seems pretty quiet around here. if you do decide to try it out, would be great for you to post your experience here.
i'm not much familiar with it, i just did a quick google for clinical trials and it seems like weight loss results are about on par with semaglutide but not as good as tirzepatide. any specific reason you want to try it?
yeah go for it, i realized after that my reply may have come across as argumentative, i didn't mean for it to. i'm curious about it too, and also curious how people make the decisions on which products to use. basically i originally chose tirz because it showed greater weight loss percentages than semaglutide and i needed to lose over 20%. but other people decide for different reasons (like the heart rate thing, some people decide on price, availability of compound, etc). i think it's interesting that it seems like people do develop a bit of loyalty to their first glp1 if it works for them.
but i haven't seen much talk about survo so was just wondering how it caught your attention.
if you go for it, good luck.
Google isn't helping me here and I'm feeling incredibly dumb for not quite understanding what these numbers mean.This may help many of you guys out, have a look at the Ki values.
Google isn't helping me here and I'm feeling incredibly dumb for not quite understanding what these numbers mean.
Thank you, I appreciate this breakdown!Had to use chatgpt...
The GLP-1 K value is a measure of the binding affinity of a ligand (such as a GLP-1 receptor agonist) to the GLP-1 receptor. GLP-1 (glucagon-like peptide-1) is a hormone that plays a role in glucose metabolism, and its receptor is a target for drugs used in the treatment of type 2 diabetes and obesity.
Key points about the GLP-1 K value:
The GCGR KiK_iKi value refers to the inhibition constant for the glucagon receptor (GCGR). It measures how effectively a compound, such as a drug or inhibitor, can block the interaction of glucagon (or another ligand) with the glucagon receptor.
- Definition of K value:
- The "K" generally refers to a dissociation constant (KdK_dKd) or inhibition constant (KiK_iKi), depending on the context.
- KdK_dKd: Reflects the concentration of ligand at which half of the available receptors are bound.
- KiK_iKi: Indicates the potency of a compound in inhibiting receptor binding.
- Units:
- The KdK_dKd or KiK_iKi is typically expressed in molar concentrations (e.g., nM, μM).
- Lower KdK_dKd or KiK_iKi values indicate higher affinity, meaning the ligand binds more tightly to the receptor.
- Significance in GLP-1 receptor agonists:
- A low K value suggests a strong and specific interaction between the drug and the GLP-1 receptor.
- Drugs like semaglutide and liraglutide are engineered to have high affinity and prolonged activity at the GLP-1 receptor, often reflected in low KdK_dKd values.
- Experimental determination:
- The KKK value is determined through in vitro binding studies, using methods like radioligand binding assays or surface plasmon resonance.
Breaking Down the Term:
- GCGR (Glucagon Receptor):
- GCGR is a G-protein-coupled receptor (GPCR) that binds glucagon, a hormone involved in glucose metabolism. Activation of GCGR stimulates glucose production in the liver, playing a key role in blood sugar regulation.
- KiK_iKi (Inhibition Constant):
- KiK_iKi quantifies the potency of an inhibitor in preventing a ligand (like glucagon) from binding to the receptor.
- It is defined as the equilibrium constant for the dissociation of the inhibitor-receptor complex.
- Lower KiK_iKi values indicate higher inhibitory potency because the compound binds more tightly to the receptor.
- Units:
- KiK_iKi is typically expressed in molar concentrations (e.g., nanomolar [nM] or micromolar [μM]).
- How it’s Measured:
- KiK_iKi is determined experimentally, often through competitive binding assays. These assays involve measuring how well an inhibitor competes with a radiolabeled or fluorescent ligand for binding to the receptor.
- Significance:
- KiK_iKi helps assess the efficacy of potential drugs targeting the glucagon receptor, particularly for conditions like type 2 diabetes.
- Drugs with low KiK_iKi values for GCGR might act as antagonists to reduce excessive glucagon activity, which can help in managing hyperglycemia.
Thank you, I appreciate this breakdown!
I haven't dipped my toes in yet, but what you just did is getting pretty close to convincing me.Yeah I find myself using chatgpt more and more for answers to random questions. Remarkable tech really... one of those innovations that changed the landscape seemingly overnight. Maybe not changed for the better either now with pretend experts but really are just quick with ChatGPT.
If I use it, I usually say something like "From ChatGPT"...
Do remember that ChatGPT (and other AIs) will confidently create false or not fully correct information on a regular basis, especially with more niche topics like this.Yeah I find myself using chatgpt more and more for answers to random questions. Remarkable tech really... one of those innovations that changed the landscape seemingly overnight. Maybe not changed for the better either now with pretend experts but really are just quick with ChatGPT.
If I use it, I usually say something like "From ChatGPT"...
Tried both serv and maz. Didn't seem to have as good appetite suppression so went back to tirz after 1 vialNot much activity here.... There's a vendor with a good price on Survodutide and I'm strongly considering picking up a couple kits to research.
