Cerebrolysin: first cycle

Chili777 said:
My ampules say 5 years. Just got them this week.
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I kind of want to buy just to have them on hand in case someone in my family has a stroke. Instead of waiting 9 weeks.

I think for stroke it needs to be administered within the first 24-48 hrs to reverse the stroke effects
Chili777 said:
No, my head might explode. 🤯 I've just heard good things about P21 and I think I'll start with that first. P21 was originally derived through epitope mapping of Cerebrolysin. It's synthetic can be used IN. Then I'll do the cerebrolysin in several months.
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I'm just reading more about P21, I am curious on what you are planning to take it for and what dosage. From gemini (interesting stuff):

Risks of p21 (Overexpression/Dysregulation):
  • Promoting Cancer Progression: Paradoxically, high levels of p21 can inhibit apoptosis (programmed cell death) by suppressing Stress-Activated Protein Kinase (SAPK) and Apoptosis Signal-Regulating Kinase 1 (ASK1), potentially allowing cancer cells to survive and thrive.
  • Metabolic Disorders/Diabetes: Elevated p21 is linked to pancreatic
    1774732980059.gif

    -cell dysfunction, accelerating cellular senescence and triggering apoptosis, which reduces
    1774732980067.gif

    -cell mass and impairs insulin secretion.
  • Tissue Dysfunction (Aging): Accumulation of p21-high cells in adipose tissue is linked to chronic inflammation and insulin resistance.
  • Skeletal Muscle Atrophy: High p21 expression is associated with fibrosis and impaired function in skeletal muscle.
    National Institutes of Health (.gov)National Institutes of Health (.gov) +4
Therapeutic Targeting (p21 Suppression):
  • Senotherapy: Eliminating p21-high expressing cells has been shown to improve glucose tolerance, reduce insulin resistance, and extend the healthspan in mice.
  • Cancer Sensitivity: Reducing p21 levels can increase the sensitivity of cancer cells to radiotherapy and chemotherapy by eliminating the G1 checkpoint and forcing them into apoptosis.
    PubMed Central (PMC) (.gov)PubMed Central (PMC) (.gov) +2
Benefits and Risks of P021 Peptide (Experimental Therapy):
Note: P021 is a specific neurotrophic factor small-molecule mimetic under investigation for Alzheimer’s, distinct from the p21 protein.
  • Benefits: Studies show it can rescue cognitive deficits, neurogenesis, and synaptic damage in Alzheimer's mouse models.
 

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itsapinthing said:
I kind of want to buy just to have them on hand in case someone in my family has a stroke. Instead of waiting 9 weeks.

I think for stroke it needs to be administered within the first 24-48 hrs to reverse the stroke effects

I'm just reading more about P21, I am curious on what you are planning to take it for and what dosage. From gemini (interesting stuff):

Risks of p21 (Overexpression/Dysregulation):
  • Promoting Cancer Progression: Paradoxically, high levels of p21 can inhibit apoptosis (programmed cell death) by suppressing Stress-Activated Protein Kinase (SAPK) and Apoptosis Signal-Regulating Kinase 1 (ASK1), potentially allowing cancer cells to survive and thrive.
  • Metabolic Disorders/Diabetes: Elevated p21 is linked to pancreatic
    View attachment 18447

    -cell dysfunction, accelerating cellular senescence and triggering apoptosis, which reduces
    View attachment 18450

