anyone bonk after upping reta dose?

[tendency]

Hey all - curious thing happened to me today: after upping my reta dose today from 2 to 3mg I bonked after about 6 hours. Just like if I had been hammering on my bike for 3 hours. Shakiness, dizziness coupled with some nausea, it was quite bad. Had to onboard some serious pie and a little ice cream and that took care of it after about 30 minutes. Anyone else with similar? I guess I ramped dose to quickly from 2 to 3?

 

[ostrichsak]

Sounds like maybe an electrolyte issue if simple carbs corrected it. How hydrated were you?

 

[JoonyO]

Blood sugar problem, no?

 

[Nathanologist]

I came here thinking something completely different happened after the dose injection… no, I’ve never “bonked” like that after, but I have bonked after. I didn’t notice anything spectacular, other than the allodynia adding a little je ne sais quoi to the whole experience.

Sounds like dehydration or hypoglycemic episode. I’ve never noticed either immediately following, but scattered throughout the week it has happened.

 

[miss-sanne]

Agree, bloodsugar issue or dehydration.
I forget to drink on reta, so I have to have a schedule. I get dizzy and uncomfortable, and know, I need fluids.

 

[Calm Logic]

A glucose meter is great to have anyway, at about $10 to $15 at Amazon or Walmart for a meter kit.

Protein drinks often have a good amount of electrolytes like sodium, potassium, magnesium, and especially calcium, though they are not as hydrating as IV/electrolyte drinks or coconut water. I use both protein drinks and electrolyte drinks, drinking one or the other soon after waking. I never became dehydrated until starting GLPs:

GLP-1 receptor agonists (GLPs) commonly cause or exacerbate dehydration through a few mechanisms:

1. GI Side Effects: Nausea, vomiting, and diarrhea are common side effects that lead to significant and rapid loss of both fluid and electrolytes.
   
   
2. Decreased Thirst/Appetite: The medication can suppress both your hunger and your thirst drive, causing you to unintentionally drink less throughout the day.
   
   
3. Kidney Strain: Severe dehydration due to GI side effects can, in turn, lead to kidney issues (acute renal injury).

But if have nausea again, you may want to ask your doctor for some Zofran to help with your "Zepbound."

 

[Calm Logic]

Blood sugar problem, no?

Google Gemini agrees that hypoglycemia is more likely than dehydration to be the main contributing factor:

Always carry a source of fast-acting sugar (glucose tablets, juice box, hard candy) for immediate use if you feel the shakiness and dizziness returning...

While your symptoms pointed to low blood sugar, hydration is vital for overall function and can prevent symptoms that sometimes overlap with hypoglycemia.

 

[tendency]

I agree with the blood sugar thesis, just felt like my glucose levels crashed and burned hard. Interesting. Think I ramped my doseage too quickly and injected to close together (I do 2 injections/week).

Other thing I've noticed is I need to keep my carb levels up while on reta; reta+low carb does not seem to agree with my disposition.

 

[Sidney]

Yes! I actually stopped taking Reta so I could train for half marathon because I kept bonking on long runs during training (even on microdose of 0.5mg Reta). That worked and now that I am done with my race, I have resumed Reta.

I have always had low blood pressure to the point of orthostatic hypotension and passing out from standing to quickly. I also think I may struggle with hypoglycemia but have not tested that theory. I have been toying with idea of getting glucose monitor. I think certain people (perhaps with predisposing low BP or hypoglycemia) may be more prone to bonking on Reta.

 

[tendency]

Yes! I actually stopped taking Reta so I could train for half marathon because I kept bonking on long runs during training (even on microdose of 0.5mg Reta). That worked and now that I am done with my race, I have resumed Reta.

I have always had low blood pressure to the point of orthostatic hypotension and passing out from standing to quickly. I also think I may struggle with hypoglycemia but have not tested that theory. I have been toying with idea of getting glucose monitor. I think certain people (perhaps with predisposing low BP or hypoglycemia) may be more prone to bonking on Reta.

Huh, interesting! Sounds like you'll need to stop it for serious training, at least some folks.

 

[GLPSecret]

Reads like a blood sugar / hydration issue mate.

Ensure electrolytes in water and fruit for natural sugars!

 

[ZippityDooDah]

Hey all - curious thing happened to me today: after upping my reta dose today from 2 to 3mg I bonked after about 6 hours. Just like if I had been hammering on my bike for 3 hours. Shakiness, dizziness coupled with some nausea, it was quite bad. Had to onboard some serious pie and a little ice cream and that took care of it after about 30 minutes. Anyone else with similar? I guess I ramped dose to quickly from 2 to 3?

I don't know if I've ever heard the word "bonked" used to describe those symptoms before lol. I've always associated it with someone hitting their head. 🤪

My first few months on tirz I had occasional "bouts" similar to what you describe that were almost always attributable to forgetting to eat or drink, not eating or drinking enough, or something that I did eat or drink not agreeing with me. Once I established a better routine and made efforts to include things like electrolytes and protein shakes when I knew I hadn't eaten enough, those kind of episodes became few and far between.

I tend to doubt that a 1mg increase in dosage (despite it being a 50% increase over your previous dose) would have such a dramatic effects of any kind beyond the usual side-effects.