Anyone have experiences good or bad with Survo? Care to share?
I am in maintenance and like trying different things, but I only used it for a month. But it felt very similar to tirz in my opinion. I would recommend it as an alternative and imagine it would be a good candidate for weight loss.Not much activity here.... There's a vendor with a good price on Survodutide and I'm strongly considering picking up a couple kits to research.
Anyone have experiences good or bad with Survo? Care to share?
Surv has a higher % of GCGR than Reta!
The GCGR being the fat targeting burner in both compounds.
I’m considering experimenting with stacking them both
Not much activity here.... There's a vendor with a good price on Survodutide and I'm strongly considering picking up a couple kits to research.
Anyone have experiences good or bad with Survo? Care to share?
Was just talking with someone about the lengths of these GBs - it might be next year before any of this stuff shows up!Not yet. I’ve got NAD+ and MOTS-c on order though. Been on order so long I need to re-read on how to start these.
Not yet. I’ve got NAD+ and MOTS-c on order though. Been on order so long I need to re-read on how to start these.
who am I chopped liver? it seems to be doing a really good job. my heart rate is hovering around 100 which is borderline high.I'm super interested in survo, but I have a freezer full of Sema and have some tirz arriving tomorrow.... I might just take the leap. I am just hesitant because I haven't seen anyone else on it. Keep meaning to join other forums to see if anyone has actually tried it.
You quoted a post I made in NOVEMBER.who am I chopped liver? it seems to be doing a really good job. my heart rate is hovering around 100 which is borderline high.
i know, i just like to pick on you because i like you.You quoted a post I made in NOVEMBER.
That's how you train little girls to tolerate their boyfriends treating them like shit. Tell them boys are only mean because they like them.i know, i just like to pick on you because i like you.
like in second grade...
Survo (GLP1R) + GCGR) + Tirz (GIPR + GLP1R = Reta (GLP1, GCGR, GIPR)Hey Ming.
I’m totally in agreement with staying with what got me the results I wanted.
However, tirz fatigue the 1-2 days after injection, although not bad, is something I’d like to get away from.
Survo seems to not cause fatigue, per reports, plus it is better at treating fatty liver and liver fibrosis, which is in my family history.
Those are 2 good reasons to switch.
How did it work for you? I'm considering stacking it tirz also. Just to see if that GCGR helps any.I've just started stacking Soro with Triz this week. I'm hoping it will stop my plateau.
I add 1mg Survo 4 days after I do my Triz injection as a stack. Seems to keep the suppression going. I'm on max Triz, and it only seems to last for 4 days now. Adding the Survo on day 4 gets me to day 7 for the next Triz shot.How did it work for you? I'm considering stacking it tirz also. Just to see if that GCGR helps any.
Survo really knocks down the food noise when used with Triz for me.How does survo compare in “feels” to reta or tirz?
Which do you guys think is the stronger drug?
Survo really knocks down the food noise when used with Triz for me.
start a 1mg survo it clogs you up pretty good to startCurrently im at 12mgs reta (6mgs twice a week) if I needed to change to survo how strong a dose would I need?
Also how strong is survo for fatty liver?
I'm using Triz as my base. But when it started to loose its effectiveness, I started stacking with Reta and Cargi. That worked great, except for the fatigue. Never had the Tachycardia.
Now I do Triz and Servo, and for me this is the magic bullet.
Survo really knocks down the food noise when used with Triz for me.
Reta spiked my rate to ~125 after only 2 hrs. after my first dose, and it took 4 weeks after stopping to return to my normal 68-70.
Started Tirz then at 2.5, have advanced to 7.5 every 5 days and and Surv2 3 days later and still normal HR.
One thing I was recommended to try with the Tirz after a few weeks was add 1mg of Survo 3 days after every Tirz. Adds more GLP-1 and Glucagon which makes it work a lot like Reta without the cardiac side effect and helps with the food noise. Absolutely happy with that so far. Problem is, one-size-fits-all doesn't work well in this research effort.
5 mg Tirz every 5 days with 2mg Survo 3 days later. Losing 2 - 3 lbs weekly, good satiety and the Survo took care of the food noise. Liking this combo.
Absolutely no suppression from 2mg or 4mg Reta. I was on 7.5mg Tirz then decided to stack with reta as a last push for the last 15lbs.
Idk what or how Reta does it, but those last 15lbs FELL OFF. I was dosing Tirz every 5 days, reta 2 days after Tirz.
I think if you don't struggle with overthinking about food, reta might be a solid single choice for you. But if you do, it's a good option to stack with a good suppression.
If your looking for something different then Tirz, Survo is a great place to start too
I got a R24 kit from PGB that im letting go 350 shipped usps tracking
I stopped Reta after better results with survo and tirz
I have noticed being more tired during the day since dropping it. I've been off it for about a month and my heart rate has only dropped marginally.Your tachycardia with reta didn't mean more energy, right?