GLP-1 Forum

Can I re-inject tirz after 5 days?

FatPanda

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Sep 20, 2025
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Houston, TX
I took 2.5 mg of tirz on Wednesday, and it made a big difference with some mild side effects of nausea. It's been 4 days I think both benefits (as well as the side effects) are gone now. Can I give myself another 2.5 tomorrow? I know that doctors recommend not giving yourself a dose less than 5 days since your last inject with sema. I was wondering if it is safe to do so with tirz? Kind in a rapid weight gain crisis right now, so I am wondering if the benefits outweigh the risks of side effects.
 
I've been injecting Mon and Thurs for months. This works much better for me than once a week.
 
The short story is that if you're just starting with tirzepatide, stick to standard protocol of 2.5mg once a week, increasing dose by 2.5mg every four weeks. Side effects might diminish as your body gets used to it.

That said...

Tirzepatide has a half-life of five days, and some people experience food noise after that point. Most do fine on days 6 & 7.

So for that case, and when titration introduces intolerable side effects, and as a tactic to break stalls, "split-dosing" is used. There are online tools that help visualize and calculate the split... do a search.
 
I have never had any side effects but I did need to titrate to high doses to get any kind of satiety too. I followed the standard protocol of weekly injections, titrating up every 4 weeks until 12.5mg and then found some satiety and food noise reduction.

However, I found I got headaches on day 1-2, and hunger suppression was really high. I was then feeling no satiety in days 6-7.

I researched alternatives and played with dosing charts a bit. My 'perfect' days 3-5 I was somewhere between 12-16mg in my system so I looked into how to keep myself around that level, rather than highs of 19-20mg and lows of 8-9mg.

For me, it means dosing 6.6mg every 3 days. I stay perfectly in my ideal zone, no headaches or extreme suppression, lots of satiety with meals, no food noise, and no weakening effects at the end.
 
2.5 mg of tirz on Wednesday made a big difference side effects of nausea. 4 days I think both benefits are gone now. Kind in a rapid weight gain crisis right now
I just removed words from your post so it warrants a reread. So on the 4th or 5th day you woke up in a rapid weight gain mode? Being hungry/eating shouldn't be confused with weight gain mode.

Thousands of people tested this drug as directed. You can either follow their overwhelmingly successful path or venture on your own. If you're the type of person who reaches for the second pint of Häagen-Dazs before scraping out the contents of the first you might come back to us way to soon asking why 15mg isn't effective.

Historically people getting "feelz' in early dosing on GLPs tend to have quick or even super responder results. IMO give each dose 4 weeks and eat when your hungry. Eating plus guilt is how some of us got fat in the first place!
 
Follow the advice people are giving you, once a week then go up on dose, once your body gets used to it then you can go every 5 days. Don't think more is better because its not.
I been on 7.5 for 2 months now and loosing about 1LB every week but I also been putting a lot of muscle on since, I go to gym because I don't want to loose muscle.
 
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