BPC-157 and KPV- Is it worth?

[Stormblessed91]

Hello, Im a 34 year old with chronic pain. 3 bulging discs, 3 pinched nerves in my neck and a pinched nerve in my lower back. I also have arthritis in my toes, knee and back. Plus a couple of other pleasant things going on. I started KPV last Monday and was wondering if it was worth it to get a couple vials of BPC-157 to go along with it. I know it comes in KLOW and the wolverine blend but as a standalone (or with my KPV) is it worth?

 

[Calm Logic]

Nobody knows for sure. There are zero human studies with KPV. Weak human evidence with BPC. The GLPs are worth billions and are anti-inflammatory, so upping/maintaining the dose on those is arguably the most important thing.

Personally, I am a fan of Dr. Lee. So yes, get some BPC. It's worth a shot and relatively inexpensive. Even with pets, BPC is the most recommended peptide. I now have three dogs on BPC capsules (since easier than the shots for them). It's just been a few days, so all I know is that it is well tolerated.

BPC is extremely well tolerated in animal studies. There is no known toxic level of it.

A somewhat related thread:

Peptides for a tweaked back

So I just tweaked my back pretty good. For the second time in the same spot and pretty sure it’s a herniated disk. When it happened the first time I felt it for months. I did nothing to help it but it got better and better for a month and then it was just a dull pain that I thought would last...

glp1forum.com

 

[wxmanbc]

Nobody knows for sure. There are zero human studies with KPV. Weak human evidence with BPC. The GLPs are worth billions and are anti-inflammatory, so upping/maintaining the dose on those is arguably the most important thing.

Personally, I am a fan of Dr. Lee. So yes, get some BPC. It's worth a shot and relatively inexpensive. Even with pets, BPC is the most recommended peptide. I now have three dogs on BPC capsules (since easier than the shots for them). It's just been a few days, so all I know is that it is well tolerated.

BPC is extremely well tolerated in animal studies. There is no known toxic level of it.

A somewhat related thread:

Peptides for a tweaked back

So I just tweaked my back pretty good. For the second time in the same spot and pretty sure it’s a herniated disk. When it happened the first time I felt it for months. I did nothing to help it but it got better and better for a month and then it was just a dull pain that I thought would last...

glp1forum.com

Advil works much better than both of them. They are no magical cure to any serious injury.

 

[Calm Logic]

Advil works much better than both of them. They are no magical cure to any serious injury.

NSAIDs are rarely recommended as a long-term solution. But one can also be prescribed gabapentin and duloxetine along with an NSAID like meloxicam or higher-dose naproxen. Pain specialists offer opiods, epidural injections, nerve ablation, nerve stimulation, etc.

 

[Bird_of_Hermes]

I’ve stayed away from bpc due to a hepatic hemangioma that I have. Not that I’m worried about this peptide somehow making it malignant, I don’t really want to make it larger… and taking a drug that is supposed to induce new vascular systems seems like a poor idea.

On the other hand, there are tons of people running around with hemangiomas that don’t know about them, and there is a pretty high chance there are a good number of these people here that are taking bpc without knowing. So, meh?

All that said, I will be trying kpv, mostly for the digestive system benefits. I know the oral version should be better for this, but… I’m not convinced.

 

[Calm Logic]

A ranking of potential cancer risk from higher to lower, with BPC in the middle, per Google Gemini:

TB-500 > Exogenous hGH > Tesamorelin > BPC-157 > Glutathione > GHK-Cu > KPV

KPV is anti-tumor, if anything, with not even a theoretical cancer risk.

 

[px1984]

Ive just started KPV as i have UC and looking for ways to help with general inflammation of the gut area and whilst others have said there isn't any solid human trials but the few trials/anecdotal stuff in this area is positive as well as the theoretical medical benefit do make sense. Ive opted for subQ because its still a long way to get down to the right area for oral plus should get general benefit as well.

For those of use living with chronic inflammation then for a few dollars a month its worth any benefit even placebo 🤣 Ive got BPC coming but even though there is no real evidence to suggest any risks im still cautious of that.

 

[JourneyToPerfection]

I take BPC157, KPV, and TB500 daily and have been for about 5-7 weeks now. I had sciatica from two bulging disks in my early 20’s (so ten years ago) and was in an accident 3 years ago that gave me severe whiplash and lingering muscle pain. I was also in a lot of horse riding and motorcycle accidents when I was younger.

My pain levels have improved at least 80% over the past month. I temporarily ran out of the TB500 and noticed my neck pain returning which receded again once I got another kit. I rate all 3 of them.

Hope this helps x

 

[Flash-BCR]

I take BPC157, KPV, and TB500 daily and have been for about 5-7 weeks now. I had sciatica from two bulging disks in my early 20’s (so ten years ago) and was in an accident 3 years ago that gave me severe whiplash and lingering muscle pain. I was also in a lot of horse riding and motorcycle accidents when I was younger.

My pain levels have improved at least 80% over the past month. I temporarily ran out of the TB500 and noticed my neck pain returning which receded again once I got another kit. I rate all 3 of them.