    -cell mass and impairs insulin secretion.
  • Tissue Dysfunction (Aging): Accumulation of p21-high cells in adipose tissue is linked to chronic inflammation and insulin resistance.
  • Skeletal Muscle Atrophy: High p21 expression is associated with fibrosis and impaired function in skeletal muscle.
    View attachment 18448National Institutes of Health (.gov) +4
Therapeutic Targeting (p21 Suppression):
  • Senotherapy: Eliminating p21-high expressing cells has been shown to improve glucose tolerance, reduce insulin resistance, and extend the healthspan in mice.
  • Cancer Sensitivity: Reducing p21 levels can increase the sensitivity of cancer cells to radiotherapy and chemotherapy by eliminating the G1 checkpoint and forcing them into apoptosis.
    View attachment 18449PubMed Central (PMC) (.gov) +2
Benefits and Risks of P021 Peptide (Experimental Therapy):
Note: P021 is a specific neurotrophic factor small-molecule mimetic under investigation for Alzheimer’s, distinct from the p21 protein.
  • Benefits: Studies show it can rescue cognitive deficits, neurogenesis, and synaptic damage in Alzheimer's mouse models.
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Those are all the bad parts of neurogenesis, agreed. I hope to limit that by using P21 IN, at 500 mcg per day. IN administration focuses the peptide on the neural pathways and reduces systemic action. I've reviewed several studies and all have been in vivo, and rats typically are given much higher doses per kg than would be suitable for human use. However, we are all our own research subjects.

The benefits I'm focusing on are: Promotes neurogenesis, enhances synaptic plasticity, and has shown significant cognitive benefits in preclinical models of Alzheimer's disease, traumatic brain injury, and age-related cognitive decline. Anecdata reports positive and noticable results in subjects that have used it.
 
Chili777 said:
No, my head might explode. 🤯 I've just heard good things about P21 and I think I'll start with that first. P21 was originally derived through epitope mapping of Cerebrolysin. It's synthetic can be used IN. Then I'll do the cerebrolysin in several months.
Click to expand...
What made you gravitate towards doing the P21 first? I'm in that same groupbuy as you and I have Cerebrolysin on the way.
 
PinKushn said:
What made you gravitate towards doing the P21 first? I'm in that same groupbuy as you and I have Cerebrolysin on the way.
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Because I have surgery next month and I'd have to interrupt the cerebrolysin protocol for a week. I'm not sure that won't effect the results. With P21 and dosing IN, I won't have to and I can take it with me. That's the main reason.

You're in the P21 Adamantine GB, too? I have my first kit coming next week. The GB will be a spare, for now.
 
Chili777 said:
Those are all the bad parts of neurogenesis, agreed. I hope to limit that by using P21 IN, at 500 mcg per day. IN administration focuses the peptide on the neural pathways and reduces systemic action. I've reviewed several studies and all have been in vivo, and rats typically are given much higher doses per kg than would be suitable for human use. However, we are all our own research subjects.

The benefits I'm focusing on are: Promotes neurogenesis, enhances synaptic plasticity, and has shown significant cognitive benefits in preclinical models of Alzheimer's disease, traumatic brain injury, and age-related cognitive decline. Anecdata reports positive and noticable results in subjects that have used it.
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I am really interested to hear your experience after (and during)

Good luck on the surgery, hope all goes well
 
latviantower said:
As Zippity has astutely pointed out, gauge differences are literally “splitting hairs” - it must be purely psychological that a 31g insulin needle is painless but a 27g causes you to shriek.
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As a newbie with needle phobia, I should have paid more attention when I got my 1st 100 box of easytouch insulin syringes for my peps. I didn't realize I clicked on 27g so when they came, I just went for it anyways and I haven't had an issue other than having to psychologically & spiritually prep myself for a week before my 1st pin. This should make the IM less intimidating.
 
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evilution said:
I just need to find a vendor that can be trusted. I'm all in on taking the Cerebro stick.
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I think earlier in this thread folks said they ordered true Cerebrolysin manufactured in Russia under license from Austrian patent owner EverPharm. I’ve had DM’s saying it was $55 per 5 pack plus shipping. Logistics sounded pretty daunting though. Long delays with no updates.
 
latviantower said:
I think earlier in this thread folks said they ordered true Cerebrolysin manufactured in Russia under license from Austrian patent owner EverPharm. I’ve had DM’s saying it was $55 per 5 pack plus shipping. Logistics sounded pretty daunting though. Long delays with no updates.
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Long delays with no updates? Not a whole lot different from most of my china orders. Just sayin.
 
