Sudden hunger on reta/ tirz

[FatPanda]

My lab rat is currently pinning 7.5 tirz and 4 reta. (There are also cycles of NAD+, Mots-c or KLOW80). Last night was the first night pinning TESA for my rat.

My weight loss has stalled the past week, the scale has gone up a little, while it's not a clear sign on its own, I was consistently losing about 1-2 pounds a week prior for several months.

My main concern is that I have been noticeably hungry, so much more hungry, and my heart rate is no longer elevated.

I have only been on reta and Tirz for about 5 months.

I feel like I'm already on a high dose, but wondering what could be going on to have sudden changes in results with the same vial. It's not particularly close to my cycle (2 weeks until cycle).

 

[randompersonrandom]

Every several weeks, I am suddenly very hungry for the kinds of foods I generally don't want to eat while I'm working on weight loss; I'm super interested in potstickers, enchiladas, steamed buns, cheese, pie, and all sorts of other stuff that I ordinarily have no problem making a "when I'm out and it's an event" food.

I gain 3-4 pounds, can definitely see that I look fat in the stomach area, and gnash my teeth/rend my garments that my meds have stopped working, this is it, everything is terrible.

Then I bleed from my lady parts and it all goes RIGHT back to where it all was before. The 3-4 pounds falls off in a day or two and I stop eating everything, and I go "Oh. hurr."

I know you mentioned it's not yet time for your cycle, but bodies are weird, and lady bodies more so. A week is just not long enough to get worried.

 

[ThatNextGril]

This is interesting! I've been on tirz at 12.5 for the past 4 months. I tried titrating up o 15 but the sides had me feeling exhausted and just off. So, I've stuck with the 12.5 as it's been doing fine keeping the food noise signal switched off and I can easily control hunger/satiation. But the stall is annoying me as I really do want to drop off another 10# by mid-March before a trip I have planned. So... I started adding reta this weekend. i pinned 1mg on Friday and aside from feeling slightly nauseous a bit after every meal, nothing different exhibiting (which yeah, cuz I just started!). Pinned another 1mg today to see what happens. I've been on tirz for over a year and sema for over a year before that, so I feel comfortable that playing around with the reta doses won't send me to the toilet (or the ER!). But, I do oddly notice that I'm kinda hungry this weekend, which I usually am not with just the tirz. I'm post menopause and on HRT, so no monthly activity to add flavor to my feeling hungry.

I'm now wondering if I should pick up some survo and add that to the tirz instead. I really just want the glucagon/fat burning burst more then the rest. I'm hoping if I can get the fires going for 6-8 weeks, then after my trip I can just go back to tirz as I do really like it as an overall stabilizer - for me there are no sides at all, and it does what it says on the tin.

 

[joseblo]

My lab rat is currently pinning 7.5 tirz and 4 reta. (There are also cycles of NAD+, Mots-c or KLOW80). Last night was the first night pinning TESA for my rat.

My weight loss has stalled the past week, the scale has gone up a little, while it's not a clear sign on its own, I was consistently losing about 1-2 pounds a week prior for several months.

My main concern is that I have been noticeably hungry, so much more hungry, and my heart rate is no longer elevated.

I have only been on reta and Tirz for about 5 months.

I feel like I'm already on a high dose, but wondering what could be going on to have sudden changes in results with the same vial. It's not particularly close to my cycle (2 weeks until cycle).

Tesa and other ghrelin/gh secretegagues may well inhibit GLP1 signaling at high doses. So your Tirz probably doesn't like them. Also, these hormones are known to increase water weight anyway, so you may not get both appetite suppression and body re-comp simultaneously.