Hope this helps x

I have a compression injury in my lower back from my misspent youth. When I am not doing regular walks/hikes, the pain gets pretty severe...I started low dose BPC about the same time as I started back with walks (I am hyper drug sensitive). It pretty much hurt every step. A couple of weeks later, I started KPV, also low dose. My pain started getting better, but I attributed it mostly to the strengthening of my back from the walks (and the 20lb weight loss)...Then last week, I upped the BPC dose to 500mcg and pain dropped off considerably. I upped the the KPV to 500mcg and pain levels dropped again. Up until the increased doses, the pain decline had been linear, but these were more drop offs. It is still probably just the back getting stronger from exercise and weight loss, but it is such a relief not to be hobbled all the time with pain that I am not discounting that the peps are doing their thing too. I am adding TB500 this weekend and will go straight to 500mcg... 👍

 

[JourneyToPerfection]

I have a compression injury in my lower back from my misspent youth. When I am not doing regular walks/hikes, the pain gets pretty severe...I started low dose BPC about the same time as I started back with walks (I am hyper drug sensitive). It pretty much hurt every step. A couple of weeks later, I started KPV, also low dose. My pain started getting better, but I attributed it mostly to the strengthening of my back from the walks (and the 20lb weight loss)...Then last week, I upped the BPC dose to 500mcg and pain dropped off considerably. I upped the the KPV to 500mcg and pain levels dropped again. Up until the increased doses, the pain decline had been linear, but these were more drop offs. It is still probably just the back getting stronger from exercise and weight loss, but it is such a relief not to be hobbled all the time with pain that I am not discounting that the peps are doing their thing too. I am adding TB500 this weekend and will go straight to 500mcg... 👍

I’m not doing a ton of exercise at the moment (or in the past few years) due to multiple reasons with pain & fatigue being one of them, so I can say with all certainty that it’s been those 3 peptides alleviating my pain. I’m on a few others as well but these are the 3 that are linked to pain relief/management. Especially the TB500 😍

 

[Flash-BCR]

I’m not doing a ton of exercise at the moment (or in the past few years) due to multiple reasons with pain & fatigue being one of them, so I can say with all certainty that it’s been those 3 peptides alleviating my pain. I’m on a few others as well but these are the 3 that are linked to pain relief/management. Especially the TB500 😍

Yeah, I am excited to add the TB500 this weekend. I tend to be methodical and wanted to add the BPC/KPV/TB one at a time to see what each did...What a relief to be able to move around without pain being top of mind all the time 👍 Good luck with your, 'journey-to-perfection'...

 

[Bioexplorer]

Advil works much better than both of them. They are no magical cure to any serious injury.

Yep. Lots of anecdotal evidence on these Peptides but feelz can't be trusted. I can't say I noticed anything with BPC-157. Maybe some pain reduction on KPV but nothing as effective as a good NSAID.

Diclofenac is a miracle drug for joint or back pain. Get a Rx immediately if your kidneys are good. Unfortunately, I can't take NSAIDs and am still looking for alternatives.

 

[Calm Logic]

BPC does work miracles in rodents. But for us humans, physical therapy is going to be more effective, addressing the underlying mechanical issues. With my dog with mild arthritis, I still have to use meloxicam or a veterinary NSAID like Carprofen. Hopefully, the BPC will at least help prevent ulcers from NSAID use.

My philosophies about the non-GLP peptides:

1) Taking several peptides may be the best hope/synergy. But on the positive side, most of the peptides have multiple benefits and therefore more potential for synergistic effects. (So for BPC, KLOW -- mixed in the vial, syringe, or taken separately -- is a way to start strong. On the other hand, some people swear by KPV as their favorite non-GLP, adding on to the anti-inflammatory benefits of their GLP use.)

2) For some peptides like BPC and KPV, taking at least twice a day may be more effective than a single daily dose that is higher. And some peptides may be more effective if taken at bedtime, etc:

For a standard protocol involving BPC-157 and TB-500, the most optimal times to dose are right before bed (nighttime) or post-workout. If you are pinning once a day, before bed is arguably the best choice.

3) As with Epitalon for restorative sleep, any peptide that helps with energy levels or exercising more is a winner for chronic pain. People think of MOTS-c and NAD+ for energy, but neuropeptides like PE-22-28 may help with energy if helping mood and cognition.

4) Some peptides are already human drugs and so may be worth more attention. For example, TA1 is a drug in other countries (Zadaxin) that may help any immune-related inflammation. TA1 is also in the Dr. Lee's "top 3" (BPC, Epitalon, and TA1). Besides TA1, another underrated peptide is ARA-290, with more objective human studies than BPC. ARA-290 lowered A1c and showed visible changes in nerve growth vs placebo.

5) Fixing GI inflammation with BPC or KPV can help systemic inflammation, such as from leaky gut syndrome (another source of immune-related inflammation). The same is true with anti-inflammatory diets (like starch-based, whole-food diets espoused by the late Dr. John McDougall).

Diclofenac is a miracle drug for joint or back pain. Get a Rx immediately if your kidneys are good. Unfortunately, I can't take NSAIDs and am still looking for alternatives.

That is a good reminder about the gel version too (brand name Voltaren).

As mentioned in another thread, inversion tables are another option, helping at least in the short term with relief from decompression.

 

[fatjacked]

I have many of the same problems as you, and the short answer is, I think these peps help for maintenance and preventing things from escalating, but if you are in acute pain or having a flare-up, they won't do much. I am currently taking KLOW blend and have previously run a couple cycles of wolverine. I am also on tirz and agree with others who say it's probably the most impactful ingredient for this problem set, due to the positive downstream effects of weight loss in addition to the general anti-inflammatory and systemic benefits, some of which we are only starting to understand. Good luck and I hope you can get things moving in the right direction! I really feel like momentum, habit and consistent movement / training is the key with these long term injuries and chronic pain issues. We have to get strong and stay strong, not for the looks or some toxic alpha bullshit or anything like that, but because it makes us resilient and protects against the wear and tear that makes these injuries disabling over time.