AmoPure Tirz
- Thread starter Luluxoxo
- Start date
PeptideJedi
GLP-1 Member
Yes..you will see several posts here on it..it's what has kept me from ordering any more actually...it doesn't seem to sting everyone 🤷
geoguy78
GLP-1 Specialist
Out of curiosity, was it the T15 or the T30 that burned?
The 30mg
You can try to contact them and ask for a replacement, in the past they have done this without a problem, you just need to provide proof that the old kit was destroyed.
geoguy78
GLP-1 Specialist
Oh boy.... I'm about to crack open some "Labor Day 30" this week or next, fingers crossed I got one of the no-burn kits
ThePepPlanner
New Member
I just popped open a T60 this weekend - no sting. I would reach out. Might just be that batch
Fonkymonky
GLP-1 Member
I got the T10 yesterday and it stings like a MF. I reached out to Amo and they refuse to replace it.
Vacation4us
GLP-1 Enthusiast
Happy to hear this as a just ordered a kit “L60”. I wonder why the sting, if it’s not the alcohol. Tirz isn’t known to be spicy. Now B complex ouch. I literally had one client say she was paralyzed with the pain after I gave her a shot. Like WTF? I do tell everyone it’s spicy but honestly people have different tolerances.
Guess I will be finding out soon enough.
zpped
GLP-1 Specialist
No reports of sting on any of t60. only the lower dose batches. No one knows what it is, best guess I ever heard was TFA leftover from the finishing process.
Any way to test for that?
moonpies4misfits
GLP-1 Specialist
I got T15 right before the labor day sale and I have no stinging. I do however reconstitute a few days ahead of time. I remember seeing someone else say their 2nd and 3rd doses didn't sting nearly as much as the first. Not sure what the science behind that would be, but I am curious if theres any correlation.
1. Did the people who did experience stinging pin shortly after reconstituting?
2. Did they even bother with a 2nd dose after the bad experience with the first one, and if so, was it as intense?
4. Did anyone who experienced stinging ever get around to PH testing their vial?
3. Did those who didn't experience stinging pin immediately after recon or did it sit a while beforehand?
I may try to pin immediately after reconstitution on my next vial and see if I notice a difference.
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The TFA contamination suggestion led me down an interesting rabbit hole.
Do a find on that page for TFA.
From what I read about TFA, it's pretty nasty stuff which would explain the burn. It doesn't break down in the environment... one of those forever chemicals.
All the studies I find only discuss environmental exposure to TFA which isn't a problem. One document I read said that you could be exposed to 1000x current levels in the environment and it wouldn't be a problem. But I'd guess those levels are measured in parts per million. I'd reckon contamination in your peps would be measured in vastly higher amounts.
I don't think TFA is a health risk for those who may have been exposed. But I'm not sure I'd want to inject myself with it and endure the burn knowing it's some weird fucking chemical that never breaks down. It doesn't bio-accumulate though, so I guess you'd eventually piss it out.
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I did take a "tester dose" to check for stinging about 30 minutes after reconstituting. T30 from TX, fresh bottle of Hospira, dissolved quickly. I researched a 2mg dose and did use 3ml of water because 3 different RS are sharing and the 3ml makes the math fool-proof.
No adverse reactions for any subjects.
I do wonder if maybe whatever they are using as a buffer( or whatever it is called) instead of mannitol is what is causing the reaction. Perhaps it is a mild allergic reaction? I don't know and I do feel bad for the people who are experiencing problems.
moonpies4misfits
GLP-1 Specialist
That brings up another point I forgot to mention! I wonder if there is anyone who has multiple people drawing doses from the same batch, and if they all had the same experience. I wonder if anyone is willing to do a vial swap to test this theory out.
Ok, so just for clarity, after reconstituting I pulled the 2mg straight from the vial it came in and injected. No stinging or adverse reaction. Then I drew it up and put in in a sterile cartridge for an insulin pen and the next day injected 2 separate RS (fresh pen needles for each of course) and they reported no stinging or adverse reactions. I think about 7 or 8 injections have been given since then and no problems have been reported.
Hope this information is helpful in some way, I understand it is subjective but like I said I do feel bad about people who are having a poor experience.
I would be willing to do a vial swap of T 30.
zpped
GLP-1 Specialist
there was at least one report of a couple using one vial that both were stung.
Fonkymonky
GLP-1 Member
I pinned right after reconstituting. Like I always did, previously with stuff from another vendor and I never had problems. I only pinned one time with the Amo stuff so far…not eager to go for a second round because it stang a lot and I also feel the stuff doesn’t really work. This is day two after pinning and I feel hungry. First time since may (when I started Tirz) that I feel hungry again. I feel mad and ripped off.
scarywood75
Scarlett Johansson
It does not mean much, the most accurate ways would be to send on vial for testing, if they don't work for you anyway.
