Colitis and GLPs?

[Wallydog]

I've been on tirz since Mar 25 I had a strange occurrence in March 26 that has returned again now. Out of nowhere I developed serious bloody diarrhea that concerned me enough to visit the ER. Not blood in the stool. Blood that would make you think you've got serious GIT damage going on. After a few tests (MRI?) they said my colon was pretty inflamed and it was likely a virus causing colitis that would pass eventually. I needed 2.5L of fluids but was sent on my way and I recovered after a couple of tough days. Now, I'm seeing something similar happening again although not quite as severe but very concerning. I hope this isn't related to my use of tirz somehow but it sure seems hard to believe I picked up another virus causing this. Anyone experience anything like colitis after being on the GLP1 agonists?


---- Sorry about the graphic description but I felt it was necessary to distinguish from the diarrhea we can see as a side effect of these drugs.

 

[spanky2026]

Long time IBS sufferer here, until I began Tirz and that just stopped. But yes, I recognize colitis and had a similar but much less severe issue lately that I laid blame to something I ate, literally, a gaseous veggie that I knew didn't agree with me pre GLP, and it certainly didn't now! Tore my gut up for a week, my lower abdomen felt rawly irritated the whole week before finally settling down. As Ive said my whole life, vegetables want to kill you. I'm sticking to meat.

All that to say, is it possible it's also something that severely irritated your gut, and because things in there move slower now, it has more time to bounce around and cause trouble?

 

[Gr33dyOctopus]

I've been on tirz since Mar 25 I had a strange occurrence in March 26 that has returned again now. Out of nowhere I developed serious bloody diarrhea that concerned me enough to visit the ER. Not blood in the stool. Blood that would make you think you've got serious GIT damage going on. After a few tests (MRI?) they said my colon was pretty inflamed and it was likely a virus causing colitis that would pass eventually. I needed 2.5L of fluids but was sent on my way and I recovered after a couple of tough days. Now, I'm seeing something similar happening again although not quite as severe but very concerning. I hope this isn't related to my use of tirz somehow but it sure seems hard to believe I picked up another virus causing this. Anyone experience anything like colitis after being on the GLP1 agonists?


---- Sorry about the graphic description but I felt it was necessary to distinguish from the diarrhea we can see as a side effect of these drugs.

Holy crap buddy! Scary scary stuff. Ive never hear of anything like this associated with tirz.. but wr all know that there are always rare outliers for jsut aboht anything so it is certainly possible...

 

[New2ton]

I've been on tirz since Mar 25 I had a strange occurrence in March 26 that has returned again now. Out of nowhere I developed serious bloody diarrhea that concerned me enough to visit the ER. Not blood in the stool. Blood that would make you think you've got serious GIT damage going on. After a few tests (MRI?) they said my colon was pretty inflamed and it was likely a virus causing colitis that would pass eventually. I needed 2.5L of fluids but was sent on my way and I recovered after a couple of tough days. Now, I'm seeing something similar happening again although not quite as severe but very concerning. I hope this isn't related to my use of tirz somehow but it sure seems hard to believe I picked up another virus causing this. Anyone experience anything like colitis after being on the GLP1 agonists?


---- Sorry about the graphic description but I felt it was necessary to distinguish from the diarrhea we can see as a side effect of these drugs.

I have UC and I've not experienced this since I started GLPs.
Perhaps this is an obvious question, but did you start a new kit? If so, was the kit tested?
I saw a post several months ago about someone having very similar symptoms after starting a new kit, which if memory serves me, turned out to be orange cap T30.

 

[FartfulCodger]

I've never read about this as a side effect, and nothing like this has happened to me since I started Tirz 7 months ago.

The good news is that there are multiple peptides that show promise in treating colitis: KPV, BPC-157, and GHK-Cu. The oral versions would probably work better, if they're available.

 

[Troposphere]

Another with UC here. Been on GLPs since mid March and KLOW blend since the second week of April.

Recent blood tests showed low scores for inflammation markers, but calprotectin was slightly elevated. Got a scope in two weeks so I will report back. Just adding my $0.02 as another data point.

Sorry this is happening to you, flare ups are never fun.