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  1. TooBigtoFail

    Do you add a bit more tirz to account for any air bubbles and product left in the syringe?

    No. I use EasyTouch 1ml syringes for injections and never noticed any leftover. 3ml syringes yes, but they are only used to draw. I use a scale (+/- 1mg precision) with every vial and a quick test was inconclusive, as the difference between a new and used syringe, was within the margin of...
  2. TooBigtoFail

    Bac water vs bac saline

    Welcome. Bac saline is fine. The Eli Lilly Tirz vials/pens they ship use Saline Bac water. I use Hospira Saline Bac water with my Tirz and other peptides. It is cheaper, is isotonic, and is compatible with many/most peptides.
  3. TooBigtoFail

    Cagri (still) nothing, in fact the opposite ???

    ouch. After 6 months on Tirz, reaching 10mg/w, I began to stall (no loss for two weeks). Added Cagri 0.3mg/w and got 100% food noise suppression (and quite nauseous, and many smells became intolerable). Started to loose again. A few months later, stalling again and added Reta 1mg (Tirz/Cagri...
  4. TooBigtoFail

    Greetings

    Welcome to the forum.
  5. TooBigtoFail

    RHR and Retatrutide

    On Tirz. Been stacking Reta for 6 months, 1.75mg. Started low due to RHR posting/noise. On 2.5mg for past month, no change to heart rate that I could measure. Always mid 70's.
  6. TooBigtoFail

    SLU-PP-332 - This made me chuckle

    Did try SLU a month ago, for one week. Gained two lbs. Made me edgy, like caffeine. 1/2mg, twice a day, sublingual. Will try again soon. Trying to only run one pep cycle at a time.
  7. TooBigtoFail

    What’s The Difference

    My issues are at best anecdotal. Am told, just part of getting old. But if they are related, is it contamination or glp1? That is why am using Nex for now, based on their Telegram chats.
  8. TooBigtoFail

    Can we talk about retatrutide?

    Get familiar with Janoshik lab reports. You want 99%+ purity. I buy from US warehouse to avoid CBP hassles and delays. When you did recon, was bac, syringes, etc supplied to you? Do you know the longevity of USP bac water? You recon'd one vial at a time, single dose, single use, no...
  9. TooBigtoFail

    Beat up 53 year old checking in.

    Was riding dirt bikes/motocross when young. Body felt old by the time I reached 35. I am nowhere near as damaged as you are describing. Ouch! After one year on glp1, I am down 70 lbs. Been cycling Glow, on/off. And cycling TA1/Epitalon. Is very hard to determine what has been most effective...
  10. TooBigtoFail

    Cagrillintide questions

    I started at 0.13mg a week, six months ago. For peps, I often start with only a 10% dose to test my tolerance. The appetite suppression started within a few days. Even at 0.13mg, I felt quite nauseous for a few weeks, less later on, but still present. I stopped 3 weeks ago (was at 0.9mg a...
  11. TooBigtoFail

    What’s The Difference

    After the fall of QSC and Tuk last year, I started to doubt the quality of my stash. I cannot exactly match each kit to their COA. With my US supplier, each box has a batch number, easily matched to a COA, and a strong community around the name. I buy pre orders, and large doses. So far, so...
  12. TooBigtoFail

    2nd Attempt, From South Florida

    Welcome and congrat. Looks like you are on Reta. What dosage? No stall yet? 24 lbs in 6 months is good. Some members report dropping 2+ lbs a week at the beginning on reta. Sema/tirz, a bit less. Patience.
  13. TooBigtoFail

    Reuters: FDA to screen all imports, exemptions for low-value shipments revoked

    I watched TV show two nights ago "Contraband: Seized at the airport", a 2025 episode. Because they had a bunch of small boxes of same sizes, and a few other queues that made it suspicious, they opened some boxes. Saw labels with BT10, CU50, etc, in 2 part plastic trays for peptides. "research...
  14. TooBigtoFail

    Orange top cagri from Tracy?

    Yes, was Jano #52244. Same YSD-55 055C-S5MG code on my box. Orange cap. Made me nauseous early on. Now, not as much. Never sent for testing to confirm it was Cagri.
  15. TooBigtoFail

    Split Dose with Zep Vials

    To split dosage effectively, try this site https://glp1plotter.com/. Figure out the peak residual for a 7 days cycle, then find the matching peak for 3/4/5 days. Search the forum and scientific studies on Bac for pro/cons on longevity, and pep degradation over long time periods. Keep the vial...
  16. TooBigtoFail

    Dry eyes on Tirzepatide

    I was told I was getting old, and using my computer screen too much. Most of my doctors have no clue about Sema/Tirz side effects. Could not scientifically blame Tirz for dry eyes. Read up on Regenex/RGN-259 (TB4). I am doing Glow protocol. Either TB4 is helping or my body has adapted to...
  17. TooBigtoFail

    Needle size?

