Considering Survodutide
- Thread starter brentm
- Start date
seems pretty quiet around here. if you do decide to try it out, would be great for you to post your experience here.
i'm not much familiar with it, i just did a quick google for clinical trials and it seems like weight loss results are about on par with semaglutide but not as good as tirzepatide. any specific reason you want to try it?
i'm not much familiar with it, i just did a quick google for clinical trials and it seems like weight loss results are about on par with semaglutide but not as good as tirzepatide. any specific reason you want to try it?
i saw that one trial, the highest dose was 4.8mg. promo price is 100mg for $170 so that's about 20 doses for $170, seems about the same per dose as tirz. (not saying that's good or bad, just working out the math here out loud)
I'm on Tirz now...
It's really between Retatrutide and Survodutide... Reta can cause an increase in resting heart rate, where Survo is reported not to have that side effect. That's the main reason I'm curious about Survo.
Why not blaze some new territory? But then Reta 100mg is 125 on promo...
yeah go for it, i realized after that my reply may have come across as argumentative, i didn't mean for it to. i'm curious about it too, and also curious how people make the decisions on which products to use. basically i originally chose tirz because it showed greater weight loss percentages than semaglutide and i needed to lose over 20%. but other people decide for different reasons (like the heart rate thing, some people decide on price, availability of compound, etc). i think it's interesting that it seems like people do develop a bit of loyalty to their first glp1 if it works for them.
but i haven't seen much talk about survo so was just wondering how it caught your attention.
if you go for it, good luck.
but i haven't seen much talk about survo so was just wondering how it caught your attention.
if you go for it, good luck.
Nah, I didn't take it as argumentative at all.
I started on Semaglutide because it was the lowest cost compound option. And I think my provider steered me that direction thinking we'd always have Tirz in our back pocket should Sema not work.
I'm super interested in survo, but I have a freezer full of Sema and have some tirz arriving tomorrow.... I might just take the leap. I am just hesitant because I haven't seen anyone else on it. Keep meaning to join other forums to see if anyone has actually tried it.
Lullabytreehugger
GLP-1 Enthusiast
Google isn't helping me here and I'm feeling incredibly dumb for not quite understanding what these numbers mean.
Had to use chatgpt...
The GLP-1 K value is a measure of the binding affinity of a ligand (such as a GLP-1 receptor agonist) to the GLP-1 receptor. GLP-1 (glucagon-like peptide-1) is a hormone that plays a role in glucose metabolism, and its receptor is a target for drugs used in the treatment of type 2 diabetes and obesity.
The GLP-1 K value is a measure of the binding affinity of a ligand (such as a GLP-1 receptor agonist) to the GLP-1 receptor. GLP-1 (glucagon-like peptide-1) is a hormone that plays a role in glucose metabolism, and its receptor is a target for drugs used in the treatment of type 2 diabetes and obesity.
Key points about the GLP-1 K value:
- Definition of K value:
- The "K" generally refers to a dissociation constant (KdK_dKd) or inhibition constant (KiK_iKi), depending on the context.
- KdK_dKd: Reflects the concentration of ligand at which half of the available receptors are bound.
- KiK_iKi: Indicates the potency of a compound in inhibiting receptor binding.
- Units:
- The KdK_dKd or KiK_iKi is typically expressed in molar concentrations (e.g., nM, μM).
- Lower KdK_dKd or KiK_iKi values indicate higher affinity, meaning the ligand binds more tightly to the receptor.
- Significance in GLP-1 receptor agonists:
- A low K value suggests a strong and specific interaction between the drug and the GLP-1 receptor.
- Drugs like semaglutide and liraglutide are engineered to have high affinity and prolonged activity at the GLP-1 receptor, often reflected in low KdK_dKd values.
- Experimental determination:
- The KKK value is determined through in vitro binding studies, using methods like radioligand binding assays or surface plasmon resonance.
Breaking Down the Term:
- GCGR (Glucagon Receptor):
- GCGR is a G-protein-coupled receptor (GPCR) that binds glucagon, a hormone involved in glucose metabolism. Activation of GCGR stimulates glucose production in the liver, playing a key role in blood sugar regulation.
- KiK_iKi (Inhibition Constant):
- KiK_iKi quantifies the potency of an inhibitor in preventing a ligand (like glucagon) from binding to the receptor.
- It is defined as the equilibrium constant for the dissociation of the inhibitor-receptor complex.
- Lower KiK_iKi values indicate higher inhibitory potency because the compound binds more tightly to the receptor.
- Units:
- KiK_iKi is typically expressed in molar concentrations (e.g., nanomolar [nM] or micromolar [μM]).
- How it’s Measured:
- KiK_iKi is determined experimentally, often through competitive binding assays. These assays involve measuring how well an inhibitor competes with a radiolabeled or fluorescent ligand for binding to the receptor.
- Significance:
- KiK_iKi helps assess the efficacy of potential drugs targeting the glucagon receptor, particularly for conditions like type 2 diabetes.
