Current thoughts on cagri and Alzheimer's?

[Wellwell]

So where do we stand on the possibility of cagri causing Alzheimer's and other negative long term affects? I've only been able to find a post about a post and Google tells me nothing. Any links I can read?

 

[AndyPanda]

So where do we stand on the possibility of cagri causing Alzheimer's and other negative long term affects? I've only been able to find a post about a post and Google tells me nothing. Any links I can read?

It is being researched to treat Alzheimer’s in addition to diabetes and obesity.

An amylin analog used as a challenge test for Alzheimer's disease - PMC

Preclinical studies demonstrate the potential of amylin in the diagnosis of Alzheimer's disease (AD). We aimed to lay the foundation for repurposing the amylin analog and a diabetes drug, pramlintide, for AD in humans. We administered a single ...

pmc.ncbi.nlm.nih.gov

I recently ordered a 10mg kit from SRY, because I am willing to take the risk and have not seen anything other than conjecture on here and another forum that discusses the whole brain/blood barrier drama. That drama was blown out of proportion by non-experts. Nobody has anything solid to support their claims.

Now, none of us that I am aware of have a PhD in Pharmacology or Biochemistry, especially myself. We are all taking risks with a lot of these peptides. Some have not even had in depth studies conducted in humans. I think this is no more dangerous than other substances we are putting into our bodies that actually have evidence of strong negative side effects. For example, the HGH and GHRH peptides that can accelerate tumor growth.

 

[hexagonal]

The concern might be around fibrils/oligomers.

If so, we've got a few threads on here but nothing definitive. We were waiting to see what the deal was with the pH on the single chamber cagrisema pen, but I don't think we've had any news there in a while.

 

[brentm]

It is being researched to treat Alzheimer’s in addition to diabetes and obesity.

An amylin analog used as a challenge test for Alzheimer's disease - PMC

Preclinical studies demonstrate the potential of amylin in the diagnosis of Alzheimer's disease (AD). We aimed to lay the foundation for repurposing the amylin analog and a diabetes drug, pramlintide, for AD in humans. We administered a single ...

pmc.ncbi.nlm.nih.gov

.

Now, none of us that I am aware of have a PhD in Pharmacology or Biochemistry, especially myself. We are all taking risks with a lot of these peptides. Some have not even had in depth studies conducted in humans. I think this is no more dangerous than other substances we are putting into our bodies that actually have evidence of strong negative side effects. For example, the HGH and GHRH peptides that can accelerate tumor growth.

I don't think you need a PhD to figure out that Cagrilintide is not the drug they're testing in your citation. Reading comprehension might be helpful, however.

Pramlintide and cagrilintide are different, though they both relate to amylin, a hormone involved in glucose control and appetite regulation

Pramlintide isn't Cagrilintide. Pramlintide is FDA approved. Cagrilintide is not.

The question shouldn't be "does cagri cause Alzheimer's?". The question should be is black market Cagri as safe as the product in FDA trials?

Who's to say black market Cagri has more or less of a propensity to tangle and turn into fibrils and oligomers than the real trial drug?

 

[brentm]

So where do we stand on the possibility of cagri causing Alzheimer's and other negative long term affects? I've only been able to find a post about a post and Google tells me nothing. Any links I can read?

If you really want to read the FUD about oligomers and fibrils... Read this thread.

Post in thread 'In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)'

Nov 30, 2024

View attachment 4063

Don't they speak to the different pH levels (4 and 7.5) while subjecting Cagri to mechanical stress?

And they couldn't form any fibrils? Are you saying that this is incorrect and they didn't use the right equipment to test for formation of harmful molecules?

Fibrils are of secondary importance in this discussion. You could almost leave them out of it.

The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.

And yes, they subjected many different amylin analogues to mechanical stress to see which ones...

• secretweapon

• 

SecretWeapon states that "1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency."

pH 7.5 is neutral and around our body's pH.

So my question is, even if you tweak the reconstituted vial's pH to be acidic (4), was the product prepared in a manner where fibrillation did not take place? In other words, did your upstanding, totally honest, not going to screw you, I swear, Chinese chemist prepare the solution in an environment that was in the acidic pH range?

I believe the oligomers and fibrils aren't just a concern for the human brain. There are other health related concerns..

I'll let you make your own conclusion on the safety of black market Cagrilintide. The jump to Alzheimers is a long one since it's generally progresses slowly and later in life. So most people that get some form of dementia are usually diagnosed and categorized, but you don't really know what it was until you autopsy the brain.

So take comfort in that.

 

[chmuse]

If you really want to read the FUD about oligomers and fibrils... Read this thread.

Post in thread 'In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It)'

Nov 30, 2024

View attachment 4063

Don't they speak to the different pH levels (4 and 7.5) while subjecting Cagri to mechanical stress?

And they couldn't form any fibrils? Are you saying that this is incorrect and they didn't use the right equipment to test for formation of harmful molecules?

Fibrils are of secondary importance in this discussion. You could almost leave them out of it.

The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way.

And yes, they subjected many different amylin analogues to mechanical stress to see which ones...

• secretweapon

• 

SecretWeapon states that "1. Almost every single amylin analogue fibrillated at pH 7.5 (including cagrilintide). The only one that didn't was rejected for low potency."

pH 7.5 is neutral and around our body's pH.

So my question is, even if you tweak the reconstituted vial's pH to be acidic (4), was the product prepared in a manner where fibrillation did not take place? In other words, did your upstanding, totally honest, not going to screw you, I swear, Chinese chemist prepare the solution in an environment that was in the acidic pH range?

I believe the oligomers and fibrils aren't just a concern for the human brain. There are other health related concerns..

