GLP-1 Forum

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  1. TooBigtoFail

    stacking glp’s

    As I wrote before: Over a year ago, started Tirz, slowly up to 10mg/week. After 6 months of low energy, added Cagri, low doses, as Tirz effect was slowing down to 0.5# a week. Cagri made me nauseous but had 0 food noise. No energy boost. 3 months later, added Reta low dose (0.5, 1.0, 1.5mg) to...
  2. TooBigtoFail

    Average costing tirz ,years worth

    Please confirm you are not starting at 15mg/week? Starting dose is 2.5mg/week, for 4 weeks, etc.
  3. TooBigtoFail

    A pen is...

    I recently started using Pen's. When you pin different peps daily, you generate much medical waste. With the pen, is now minimal. I can put 5-10 doses in a cartridge. Do more poking the vial each day. I like the fact there is no air in the cartridge. Studies show 'dirty' air from the...
  4. TooBigtoFail

    Can Reconstituted Reta be Re-Aliqouted and Frozen

    Note: the 28 days is for a hospital environment with multi-users/patients, multi-use. I go to 60 days often with recon. My Compounding Pharma shipped Tirz recon with a Beyond use Date of one year later, with 0.9% benzyl. Go figure. There is a reason why labs use specialized equipment to...
  5. TooBigtoFail

    Tirz and insomnia

    I still sleep a full night (sometime 8-9hrs) , after one year of Tirz, and above max dose.
  6. TooBigtoFail

    Retatrutide Overdose

    If frickyeahbby is not trolling, I am glad he is ok, and find his feedback informative. A very good reminder. Impressive how much abuse the human body can take.
  7. TooBigtoFail

    Mazdutide & Survodutide - new GLP-1's

    The full report but I cannot find the "Check out the Investigational/Trial Medications folder."
  8. TooBigtoFail

    Cagri + reta

    Over a year ago, started Tirz, slowly up to 10mg/week. After 6 months of low energy, added Cagri, low doses, as Tirz effect was slowing down to 0.5# a week. Cagri made me nauseous but had 0 food noise. No energy boost. 3 months later, added Reta low dose (0.5, 1.0, 1.5mg) to test RHR. No issues...
  9. TooBigtoFail

    Question about stacking and syringes

    I spent hours searching for sterile 5 or 10ml vials: UV treated, EO, Steamed, and none inspired confidence, including Amazon. I use Under Ground as they also send them to a lab for analysis. You only need about 1ml of bac to recon, and transfer to the next vial. If you fill the vial to the...
  10. TooBigtoFail

    Question about stacking and syringes

    I use the same: Easy Touch 31-gauge, 1mL 8mm. I use the 0.5ml also as I find the plunger is easier to push in. My compounding Pharma started me on the 31G 8mm so I stayed with that. I find Tirz 'thicker' that other peps, and drawing the recon tend to generate micro bubbles in the syringe when...
  11. TooBigtoFail

    POSSIBLE SCAM Possibly scammed by HK impersonator

    Hopefully this will help the community learn.
  12. TooBigtoFail

    Where is everyone getting acetic acid?

    With AA at 0.6% concentration, I use 75% AA and 25% bac for reconstitution. Vinegar is not USP, not filtered for sediment, etc. If your vinegar is 6% AA, then maybe a few drops in 1ml of bac, test the pH, and then filter it. I googled and found many AA 0.6% suppliers. Carolina.com for lab...
  13. TooBigtoFail

    Why is it burning?

    Yes, possibly. You could filter it and had bac to it to stabilize it, stopping it from getting worst. UV? I do not remember any product you can add to kill bacteria, without destroying recon. Sterile water is for single use. Once opened, its starts to deteriorate quickly (bacteria count...
  14. TooBigtoFail

    Friend with extreme fatigue - advice

    I suggest a blood test first. Get a baseline on all the bad numbers and get a reality check. Read up on Sema, Tirz, and Reta literature to ensure he does not have a pre existing condition. Are Rybelsus tablets available as grey? I have switched to Pen's for the cost reduction, etc, etc. May be...
  15. TooBigtoFail

    A Question for Experienced Researchers

    Without your testing, Imagine the damage this could have caused to the folks downstream. Its bad enough the content between vials in the same kit, can vary by +/-10%, but this sloppiness is over the top. Name please. Thanks for sharing.
  16. TooBigtoFail

    Crap... 15mg Triz and hungry..

