Amyloid fibril formation

clayd said:
I know not everyone is a scientist but if you are injecting this into your own body and this is a concern, you really should try to read and understand this: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00565

maybe ask chatgpt to help explain the parts to you that you don't understand.
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That doesn't sound like a good solution. The bottom-line question is whether something is safe enough to try. I wouldn't trust ChatGPT on any question involving safety.
 
I have 9 vials of 10mg cagri from QSC that I am looking to sell as well. It works for me but the fatigue I get from it is too much. Thinking about just stacking sema with reta to help with appetite suppression instead.
 
echohunter said:
I have 9 vials of 10mg cagri from QSC that I am looking to sell as well. It works for me but the fatigue I get from it is too much. Thinking about just stacking sema with reta to help with appetite suppression instead.
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stacking sema and reta is just going to give you worse results than just using reta. they are competing for the same receptor.
 
zpped said:
stacking sema and reta is just going to give you worse results than just using reta. they are competing for the same receptor.
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According to some chart I’ve seen on this forum, Reta has very low GLP-1 activity, compared to Sema. Anecdotally people have said Reta doesn’t provide as much appetite suppression as Sema, or even Tirz. Using Sema to make up for Reta’s lower GLP-1 activity seems to make sense to me.
 
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echohunter said:
According to some chart I’ve seen on this forum, Reta has very low GLP-1 activity, compared to Sema. Anecdotally people have said Reta doesn’t provide as much appetite suppression as Sema, or even Tirz. Using Sema to make up for Reta’s lower GLP-1 activity seems to make sense to me.
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You (and many others) are making it out to be much simpler than it is. Adding in the sema just kicks the reta off the receptor and you're not using the reta to its full effect. They mix with albumin and cause completely unstudied interactions. Do whatever you want though, it's probably not dangerous but almost certainly less effective. There is a reason they picked the balance for reta that they did.
 
Yeah. If fibrils are forming, It won't do anything to existing fibrils, but it should help prevent additional ones.

I would get the PH to 4.0 and filter after if I was going to use cagri. Stop new growth and potentially get any that had clumped together enough for the filter to catch.
 
zpped said:
You (and many others) are making it out to be much simpler than it is. Adding in the sema just kicks the reta off the receptor and you're not using the reta to its full effect. They mix with albumin and cause completely unstudied interactions. Do whatever you want though, it's probably not dangerous but almost certainly less effective. There is a reason they picked the balance for reta that they did.
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This is why I think people stacking reta with anything else are on a fool's quest. Yes, they might be seeing results that make them happy, but it was designed the way it is for a reason and if they just followed the dosing schedule to a high enough dose they'd likely see better results on reta alone. Sanofi designed a triple agonist that was completely balanced and they stopped development. Seems to me a lot of people stack with Reta because it sucks at appetite suppression at the lower doses, and many of us trying to lose weight are (understandably) afraid of eating. I plan on trying it for maintenance, because my impression of it is that it's for upping your metabolism, not suppressing your appetite. I want to be able to enjoy pizza during maintenance;)
 
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