anyone else getting considerably better results with Tirz compared to Reta?

[timewalk]

I have found great success with using Tirz + increased cardio + habits I already had in previous cuts. it was much easier than any cut I've ever done before, other than harsh metabolic sides for the first few weeks. Tirz rocks. this was November 2024 until about March 2024.

around that time I was transitioning to maintenance and decided to get some Reta. the mechanism appears to be strictly better and research shows greater weight loss.
well, after months of playing with dosages, I have concluded that with Reta compared to Tirz:

• I get much weaker apppetite suppression
• it makes me more likely to binge (an old habit) and less likely to stop mid-binge and question myself
• skin sensitivity is a serious problem. with Tirz it was negligble
• I feel less energetic overall

on multiple occasions I have done A/B testing with Tirz, specifically right now. I think I've taken a total of 6mg Tirz in the span of almost two weeks. appetite suppression is just so much stronger, it's ridiculous - with Reta I'm not getting that at 8mg. it feels like I can choose to eat, or can choose not to, and my body doesn't care one way or the other (though I still enjoy the act of eating... old habits die hard)

sorry if that was a little long, but anybody else experiencing something like this? shouldn't Reta be better?

 

[Zydeceltico]

• I get much weaker apppetite suppression
• it makes me more likely to binge (an old habit) and less likely to stop mid-binge and question myself
• skin sensitivity is a serious problem. with Tirz it was negligble
• I feel less energetic overall

.......... appetite suppression is just so much stronger, it's ridiculous - with Reta I'm not getting that at 8mg. it feels like I can choose to eat, or can choose not to, and my body doesn't care one way or the other (though I still enjoy the act of eating... old habits die hard).........

It's really interesting to me how all of our metabolisms and physiological characters seem to be all just a little bit different from each other.

I have not tried Ret -yet- but considered it after four months of T and considerable weight loss on 7.5mg ultimately (lost 36# and am at GW). At some point, T wasn't quite giving me what you describe above and I tried stacking Surv with it - et voila!!! With that combo, RS experiences exactly verbatim what you describe above for your RS on T alone. Especially the "choose or choose not...though I still enjoy the act of eating." Flippin' liberating!

 

[mlke6]

It's really interesting to me how all of our metabolisms and physiological characters seem to be all just a little bit different from each other.

I have not tried Ret -yet- but considered it after four months of T and considerable weight loss on 7.5mg ultimately (lost 36# and am at GW). At some point, T wasn't quite giving me what you describe above and I tried stacking Surv with it - et voila!!! With that combo, RS experiences exactly verbatim what you describe above for your RS on T alone. Especially the "choose or choose not...though I still enjoy the act of eating." Flippin' liberating!

Did you start stacking before increasing your dose of T. Up to 15 mg?

 

[yeeeee333]

Evrything I’ve read and heard is that Reta appetite suppression is nowhere near that of Tirz, Sema, or Cag.

I’ve started on Reta and definitely feel some suppression, but definitely resonate with still feeling hungry

 

[Zydeceltico]

Did you start stacking before increasing your dose of T. Up to 15 mg?

Yes. I had been at 7.5T for several weeks and was considering going up to 10 but decided against it due to reviewing other's research regarding the add-on effect of Surv and at least for my RS it has delivered as - and beyond - expected. I never went above 7.5 T. Started with .6mg S back-to-back w/ 7.5 T. Now at 1.2 S and staying at 7.5 T. YMMV

 

[BooneDonk]

Evrything I’ve read and heard is that Reta appetite suppression is nowhere near that of Tirz, Sema, or Cag.

I’ve started on Reta and definitely feel some suppression, but definitely resonate with still feeling hungry

I’ve seen highest suppression between 2 and 4 days after pin. Got up to 3mg every 3 days and nada. Nothing doing. Swapped to 6mg every 6 days for three weeks and day 5 was starving Marvin. Went with 5mg and going to try every 5 days starting last night. Let’s see if I can level out hunger. Odd how different it is for different subjects.

 

[feijao]

I am a Tirz guy over Reta for sure. Everything that most people talk about Reta being is what Tirz does for me. I have several IRL friends that Reta has worked really well for though. Just have to find your thing... 👍

 

[CrimsonTaco47]

Man, I actually miss my tirz. I did Mounjaro 3 years ago for about 10 months. Sw: 278lbs and my lowest weight was 190lbs then my insurance cut me off cold turkey. Decided the best way to gain it all back was to get pregnant lol lost almost 90lbs and was strength training like crazy. I felt amazing and had never been so close to a goal weight before.
1 year postpartum I started compounded sema from a telehealth and lost nothing/felt nothing. Learned about grey market and I’ve been on Reta for about 6 months and gone from 265lbs- 225lbs. Definitely losing slower and way less appetite suppression.
I do think the slower weight loss is better in the long-term as far as skin, muscle retention, just overall health but I’m not gonna lie and pretend I’m excited about losing slower lol. I also had so much motivation to workout last time…maybe it’s the Reta vs tirz or maybe it’s the Tasmanian devil child I added to my crew but I’m exhausted and have no motivation to workout hard like I did last time.

I chose Reta since it’s supposed to be better than tirz but I do kind of miss it. But my freezer stash won’t even let me consider it again lmao

 

[Thistley]

This is kinda what I didn’t want to hear 🤨

Coming off a 13 month tirz journey, last few months was at 15mg and nothing happening. Still have a fair bit to lose.

