead , it can cause skin sensitivity as well, but does not seem to happen as often with it as with reta, so you might be able to tolerate higher doses of tirz , which might be more effective, but there is no way to predict how likely this is to be better than the reta you are on now.
 
Coktail said:
Hello,

thank you for your reply. I am 54 years old, my hight is 178 cm. No muscles, not doing gym.
I am targeting 76 kgs. I not just use Reta i also changed my diet, no alcohol, no sugar, no bread and so on. I really dont count the calories but eat twice a day.

i increase to 5 mg then back to 4 mg because when i inject 5mg i got low blood preasure and dizzy. Also have skin pain.(like a sunburn)
I inject reta every monday and sundays i got more hungry.

Regards
Click to expand...
I'll second lessthanhalf's advice! Splitting the dose may really help your sides. When I was on Reta, I started getting allodynia (the burning skin feeling) around 5mg, and I had to stabilize for a few weeks for it to mostly go away. It really helped to go 2.5mg x 2/week. If you use one of the blood concentration plotters (like bellow in this footer), you'll see that the peak blood level is lower, but the minimum is actually higher! So you'll minimize the side effects while keeping the hunger suppression.

The only reason not to do this is that there are some reports that higher peak levels are what make the glucagon (fat burning) agonist really work. So 1/week may get you better weight loss, if your side effects moderate.
 
So only 3 weeks at 2.5mg. I would give it a couple more weeks as the half life is 7 days. You might be a slow responder.

If you don't lose weight in a few weeks, I'd go to 4mg for a month. See if you have side effects.

Be patient, you'll find your number. Trust your scale. Not your feelings.
 
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