I'm saying that because on the r/mounjaro Reddit, plenty of people complains about ineffective pens/vials and I doubt it's actually the case, but just perception.
Not AmoPure, but I currently share a pharmacy compound tirz vial and experienced sting/burn, but the other person did not. Both injected at same time. Also, other person is on higher dose. I had to ice area for about 30 minutes. Burn/sting happened 3 times consecutively, then no more. Prior to this, no sting/burn for initial few weeks at injection site.
One more thing, I've bruised easily with no sting in the past, but not all the time. Other person has not bruised.
Fonkymonky
GLP-1 Member
There is a clear difference in quality with the stuff I got from the other vendor. It is not perception. I am using Tirz from the other vendor since may and It worked as a charm. Maybe a bit too much even. I had to force myself eating some days. I felt full all the time. Unfortunately the vendor is not available anymore and I had to switch to Amo. This is the first time in my Tirz journey I switched vendors. Normally on day two after injection the Tirz is in full effect and I am not hungry whatsoever. Now it feels as if I didn’t use any product. If it wouldn’t sting so much I would take an extra dose but I will not because I don’t trust it. I feel like I have thrown away money. The fact that they don’t want to replace it makes it worse.
scarywood75
Scarlett Johansson
Again, this is something that happens with the real stuff as well, this is just the most recent one, but there's tons of posts like this - https://www.reddit.com/r/mounjarouk/s/MDYBt8zNC1
Not trying to defend the seller, but I think there's lot of opportunistic people over here that may try to get free products and so they could be more caution/restrictive about who they refund.
The stinging is abnormally high for this seller, but if you have trust issue the best option is to send some for testing.
Not trying to defend the seller, but I think there's lot of opportunistic people over here that may try to get free products and so they could be more caution/restrictive about who they refund.
The stinging is abnormally high for this seller, but if you have trust issue the best option is to send some for testing.
Fonkymonky
GLP-1 Member
The thing is that I have been off the product for two weeks since I didn’t find a new supplier immediately so I doubt that my body would have adapted to the dose. Of course getting it tested is the only way to be sure about it. I am thinking on doing so.
scarywood75
Scarlett Johansson
Oh yeah that's a very important details, you can look at plot calculator, but the concentration you had in your body when you stopped was higher than currently because of build up and half life.
To build back up in your case, it's about 3-4 weeks up until where you were before stopping.
So this could also explain why you didn't feel anything.
Fonkymonky
GLP-1 Member
I hope that is the case then.
Vacation4us
GLP-1 Enthusiast
My sister just started her journey on RX Zepbound loved the first few weeks , texted me yesterday “WTF I am starving food noise is back, what happened “ I told her not to worry it happens and if she ate more it was fine it’s not a race.
She’s on her third dose of 5 mg ( doctor had her start at 5 mg)
My point is not feeling the medication happens even with the real deal.
I’m a nurse and have bruised multiple times. It happens when you hit a blood vessel. You can’t see under your skin to avoid those tiny vessels.
So far I have only been on Rx Wegovy and Zepbound. Sometimes it stings sometimes I don’t even feel it.
I think there is definitely added apprehension when injecting peps from China. I know I am very nervous about the order I just placed for T60.
@Fonkymonky if your so apprehensive that you might never use what you ordered, testing will help prove they are crap, so you can ask for a refund, or prove their legit so you don’t have to toss them. Just a thought.
She’s on her third dose of 5 mg ( doctor had her start at 5 mg)
My point is not feeling the medication happens even with the real deal.
I’m a nurse and have bruised multiple times. It happens when you hit a blood vessel. You can’t see under your skin to avoid those tiny vessels.
So far I have only been on Rx Wegovy and Zepbound. Sometimes it stings sometimes I don’t even feel it.
I think there is definitely added apprehension when injecting peps from China. I know I am very nervous about the order I just placed for T60.
@Fonkymonky if your so apprehensive that you might never use what you ordered, testing will help prove they are crap, so you can ask for a refund, or prove their legit so you don’t have to toss them. Just a thought.
Vacation4us
GLP-1 Enthusiast
PS for any of you younger gals. My retirement job is placing IV’s at a med spa. Whenever a gal says oh why did I feel the needle this time. 99% of the time it’s around their cycle.
Same nurse, same gage IV, same AC location, different time of the month. We are definitely more sensitive at that time.
Same nurse, same gage IV, same AC location, different time of the month. We are definitely more sensitive at that time.
ImSW1
New Member
I started a T60 vial from Amo a month ago, so 4th shot last Monday. First shot, didn't feel any stinging going in, then it came on and lasted for about 30 minutes. 2nd shot, same. 3rd shot, little stinging going in, and for about 2 minutes after. 4th shot, back to 30 minutes of stinging. No ryhme or reason to the stinging.