- Drugs with low KiK_iKi values for GCGR might act as antagonists to reduce excessive glucagon activity, which can help in managing hyperglycemia.
Thank you, I appreciate this breakdown!
Yeah I find myself using chatgpt more and more for answers to random questions. Remarkable tech really... one of those innovations that changed the landscape seemingly overnight. Maybe not changed for the better either now with pretend experts but really are just quick with ChatGPT.
If I use it, I usually say something like "From ChatGPT"...
I haven't dipped my toes in yet, but what you just did is getting pretty close to convincing me.
Do remember that ChatGPT (and other AIs) will confidently create false or not fully correct information on a regular basis, especially with more niche topics like this.
If you're using ChatGPT 4o, one of the ways to help it weed itself out by asking "are you sure?" and have it give you supporting source data at the end of each prompt response 🙂
I too am considering survo for long-term maintenance, due to lower/no side effects of fatigue like tirz, and studies showing greater reduction in liver fat. I'm already at goal weight and on maintenance dose of 5 mg tirz. I've got 2-3 yrs of tirz supply to either go through, or sell off. Hesitant to sell my tirz, because it would be at a loss $$ compared to what I paid. Have a kit of reta on the way, which will be a new try. Thankful for our shared research experiences!
Huckleberry1
New Member
Tried both serv and maz. Didn't seem to have as good appetite suppression so went back to tirz after 1 vial
NUMBERS999
New Member
Surv has a higher % of GCGR than Reta!
The GCGR being the fat targeting burner in both compounds.
I’m considering experimenting with stacking them both
The GCGR being the fat targeting burner in both compounds.
I’m considering experimenting with stacking them both
Letits Now
New Member
I am in maintenance and like trying different things, but I only used it for a month. But it felt very similar to tirz in my opinion. I would recommend it as an alternative and imagine it would be a good candidate for weight loss.
You don’t ask, but I also tried maz and it felt like placebo.
it says the lower number is stronger so seems reta is stronger. are there studies where these numbers came from or how did someone figure out how much each one is?
I love survo! Only a few doses, as needed, at 125mcg, which is less than 1/2 the starting dose (300mcg). I'm in maintenance, have been since the fall, have slowly moved down on my tirz but there are times when I need a bit of help, not much, but to take the edge off. And since I don't want to increase the tirz - am trying to stay steady weight-wise and not lose more - the 125mcg dose just seems perfect. Of course such a small dose means a 10mg vial lasts forever, but I'm fine with that. I have not used it weekly at this point, nor am I thinking of switching over. I am not interested in cagri, nor in reta - the idea of starting over on a glp and one that requires higher dosing for the benefits I already have on tirz seems antithetical to me. For a brief moment, I had 1/2 kit of Maz but decided against it and sold it off. But survo strikes me as the right thing for now, providing just a bit of suppression when I need it. It also instantly warms me up inside. No idea what that is about.
That’s a really small dose -125 mcg. I read that the starting dose is 600 mcg (.6 mg). Pretty cool that you’re happy with what that small dose does for you.
That’s encouraging for me. You might recall I’m at that same point as you: dropped down to maintenance dose tirz 5.0 and looking to switch to something else. Have Reta that I didn’t try yet and survo on the way.
Not sure when I’ll make the jump to the new stuff.
That’s encouraging for me. You might recall I’m at that same point as you: dropped down to maintenance dose tirz 5.0 and looking to switch to something else. Have Reta that I didn’t try yet and survo on the way.
Not sure when I’ll make the jump to the new stuff.
Hi @G Vice, why are you looking to switch to something else? Just curious?
For me, tirz has all the benefits I require, and I don't feel a need at this point to stop tirz in favor of something else. I've had great luck with it, and feel why mess around? I do like the tiny bit of extra whatever that I have needed so far only once in a while that survo can help me with. All absolutely no side effects, and it seems to speed up both metabolism and digestion.
I think the survo clinical testing has two arms that relate to the ultimate maintenance dose - either 3.6 or 6. The 3.6 arm starts with a dose of 300mcg for 4 weeks and moves up to 600mcg for 4 weeks, and continues to move up every 4 weeks to 1.2mg, 2.4mg, 3.6mg, 4.8mg, and 6mg, with 3.6 being the maintenance dose. I guess the other arm started at 600mg and it's maintenance dose is 6mg.
125mcg is a tiny dose. I alway start anything far lower than a "protocol" states. And nearly always, for me, the tiny dosing works. For instance, I felt ss31 on 1mg. So I love that 125mcg of survo does what I hoped it would do.
For me, tirz has all the benefits I require, and I don't feel a need at this point to stop tirz in favor of something else. I've had great luck with it, and feel why mess around? I do like the tiny bit of extra whatever that I have needed so far only once in a while that survo can help me with. All absolutely no side effects, and it seems to speed up both metabolism and digestion.
