Body stopped responding

[Voidnoodle]

Is it possible that my body has just stopped responding to any type of GLP1 medication?

I was on Wegovy for a while - over a year. Had amazing success then my insurance stopped covering it. Was off it for about 5 weeks then started compound semaglutide. Didn’t work so I switched to Tirz peptides. Still nothing so I just added (this week) 1 mg of Survoduride.

I do get sulfur burbs but literally no cessation of food noise or appetite. I’m ravenous and gaining weight. I worked SO hard to lose the weight (I lost over 100 before taking the wegovy) and I’m terrified of gaining it all back.

I did also try cagri but it just made me so exhausted,I was falling asleep at work.

I’d love any ideas. Thank you!

 

[indolent]

Have you tried a consistently low-carb diet?

I've found that in weeks when I have carbs, I stop losing weight or even gain quite a lot (probably water retention)?

 

[Skidude]

Not sure on your timelines for the Tirz or sema, but it may just be you are having to ramp up to a dose that is effective.
100% opinion only based on much I have read, but it is my understanding for many the first starting dosages do not help for many people and they need to get up to larger doses.
Need more information on your dosing to even comment really, but if you just started back at 2.5/5/7.5 or whatever you may need to slowly titrate up to a higher dose to have the effect you are looking for.
Also, I understand sema does more for food noise than Tirz so you may be getting benefits eventually that have not kicked in yet. I cannot speak towards the cagri

 

[Voidnoodle]

Not sure on your timelines for the Tirz or sema, but it may just be you are having to ramp up to a dose that is effective.
100% opinion only based on much I have read, but it is my understanding for many the first starting dosages do not help for many people and they need to get up to larger doses.
Need more information on your dosing to even comment really, but if you just started back at 2.5/5/7.5 or whatever you may need to slowly titrate up to a higher dose to have the effect you are looking for.
Also, I understand sema does more for food noise than Tirz so you may be getting benefits eventually that have not kicked in yet. I cannot speak towards the cagri

Thanks for responding!

Since switching to Tirz, I’ve done two weeks at 7.5 and then this week went up to 10mg.

 

[Skidude]

It is odd that you had so much success with sema name brand but not compound.
I am far from an expert on this, but some combine sema and tirz for the food noise.
I would suggest other diet based recommendations, but after losing 100lbs this is not your first rodeo.
I would love to see what others say.

 

[Calm Logic]

According to this article, you may want to ask your doctor to add phentermine or Qsymia (phentermine/topiramate):

Why Do GLP-1 Drugs Stop Working, and What to Do About It?

Everybody has a set point, and every weight loss intervention eventually leads to a plateau, so it helps to have a variety of tools to support patients.

www.medscape.com

Several strategies can be used to help patients break through a plateau. One is to try multiple weight loss agents with different targets — something often done in the real world, Stanford said. "You don't see this in the studies, which are focused on just one drug, but many of our patients are on combination therapy. They're on a GLP-1 drug plus phentermine/topiramate plus metformin, and more. They're usually on three, four, five drugs, similar to what we would see with resistant hypertension."

If a patient plateaus on a GLP-1 drug, Stanford might add phentermine. When the patient reaches a plateau on phentermine, she would switch again to another agent. "The goal is to use agents that treat different receptors in the brain," she said. "You would never use two GLP-1 agonists; you would use the GLP-1, and then something that treats norepinephrine, for example."

I have not tried Qsymia myself, but it seems very promising. It is a combination of phentermine and topiramate that can be taken long-term, unlike phentermine (which is given at a higher dose when taken by itself).

(There is also a savings program for Qsymia, including direct pricing for home delivery: "After benefits verification, if Qsymia is not covered, the cash price is $98 across all doses and product packs." "$98 home delivery pharmacy pricing includes 6-week New Patient Packs, 6-week Titration Packs and all 30-day prescriptions. Additional shipping and handling costs will apply.")

 

[Calm Logic]

Reta does come to mind since it can raise heart rate like phentermine.

But a non-GLP I came across is teso (tablets), which is stimulating like phentermine but can be taken longer-term:

Tesofensine - Wikipedia

en.wikipedia.org

Thread 'Teso is awesome.'

Sep 15, 2024

This is not medical advice:

If you have GLP1 fatigue and/or anhedonia, you should read up on tesofensine. It was originally aimed at neurodegenerarive disorders such as Alzheimer’s and Parkinson’s. Some benefits include:

— Mood enhancement/improvement
— Energy increase
— Appetite suppression

Warning: do not take while on SSRI medication. This can cause serotonin syndrome.

After 8 days of ~125mcg, my own personal research reflects those beneficial outcomes. It’s been a great week and I’m looking forward to the next one!

UPDATE

Day 9 (9/15)...

• peptideusername
• Replies: 115
• Forum: Tesofensine

• 
• 

Tesomet, which apparently ran out of funding, combined teso with metoprolol:

Tesomet - Saniona

Tesomet is an investigational fixed-dose combination therapy of tesofensine (a triple monoamine reuptake inhibitor) and metoprolol (a beta-1 selective blocker). Saniona is advancing Tesomet for hypothalamic obesity and Prader-Willi syndrome, two severe rare disorders characterized by obesity and...

saniona.com

Another option is OTC continuous glucose monitoring. Since I am responding well to tirz, the only tech I use is my Fitbit (which is good for monitoring resting heart rate if I ever try reta).

Regarding cost, phentermine (or metformin) may be the cheapest way to augment for now. (I would also get some new bloodwork done to check A1c, lipids, etc., such as to see if they are still responding to the GLP-1s.)

More info:

N

Post in thread 'Ok, I’m bored. And semi addicted. What’s next?'

Dec 3, 2024

I've been using Tesofensine since July with 10mg/week of tirz. Tirz was great for losing my first 50 lbs., but then my weight loss pace slowed down by half. For 7 months, I was only losing 0-5 lbs even though I still had 90 lbs to lose. Even on tirz, my metabolism is still a good bit slower than average for my height and weight.

Tesofensine supposedly speeds up your metabolism. Sure seems like it! I lost 6 lbs the first month. Added 2mg/week of reta the second month, but that was the only vial I had to experiment with. I lost 8 lbs that month. I went back to just tirz/tesofensine...

• NolaJen1120

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Post in thread 'whats your weight loss stack?'

Oct 25, 2024

Currently on Tirz since June (Sema before that from March) with 37 pound loss so far.
Have stacked AOD (cycled off 3 weeks ago) and loved it.
Have been researching Tesa and Ipa for the past 3 weeks and have seen a great reduction in abdominal fat. Really phenomenal.
I added Tesofensine this past week and bam! The weight is melting off and there’s been great energy.
I also add a very low dose of Reta mid week for energy and appetite suppression - but from what I’ve seen from the Teso I will probably d/c the Reta.

• stephaniemeador

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Post in thread 'Peptides for Belly Fat: Which One Works?'

Nov 15, 2024

Research AOD, Ipamorelin and Tesamorelin. Those are the most common that come up for targettig belly fat.

• Key-Baby314

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