    Congrats and be patient. Protein drinks later in the day (60% of daily requirements in 11oz). Try Cagri with Tirz. For me, and many folks, it worked wonders, 0 appetite. Many smells became intolerable. Cagri is a dual amylin and a good companion to all GLP1. I would titrate up slowly, and...
  17. TooBigtoFail

    How It’s Un-Made

    congrats. You could drop 3+ lbs a week with your training.
  18. TooBigtoFail

    When is the right time & how to wean off Tirzepatide

    I found this study: https://www.epicresearch.org/articles/patients-with-higher-initial-bmis-and-greater-weight-loss-while-on-glp-1s-most-likely-to-maintain-or-continue-weight-loss-after-stopping-glp-1s You can read up on "epigenetic memory of fat cell", how your body will try to get back to...
  19. TooBigtoFail

    Facial Changes and Skin Conditions in Patients on GLP-1 Receptor Agonists

    imo, because my body's inflammation has gone down ( lower A1C, BP, cholesterol, etc), I am now giving my body energy to heal itself, to do what it does best. Like reducing psoriasis, etc. Eating Doritos, cheap chocolate, junk food with fillers and additives messes up your skin. You cut the...
  20. TooBigtoFail

    Hospira BAC Availability

    They have a new URL. Is posted on the old form.
  21. TooBigtoFail

    Hospira BAC Availability

    If you inject 2mg of Glow50/10/10 per day, 1 vial will last 25 days. 25 days later, you recon the next vial of glow. That's one Hospira bottle (if you only keep the used Hospira for 28 days as directed on the bottle). 10 vials = 5 Hospira. Now, as you are willing to buy bac from any source, and...
  22. TooBigtoFail

    Do you add a bit more tirz to account for any air bubbles and product left in the syringe?

    No. I use EasyTouch 1ml syringes for injections and never noticed any leftover. 3ml syringes yes, but they are only used to draw. I use a scale (+/- 1mg precision) with every vial and a quick test was inconclusive, as the difference between a new and used syringe, was within the margin of...
  23. TooBigtoFail

    Bac water vs bac saline

    Welcome. Bac saline is fine. The Eli Lilly Tirz vials/pens they ship use Saline Bac water. I use Hospira Saline Bac water with my Tirz and other peptides. It is cheaper, is isotonic, and is compatible with many/most peptides.
  24. TooBigtoFail

    Cagri (still) nothing, in fact the opposite ???

    ouch. After 6 months on Tirz, reaching 10mg/w, I began to stall (no loss for two weeks). Added Cagri 0.3mg/w and got 100% food noise suppression (and quite nauseous, and many smells became intolerable). Started to loose again. A few months later, stalling again and added Reta 1mg (Tirz/Cagri...
  25. TooBigtoFail

    RHR and Retatrutide

    On Tirz. Been stacking Reta for 6 months, 1.75mg. Started low due to RHR posting/noise. On 2.5mg for past month, no change to heart rate that I could measure. Always mid 70's.
  26. TooBigtoFail

    SLU-PP-332 - This made me chuckle

    Did try SLU a month ago, for one week. Gained two lbs. Made me edgy, like caffeine. 1/2mg, twice a day, sublingual. Will try again soon. Trying to only run one pep cycle at a time.
  27. TooBigtoFail

    What’s The Difference

    My issues are at best anecdotal. Am told, just part of getting old. But if they are related, is it contamination or glp1? That is why am using Nex for now, based on their Telegram chats.
  28. TooBigtoFail

    Can we talk about retatrutide?

    Get familiar with Janoshik lab reports. You want 99%+ purity. I buy from US warehouse to avoid CBP hassles and delays. When you did recon, was bac, syringes, etc supplied to you? Do you know the longevity of USP bac water? You recon'd one vial at a time, single dose, single use, no...
  29. TooBigtoFail

    Cagrillintide questions

    I started at 0.13mg a week, six months ago. For peps, I often start with only a 10% dose to test my tolerance. The appetite suppression started within a few days. Even at 0.13mg, I felt quite nauseous for a few weeks, less later on, but still present. I stopped 3 weeks ago (was at 0.9mg a...
  30. TooBigtoFail

    What’s The Difference

    After the fall of QSC and Tuk last year, I started to doubt the quality of my stash. I cannot exactly match each kit to their COA. With my US supplier, each box has a batch number, easily matched to a COA, and a strong community around the name. I buy pre orders, and large doses. So far, so...
  31. TooBigtoFail

    Reuters: FDA to screen all imports, exemptions for low-value shipments revoked

    I watched TV show two nights ago "Contraband: Seized at the airport", a 2025 episode. Because they had a bunch of small boxes of same sizes, and a few other queues that made it suspicious, they opened some boxes. Saw labels with BT10, CU50, etc, in 2 part plastic trays for peptides. "research...
  32. TooBigtoFail

    Orange top cagri from Tracy?

    Yes, was Jano #52244. Same YSD-55 055C-S5MG code on my box. Orange cap. Made me nauseous early on. Now, not as much. Never sent for testing to confirm it was Cagri.
  33. TooBigtoFail

    Split Dose with Zep Vials

    To split dosage effectively, try this site https://glp1plotter.com/. Figure out the peak residual for a 7 days cycle, then find the matching peak for 3/4/5 days. Search the forum and scientific studies on Bac for pro/cons on longevity, and pep degradation over long time periods. Keep the vial...
  34. TooBigtoFail

    Dry eyes on Tirzepatide

    I was told I was getting old, and using my computer screen too much. Most of my doctors have no clue about Sema/Tirz side effects. Could not scientifically blame Tirz for dry eyes. Read up on Regenex/RGN-259 (TB4). I am doing Glow protocol. Either TB4 is helping or my body has adapted to...
  35. TooBigtoFail

    Needle size?

