Adding tirz on Reta

[DazDillinger]

Currently on 6mg Reta and everything going as planned. I’ve been up to 10.5 before no issues other than skin sensitivity. Rather than keep going up I wanted to try adding 2.5 tirz for the inflammatory benefits and appetite suppression. Was going to wait until I go on vacation so I don’t have to bring anything with me. How long does it take to feel the added suppression from tirz and do you think this is a good idea? Thanks!

 

[Sunflower80]

I've done the opposite. I added reta to my tirzepatide - which was always low dose for me (I never went higher than 5 mg on Tirz). I added 2.5 of reta - it helped me drop the last 10 lbs to my goal weight but I had a few low blood sugar episodes with the combo. (My lowest glucose reading was an alarming 45 md/dL with my average while on both was 75-85 mg/dL). Tirz purportedly shows appetite suppression within 12h of injection but my experience has been that it kicks in within 4h. You should also be aware that there's a greater chance of dehydration and subsequent blood pressure tanking with Tirz because it blunts your thirst as well as appetite.

 

[woundcarping]

When are you going on vacation?

Adding 2.5mg of Tirz will take ~24 hours to peak, but starting out the noise cancelling can take a couple-few days to start. It's not particularly fast acting, especially if you don't have a base level already established.

If you're going to start taking it chronically, why not start now?

Cagri could be more of a PRN style appetite suppressor, but it can still the better part of a day to flatten your appetite (no first hand experience).

 

[AxlBundy]

Adding Sema to Reta makes more sense, not interfering with the GIP receptor