    Did bleed in the beginning. Was pinning at 45 degree angle, in areas with low fat, pinching the skin too hard. I now use love handles/fatty areas, 90 degree pin, and gently grab the skin to pin. I avoid the belly. Do not poke too many stoppers/vials before you pin the skin. The needle gets...
  18. TooBigtoFail

    Just a guy with food noise

    Welcome. Not sure how to get you less nervous pre injection. Fear of needles? of feeling sick? I was prescribed Ondansetron 4mg at the beginning of Tirz. for nausea. Did not have to use it but came close many times. I prefer Tums (and I get my calcium). I know someone who throws up for 24hrs...
  19. TooBigtoFail

    Sterilizing injection pen cartridges

    I will be trying out injection pens soon. I will not be fiddling with home sterilization of cartridges: Non sterile water, non sterile pressure cooker, etc. I would make it worst, IMO. Am I missing something? I see EO processed vials are cheap and available. If I doubt the EO processed, I...
  20. TooBigtoFail

    Peptide shelf life

    When I recon a vial, and is not under a good vacuum, it goes to the garbage. Some vials are better sealed than others, sure, but I cannot predict the future performance of those stoppers, either at -20f or 38f. Is it the cheap plastic stopper or poorly built assembly line, I will never know...
  21. TooBigtoFail

    Who is currently or was previously above a 15mg dose?

    Great feedback. Any updates? Am on tirz 8.3mg@3 days (= 16mg/week). Plan is to increase 1 mg a month, re-evaluate at 20mg, if is still loosing go to 25mg a week. I need to loose another 30-35 lbs, and clear up 585mg of tirz. Then plan to maintain on Reta for one year. Glad others have tried...
  22. TooBigtoFail

    Tirz to Reta - feedback pls

    Congrats on the 80 lbs in 6 months. Reta half life is 6 days. When I stalled 6 months ago, I added a bit of Cagri, and a few months later, 1.5mg of Reta. Even at the low dosage, I felt nauseous the first few weeks for each. To minimize the stomach issues, I do TZ 8.7mg@3 days, and 70 lbs...
  23. TooBigtoFail

    Do try this at home!

    Congrats. What an achievement.
  24. TooBigtoFail

    Alternative to HOSPIRA Bac

    Ask yourself: my is it so much cheaper? Because is not USP (Not certified for human injection). I used to by from Amazon 3ml 'research' bac for $3 (sold in pack of 10 for $30). Was trying to minimize waste. Never had an issue but switched to Hospira, a true 'Bacteriostatic' water. Lucky me, I...
  25. TooBigtoFail

    Is this safe?

    Any B12 in your mix? Do you have a baseline source? something to compare with? Except for ghk, all my pucks are near snow white in color. All my lyophilized vials are under vacuum and when I add bac, the vial sucks the water from the syringe, often without pressing the plunger. When under...
  26. TooBigtoFail

    How dangerous could reta be worst case scenario

    We cannot do all the research for you. ;) And most are not doctors..... Should read up on the published studies, like SURMOUNT by EL, and the number of test subjects. They explain side effects, and their severity. Suggest you compile your list of concerns, and ask members. A racing heart...
  27. TooBigtoFail

    GHK-CU

    1.5mg per day.
  28. TooBigtoFail

    GHK-CU

    Not me. I am near the end of my 3rd 50mg vial of Glow in past 6 months. Lost 70 lbs, and still going, but the belly wrinkles are not getting worst. Hands also less wrinkled. Body's natural recovery? Good hydration? Not scientific at all. My dermatologist said that I will need surgery/tummy...
  29. TooBigtoFail

    Anyone have this reaction before ?

    Sorry, was not about the paper calculation, but how do you draw exactly 6.25u on a syringe? Just to clarify, are saying .0625 ml / 0.0625cc? I use similar (thinner) Easy Touch 31G 1cc(1ml) 5/8", and would be hard press to see the difference between 6 or 7u unless I use a magnifying glass. And...
  30. TooBigtoFail

    Anyone have this reaction before ?

    For tirz, my doses are always with 45u-50u of bac, just like Eli Lilly use (yes, half of the syringe). I don't see how you can be using a precision of 6.25u? Tell me more about the syringe? a 0.3cc? I barely can see the difference between 45u and 46u on my 1cc syringe. And yes, inject 10-20u of...
  31. TooBigtoFail

    Research Grade Cagrilintide !

    Fibril stories are based on old studies derived from pramlintide. Cagri is a modified version (read N14E and V17R mutations, etc) to mitigate that concern and, other improvements (C-20) to provide a long-acting version so you pin only once a week. I am not a medical professional, but I read...
  32. TooBigtoFail

    What size vial for Reta is best, taking 5mg weekly

    I try to recon to have enough for 6 weeks, and at max 8 weeks. At some point, you will titrate up to 8, possibly 12mg per week. Keep that is mind.
  33. TooBigtoFail

    Pinning every 5 and 6 days.

    Based on studies, as time goes on, Tirz (glp1) becomes less effective, and the weekly loss diminishes a lot. Is almost a waste of time (and money) after 50-60 weeks. I am down 70lbs in 48 weeks. From 5mg on, I titrate up just over 1 mg a month, trying to drop at least one pound a week. A...
  34. TooBigtoFail

    Blood Sugar Checks?

