Anyone suddenly become intolerant to Tirz overnight?

[Mara_aa]

THIS IS EXACTLY HOW I FELT! I had to force myself to do everything for the last 10 days.


You might be right about the accumulation thing. The last dose of 5mg I took last sunday was from a new vial, as the last vial didn't even even last 4 weeks. I am thinking this new vial might be more than the 20mg it was supposed to be. Plus this time I reserved some of the BAC to prime the filter and flush the last bit of reta out of it after I filtered it. The COA some guy showed me of the vial he had tested from that same batch had 22mg in it. That's the only thing I can think of. I was supposed to take my dose last night but I figured I better wait until I'm well.
Since I feel a lot better today, I think I am going to pin 2mg tonight and then another 2mg on Friday morning if things go well.

I don't blame you for being apprehensive about starting back up. I never want to feel like that again and I'm sure you don't either. I guess that's risk we take doing these China peps. I'm 12lbs from my goal and I'm not in a big hurry so I am gonna split for a while and see how it goes.

The “I have to force myself to function like a normal human being” part has been one of the scariest aspects for me too. It’s such a strange kind of malaise because it feels way beyond ordinary nausea or fatigue.

Your theory about the vial actually makes a lot of sense, especially combined with the accumulation possibility. A slightly overdosed vial + delayed build-up could absolutely explain why it suddenly felt so disproportionate after previously tolerating it.

Hearing that you already feel much better today gives me a lot of hope, because I’m also improving… just frustratingly slowly haha

Your split-dose plan sounds really reasonable and cautious to me. Please report back how it goes, because right now I feel emotionally betrayed by syringes and I need success stories…

Also congratulations on being only 12 lbs from goal, honestly at that point taking things slowly and carefully sounds very wise.

 

[sheilarae74]

The “I have to force myself to function like a normal human being” part has been one of the scariest aspects for me too. It’s such a strange kind of malaise because it feels way beyond ordinary nausea or fatigue.

Your theory about the vial actually makes a lot of sense, especially combined with the accumulation possibility. A slightly overdosed vial + delayed build-up could absolutely explain why it suddenly felt so disproportionate after previously tolerating it.

Hearing that you already feel much better today gives me a lot of hope, because I’m also improving… just frustratingly slowly haha

Your split-dose plan sounds really reasonable and cautious to me. Please report back how it goes, because right now I feel emotionally betrayed by syringes and I need success stories…

Also congratulations on being only 12 lbs from goal, honestly at that point taking things slowly and carefully sounds very wise.

I took 2mg last night and I still feel ok. I am going to pin that dose every 3.5 days for a while and see how it goes.

 

[chipsandsalsayall]

Yes, this has happened to me, one time. I had been on Zepbound for about 6 months, then had to change to compounded (not gr*y). About 2 month into the compounded (7.5 mg IIRC), I got really bad nausea, diarrhea, and all manner of gastric rumblings and burps. Bad, I mean really bad. I didn't eat anything rich or greasy. Nothing was different. Then after about 2 - 3 days it subsided and never happened again. I almost went to the doctor, but I'm stubborn. Never has happened again. Weird.

 

[lessthanhalf]

Malaise or an illness response is a GLP-1 effect, and often goes with nausea and or food aversion. Basically designed to get you to lie down and rest and recover, and feel like crap while you do it so you are not inclined to get up and do anything. I definitely had all of those on ozempic , even at low doses. The circuits in the brain for malaise and nausea are linked and get activated by illness or toxic substances, or by GLP-1 activation. Thankfully the malaise side effect does not seem to be very common, and is definitely dose dependent. The GIP agonism in tirz and reta act against this effect making it less of an issue.

 

[lil ghost]

After 5 weeks at 3 mg, everything happened all at once, as if I had injected 30 mg instead of 3 mg. Same vial, NO dosing mistake, no math crimes committed.

My stomach basically factory-reset itself. I got hit with nausea unlike anything I’ve ever experienced, extreme weakness, and a general feeling of absolute doom.