I think the survo clinical testing has two arms that relate to the ultimate maintenance dose - either 3.6 or 6. The 3.6 arm starts with a dose of 300mcg for 4 weeks and moves up to 600mcg for 4 weeks, and continues to move up every 4 weeks to 1.2mg, 2.4mg, 3.6mg, 4.8mg, and 6mg, with 3.6 being the maintenance dose. I guess the other arm started at 600mg and it's maintenance dose is 6mg.
125mcg is a tiny dose. I alway start anything far lower than a "protocol" states. And nearly always, for me, the tiny dosing works. For instance, I felt ss31 on 1mg. So I love that 125mcg of survo does what I hoped it would do.
Huckleberry1
New Member
Huckleberry1
New Member
Tried for a month. It doesn't work as well as tirz. Will probably use once I reach maintenance
Hey Ming.
I’m totally in agreement with staying with what got me the results I wanted.
However, tirz fatigue the 1-2 days after injection, although not bad, is something I’d like to get away from.
Survo seems to not cause fatigue, per reports, plus it is better at treating fatty liver and liver fibrosis, which is in my family history.
Those are 2 good reasons to switch.
I’m totally in agreement with staying with what got me the results I wanted.
However, tirz fatigue the 1-2 days after injection, although not bad, is something I’d like to get away from.
Survo seems to not cause fatigue, per reports, plus it is better at treating fatty liver and liver fibrosis, which is in my family history.
Those are 2 good reasons to switch.
@G Vice,
So sorry you still have that tirz fatigue, and to get away from the fatigue and having the family history of what survo addresses are both excellent reasons to switch! I haven't had that fatigue in a long time, I forget that some, even in maintenance, still have to deal with it. Also, the ss31 I'm researching has been incredible for my energy. No other "energy" pep but that one for the last 7 weeks and I never want to stop it! But onto mots next for me. Have you done the ss31/mots/nad protocol?
So sorry you still have that tirz fatigue, and to get away from the fatigue and having the family history of what survo addresses are both excellent reasons to switch! I haven't had that fatigue in a long time, I forget that some, even in maintenance, still have to deal with it. Also, the ss31 I'm researching has been incredible for my energy. No other "energy" pep but that one for the last 7 weeks and I never want to stop it! But onto mots next for me. Have you done the ss31/mots/nad protocol?
Was just talking with someone about the lengths of these GBs - it might be next year before any of this stuff shows up!
YMMV but NAD+ was a energy boost for me.... Had some of my best naps on MOTS-C. MOTS-C made me tired.....
mcmanis
Brand New Member
I've just started stacking Soro with Triz this week. I'm hoping it will stop my plateau.
Super Trips
GLP-1 Enthusiast
its not as fast acting as cagri but it does add nicely to tirz
raw_oyster_eater
lemon bottle brewer
who am I chopped liver? it seems to be doing a really good job. my heart rate is hovering around 100 which is borderline high.
You quoted a post I made in NOVEMBER.
raw_oyster_eater
lemon bottle brewer
That's how you train little girls to tolerate their boyfriends treating them like shit. Tell them boys are only mean because they like them.
How about train boys not to be dicks?
/soapbox
I'm glad the survo works for you 😂
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Super Trips
GLP-1 Enthusiast
Survo (GLP1R) + GCGR) + Tirz (GIPR + GLP1R = Reta (GLP1, GCGR, GIPR)
How did it work for you? I'm considering stacking it tirz also. Just to see if that GCGR helps any.
tncc_rn
GLP-1 Member
I add 1mg Survo 4 days after I do my Triz injection as a stack. Seems to keep the suppression going. I'm on max Triz, and it only seems to last for 4 days now. Adding the Survo on day 4 gets me to day 7 for the next Triz shot.
Used to do Triz+Cargi and then Reta+Cargi 4 days later, but its just to much injecting at the end of the week.
Triz/Survo is more convenient....
Lullabytreehugger
GLP-1 Enthusiast
How does survo compare in “feels” to reta or tirz?
Which do you guys think is the stronger drug?
Which do you guys think is the stronger drug?
tncc_rn
GLP-1 Member
Survo really knocks down the food noise when used with Triz for me.
I agree.. I really dig it.
Super Trips
GLP-1 Enthusiast
survo is alot like sema but about 2- 3x stronger at first
Lullabytreehugger
GLP-1 Enthusiast
Currently im at 12mgs reta (6mgs twice a week) if I needed to change to survo how strong a dose would I need?
Also how strong is survo for fatty liver?
Also how strong is survo for fatty liver?
Super Trips
GLP-1 Enthusiast
start a 1mg survo it clogs you up pretty good to start
Calm Logic
GLP-1 Specialist
Is there any consensus at all about tirz + reta vs. tirz + survo? It seems the answer is "hell no"?
I am leaning towards trying survo first:
Edited to add:
I am leaning towards trying survo first:
Edited to add:
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Calm Logic
GLP-1 Specialist
Your tachycardia with reta didn't mean more energy, right?
I have noticed being more tired during the day since dropping it. I've been off it for about a month and my heart rate has only dropped marginally.
Heck, if in another month it still hasn't dropped, I may as well go back to Reta.