    Never had glucose issues. I do CMP every 4-6 months. Was worried about hypoglycemia or coma, but no wild swings detected. I do titrate up very slowly.
  35. TooBigtoFail

    Storage Case

    Amazon, Essential oil carrying case, for 3ml vials. Are held firmly in. Cheap, simple, and in multiple shape and sizes.
  36. TooBigtoFail

    Airport Security Peptide

    You have the wrong state of mind. You are already making yourself guilty, and they can spot that. I recon 1 vial and put it with my checked bag, with my personal items, along my perfume bottles and other liquids (eye drops, etc). I put syringes, alcohol, etc in a separate small wrap in the...
  37. TooBigtoFail

    Pinning every 5 and 6 days.

    When you change dosage, the effect can take 1-2+weeks. Try this calculator : https://glp1plotter.com/ to help adjust dosage based on number of days. I am doing 8.5mg every 3.5 days. Read up on half-life. Worth it.
  38. TooBigtoFail

    High-Dose Tirz Weight Loss

    Congrats. Impressive. I am at 22mg peak on Tirz, so this will help me push towards a peak of 28mg. And for 8 months, wow. Are you doing occasional blood tests? Any out of range results due to higher dosage?
  39. TooBigtoFail

    My Cagri Chronicle: ongoing updates on progress with cag starting October 2024

    details? dosage, how often, for how long? any other pinning/stacking? For me, 0.8mg Cagri, once a week(5+months), with Tirz (1 year) at max dose, works very well: from zero food noise to just a bit. Not everyone react the same.
  40. TooBigtoFail

    Peptide interaction chart

    Watch out if a vial has a strong vacuum. It wants to pull in the content of the syringe. I suspect the limit is based on the amount of liquid you are willing to inject at once.
  41. TooBigtoFail

    Reta from one supplier (but not others) burning when injected.

    Try more bac. For most peps, I use 25-40u.Tirz 45u. For me, only Ghk-cu stings. Reta does not stink but am only at 1.5mg doses. When you added Bac to the 'bad' vial, was the water sucked in without pressing the syringe? That would indicate vacuum (no air) and a good sign. I always expect my...
  42. TooBigtoFail

    Tirz Freezing/Defrosting

    For Tirz, is your call: to freeze or not to freeze. Like many, I have a lot of vials of various peps and I have a good freezer where the temp is -8F (-22c), +/- 2 degrees (my Blink camera inside says so). I freeze all my lyophilized peps. According to studies and Jano, refrigeration is...
  43. TooBigtoFail

    Tirz Freezing/Defrosting

    Recommended to not refreeze due to risk of breaking the seal and allowing air/moisture in. Should be fine in frigo for 6+ months if lyophilized (Studies are all over the place on this). I would not travel by air with an ice pack of any sort or a vial with 'white powder'. I travel with...
  44. TooBigtoFail

    Bacteriostatic Solution Sodium Chloride

    Nacl is to make the solution more isotonic. From the Tirz patent: It is further desirable to match the tonicity (i.e., osmolality) of body fluids at the injection site as closely as possible when administering the compositions because solutions that are not approximately isotonic with body...
  45. TooBigtoFail

    Hospira BAC Availability

    Yes. First time. Used 25ml out of one bottle this month. Found no noticeable difference, maybe injection sites are less visible (or my skin is getting used to the pinning). Experimenting as Lilly does have Nacl in their pens (isotonic).
  46. TooBigtoFail

    Has this happened to anyone else?

    Great subject. Yes did happen. Painful learning. I recap, place in old milk jug, and then trash. I will evaluate the single hand scoop or direct trash to avoid recap. This should be on cheat sheet for newbies.
  47. TooBigtoFail

    New to Reta – Waiting on OAC, Anyone Pinned Nexaph Already?

    I have used Nexa 12mg Reta. No issues to report. Having stacked Tirz, Cagri and Reta, if food noise is annoying you, add Cagri. Low doses can reduce the food craving or completely stop you from eating altogether. Works wonder for me as I am at max dose for Tirz.
  48. TooBigtoFail

    BAC Water vs NaCl Water vs Benzyl Alcohol vs ??? :)

    I recently switched to Hospira Saline Bac with Benzyl (yes, the lime/green cap) as 'research'. I noticed that Novo and Lilly use an isotonic mixture for their glp1, which has Nacl. Why would they waste $$ adding saline? More resilient during transport? As they ship recon, maybe it helps shelf...
  49. TooBigtoFail

    Peptide interaction chart

    Anything new on this subject? Better chart? Combinations in one vial or draw from multiple vial into one syringe? I read that amino acids each have specific charges at their termini - the amino (N-terminal) and carboxyl (C-terminal) ends and mixing them will effect their 'therapeutic'...
  50. TooBigtoFail

    Which approach works for you?

    Welcome. It is good to be nervous. This is research. You will find the 'official' recommendations from Eli, Novo, Hospira, NIH and all their publications. A solid start. Then you will find folks with high risk tolerance and a passion for gambling. I keep one year supply of lyop. vials in a cube...
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