Allodynia Hell

YoYoFat

YoYoFat

GLP-1 Specialist
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Oct 12, 2024
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Been on Tirz since August 2024. Maintenance since late May/early June 2025. Dosing 8mg/week, split into two doses (once every 3.5 days). Haven’t increased my dose since February. Last two doses I used an old vial of Skye I got last September (not wasting that $$$ stuff!). Before that, I was exclusively using Nexa in 2025 with literally zero issues.

Allodynia arrived last week. Started on my inner thigh, moved to my mid-quad, and how is on my outer hip.

It’s MADDENING.

What is causing this and how do I make it go away other than just stopping the Tirz altogether?

Filler in the Skye vial?

Vitamin deficiencies from long term GLP-1 use? Which ones?

How long does it last?

Help me not lose my mind!
 
I tackled it with hot shower, lots of thick lotion after shower and then roll on lidocaine OTC. Had to take Benadryl for bedtime too. I definitely had this more 2 years ago when I started. I started with Skye Tirz also. It eventually went away after @5-6 months. Also switched vendors around that time. Coincidence? Good luck
 
I’m on sema/cagri and mine comes and goes. If I’m working out and stretching it quiets down.

I’m just realizing that I had some long underwear on last week and that didn’t bother me. But regular pants do when they brush against my skin. Maybe now that it’s cooling off I’ll just wear long underwear until spring.
 
8mg isn't a normal dosage for tirz. I'm curious why you deviated. Not saying it's the cause, just curious why people don't follow EL's dosage guidelines

Was that vial's BUD past date? And how far past the date was it?
 
YoYoFat said:
Been on Tirz since August 2024. Maintenance since late May/early June 2025. Dosing 8mg/week, split into two doses (once every 3.5 days). Haven’t increased my dose since February. Last two doses I used an old vial of Skye I got last September (not wasting that $$$ stuff!). Before that, I was exclusively using Nexa in 2025 with literally zero issues.

Allodynia arrived last week. Started on my inner thigh, moved to my mid-quad, and how is on my outer hip.

It’s MADDENING.

What is causing this and how do I make it go away other than just stopping the Tirz altogether?

Filler in the Skye vial?

Vitamin deficiencies from long term GLP-1 use? Which ones?

How long does it last?

Help me not lose my mind!
Click to expand...
Dump the Skye tirz. Its not worth it no matter what you paid. If you don't have any other supply, bite the bullet and buy some more from Nexaph unless you are willing to wait.

You should be taking a daily multivitamin anyway so do that. Even a cheap generic multivitamin is better than nothing. I would also consider more vitamin D and B complex because those are linked with that condition (according to google anyway)
 
MsGizmo said:
Dump the Skye tirz. Its not worth it no matter what you paid. If you don't have any other supply, bite the bullet and buy some more from Nexaph unless you are willing to wait.

You should be taking a daily multivitamin anyway so do that. Even a cheap generic multivitamin is better than nothing. I would also consider more vitamin D and B complex because those are linked with that condition (according to google anyway)
Click to expand...
I have enough Nexa to last me 10 years. I just used the Skye because I have it and didn’t want it to go to waste and wanted to use up the last of my BAC with a smaller dose vial.

I have a multivitamin daily as well as a B12, but the multivitamin doesn’t have even 100% of most nutrients.

I read somewhere that Zinc helps, so I’ve got Amazon on the way with that too.
 
YoYoFat said:
Been on Tirz since August 2024. Maintenance since late May/early June 2025. Dosing 8mg/week, split into two doses (once every 3.5 days). Haven’t increased my dose since February. Last two doses I used an old vial of Skye I got last September (not wasting that $$$ stuff!). Before that, I was exclusively using Nexa in 2025 with literally zero issues.

Allodynia arrived last week. Started on my inner thigh, moved to my mid-quad, and how is on my outer hip.

It’s MADDENING.

What is causing this and how do I make it go away other than just stopping the Tirz altogether?

Filler in the Skye vial?

Vitamin deficiencies from long term GLP-1 use? Which ones?

How long does it last?

Help me not lose my mind!
Click to expand...
With reta, the suggestion for allodynia is often zinc- do you take it?
 
YoYoFat said:
Been on Tirz since August 2024. Maintenance since late May/early June 2025. Dosing 8mg/week, split into two doses (once every 3.5 days). Haven’t increased my dose since February. Last two doses I used an old vial of Skye I got last September (not wasting that $$$ stuff!). Before that, I was exclusively using Nexa in 2025 with literally zero issues.

