Another Teso ADHD Story

[Nopenada]

Started yesterday. Took 1/3 of a 500mg pill. Ended up slightly jittery and a little short fused, so today I cut back to 1/4. This appears to be the sweet spot at the moment.

I’ve spent my entire life with the worst of both worlds: Inattentive ADHD and extreme low energy, which is probably undiagnosed chronic fatigue.

I’ve always been jealous of people who can walk around their house and kinda clean as they go and just generally keep up with things. Or hell, people who could go all day, not have a nap, and still have the energy to go out in the evening. That has literally never been me. So suddenly being able to move and think and do on Teso is completely wild.

I did my research before starting but I’m baffled. This stops reuptake of several brain chemicals. Does that mean reverse-engineering this, my problem is too fast reuptake?

In other news, the Reta was ruining my life with the adhedonia, but thinking of maybe giving it another shot in conjunction with teso and seeing how that works.

 

[5byfive]

Describes my wife perfectly (going into research mode).

 

[sheilarae74]

I’ve spent my entire life with the worst of both worlds: Inattentive ADHD and extreme low energy, which is probably undiagnosed chronic fatigue.

Same. Maybe this is something I need to research as well.

 

[HereKittyKitty]

If Reta is causing anhedonia why not try a different glp/gip?

 

[Neurogroot]

Generally, ADHD meds like Adderall, Ritalin, Vyvanse, etc are classified as “Dopamine Reuptake Inhibitors”. So, your hunch about the reuptake is pretty accurate. There are ways to help manage this a little more effectively (with or without ADHD meds). Of course, everyone is different so it may work or not work for you.

How far you want to take it is up to you. I believe Nootropics are a good start, so check out Anhedonia and nootropics to get you started. There are other categories to look into, but I don’t want to risk breaking rules mentioning in forum.

 

[RosebudFox]

Started yesterday. Took 1/3 of a 500mg pill. Ended up slightly jittery and a little short fused, so today I cut back to 1/4. This appears to be the sweet spot at the moment.

I’ve spent my entire life with the worst of both worlds: Inattentive ADHD and extreme low energy, which is probably undiagnosed chronic fatigue.

I’ve always been jealous of people who can walk around their house and kinda clean as they go and just generally keep up with things. Or hell, people who could go all day, not have a nap, and still have the energy to go out in the evening. That has literally never been me. So suddenly being able to move and think and do on Teso is completely wild.

I did my research before starting but I’m baffled. This stops reuptake of several brain chemicals. Does that mean reverse-engineering this, my problem is too fast reuptake?

In other news, the Reta was ruining my life with the adhedonia, but thinking of maybe giving it another shot in conjunction with teso and seeing how that works.

Thanks for posting. I am undiagnosed, but I suspect I have ADHD and have had therapists casually reaffirm my suspicion. I do well when I take adderall. Sometimes certain stimulants just make me dizzy. My interest is piqued, and I'll likely be checking into this.

 

[lessthanhalf]

Once the neurotransmitters are released into the synapse, and have their effect, they are then actively removed from the synapse by various different active transporters that reuptake it back into the cells. Blocking this reuptake means the neurotransmitters hang around for longer in the synapse and can have a stronger or more prolonged effect. Exactly which reuptake mechanisms get blocked and where in the synapse is different for different drugs. Tesofensine is more or less like a snri antidepressant/adhd drug except with added dopamine reuptake blocking. It does have a very long half life, around a week, quite a few people online who have taken it found over time they got more significant side effects from it accumulating and ended up using very infrequent doses often once a week. It has not had a lot of human studies, has been studied for weight loss, but not as far as I know for antidepressant or adhd treatment in humans, but there are many reasons to believe it could work for those issues based on its mechanism of action.

 

[Nopenada]

If Reta is causing anhedonia why not try a different glp/gip?

I have some weird blood sugar issue that doctors have shrugged off because I’m not diabetic and not obese and I suspect it is the glucagon effect (I think that is what it is called) of the Reta that has been keeping those symptoms in check.

I’ve got some Tirz coming to give that a shot, so I’m willing to try the switch and see if my blood sugar behaves.

 

[HereKittyKitty]

They're all - Reta, Tirz, Sema, Lira - going to work on your blood sugar.

 

[samIam]

Generally, ADHD meds like Adderall, Ritalin, Vyvanse, etc are classified as “Dopamine Reuptake Inhibitors”. So, your hunch about the reuptake is pretty accurate. There are ways to help manage this a little more effectively (with or without ADHD meds). Of course, everyone is different so it may work or not work for you.

How far you want to take it is up to you. I believe Nootropics are a good start, so check out Anhedonia and nootropics to get you started. There are other categories to look into, but I don’t want to risk breaking rules mentioning in forum.

Thanks for this information I'm going to have to dig into this 😊

 

[Nopenada]

They're all - Reta, Tirz, Sema, Lira - going to work on your blood sugar.

Perhaps. A friend of mine on Tirz was getting a hard time from his doctor for years for bad A1C numbers before the meds. His A1C is now perfect.

But since my issue is undefined and Reta is the only triple antagonist (that I know of) it is hard to say what it is about Reta that fixes my unidentified problem.

 

[HereKittyKitty]

Both GLP-1 and GIP work on blood sugar. (Sema and Torz) Glucagon boosts fat metabolism and energy burn. The additional component in Reta.

 

[Nopenada]

Both GLP-1 and GIP work on blood sugar. (Sema and Torz) Glucagon boosts fat metabolism and energy burn. The additional component in Reta.

Jury still out for me. Based on everything I do know, it appears to be Idiopathic Postprandial Syndrome.

