Anyone Switch From Reta to Tirz?

[PepPepM]

I have been on Reta for nearly 1.5 years now and found it to be quite effective at first but I have now titrated up to about 9mg per week and finding that the same effects are not there. I know that Tirz has a greater effect on food noise suppression and I am considering switching to Tirz. I also have heard some good anecdotes on combining reta with Cagri to get that enhanced food noise suppression.

Wondering if anyone here has had experience switching from Reta to Tirz or adding Cagri to their stack?

 

[SoCalGirl]

I have been on Reta for nearly 1.5 years now and found it to be quite effective at first but I have now titrated up to about 9mg per week and finding that the same effects are not there. I know that Tirz has a greater effect on food noise suppression and I am considering switching to Tirz. I also have heard some good anecdotes on combining reta with Cagri to get that enhanced food noise suppression.

Wondering if anyone here has had experience switching from Reta to Tirz or adding Cagri to their stack?

So interesting you wrote this! I have been thinking about swapping Reta for Tirz for the last two weeks or so.

I did add Cagri to the Reta and it did work for the food noise that Reta does not address with some of us. Started at .25mg Cagri and upped to .5mg now weekly. Using 3.5mg of Reta. Works perfectly. I want to switch because I "think" that I had less inflammation with Tirz. Crazy? Maybe...

 

[woundcarping]

I have been on Reta for nearly 1.5 years now and found it to be quite effective at first but I have now titrated up to about 9mg per week and finding that the same effects are not there. I know that Tirz has a greater effect on food noise suppression and I am considering switching to Tirz. I also have heard some good anecdotes on combining reta with Cagri to get that enhanced food noise suppression.

Wondering if anyone here has had experience switching from Reta to Tirz or adding Cagri to their stack?

There just was a thread on this.

What are you wanting to accomplish?

Why did you stop moving up the dose at 9mg?

 

[gusterbuster]

I would stack vs swap. My rational is instead of playing this titrate down of reta and up on tirz or cold turkey reta and start with low dose tirz, you already have your baseline and add to it.

I stack sema with reta as reta is a poor glp 1 agonist. So sema fills that gap and I get the skin sensation over 8mg reta.

 

[Devilseye]

Ive done this. I started with tirz actually and found food noise suppression to be great. Steady consistent weight loss. I travjed everyghing. Daily weight loss, waist circumference, etc. Then switched to 8mg reta. Found that food noise was much higher, more side effects (HR increase, skin itching for me), and weight loss was more or less in par with tirz and even slitghly lower actually for some weeks. Decided to switch back to tirz and survo (for the GCGR activation) and get the best of everything. Couldnt be happier really. Doing 10mg tirz with 2.4mg survo. Weight loss has increases for sure and most days i can go without eating for a good while. Allows me to do intermittent fasting without issue.

TLDR: I recommend it. Weight loss is about on par, quality of life is up, and side effects down.

I say go for it!

 

[PepPepM]

Ive done this. I started with tirz actually and found food noise suppression to be great. Steady consistent weight loss. I travjed everyghing. Daily weight loss, waist circumference, etc. Then switched to 8mg reta. Found that food noise was much higher, more side effects (HR increase, skin itching for me), and weight loss was more or less in par with tirz and even slitghly lower actually for some weeks. Decided to switch back to tirz and survo (for the GCGR activation) and get the best of everything. Couldnt be happier really. Doing 10mg tirz with 2.4mg survo. Weight loss has increases for sure and most days i can go without eating for a good while. Allows me to do intermittent fasting without issue.

TLDR: I recommend it. Weight loss is about on par, quality of life is up, and side effects down.

I say go for it!

This is something I haven't considered (Tirz + Survo), do you find that the Survo side effects are less despite the stronger glucagon receptor activation compared to Reta?

 

[Devilseye]

This is something I haven't considered (Tirz + Survo), do you find that the Survo side effects are less despite the stronger glucagon receptor activation compared to Reta?

Side effects are basically non existent for me at least. Only downside is a slight increase in cost compared to reta. But my weight loss and appetite suppression has been fantastic. Survo is much much stronger than reta at GLP1R which is probably why.

Since the price from china is not cost-prohibitive, its a no brainer for me and i intend to stay on the stack for a while. Like reta, survo is great at visceral fat which i want to get rid of as much as i can. Its actually one of its main indications.

I highly recommend the stack.