    Did bleed in the beginning. Was pinning at 45 degree angle, in areas with low fat, pinching the skin too hard. I now use love handles/fatty areas, 90 degree pin, and gently grab the skin to pin. I avoid the belly. Do not poke too many stoppers/vials before you pin the skin. The needle gets...
  36. TooBigtoFail

    Sterilizing injection pen cartridges

    I will be trying out injection pens soon. I will not be fiddling with home sterilization of cartridges: Non sterile water, non sterile pressure cooker, etc. I would make it worst, IMO. Am I missing something? I see EO processed vials are cheap and available. If I doubt the EO processed, I...
  37. TooBigtoFail

    Peptide shelf life

    When I recon a vial, and is not under a good vacuum, it goes to the garbage. Some vials are better sealed than others, sure, but I cannot predict the future performance of those stoppers, either at -20f or 38f. Is it the cheap plastic stopper or poorly built assembly line, I will never know...
  38. TooBigtoFail

    Who is currently or was previously above a 15mg dose?

    Great feedback. Any updates? Am on tirz 8.3mg@3 days (= 16mg/week). Plan is to increase 1 mg a month, re-evaluate at 20mg, if is still loosing go to 25mg a week. I need to loose another 30-35 lbs, and clear up 585mg of tirz. Then plan to maintain on Reta for one year. Glad others have tried...
  39. TooBigtoFail

    Tirz to Reta - feedback pls

    Congrats on the 80 lbs in 6 months. Reta half life is 6 days. When I stalled 6 months ago, I added a bit of Cagri, and a few months later, 1.5mg of Reta. Even at the low dosage, I felt nauseous the first few weeks for each. To minimize the stomach issues, I do TZ 8.7mg@3 days, and 70 lbs...
  40. TooBigtoFail

    Do try this at home!

    Congrats. What an achievement.
  41. TooBigtoFail

    Alternative to HOSPIRA Bac

    Ask yourself: my is it so much cheaper? Because is not USP (Not certified for human injection). I used to by from Amazon 3ml 'research' bac for $3 (sold in pack of 10 for $30). Was trying to minimize waste. Never had an issue but switched to Hospira, a true 'Bacteriostatic' water. Lucky me, I...
  42. TooBigtoFail

    Is this safe?

    Any B12 in your mix? Do you have a baseline source? something to compare with? Except for ghk, all my pucks are near snow white in color. All my lyophilized vials are under vacuum and when I add bac, the vial sucks the water from the syringe, often without pressing the plunger. When under...
  43. TooBigtoFail

    How dangerous could reta be worst case scenario

    We cannot do all the research for you. ;) And most are not doctors..... Should read up on the published studies, like SURMOUNT by EL, and the number of test subjects. They explain side effects, and their severity. Suggest you compile your list of concerns, and ask members. A racing heart...
  44. TooBigtoFail

    GHK-CU

    1.5mg per day.
  45. TooBigtoFail

    GHK-CU

    Not me. I am near the end of my 3rd 50mg vial of Glow in past 6 months. Lost 70 lbs, and still going, but the belly wrinkles are not getting worst. Hands also less wrinkled. Body's natural recovery? Good hydration? Not scientific at all. My dermatologist said that I will need surgery/tummy...
  46. TooBigtoFail

    Anyone have this reaction before ?

    Sorry, was not about the paper calculation, but how do you draw exactly 6.25u on a syringe? Just to clarify, are saying .0625 ml / 0.0625cc? I use similar (thinner) Easy Touch 31G 1cc(1ml) 5/8", and would be hard press to see the difference between 6 or 7u unless I use a magnifying glass. And...
  47. TooBigtoFail

    Anyone have this reaction before ?

    For tirz, my doses are always with 45u-50u of bac, just like Eli Lilly use (yes, half of the syringe). I don't see how you can be using a precision of 6.25u? Tell me more about the syringe? a 0.3cc? I barely can see the difference between 45u and 46u on my 1cc syringe. And yes, inject 10-20u of...
  48. TooBigtoFail

    Research Grade Cagrilintide !

    Fibril stories are based on old studies derived from pramlintide. Cagri is a modified version (read N14E and V17R mutations, etc) to mitigate that concern and, other improvements (C-20) to provide a long-acting version so you pin only once a week. I am not a medical professional, but I read...
  49. TooBigtoFail

    What size vial for Reta is best, taking 5mg weekly

    I try to recon to have enough for 6 weeks, and at max 8 weeks. At some point, you will titrate up to 8, possibly 12mg per week. Keep that is mind.
  50. TooBigtoFail

    Pinning every 5 and 6 days.

    Based on studies, as time goes on, Tirz (glp1) becomes less effective, and the weekly loss diminishes a lot. Is almost a waste of time (and money) after 50-60 weeks. I am down 70lbs in 48 weeks. From 5mg on, I titrate up just over 1 mg a month, trying to drop at least one pound a week. A...
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