The same thing happened to me! On Friday, I took my standard dose of 2.5 mg of tirz and then woke up on Saturday with horrible nausea and I was unable to eat or drink anything. I vomited on Sunday after trying to eat something and I've been weak, shaky, and dead tired since. I'm definitely skipping my next dose and lowering it next time I take it.

 

[Mara_aa]

I took 2mg last night and I still feel ok. I am going to pin that dose every 3.5 days for a while and see how it goes.

Please keep updating if you can, because I am now emotionally invested in your nervous system lol

 

[Mara_aa]

Yes, this has happened to me, one time. I had been on Zepbound for about 6 months, then had to change to compounded (not gr*y). About 2 month into the compounded (7.5 mg IIRC), I got really bad nausea, diarrhea, and all manner of gastric rumblings and burps. Bad, I mean really bad. I didn't eat anything rich or greasy. Nothing was different. Then after about 2 - 3 days it subsided and never happened again. I almost went to the doctor, but I'm stubborn. Never has happened again. Weird.

The fact that it never happened again afterwards is incredibly reassuring to read right now.
What you describe sounds very similar to this strange “sudden hit by a truck after months of stability” pattern that several people in this thread seem to have experienced.
I’m really hoping mine ends up being just temporary GLP chaos too

 

[sheilarae74]

Please keep updating if you can, because I am now emotionally invested in your nervous system lol

I will next week, I promise. 😁

 

[sheilarae74]

Please keep updating if you can, because I am now emotionally invested in your nervous system lol

Well, I been doing 2.5mg every 3.5 days since and it is working very well. The only time I feel any nausea is when I am not getting enough hydration and I don't ever get super exhausted if I eat enough protein. I also added Nicotinamide Riboside and methylene blue to my supplement regimen and my energy level is a lot better. I have been able to accomplish quite a bit around the house every weekend, so I think I made the right decision to split my dose 2x weekly.

 

[Mara_aa]

Well, I been doing 2.5mg every 3.5 days since and it is working very well. The only time I feel any nausea is when I am not getting enough hydration and I don't ever get super exhausted if I eat enough protein. I also added Nicotinamide Riboside and methylene blue to my supplement regimen and my energy level is a lot better. I have been able to accomplish quite a bit around the house every weekend, so I think I made the right decision to split my dose 2x weekly.

I’m really happy to hear that, it sounds like you found a schedule that works very well for your body.
Also very interesting about the Nicotinamide Riboside and methylene blue improved energy and motivation can make such a huge difference overall. Being able to get things done around the house again is honestly a really good sign that your balance is improving. 😊

I’m still struggling a bit on my side. After 4 weeks off Tirz, I honestly haven’t seen any major improvement overall, other than the return of hunger and constant food noise. So at this point I’m starting to think Tirz probably wasn’t the main cause of how bad I was feeling.
I do see a few small improvements here and there, but it’s very inconsistent… kind of like taking one step forward and one step back. And honestly, I really feel like I need to restart Tirz because the food noise coming back has been very difficult for me.

 

[lessthanhalf]

Assuming you have not already been back to the doctor, getting checked out again is probably sensible. Not really sure how the Italian health system works , but hopefully basic medical treatment is easier to access than in the US.

If I had to guess, it sounds more like just a nasty virus with some post viral fatigue / symptoms, which is really pretty common and most of the time does not last that long.

But 3 weeks of feeling unwell is easily enough to justify getting checked out again, most likely you will not get a useful answer or anything that actually fixes the problem, but just excluding things that are treatable like iron deficiency and anaemia and diabetes etc is probably reasonable. Without more specific symptoms , the odds are there will not be a specific diagnosis to find, but that does not mean getting checked out is a bad idea.

Really hard to say if the tirz had anything to do with it now, sounds increasingly likely it was nothing to do with it but hard to be certain. It probably makes sense to wait on restarting tirz until you have been checked out and maybe on feeling a bit better, a calorie deficit is not likely to help feeling tired.

