Do y’all test every time you order? re: Amopure stinging

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Sseker

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Hey all! Newbie to the grey market here. Been using compounded Tirz since May and looking to make the switch over to reconstituting and maybe adding/swapping for Reta. I’ve been educating myself as much as possible on this forum and I’m so grateful to y'all for sharing info and helping out newbies like me!

My question is: do you guys make it a practice to send a vial in every time you get another order in? Or do you feel safe just trusting some vendors that other users have tested and used successfully? I’ve seen some posts about group testing but honestly I’m a little confused on the logistics on how those work (any pointers would be helpful thanks!)

The reason I’m asking now was that (based on my reading from this forum) I was going to purchase some T15 and R10 from Amopure today to catch their sale. But then I’ve been seeing some posts from users experiencing burning/stinging and getting a little spooked. Is it normal for otherwise trustworthy vendors to have bad batches? Nervous! Thanks for any tips.
 
Sseker said:
Hey all! Newbie to the grey market here. Been using compounded Tirz since May and looking to make the switch over to reconstituting and maybe adding/swapping for Reta. I’ve been educating myself as much as possible on this forum and I’m so grateful to y'all for sharing info and helping out newbies like me!

My question is: do you guys make it a practice to send a vial in every time you get another order in? Or do you feel safe just trusting some vendors that other users have tested and used successfully? I’ve seen some posts about group testing but honestly I’m a little confused on the logistics on how those work (any pointers would be helpful thanks!)

The reason I’m asking now was that (based on my reading from this forum) I was going to purchase some T15 and R10 from Amopure today to catch their sale. But then I’ve been seeing some posts from users experiencing burning/stinging and getting a little spooked. Is it normal for otherwise trustworthy vendors to have bad batches? Nervous! Thanks for any tips.
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I ordered S20 and was hoping to see if any had seen testing for the batch from Amopure, but will probably still send in one to test.

From what I've read, it may not be 100% the case, the BAC used can cause the sting. Mostly ones from Amazon I believe. I got Hospira that was suggested to try. My last order from another site came with BAC, but not sure the brand. It stung at times. The one from a C.Pharmacy I recieved prior also stung at times & bruised occasionally...so I'm not certain where the problem is from.
 
seanc34 said:
Bought some T60 and don’t plan to test it tbh. Def riskier but many are here due to financial constraints and testing each order may not be realistic
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Yea, that makes a lot of sense to me. I was thinking the same thing but I wasn’t sure if I was being too cavalier about it. Thanks for the input!
 
I've never done this before but now I have two batches of T30 on the way. Amopure has a lot of people testing it right now and quite a few tests already available publicly, so I'm on the fence as to whether i will test or not. Order #2 is part of a GB happening right now so I need to figure out how the GB testing thing works. One thing I haven't seen in all my research of this community, is anyone having a serious issue with either of the two vendors I've ordered from other than scattered reports of stinging, or vials being underfilled/lower purity.
 
Yeah I bought T60 and don't plan to test it. The price is unbeatable during the labor day sale, and they are generally a well regarded company. I can get over a bit of stinging as long as it's not causing anything serious.
 
the stinging is an ongoing issue for which we still don't have an answer, but their test results starting to come back, with first published today for Tirz30 tested as 31mg and 99.6% pure
the stinging must be something related to their filler
 
Sseker said:
Hey all! Newbie to the grey market here. Been using compounded Tirz since May and looking to make the switch over to reconstituting and maybe adding/swapping for Reta. I’ve been educating myself as much as possible on this forum and I’m so grateful to y'all for sharing info and helping out newbies like me!

My question is: do you guys make it a practice to send a vial in every time you get another order in? Or do you feel safe just trusting some vendors that other users have tested and used successfully? I’ve seen some posts about group testing but honestly I’m a little confused on the logistics on how those work (any pointers would be helpful thanks!)

