I'll trade you my 12.5mg vials for your 30's, then you won't have to feel bad, lol jk
Sema has a 5 day half life - that's why it wans at day 4/5. I'm honestly a bit shocked you are getting any help at all from .25mg!
I went 3 weeks on each dose and didn't notice any help at all until I hit 1mg.. then experienced what you are - about 4 days of help.
Don't be in a rush to increase your dose if it's working for you! If you are getting adequate help for 4 days on .25mg, I'd say try another .25 3-4 days out from first dose. Milk that low dose as long as you can! Then it will take longer to work up to the full dose and you'll hopefully reach your goal before you have to switch or add something else.
I don't think it ever lasted a full 7 days for me, I was always eating more and snacking on days 6-7.
15 months later I'm up to 3.5mg weekly with .75mg cagri 3 and 5 days after.
I've stalled twice... First time cagri broke my stall, second time I increased from 2.4 to 3mg, then to 3.5mg and that broke it.