 

[tendency]

I have been on Reta for nearly 1.5 years now and found it to be quite effective at first but I have now titrated up to about 9mg per week and finding that the same effects are not there. I know that Tirz has a greater effect on food noise suppression and I am considering switching to Tirz. I also have heard some good anecdotes on combining reta with Cagri to get that enhanced food noise suppression.

Wondering if anyone here has had experience switching from Reta to Tirz or adding Cagri to their stack?

Yes, I switched from reta to tirz .. there's a number of threads on this topic if you search. Just go low and slow when moving from one to the other.

 

[FartfulCodger]

I made the switch. Both ways. I started out on Tirz in November, lost 25 pounds in 2 months. I was elated, but got greedy and wanted to lose at a faster rate. Reta was the "in" thing and I was impressed with the other benefits I'd read about. Started scaling into Reta in mid-January while scaling out of Tirz. Noticed pretty quickly that the appetite suppression I had come to rely on--the cornerstone of my weight loss strategy--was fading. I was getting hungrier faster. So I added Cagrilintide, starting small, and that worked great in conjunction with the other two. So I thought I had a good plan going forward. I'd eventually phase out Tirz and be on just Reta and Cagri. After that, I could phase out the Cagri once Reta's appetite suppression kicked in, supposedly at higher doses. Sounds like a great plan, right?

But as I increased my Reta dose, I started to get allodynia--a really annoying side-effect that can affect your sleep and ability to exercise (back pain). I got so sick of it that I started phasing out Reta, dramatically, and started at my old Tirz dose. Appetite suppression came back, thank goodness, especially as I was still on Cagri. It took a few weeks for the allodynia to fade away, and I felt much better.

Today I'm about 12mg Tirz and 2mg Cagri weekly. I split that into multiple doses so that the hunger (or lack thereof) stays constant. I also take about 1mg of Reta weekly, just because I know it's a really great product and I feel like I can ultimately beat the allodynia if I just keep some Reta in my system (other Reta users who've had allodynia say it eventually goes away). I want to have a solid maintenance strategy once I reach goal weight, and hope that Reta can be part of that, or maybe all of it.

I believe all the people who have had a very positive experience with Reta. It truly is a miracle drug. But it wasn't right for me at the time, or maybe I introduced it the wrong way. I feel like I'll have some more latitude to play around with it once I reach goal weight.

 

[JokeyJo]

I’m about to do this. I did ok on Tirz.

Swapped to Reta, and the anhedonia is bad, plus I’m getting bad anxiety and feelings of dread and doom. If those feelings are even possibly due to Reta it’s not worth it for me. Plus the anhedonia feels worse than the anhedonia you get from Tirz.
So I’m about to move back to it.

 

[lessthanhalf]

Reta is a more effective drug for weight loss than tirz. To switch to tirz there really needs to be a reason. Feeling like it is less effective cannot be interpreted in isolation.
Are you at your goal weight? how much did you lose? age height etc. Are you losing or gaining weight now.?
If you have lost a lot of weight it is normal to need less calories in and to be more hungry, if your weight is not increasing then the drug is working fine in maintaining weight, but not enough to lose more, this is just the new normal for you on that dose of drug.
If you still want to lose more weight and do not have side effects that are a problem, increasing the dose is by far the simplest and easiest way to do that. Swapping or adding in another only really makes sense if you cannot increase doses due to side effects or are already at 12mg, and even then increasing might make sense if no side effects.
Adding in new drugs carries small but real risks of new side effects and drug allergies.
Adding low dose cagri makes much more sense than swapping to tirz or tirz/survo, but I would increase to 12mg first.

 

[SoCalGirl]

Just gotta jump in here and tell y'all I LOVE how we experiment and find unique solutions to our issues. I LOVE this forum. I've tried them alllll and keep coming back here. Such a great group of smart, experimental folks who are willing to share their journey - the good, the bad, the ugly, and sometimes the scammed! 😍

 

[PepPepM]

Just gotta jump in here and tell y'all I LOVE how we experiment and find unique solutions to our issues. I LOVE this forum. I've tried them alllll and keep coming back here. Such a great group of smart, experimental folks who are willing to share their journey - the good, the bad, the ugly, and sometimes the scammed! 😍

Getting scammed is the character building canon event that bonds us all

 

[SoCalGirl]

Getting scammed is the character building canon event that bonds us all

I have SO MUCH CHARACTER it hurts 🤣