Could GLP1 patches be in our future?

[clayd]

I saw on reddit that there's some companies out there selling glp1 skin patches that I'm sure are pure snake oil.
But I did some googling and saw that there's a company that has come up with a real patch that they say successfully delivers semaglutide in pre-clinical trials and is starting clinical trials this year. But yikes, the website for this company says the patch works by delivering the meds via "microneedles"

Honestly a weight loss patch sounds awesome and I hope these efforts come to fruition.

Anodyne Nanotech Achieves Breakthrough in Transdermal Delivery of GLP-1 Drugs

Anodyne Nanotech, a clinical-stage biotech company, today announced promising preclinical results for its proprietary HeroPatch™ platform, demonstrati

www.businesswire.com

Home | Anodyne Nanotech

www.theheropatch.com

 

[TrashPanda]

The microneedles are probably exosomes which is "the next big thing" in skincare, people seem to rave about Reedle shot.

 

[Galora]

I'd assume the transdermal/micro-needle could be something like what the CGM looks like in the Libre glucose monitor, maybe? But instead of measuring the glucose in interstitial fluid, they do a a release system to slowly get a GLP-1 dosage throughout the life of the patch.

I could see how this might be usable vs. the other release systems that are questionable at best (I saw gummies and sublingual -- full BS in my world).

I'd like to see peer reviewed clinical studies of efficacy. Honestly between the patch vs. subQ injection, I stay with subQ all the way.

 

[JohnnyGobbs]

Sub Q rules. Who doesn’t like the ritual of pinning/shooting. It’s cool af

 

[clayd]

I'd assume the transdermal/micro-needle could be something like what the CGM looks like in the Libre glucose monitor, maybe? But instead of measuring the glucose in interstitial fluid, they do a a release system to slowly get a GLP-1 dosage throughout the life of the patch.

I could see how this might be usable vs. the other release systems that are questionable at best (I saw gummies and sublingual -- full BS in my world).

I'd like to see peer reviewed clinical studies of efficacy. Honestly between the patch vs. subQ injection, I stay with subQ all the way.

yeah looks like they're kicking off clinical trials now

but yeah i'm fine with SQ, however many people may not be and an alternative would be good

 

[AndyPanda]

I'd assume the transdermal/micro-needle could be something like what the CGM looks like in the Libre glucose monitor, maybe? But instead of measuring the glucose in interstitial fluid, they do a a release system to slowly get a GLP-1 dosage throughout the life of the patch.

I could see how this might be usable vs. the other release systems that are questionable at best (I saw gummies and sublingual -- full BS in my world).

I'd like to see peer reviewed clinical studies of efficacy. Honestly between the patch vs. subQ injection, I stay with subQ all the way.

If they are anything like the patches that already exist, they are more like the ones on Zitstikas. You can barely even feel them. I would be hard to convince there is any real alternative to injections.

 

[clayd]

If they are anything like the patches that already exist, they are more like the ones on Zitstikas. You can barely even feel them. I would be hard to convince there is any real alternative to injections.

the only thing that was mildly convincing to me was the fact that this company's patches are basically a bandaid full of little needles that quietly inject you with meds for a week.

 

[afrayy]

Sub Q rules. Who doesn’t like the ritual of pinning/shooting. It’s cool af

This development reminds me of the "derms" from a book I read called Neuromancer. The book is about a cyberpunk dystopian future (in fact it is probably THE progenitor of cyberpunk dystopias) and derms are essentially these patches that deliver a constant level of a drug. there is even a character that prefers to pin their drugs old school and calls derm users "pedestrians".

The future is now yall.

 

[Vicki]

The microneedles are probably exosomes which is "the next big thing" in skincare, people seem to rave about Reedle shot.

You might be thinking of micro spicules which are added into some creams which they say is like micro needling. The creams can then contain exosomes or different growth factors.

However, microneedles aren't the same as exosomes.

 

[DwightTheDelight]

Do it, Tracy, I dare you.

 

[TooBigtoFail]

Check Invisicare patent, by Skinvisible. Why not use an insulin pump? How about nicotine or estrogen patches? They work. Why not glp1? I am experimenting with GHK, applied on Tegaderm transdermal patches. There is a patent on such (WO2019167070A1) . GHK-cu mixed with a gel similar to Neutrogena skin cream, to get the product below the skin. Patch over an area with surface veins to get into the blood stream. Leave patch on 24hrs+ at a time as GHK has a very short half life. I am following the instructions. Done 10hrs a day for 25 days. My whiskers are the same. But GHK results are slow anyway.