As your research subjects titrate up do you add less BAC?

[Inertia00]

I've been searching and can't seem to find an answer for this question: As your research subjects titrate up do you add less BAC?

For my research I went low and slow. I had my trial run at .5/.75/1/1.5/2mg every 6 days. I reconstituted 1ML BAC to 10mg and was administering 20 units SC at the highest dosage. I am about to Recon my second 10mg.

As we titrate up do people really admin 60, 80, 100units SC or do you reduce your BAC to something more reasonable? These higher dosages for SC injections seem like a lot. I'm wondering what folks are doing for recon? Does someone on 12mg really admin 120units SC?

Wondering from the veterans, What's your recon strategy, any limits to how little BAC you can safely recon with?

Thanks in advance.

 

[Slogger]

I'm not able to answer all your questions but this is what I am currently doing. I pin tirz from 30mg vial. This last vial I only put in 2mL of bac water instead of 3mL so my pin amount is reduced and I haven't noticed any issues. You don't say what you are pinning so I can't speak to that.

 

[Chili777]

I do. I have R50 vials. The first vial I reconned with 2 ml and the last few have been 1 ml as I worked up to 8 mg a week. I'd rather do 10 UI than 20+ UI. It's really a personal decision. I will reconn to keep any sq pin to no more than 25 IU, but that's me. Not counting NAD and a few other large ones.

 

[byefatlicia]

Yes, you can and should adjust your Bac as you titrate. I like 50 units or .5ml per dose. Use a pep calculator to get accuracy if needed🙂

 

[latviantower]

When I was doing compounded tirz, the pharmacy was lazy and had only one concentration - 10 mg/ml. By the time I got to max EL recommended dose, it was a 150 unit ordeal requiring two syringes.

When I got smarter and went gray, I adjusted. Now I use 60 mg vials with 2 ml BAC (30 mg/ml), so it’s only 50 units.

 

[woundcarping]

Yes, to a limit. I’ve read there can be interactions at higher concentrations, varied by peptide.

 

[Dos-Dox]

I decide on how much BAC based on two factors: 1) making the math easy and 2) making the volumes of my expected pins fall into a range that I can accurately measure, but not so big that it’s an unnecessarily large (injected) volume.

If you’re taking a low dosage, then sometimes it helps to have a larger volume so that you can accurately measure it with your syringe, so this would be a reason for a higher dilution. On the flip side, if you’re at a higher dosage, then you don’t want a super high dilution because it’s unnecessary to pin a huge volume and may lead to more of an irritation at the IS.

For almost all of my peps, I target a 10 mg/mL ratio to keep the dosage math simple. For example, if the actual mg of my vial is 23mg, then I’ll add 2.3mL. Then if I want 0.5 mg, I draw 5 IU. If I want 2.0 mg, I draw 20 IU. But again, most of my research of various peps are at low dosages currently, so I want it more accurate on the syringe on the lower end. If you were taking 20 mg of something, you wouldn’t want to draw 100 IU twice, so that wouldn’t be a good concentration to use.

For an example of a different pep, for MOTS-C, I researched at 5 mg/injection. My vials tested at 10.44 but I don’t want to do a 50 IU pin, so I use 0.52 mL BAC so that each injection is 25 IU.

Since you are specifically asking about reta, for the dosages you’re talking about, you could probably stay with a standard concentration. What will probably happen is that as you increase your dosage (or find some smoking deal you can’t pass up 🤣), you’ll probably end up buying higher mg vials, so it’s possible you could end up using more BAC for a while than you were at your lower dose until you get to significantly higher doses.

 

[Glenn]

My rat does 100 units of Tirz and 100 units of NAD+ without issue.

 

[PopTart]

I prefer my pins to be 15-30 IU but will pin up to 50 IU so I add the bac accordingly.

As far as minimum bac per vial, I generally shoot for 1ml. For vials with much smaller doses than I am pinning, I will add 1ml bac to first vial, draw that out and inject into second vial and repeat to reach a concentration that will support my ideal dosing volume.

 

[Habibibi]

I don't have a target concentration, I just try to stay around 10-50iu for my current GLP1 dosage. I also inject at multiple close sites to avoid ISRs. That's worked well for me so far.

 

[Nextlevel]

I started getting injection site reactions when i moved up to 0.2 ml up to 0.3 ml. Possible my body isn't liking the additional liquid so the last one I split to two shots one at 0.2 and the other at 0.1

 

[miss-sanne]

I have reta 60, and I use 8 mg, but still add 3 ml. Next time I'll add 2 ml.