Recent content by hexagonal

Minimal to no solid science behind their claims. We just have basically no studies supporting most of what they say this stuff does. We'll see mechanistic studies in animals held up as a reason (but look at how that turned out for AOD), some reported anecdotes, etc., but most of the effects they...

Family members and friends are notorious for blaming random shit that happened temporally close to the death for what happened even when there is no specific reason to believe it was the case. Is it possible it is related? Sure. Do we have any specific evidence here that it was? Nope. But if...

Jano has tested freezing tirz and it was largely fine. Other peptides have seen significant impact. I don't know if reta has been tested, but without having specific knowledge, I'd personally opt to not freeze it.

Realistically, we have nothing but anecdotal reports on what happens with stacking. We don't know the long term impact and risks, if any. Other glucagon agonist drugs (NN1177) have failed trials due to safety concerns - it's possible the ratio is important to keeping them safe. I personally am...

Thanks for the testing. There's some discussion over on meso that TB frag might be more desirable for most use cases than the full peptide, with the argument being that the fragment is responsible for the benefits we are after, so mg per mg we get more of the useful stuff with frag than we...

I know someone using iamhrt for it. Think there are some subreddits dedicated to female trt that probably know a lot more than I do. SteroidSourceTalk and MesoRX both have some sources that sell lower concentration injectables for women. Lots more to juggle with this side of things, though -...

No one likes being proved wrong :). And I'm just some asshole on the internet - I might not be right! I will say honestly my intention is not to dump on people or win internet points - I just want to make sure we're all looking at all the best information we can so that we have the best chance...

I think this is actually a really important point. Doing any amount of regular exercise - even if it's just half an hour a week - when you were previously doing none? That's an improvement. It will make you healthier. Waiting on a perfect program and doing nothing is just a recipe for staying...

Tirz made it impossible for me to eat enough food to hit my macros - it 100% would have prevented the behavior described. Reta, if I want to eat, I can eat. It doesn't do a whole lot for my physical hunger, either - but that's not what has gotten to me. I'd eat... just because. Think about...

The good news is, you're probably not missing out on anything, re: Machines! https://pubmed.ncbi.nlm.nih.gov/37582807/ Going to failure is still beneficial in that some studies have looked at how good we are at estimating how close to failure we are, and while the answer is "better than you...

None of us should be interested in podcast appearances and similar for anything more than entertainment value and to potentially point us towards things to learn about - we want actual science. People go on Huberman and say all sorts of nonsense all the time, same thing with Attia, etc. Random...

What biological mechanism do you believe happens with older women that causes them to stop responding to muscle growth stimulus the same way everyone else does at all stages of their life? We don't see other significant hormone changes resulting in different muscle growth stimulus being required...

When access to affordable, hyper-palatable, calorie dense food becomes widespread, people get fat. We see it time and time again as countries reach higher levels of wealth and there is greater access to global markets which has this food in abundance, obesity rates start to climb. There's a...

Which would be... not KLOW, which is what this thread is about. The blend in discussion contains these by definition.

We have good studies comparing men vs. women and they are pretty conclusive that women and men respond the same to training. Men make larger gains in absolute terms, but the relative improvement from baseline to finish is very similar. https://pmc.ncbi.nlm.nih.gov/articles/PMC11869894/...