latviantower said:
rupharma.com has a big apology to US customers - admitted Russian post was months behind. Supposedly have it down to 3-4 weeks now.
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After my reta purchase, I was hesitant about what to buy again, if any. Then I saw the 1st post on this thread, and I pulled my wallet out, ready to become a maniac impacting the slaughter of innocent swinelings. Then subsequent entries in the thread made my wallet vanish back into my pocket. Now I'm just a despo feeling like having finally found the nootropic El Dorado of his dreams only to learn that he cant have the visa to visit. Those delivery stories were horrifying.
 
I’m tempted to make a small order just to test this all out. I’m down to 23 ampoules of Chinese cerebro, so I could use some more in the stash…..

It’s $57 for a 5 pack but that’s before shipping and tariffs.
 
Smiter said:
what about the effects? and how about p-21?
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I bought P-21 but it was the wrong kind 😭 it has to have the Adamantane group to pass the BBB, otherwise it's sludge. So I have 2 kits of sludge now. I'm in a GB to get the correct one, so it will be a while for me.
 
Chili777 said:
I bought P-21 but it was the wrong kind 😭 it has to have the Adamantane group to pass the BBB, otherwise it's sludge. So I have 2 kits of sludge now. I'm in a GB to get the correct one, so it will be a while for me.
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This is going to do wonders for my confidence to buy it ASAp. I just saw this Reddit thread about P-21 vs. Cerebrolysin and was stunned enough to pull my wallet out. So how do we know if the adamantane group is present in the molecule?
 
Smiter said:
This is going to do wonders for my confidence to buy it ASAp. I just saw this Reddit thread about P-21 vs. Cerebrolysin and was stunned enough to pull my wallet out. So how do we know if the adamantane group is present in the molecule?
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If they have 2 versions, like mine did, it's the more expensive one. I also translated the Chinese after I ordered and I should have done that prior. There is no cheaping out where Adamantane is concerned. The good news is the GB is $100 less than I would have paid my vendor.
 
Chili777 said:
I bought P-21 but it was the wrong kind 😭 it has to have the Adamantane group to pass the BBB, otherwise it's sludge. So I have 2 kits of sludge now. I'm in a GB to get the correct one, so it will be a while for me.
Click to expand...
I saw a reply in a Discord discussion that said all P21 has adamantane. The poster seems to be somewhat reliable, but don't know how dependable that info is.
 
yeddie said:
I saw a reply in a Discord discussion that said all P21 has adamantane. The poster seems to be somewhat reliable, but don't know how dependable that info is.
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No, it doesn't, but it should. At least my vendor had 2 versions, one for $80 and one for $310 for 10 mg.
 
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Sara360 said:
I’m on the search for P21 with Adamantane. I found a vendor that’s selling for $290 but it doesn’t state it has Adamantane so I should assume it doesn’t?
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Adding Adamantane is a more expensive process, so the price should be reflective of that. I would assume it does have it at that price point, but confirm with the vendor.
 
Sara360 said:
I’m on the search for P21 with Adamantane. I found a vendor that’s selling for $290 but it doesn’t state it has Adamantane so I should assume it doesn’t?
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Here is what that looks like with one of my vendors. The first one is "without Adamantane" in Chinese (obviously) and the second is "with Adamantane". I should have known, but I ordered it a few months ago before I knew the whole story.
 

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Chili777 said:
Here is what that looks like with one of my vendors. The first one is "without Adamantane" in Chinese (obviously) and the second is "with Adamantane". I should have known, but I ordered it a few months ago before I knew the whole story.
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Thank you for this
 
Chili777 said:
Here is what that looks like with one of my vendors. The first one is "without Adamantane" in Chinese (obviously) and the second is "with Adamantane". I should have known, but I ordered it a few months ago before I knew the whole story.
Click to expand...
What has your experience been like? Have you seen improvements?
 
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