Cycle off or not (GHK-CU)

[Optimistic3]

I have been taking GHK-CU since 5/15/26, and I’m already seeing noticeable improvements in lines I had on my neck, they are slowly disappearing. I also fractured my collarbone 3 weeks ago so have been taking wolverine blend as well. I have been trying to decide if I should cycle off GHK-cu for 2 weeks to 30 days or just continue taking. I’ve read different things about people saying it’s not necessary to cycle off and vice vs. I will say that I feel like the the Wolverine is really helping my injury as well, so do I continue to take it until I stop Wolverine then take the cycle break, thoughts??

 

[Angelique]

I'm in the middle of a 12-week cycle of GHK-Cu as well. My understanding is that the reason for cycling off is too avoid too much copper buildup in the body, and not because of desensitization. I plan on cycling off for this reason although I suspect that copper buildup may be less of a concern the older we are.

 

[SeaGypsy]

I'm on month 3 of 2mg daily. I do not plan on cycling off as of now. I never got any sides from it and I'm over 50 so I'm going to roll with it, I will reassess later in the year after my next labs check.

 

[HereKittyKitty]

I have no intention to cycle Cu. I've been daily since February. My changes are subtle, unlike @FarmgirlRebel (search for her post!). If I remember correctly, her results were realized in a 12-week cycle.

 

[Optimistic3]

I'm in the middle of a 12-week cycle of GHK-Cu as well. My understanding is that the reason for cycling off is too avoid too much copper buildup in the body, and not because of desensitization. I plan on cycling off for this reason although I suspect that copper buildup may be less of a concern the older we are.

I have been taking zinc supplements in hope to offset this. But I agree I think it’s less of an issue the older we are

 

[HereKittyKitty]

I've heard the Zinc supplements are not necessary (effective) unless the PT has high Cu in their serum or has Wilson's Disease.