The stinging isn't significant for me, so I'm not going to stop using the Amo tirz since I'm the only one using this batch. It works really well and takes care of the majority of my food noise. I have a little food noise every 2-3 days. Take in a little more calories, then I'm good for 2-3 more days.
The stinging isn't significant for me, so I'm not going to stop using the Amo tirz since I'm the only one using this batch. It works really well and takes care of the majority of my food noise. I have a little food noise every 2-3 days. Take in a little more calories, then I'm good for 2-3 more days.
Fonkymonky
GLP-1 Member
It’s just very coincidental that this happens just at the moment I change supplier that’s all. But I get your point and I hope you are right. Being a nurse you def have more knowledge about this matter than I do so thank you for your take on this. I would get it tested but I order with Amo out of financial reasons, getting it tested would cost me around 300 euro’s. I would better get a supply somewhere else it would be cheaper than have this stuf tested. I will try it one more time next week and see how it goes. Thanks for your input!
rogertheveggie
New Member
There have now been several reports of stinging with the T60. Just FYI
Fonkymonky
GLP-1 Member
It’s not so much the needle that I feel, I can handle that, it’s like feeling burning fluid going into your body. Doesn’t feel good to say the least.
I have 2 orders of L60. No stinging from amopure. 1 was from labor day the other was 1 week ago. Double check the ph on your Bac water and possibly use a filter as directed by PepTest. Good experience all the way around for me. Great suppression with no hunger. Have to make myself eat. I came from mounjaro so I've had the real stuff. Good luck just my experience
What dose is your RS experiencing good appetite suppression?
5mg every 5 days. Triz has a shorter half life. I'm gonna add 1mg or reta to hopefully help with energy
zpped
GLP-1 Specialist
no reason to mix reta and tirz. just take reta if you're not happy with the tirz. each one is balanced differently and they use the same mechanisms so you're just throwing out the research that was done to design them.
I was staking with Reta and recently switched to Cagri and it is way more effective.
Could it also be a placebo effect? Like if you're already soured on the product because of an issue like stinging, you're more willing to find fault in other places even if it doesn't exist?
As I've said previously, I've had no issues with stinging or effectiveness from Amo. I am down almost 18lbs because of their products.
I tried cagri with triz and I made me more tired. I was wanting the bump in HR . Triz works great for me. Zero food noise with great suppression just no energy. May try MOTS-C or just run reta like zpped said. I had read some personal experience from a group and the consensus based on expirementation was small dose or reta with triz. Dionsys had said the same as zpped about the 2 glps being much the same and would not stack well. I tried adding cagri but it was so much worse on energy I dropped it. Now I am 51 so that may have something to do with it
geoguy78
GLP-1 Specialist
I've seen so many reports of Cagri just totally wiping people out, I'm starting to wonder if it's a sleep med and not a weight loss med 🤣
delululemonade
New Member
Can’t overeat if you’re asleep!
geoguy78
GLP-1 Specialist
This is a repaste from another Amo post here in the forum (I think we deserve real world reports so I'm spreading the love):
Ok, I finally took the plunge. I just reconstituted a 30mg vial of Amopure Tirz purchased during the Labor Day sale, with 1.2ml of freshly opened Hospira Bac Water. Injected 20 units (5mg) subcutaneously at the 1 o'clock position near my navel. Went in like butter with zero burning noted. The only issue I had was that the rubber stopper is pretty burly and I had to fight it with my insulin needle, dulling it in the process, so for the stick itself I had to give it a little more "oomph" than I would like. But happy to report zero burning, we'll see how effective it is. I'm already debating going up in dose but didn't want to do it with a new supplier, so we'll see how I feel next week.
Ok, I finally took the plunge. I just reconstituted a 30mg vial of Amopure Tirz purchased during the Labor Day sale, with 1.2ml of freshly opened Hospira Bac Water. Injected 20 units (5mg) subcutaneously at the 1 o'clock position near my navel. Went in like butter with zero burning noted. The only issue I had was that the rubber stopper is pretty burly and I had to fight it with my insulin needle, dulling it in the process, so for the stick itself I had to give it a little more "oomph" than I would like. But happy to report zero burning, we'll see how effective it is. I'm already debating going up in dose but didn't want to do it with a new supplier, so we'll see how I feel next week.
Fonkymonky
GLP-1 Member
I am happy for you that everything went fine and the product didn’t sting. I am looking forward to your experience on the quality.
geoguy78
GLP-1 Specialist
My heart rate definitely went up not long after injection. Was a little unsettling, hopefully that was a good sign 🤣
spacedogco
New Member
Amo T30 from a batch delivered in late August and never had a sting. And very effective. Not sure why there seem to be so many inconsistencies. Very odd.
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