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That doesn't sound like a good solution. The bottom-line question is whether something is safe enough to try. I wouldn't trust ChatGPT on any question involving safety.
Amyloid fibril formation
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LaughingDuck
New_Member
So, if it wasn't safe, would they continue to get approval? 
i think the concern is that they've made it safe with their compounding process but the rest of us may not be able to replicate that process on our ownSo, if it wasn't safe, would they continue to get approval?
JohnnyGobbs
New_Member
Is there anything I can squirt into my already reconstituted vial to uhh… make the ph lower/negate potential fibrils?
zpped
Research Enthusiast
If you believe one camp, No. If you believe the other it doesn't matter. So either way that seems pointless.
penewbie
Senior Member
It would hardly be the first time big Pharma brought a dangerous weight loss drug to market.So, if it wasn't safe, would they continue to get approval?
JohnnyGobbs
New_Member
Fair point. Will just continue to roll the dice.
Fair point. Will just continue to roll the dice.
If it worries you, you could sell your untapped vials on the p2p market.
How is Cagri working for you overall?
Where is the p2p market
JohnnyGobbs
New_Member
echohunter
New_Member
I have 9 vials of 10mg cagri from QSC that I am looking to sell as well. It works for me but the fatigue I get from it is too much. Thinking about just stacking sema with reta to help with appetite suppression instead.
zpped
Research Enthusiast
stacking sema and reta is just going to give you worse results than just using reta. they are competing for the same receptor.
echohunter
New_Member
According to some chart I’ve seen on this forum, Reta has very low GLP-1 activity, compared to Sema. Anecdotally people have said Reta doesn’t provide as much appetite suppression as Sema, or even Tirz. Using Sema to make up for Reta’s lower GLP-1 activity seems to make sense to me.
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I see some on Discords. I mean it'll take some work but I'm sure you can sling it.
zpped
Research Enthusiast
You (and many others) are making it out to be much simpler than it is. Adding in the sema just kicks the reta off the receptor and you're not using the reta to its full effect. They mix with albumin and cause completely unstudied interactions. Do whatever you want though, it's probably not dangerous but almost certainly less effective. There is a reason they picked the balance for reta that they did.
MrsRoper_1977
Research Enthusiast
Acetic acid
Yeah. If fibrils are forming, It won't do anything to existing fibrils, but it should help prevent additional ones.
I would get the PH to 4.0 and filter after if I was going to use cagri. Stop new growth and potentially get any that had clumped together enough for the filter to catch.
I would get the PH to 4.0 and filter after if I was going to use cagri. Stop new growth and potentially get any that had clumped together enough for the filter to catch.
JohnnyGobbs
New_Member
How much? I have a 5mg vial with 1ml of bac.
geoguy78
Registered
This is why I think people stacking reta with anything else are on a fool's quest. Yes, they might be seeing results that make them happy, but it was designed the way it is for a reason and if they just followed the dosing schedule to a high enough dose they'd likely see better results on reta alone. Sanofi designed a triple agonist that was completely balanced and they stopped development. Seems to me a lot of people stack with Reta because it sucks at appetite suppression at the lower doses, and many of us trying to lose weight are (understandably) afraid of eating. I plan on trying it for maintenance, because my impression of it is that it's for upping your metabolism, not suppressing your appetite. I want to be able to enjoy pizza during maintenance