 

[HereKittyKitty]

Hope you and your doctor find the source!

 

[Foggy-Hollow]

I wasn’t diagnosed adhd until about 4 years ago. Up until that time my depression med of choice was bupropion (Wellbutrin) which is an SNRI - serotonin norepinephrine reuptake inhibitor. It is sometimes rx’d off label for adhd. It is a stimulating med (at the risk of being obvious, sorry).

other news, the Reta was ruining my life with the adhedonia, but thinking of maybe giving it another shot in conjunction with teso and seeing how that works.

This VERY interesting to me. I am 0/3 with the big 3, sema was the worst for anhedonia and gave me SI (and that is very off brand for my depression). Tirz was a better but still symptomatic after a couple months of micro dose, and Reta was in between.

My biggest complaint was task initiation: which is also a main symptom of my ADHD. I have a desk job, and would stare at my computer screen wanting to start and not being able to. Not a good place.

I live in northern latitudes and this was all during late summer and fall, not a good time of year for mood. So perhaps I set myself up for failure. Best I can tell is my dopamine is fragile, and needs more support.

Tesofensine is on my short list. I am very interested in how the combo works for you. (Reta or any Glp-1 w teso.) For me: In the short term work is on overtime for about another week (stress= bad time to start) and I’m working on dopamine support… 2+ weeks before any new research here.

 

[Nopenada]

This VERY interesting to me. I am 0/3 with the big 3, sema was the worst for anhedonia and gave me SI (and that is very off brand for my depression). Tirz was a better but still symptomatic after a couple months of micro dose, and Reta was in between.

My biggest complaint was task initiation: which is also a main symptom of my ADHD. I have a desk job, and would stare at my computer screen wanting to start and not being able to. Not a good place.

This. Completely. Reta made my task paralysis so much worse and caused me to skip about half of my workouts. To be clear, I did have some problems starting tasks at my desk job prior, but I almost never missed a morning work out, as I sleep in my gym clothes and get into my workout before even being awake enough to talk myself out of it.

Took my fourth dose of Teso this morning. It was still enough in my system from Saturday to keep me reasonably productive yesterday. Went and ran 5 miles yesterday morning and then cleaned the kitchen in the afternoon.

Took the Reta yesterday morning and definitely feeling like I’ll need to time Teso doses more effectively. Waiting for it to kick in.

 

[Foggy-Hollow]

I did my research before starting but I’m baffled. This stops reuptake of several brain chemicals. Does that mean reverse-engineering this, my problem is too fast reuptake?

It slows or “inhibits” not necessarily stops reuptake. There is such a thing a serotonin syndrome when there’s an overload of serotonin in the synapses. So: no we don’t WANT to stop it, think of it as throttling the vacuum. 🙂

It might be a supply issue too. If your body doesn’t have the precursors (ingredients) or a demand signal (depending on the system) it won’t produce. I’ve had some positive results from supplementing precursors for serotonin.

There’s also interplay between hormones (as if things weren’t complicated enough). When my estrogen is low my adhd and mood go south. When my thyroid is low my estrogen dips. (I am menopausal so at least it isn’t cyclical at this time. )

I’ll add age to the list. Bodies slow down, as much as I prefer to be in denial I’m 49 and while I’m still in reasonable health, things are just dipping. Little negatives pile up easier, recovery is slower, etc.

The body is amazing at adapting, so maybe something triggered a negative adaptation. 🤷‍♀️ Stress is one example. American news and social media is drenched in cortisol. People aren’t watching Friends or Three’s Company these days.

It’s complicated. Pick the easy ones to work with and go from there. OR pick the low risk ones.

 

[Foggy-Hollow]

This. Completely. Reta made my task paralysis so much worse and caused me to skip about half of my workouts. To be clear, I did have some problems starting tasks at my desk job prior, but I almost never missed a morning work out, as I sleep in my gym clothes and get into my workout before even being awake enough to talk myself out of it.

Thank you SO SO much for sharing this.

 

[Elocin]

I know this is an older thread, but I found this so interesting. I am medicated, and still have issues with getting motivated/ starting tasks.
Thanks for sharing! I’m going to look into this some more

 

[ContainHer]

I know this is an older thread, but I found this so interesting. I am medicated, and still have issues with getting motivated/ starting tasks.
Thanks for sharing! I’m going to look into this some more

Samesies!

 

[amosmylove]

Really interesting thread. I'm glad to come across it! I was dx as adhd at 28, after 8 years of being wrongly dx as bipolar and treated with a bunch of psych meds that did nothing except add more issues and made me gain weight when I was healthy body-wise before that. Fast forward 4 years and yeah, I am definitely adhd amd have been since toddlerhood going off of family stories. My mom told me after I got properly diagnosed that she has inattentive adhd bu5 doesn't believe in medicating or diagnosing it. Thanks, Ma. 8 years of wasted life there with doctors throwing the kitchen sink at me.
Anyways, what I find curous about this is that the teso seems to have SNRI properties. I tried one years ago, welbutrin, when I wasn't happy with sertraline because of the sexual numbing. It made me go crazy. It made it seem like I was manic. I got off of it after like 2 weeks but that reaction perpetuated the false bipolar dx for another couple years because we kept bringing it up as 'that one time I definitely had a manic episode'. Turns out it was just a rare reaction to welbutrin. I am absolutely not bipolar and never have been. I just had bad depression and severe adhd symptoms that were uncontrolled/ unacknowledged for my entire life.

In any case. I'm curious about the teso after reading this but concerned about another welbutrin-esq reaction. I don't love the adderal xr I am on currently and only take it 1x a week. But the other 6 days I am a slug of a human so that's not ideal.