Current thoughts on cagri and Alzheimer's?
- Thread starter Wellwell
- Start date
It is being researched to treat Alzheimer’s in addition to diabetes and obesity.
An amylin analog used as a challenge test for Alzheimer's disease - PMC
Preclinical studies demonstrate the potential of amylin in the diagnosis of Alzheimer's disease (AD). We aimed to lay the foundation for repurposing the amylin analog and a diabetes drug, pramlintide, for AD in humans. We administered a single ...
pmc.ncbi.nlm.nih.gov
I recently ordered a 10mg kit from SRY, because I am willing to take the risk and have not seen anything other than conjecture on here and another forum that discusses the whole brain/blood barrier drama. That drama was blown out of proportion by non-experts. Nobody has anything solid to support their claims.
Now, none of us that I am aware of have a PhD in Pharmacology or Biochemistry, especially myself. We are all taking risks with a lot of these peptides. Some have not even had in depth studies conducted in humans. I think this is no more dangerous than other substances we are putting into our bodies that actually have evidence of strong negative side effects. For example, the HGH and GHRH peptides that can accelerate tumor growth.
The concern might be around fibrils/oligomers.
If so, we've got a few threads on here but nothing definitive. We were waiting to see what the deal was with the pH on the single chamber cagrisema pen, but I don't think we've had any news there in a while.
If so, we've got a few threads on here but nothing definitive. We were waiting to see what the deal was with the pH on the single chamber cagrisema pen, but I don't think we've had any news there in a while.
It is being researched to treat Alzheimer’s in addition to diabetes and obesity.
.An amylin analog used as a challenge test for Alzheimer's disease - PMC
Preclinical studies demonstrate the potential of amylin in the diagnosis of Alzheimer's disease (AD). We aimed to lay the foundation for repurposing the amylin analog and a diabetes drug, pramlintide, for AD in humans. We administered a single ...
Now, none of us that I am aware of have a PhD in Pharmacology or Biochemistry, especially myself. We are all taking risks with a lot of these peptides. Some have not even had in depth studies conducted in humans. I think this is no more dangerous than other substances we are putting into our bodies that actually have evidence of strong negative side effects. For example, the HGH and GHRH peptides that can accelerate tumor growth.
I don't think you need a PhD to figure out that Cagrilintide is not the drug they're testing in your citation. Reading comprehension might be helpful, however.
Pramlintide and cagrilintide are different, though they both relate to amylin, a hormone involved in glucose control and appetite regulation
Pramlintide isn't Cagrilintide. Pramlintide is FDA approved. Cagrilintide is not.
The question shouldn't be "does cagri cause Alzheimer's?". The question should be is black market Cagri as safe as the product in FDA trials?
Who's to say black market Cagri has more or less of a propensity to tangle and turn into fibrils and oligomers than the real trial drug?
No citations are better than misinforming people they are testing Cagrilintide as a treatment for Alzheimer's.
You should be ashamed of the advice you give people.
Moron.
She's deceased, thank you for asking.
I’m sorry.
That’s on me. I apologize to everyone. It was in poor taste.
Yes
If you really want to read the FUD about oligomers and fibrils... Read this thread.
SecretWeapon states that "1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency."
pH 7.5 is neutral and around our body's pH.
So my question is, even if you tweak the reconstituted vial's pH to be acidic (4), was the product prepared in a manner where fibrillation did not take place? In other words, did your upstanding, totally honest, not going to screw you, I swear, Chinese chemist prepare the solution in an environment that was in the acidic pH range?
I believe the oligomers and fibrils aren't just a concern for the human brain. There are other health related concerns..
I'll let you make your own conclusion on the safety of black market Cagrilintide. The jump to Alzheimers is a long one since it's generally progresses slowly and later in life. So most people that get some form of dementia are usually diagnosed and categorized, but you don't really know what it was until you autopsy the brain.
So take comfort in that.
chmuse
Public Nuisance 🦜🐧🦅🦚🦃🦢🐓🦆🦉
Yes
If you really want to read the FUD about oligomers and fibrils... Read this thread.
SecretWeapon states that "1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency."
pH 7.5 is neutral and around our body's pH.
So my question is, even if you tweak the reconstituted vial's pH to be acidic (4), was the product prepared in a manner where fibrillation did not take place? In other words, did your upstanding, totally honest, not going to screw you, I swear, Chinese chemist prepare the solution in an environment that was in the acidic pH range?
I believe the oligomers and fibrils aren't just a concern for the human brain. There are other health related concerns..
I'll let you make your own conclusion on the safety of black market Cagrilintide. The jump to Alzheimers is a long one since it's generally progresses slowly and later in life. So most people that get some form of dementia are usually diagnosed and categorized, but you don't really know what it was until you autopsy the brain.
So take comfort in that.
It's a shame none of us will get to see our own autopsies. That would be really cool.
Elon will fix this so you can just upload your consciousness to your Tesla.
chmuse
Public Nuisance 🦜🐧🦅🦚🦃🦢🐓🦆🦉
Imagine your consciousness being in the car when it gets sold for scrap metal
Isn't that what they're sold for from the dealership?
(this is not political. i've hated teslas ever since i sat in a model s back in 2013 and thought the interior was shittier than car's half their price)
chmuse
Public Nuisance 🦜🐧🦅🦚🦃🦢🐓🦆🦉
I wouldn't have any idea! I can't even tell different models of car apart.
Cloud backups?
This is the premise behind the stupid yet engaging Prime Video teevee series Upload.
peptideusername
Registered
chmuse
Public Nuisance 🦜🐧🦅🦚🦃🦢🐓🦆🦉
But then there's more than one of you... And one of them will experience the death. Maybe a transfer to the cloud