 

[rkbleddyn]

Yes, the first day I injected it, I woke up vomiting the next morning and then dry heaving for about 30 minutes, so bad, my abdomen hurt the rest of the day.

Now it's a little more tolerable, well a lot more, but it's not pleasant, especially the first couple of days after an injection. I've done 5 injections now and I still don't know if I will be able to stay with this for much longer. And I'm on 1.5mg, I could not tolerate 2.5 at all.

 

[lessthanhalf]

Yes, the first day I injected it, I woke up vomiting the next morning and then dry heaving for about 30 minutes, so bad, my abdomen hurt the rest of the day.

Now it's a little more tolerable, well a lot more, but it's not pleasant, especially the first couple of days after an injection. I've done 5 injections now and I still don't know if I will be able to stay with this for much longer. And I'm on 1.5mg, I could not tolerate 2.5 at all.

No real context to this post, If you are very sensitive to the drug and it sounds like you are to the nausea / vomiting type side effects, there is no rule about how low to drop the dose, and the fact that the side effects are worse the first 3 days suggests that lower doses twice a week might be worth trying. I would go as low as 0.5mg twice a week and see if it is ok. if you cannot tolerate that then maybe the drug is not going to agree with you ( I assume tirz based on the dose ), and after several weeks of that being ok, then increase very slowly to 0.75mg twice a week. Most of the time the nausea and vomiting do slowly improve over time, but if the side effects are that unpleasant you need to drop the dose, and I would suggest split it to twice a week, and once all that is ok increase super slow at 0.5mg per 4 weeks, or about 5 x slower than standard. Also look up glp plotter so you can see what different doses and timings do on a graph , it makes it easier to understand, and double check your dilution and dosing calculations in case the dose is higher than you think it is.

 

[Mara_aa]

Assuming you have not already been back to the doctor, getting checked out again is probably sensible. Not really sure how the Italian health system works , but hopefully basic medical treatment is easier to access than in the US.

If I had to guess, it sounds more like just a nasty virus with some post viral fatigue / symptoms, which is really pretty common and most of the time does not last that long.

But 3 weeks of feeling unwell is easily enough to justify getting checked out again, most likely you will not get a useful answer or anything that actually fixes the problem, but just excluding things that are treatable like iron deficiency and anaemia and diabetes etc is probably reasonable. Without more specific symptoms , the odds are there will not be a specific diagnosis to find, but that does not mean getting checked out is a bad idea.

Really hard to say if the tirz had anything to do with it now, sounds increasingly likely it was nothing to do with it but hard to be certain. It probably makes sense to wait on restarting tirz until you have been checked out and maybe on feeling a bit better, a calorie deficit is not likely to help feeling tired.

My doctor actually told me something very similar and advised me to wait another month and then repeat my blood tests.

Slowly I am improving and starting to feel a bit stronger again. At this point I am also increasingly convinced that the tirz had nothing to do with it.

After speaking with my doctor, it seems more likely that it was just a terrible combination of extreme exhaustion from work stress, a virus, the flu, and probably also not eating enough.

Thank you very much, your thoughts and experience really help me understand things better.

 

[Mara_aa]

Yes, the first day I injected it, I woke up vomiting the next morning and then dry heaving for about 30 minutes, so bad, my abdomen hurt the rest of the day.

Now it's a little more tolerable, well a lot more, but it's not pleasant, especially the first couple of days after an injection. I've done 5 injections now and I still don't know if I will be able to stay with this for much longer. And I'm on 1.5mg, I could not tolerate 2.5 at all.

Follow what @lessthanhalf told you. I found the same tolerance difficulties with tirz that you are experiencing, and now, after 7 months, I’m only at 2.75 mg.

I restarted with 1 mg once a week and increased very slowly. In the beginning, I couldn’t tolerate 2.5 mg at all.

Don’t give up without trying lower doses first, because the results are worth it. 🫶