70 weeks ago started tirz, 6months later, stacked Cagri (started very low), Added Reta low doses a few months later. Yes, triple stack. After 6 months on Cagri I stopped as I was getting to nauseous. Titrated Reta up slowly as I noticed glp1 take a few weeks to take effect. I stay on same dosage for one month before making a change or titrating up. Take your time. Otherwise, is hard to see which is working if changing too quicky. For Cagri, I recon'ed with AA 0.6%. Then added about 25% bac to get to pH 4-5. AA 0.6% does not sting. For me, Cagri provided 100% appetite suppression, even on low doses. In early days, I was loosing 2# a week. Now is just below 1# a week. Drink plenty of fluids and extra fibers (gummies). I weight myself each day and log everything I pin.