I'll let you make your own conclusion on the safety of black market Cagrilintide. The jump to Alzheimers is a long one since it's generally progresses slowly and later in life. So most people that get some form of dementia are usually diagnosed and categorized, but you don't really know what it was until you autopsy the brain.

So take comfort in that.

It's a shame none of us will get to see our own autopsies. That would be really cool.

 

[brentm]

It's a shame none of us will get to see our own autopsies. That would be really cool.

Elon will fix this so you can just upload your consciousness to your Tesla.

 

[chmuse]

Elon will fix this so you can just upload your consciousness to your Tesla.

Imagine your consciousness being in the car when it gets sold for scrap metal

 

[hexagonal]

Imagine your consciousness being in the car when it gets sold for scrap metal

Isn't that what they're sold for from the dealership?

(this is not political. i've hated teslas ever since i sat in a model s back in 2013 and thought the interior was shittier than car's half their price)

 

[chmuse]

Isn't that what they're sold for from the dealership?

(this is not political. i've hated teslas ever since i sat in a model s back in 2013 and thought the interior was shittier than car's half their price)

I wouldn't have any idea! I can't even tell different models of car apart.

 

[brentm]

Imagine your consciousness being in the car when it gets sold for scrap metal

Cloud backups?

 

[indolent]

Elon will fix this so you can just upload your consciousness to your Tesla.

This is the premise behind the stupid yet engaging Prime Video teevee series Upload.

 

[peptideusername]

fibrils/oligomers

oligomers and fibrils

 

[chmuse]

Cloud backups?

But then there's more than one of you... And one of them will experience the death. Maybe a transfer to the cloud

 

[StonePny]

It's a shame none of us will get to see our own autopsies. That would be really cool.

You, @chmuse, are the palate cleanser in the overly heavy, cloyingly rich, too many courses dinner that sometimes is this forum!

 

[StonePny]

Also, before any of the heavy handed guys points out this is an old thread--I KNOW!!
I was looking up info on cagri.

 

[chmuse]

Also, before any of the heavy handed guys points out this is an old thread--I KNOW!!
I was looking up info on cagri.

This is an informational thread, it's worth reviving! It's the stupid drama ones we shouldn't revive, imo.

Side note: never made it over .08 cagri, gave up. Didn't break the stall and didn't seem more effective on appetite than sema alone other than making me ill. I ate about the same amount with sema willpower without needing the added nausea.

 

[StonePny]

This is an informational thread, it's worth reviving! It's the stupid drama ones we shouldn't revive, imo.

Side note: never made it over .08 cagri, gave up. Didn't break the stall and didn't seem more effective on appetite than sema alone other than making me ill. I ate about the same amount with sema willpower without needing the added nausea.

I think this sums it up and is where I'm landing. I'm out of MOTS--that I was liking-- coming from 2 sources (one lost in the mail, one floating in pergatory) and i guess I was looking for something else to inject.

 

[nonyabizznez]

You, @chmuse, are the palate cleanser in the overly heavy, cloyingly rich, too many courses dinner that sometimes is this forum!

As to which course her dosages compare? More like an amuse bouche! 🤏

tag @chmuse crypto doser

 

[nonyabizznez]

I wouldn't have any idea! I can't even tell different models of car apart.

This didn't age well...

(Your's is the totaled one on the side of the street 😟)

 

[chmuse]

This didn't age well...

I still can't! How do you think I accidentally walked out of a dealership with a car I'd only driven around the block that it turns out needs replacement rotors and brakes? 😭

 

[ZippityDooDah]

You, @chmuse, are the palate cleanser in the overly heavy, cloyingly rich, too many courses dinner that sometimes is this forum!

Also, before any of the heavy handed guys points out this is an old thread--I KNOW!!
I was looking up info on cagri.

Sounds like you're not a fan. Please don't feel obligated to hang around if that's the case. The feds took away my handcuffs when I retired so I can't force people to stay against their will anymore.

 

[chmuse]

Sounds like you're not a fan. Please don't feel obligated to hang around if that's the case. The feds took away my handcuffs when I retired so I can't force people to stay against their will anymore.

You know, you can buy handcuffs a lot of places nowadays, and you don't need the permission of the popo to use them in private. 😘

 

[ZippityDooDah]

You know, you can buy handcuffs a lot of places nowadays, and you don't need the permission of the popo to use them in private. 😘

I'm apparently on a list.

 

[hexagonal]

I'm apparently on a list.

Because of how you were using handcuffs in private?

Must have been some wild parties.

 

[chmuse]

Because of how you were using handcuffs in private?

Must have been some wild parties.

Just don't ask him about the St Andrews Cross he'd be scandalized we brought it up in public

 

[exploitedworkerbee]

This is an informational thread, it's worth reviving! It's the stupid drama ones we shouldn't revive, imo.

Side note: never made it over .08 cagri, gave up. Didn't break the stall and didn't seem more effective on appetite than sema alone other than making me ill. I ate about the same amount with sema willpower without needing the added nausea.

You didn’t experience the effect because you stopped at .8. It works great for me up around 2mg, but the fatigue is rough.

 

[Calm Logic]

Sounds like a tough sell, unless you are really stalled for a while. But that day comes for us all, haha.

 

[chmuse]

You didn’t experience the effect because you stopped at .8. It works great for me up around 2mg, but the fatigue is rough.

I was projectile vomiting, I'm pretty sure choosing not to go up was the wise choice. There's only so much mopping you can do before deciding it's not worth it.

 

[StonePny]

Sounds like you're not a fan. Please don't feel obligated to hang around if that's the case. The feds took away my handcuffs when I retired so I can't force people to stay against their will anymore.

I was pointing out that she made a lighthearted comment after two guys were going at it pretty hard in the comments before. Which is what I meant by "heavy"
I'm not sure how you'd take offense to this?