Allodynia arrived last week. Started on my inner thigh, moved to my mid-quad, and how is on my outer hip.

It’s MADDENING.

What is causing this and how do I make it go away other than just stopping the Tirz altogether?

Filler in the Skye vial?

Vitamin deficiencies from long term GLP-1 use? Which ones?

How long does it last?

Help me not lose my mind!
Click to expand...
Get yourself a kit of ARA-290. Take 4mg per day for 28 days.
 
AndyPanda said:
Get yourself a kit of ARA-290. Take 4mg per day for 28 days.
Click to expand...
I'm taking ARA-290 for the past 28 days and it's made parts of my skin extra sensitive. It's not pain, but I'm feeling more. A light brush against my arm feels more intense than usual. Upon researching, it seems this can happen with ARA. It has, however, helped with pain I was having in my leg.
 
Bflo_Bflo_Bflo_Bfl said:
I’m on sema/cagri and mine comes and goes. If I’m working out and stretching it quiets down.

I’m just realizing that I had some long underwear on last week and that didn’t bother me. But regular pants do when they brush against my skin. Maybe now that it’s cooling off I’ll just wear long underwear until spring.
Click to expand...
Yeah, I may have had it even longer. I had been wearing leggings, and those don’t rub. But last week, I wore a loose pair of hiking pants and there was a lot of friction. And since then, I just notice it every time I move or get goosebumps. Goosebumps actually HURT on my thigh!
 
AndyPanda said:
Get yourself a kit of ARA-290. Take 4mg per day for 28 days.
Click to expand...
Hmmmm… I’ll consider it. What vendor do you use for this?

ETA: Just saw that my favorite has it and can get it to me fast. Just wish I didn’t have to buy a whole kit to try it.
 
Last edited:
YoYoFat said:
Hmmmm… I’ll consider it. What vendor do you use for this?

ETA: Just saw that my favorite has it and can get it to me fast. Just wish I didn’t have to buy a whole kit to try it.
Click to expand...
The big downside of ARA-290 is that it can take 2-3 weeks to see any effect. So even a single vial may only have a weeks worth at most. I ended up buying 3 vials, then decided to buy 2 kits from PGB just in case it worked and I didn't have more.
 
chmuse said:
With reta, the suggestion for allodynia is often zinc- do you take it?
Click to expand...
ohh this is good to know. literally logged in here to ask about bad allodynia because mine has been awful on my right thigh for like 2 months.
now to find a zinc pill/gummy that doesn't make me vomit.... sigh.
 
mopo89 said:
ohh this is good to know. literally logged in here to ask about bad allodynia because mine has been awful on my right thigh for like 2 months.
now to find a zinc pill/gummy that doesn't make me vomit.... sigh.
Click to expand...

Ahh I miss you! I'm glad the zinc suggestion helps. Also, the second quicksilver just came out and I have a copy if you need it 👀
 
chmuse said:
Ahh I miss you! I'm glad the zinc suggestion helps. Also, the second quicksilver just came out and I have a copy if you need it 👀
Click to expand...
miss you too! i honestly kinda forgot about this place? life has been so busy and all i do is work and read and sleep.

ahh thanks for the offer! i am very deep in the dungeon crawler carl universe right now and don't want to ever leave. <3
 
I got it across my whole body when I got up to 6mg Reta, it was painful and difficult to sleep, like just the touch of my clothes was awful. I skipped dosing for 1.5 weeks and reduced back down to 3mg. It's more or less gone now. I've also been using naproxen, ibuprofen, and double-dosing loratadine.

I'd say the best thing you can do is lower your dose and slowly work your way back up.
 
YoYoFat said:
Been on Tirz since August 2024. Maintenance since late May/early June 2025. Dosing 8mg/week, split into two doses (once every 3.5 days). Haven’t increased my dose since February. Last two doses I used an old vial of Skye I got last September (not wasting that $$$ stuff!). Before that, I was exclusively using Nexa in 2025 with literally zero issues.

Allodynia arrived last week. Started on my inner thigh, moved to my mid-quad, and how is on my outer hip.

It’s MADDENING.

What is causing this and how do I make it go away other than just stopping the Tirz altogether?