Tirz is still in my system but Last week started pinning Reta. 2mg ( split dose) so far I have noticed I am thinking about sweet things again when that has been totally absent for almost a year. I do still have suppression but it’s different.

All things need time to be tested out fully, one change at a time ( so you know what works) going to follow my own advice and go low and slow with the reta titration. Because there is nowhere else to go if Reta doesn’t work for me.

 

[Bunny]

Thistley....just to relate my experience. I'm at maintenance.Out of the blue developed severe anxiety on tirz. Came off abruptly for 4 weeks. Am now back on tirz at a lower dose and I add a little sema weekly to silence the food noise. No anxiety whatsoever and wonderful suppression. Hopefully Reta will click in for you but if it doesn't suit, there are plenty more alternatives to experiment with 😁Good luck.

 

[Thistley]

Thank you @Bunny that helps! I felt hopeful like I had options again when I was ready to try the Reta.

So glad to hear your solution is working well for you and even better that the anxiety has disappeared with it.

 

[slowsixstang]

I have found great success with using Tirz + increased cardio + habits I already had in previous cuts. it was much easier than any cut I've ever done before, other than harsh metabolic sides for the first few weeks. Tirz rocks. this was November 2024 until about March 2024.

Out of curiosity, what were these harsh metabolic sides?

 

[kimmykat415]

I'm v. interested in these takes. I've been considering switching to Tirz for maintenance. I find Reta to be all on or all off even at low doses and am not loving the 10 bpm increase in my resting heart rate and have been wondering if Tirz might allow me to have some appetite lessening but not the extreme lack of hunger and heart rate issue. I'm just at week 22 so time will tell if the heart rate thing resolves itself.

I've been on low doses (max 2.5mg) of Reta since May. I'm down 30 pounds (10-15 to go!). I've always craved sweets that hasn't gone away completely on Reta but now I can have one of something and then walk away. On Reta I'm pickier about all foods including sweets. It can't be some shitty protein bar that is sweet but also card board. On reta it needs to be a bite of a good piece of cake or cookie. I also don't need filler/diet foods like plain popcorn or fake pasta. With the limited amount of food I'm eating I want it to be real and good.
However, there are also days when I can forget about food entirely until the evening. --Even then I'm satisfied by an amount of food that won't come close to maintenance especially when I redouble my efforts on building muscle. So...I'm thinking maybe Tirz might be a better option for maintenance. I'm post menopause the bulk of my weight gain was hormone related so I have no idea if I'll ever be able to get off GLP1's completely but at a minimum I foresee two years on GLP1s to lock in a consistent weight and new habits so I don't ping pong back to my prior weight.

 

[mopo89]

i had zero results with tirz (or sema). reta has me within 15-20lbs of my goal weight. it has helped me beyond my wildest dreams. major appetite suppression and food noise is mostly gone.

 

[CherBear]

Because there is nowhere else to go if Reta doesn’t work for me.

Why not stack? I'm not that responsive to either sema or tirz but I stack them and man, that gets things going. Currently at 15 mg tirz + 1 mg sema weekly, and I won't go higher than that because of constipation. It's really working for me though. My thought was that if I was going off the FDA approved beaten path, it was probably safer to stack two FDA approved drugs vs using one that isn't FDA approved at all yet. I started at 0.25 mg and went to in increments of 0.25 as I stalled. When I stop losing, I'll have to reevaluate and will likely move to reta. I did try stacking with cag before sema but it did nothing for me.

 

[timewalk]

Out of curiosity, what were these harsh metabolic sides?

mostly sulfur burps and diarrhea.

 

[clayd]

I lost 50 pounds on tirz but stalled out for months with like 15-20 to go. So I've been titrating tirz down and reta up the last few weeks. Currently at tirz 10mg and reta 4mg 4 days later. I am hungrier and more likely to just scarf down a pile of crackers/bread/pizza rolls and I've gained 10 lb back. Although I am overall less interested in food until the precise moment I'm famished.

But I'm trying to stay on track because people say 8mg of reta is the magic number for those previously maxed out on tirz.

But yeah the appetite suppression is different. They say reta doesn't suppress as much as it just turns you off to food. I feel that.

Got me wondering if reta with a little cagri would be an effective combo

 

[yeeeee333]

This is kinda what I didn’t want to hear 🤨

Coming off a 13 month tirz journey, last few months was at 15mg and nothing happening. Still have a fair bit to lose.

Tirz is still in my system but Last week started pinning Reta. 2mg ( split dose) so far I have noticed I am thinking about sweet things again when that has been totally absent for almost a year. I do still have suppression but it’s different.

All things need time to be tested out fully, one change at a time ( so you know what works) going to follow my own advice and go low and slow with the reta titration. Because there is nowhere else to go if Reta doesn’t work for me.

Could look into testing Cagri along with your Tirz or Reta - I hear that has very promising appetite suppression benefits.

 

[Thistley]

I’m actually terrified of what @clayd described here, the thought of putting 10lb back on when it’s taken me so long on a long stall to shift it. I would agree so far the Reta makes me meh about food which is very different to how tirz felt suppression wise.

The journey is figuring it out though right and persisting through the tough spots

Thank you @CherBear and @yeeeee333 for the stacking suggestions.

Cher so glad to hear the Tirz and sema combo is working so well for you, the 1mg of sema must just be boosting you the way you need!