Filler in the Skye vial?

Vitamin deficiencies from long term GLP-1 use? Which ones?

How long does it last?

Help me not lose my mind!
Click to expand...
Can you get a prescription for Gabapentin or Topamax? I had to take it for epilepsy and migraine disorder in the past and know it’s used to combat nerve pain and fibromyalgia.

Topamax is prescribed off-label for weight loss because it makes you lose all interest in food (you just forget food is even a thing, it’s weird).
 
mopo89 said:
miss you too! i honestly kinda forgot about this place? life has been so busy and all i do is work and read and sleep.

ahh thanks for the offer! i am very deep in the dungeon crawler carl universe right now and don't want to ever leave. <3
Click to expand...
Then I hope the books make up for the work ❤️
 
Needsalife said:
Report back after you’ve taken the zinc a couple of days, please.
Click to expand...
I took zinc for a week, didn’t really seem to affect it during that period.

I really think it was something in the vial I was using.

I had been using Nexaph for a year. I grabbed an older vial of Skye (from summer 2024, before I knew about kits) just to use it up. I dose 2x week. Day of the second dose from that vial, the allodynia came on. Once I switched back to Nexaph, it went away.

Could be just a coincidence. But as “they” say it’s common for allodynia to come on after increasing your dose, and I’d been on the same dose and vendor for several months, and turn online change was that one vial….
 
I've had it for about three weeks now. I had been fine on Reta 8mg for 8 weeks, but when I increased it to 10, I started noticing my skin getting sensitive. Same vendor, etc. and Hospira BAC. I stayed at 10, figuring it would go away. Here we are week 3, the day before my shot, and it's finally gone, but I worry it will return if I do 10 again tomorrow. Oh well, I'll do it for science.
 
I am afraid to tell you nothing I tried made it go away. I started getting it on 10mg of tirz and although I don’t have it all the time I do have it regularly. Been about a year.

It travels and will be in one patch and then move to a different area of the body. Feet, arms, legs, shoulders and under my arms are most common sites. It stopped only when I stopped taking tirz. When I switched to Reta split dosing seemed fine until I got to 6mg in one dose and then it was back. Less intense than it was on tirz but still there. Under my arm is burning, feels like sunburn at present moment.

I was taking vitamin supplements the whole time and still am and it made no difference for me. I also get injection site sensitivity but it goes away quicker with Reta than it did with tirz.

I do hope you find something that works for you
 
Everyone's body ADAPTS differently. What suits you best is the best. One's own physical health is the most important
Thistley said:
I am afraid to tell you nothing I tried made it go away. I started getting it on 10mg of tirz and although I don’t have it all the time I do have it regularly. Been about a year.

It travels and will be in one patch and then move to a different area of the body. Feet, arms, legs, shoulders and under my arms are most common sites. It stopped only when I stopped taking tirz. When I switched to Reta split dosing seemed fine until I got to 6mg in one dose and then it was back. Less intense than it was on tirz but still there. Under my arm is burning, feels like sunburn at present moment.

I was taking vitamin supplements the whole time and still am and it made no difference for me. I also get injection site sensitivity but it goes away quicker with Reta than it did with tirz.

I do hope you find something that works for you
Click to expand...
 
Thankfully I only get allodynia if I have slightly more reta than usual. I have done a fair bit of research on what may help nerve pain as I have permanent cold and mildly painful toes, plus a bit of parasthesia from what I assume is an obesity caused peripheral neuropathy. PEA or palmitoylethanolamide is available from amazon and has a very large number of good quality human trials demonstrating it's effectiveness for nerve type pain and other pain types. Also alpha lipoic acid has fairly good evidence supporting its effectiveness as well for peripheral neuropathy pain.
If it is pretty annoying and stopping Tirzepatide for a while or lowering the dose is not a good option then either of these options are safe, reasonably cheap and probably as effective as any prescription medication ( at least PEA ) for that problem.
It could be worth considering swapping to semaglutide, at lower doses ( under 2.4mg/w ) skin sensation abnormalities were not common, but were very common in the much higher dose trials 9.6-16mg, Pretty sure it was more common with reta than tirzepatide.
The only vitamin deficiency that commonly causes those symptoms is vitamin b12 deficiency, but too much b6 or pyridoxine is a fairly common cause of neuropathy , anything above 50mg a day is a bad idea, less than 25 is probably safe.
 
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