The reason I’m asking now was that (based on my reading from this forum) I was going to purchase some T15 and R10 from Amopure today to catch their sale. But then I’ve been seeing some posts from users experiencing burning/stinging and getting a little spooked. Is it normal for otherwise trustworthy vendors to have bad batches? Nervous! Thanks for any tips.
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Quick question; on amopure site… am
I correct in understanding that “L” is T?
I’m ordering my first batch, and nervous too!
 
cookam54 said:
Quick question; on amopure site… am
I correct in understanding that “L” is T?
I’m ordering my first batch, and nervous too!
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Yep! You got that right. I just ended up ordering some T15 and R5; Fingers crossed for the both of us! I did email them to ask about refunding if my RS felt stinging and they reiterated what they’ve said to others on this forum: they had fixed the problem but they’d refund or replace as long as they saw proof you destroyed the old vials.
 
milos said:
the stinging is an ongoing issue for which we still don't have an answer, but their test results starting to come back, with first published today for Tirz30 tested as 31mg and 99.6% pure
the stinging must be something related to their filler
Click to expand...
wait - where can we find the test results? thanks!
 
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milos said:
the stinging is an ongoing issue for which we still don't have an answer, but their test results starting to come back, with first published today for Tirz30 tested as 31mg and 99.6% pure
the stinging must be something related to their filler
Click to expand...
I messaged them the other day after I bought some t, they said the stinging was an isolated issue and to rest assured.
 
I bought a kit of L10 about a month ago and received it after like 8 days, I think? So far no stinging (done 3 doses so far) but it definitely concerns me that their product has been doing that! Especially because at some point I want to get a couple more kits of L15 or L30.
 
For those who experienced prolonged burning, how long did you wait after reconstituting to use it?
 
kayh9 said:
I bought a kit of L10 about a month ago and received it after like 8 days, I think? So far no stinging (done 3 doses so far) but it definitely concerns me that their product has been doing that! Especially because at some point I want to get a couple more kits of L15 or L30.
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I've had 0 stinging on my kit of L30
 
While no stinging for me, one weird thing that I noticed is that the needle itself hurt more on my Amo pins. The injection itself was fine, but the initial prick definitely hurt more. The stopper definitely takes more force to push through than other vials I've tried and I wonder if it's dulling the needle a bit, or I just so happened to choose sub-par quality needles from the box for those specific injections. I know this means nothing for those who've experienced prolonged stinging, just an odd observation. Could just be a testament to the quality of my syringes. Using Easy Touch and plan on switching to BD once I go through this box.
 
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Gwenhwyfar227 said:
I have only seen 2 people claim that theirs stung. It is not a widespread issue..
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I've seen multiple reports across platforms (though I suppose it's hard to tell if they're all unique, since user names can change). Also, Amo has admitted there was something amiss, since they keep saying they corrected it. Has anyone actually asked what the problem they are admitting to is?
 
I only belong to two groups. So I may have missed others complaints. If it was a filler issue * just my assumption and I am not in the field in any way* then yes it would make sense that many had the problem.
I know some emailed them and were told it had been taken care of. I have no idea if they specifically asked what the problem was.
 
moonpies4misfits said:
While no stinging for me, one weird thing that I noticed is that the needle itself hurt more on my Amo pins. The injection itself was fine, but the initial prick definitely hurt more. The stopper definitely takes more force to push through than other vials I've tried and I wonder if it's dulling the needle a bit, or I just so happened to choose sub-par quality needles from the box for those specific injections. I know this means nothing for those who've experienced prolonged stinging, just an odd observation. Could just be a testament to the quality of my syringes. Using Easy Touch and plan on switching to BD once I go through this box.
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I noticed the same as well.
 
Just noticed that there is another whole post in this subject..seems there were quite a few folks...guess I was a lucky one.lol
 
moonpies4misfits said:
While no stinging for me, one weird thing that I noticed is that the needle itself hurt more on my Amo pins. The injection itself was fine, but the initial prick definitely hurt more. The stopper definitely takes more force to push through than other vials I've tried and I wonder if it's dulling the needle a bit, or I just so happened to choose sub-par quality needles from the box for those specific injections. I know this means nothing for those who've experienced prolonged stinging, just an odd observation. Could just be a testament to the quality of my syringes. Using Easy Touch and plan on switching to BD once I go through this box.
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I was going to try the T15 I bought from the same batch as you this week but my BAC didn’t come thru in time, so I took a regular Zep dose and got my first ever injection site reaction! So weird!! It’s just a quarter sized red circle but in 8 months I have never gotten one until now. SO WEIRD. It’s like I was destined to get some weird reaction this week no matter what lol.
 
Maybe I'm weird but I feel like if it's tirz and it's not doing anything harmful to me (like it's a filler that just stings or ph is a little off) then sting me up bro. Actually that sounds really stupid now that I say it. Don't be like me lol
 
mostlydamp said:
Maybe I'm weird but I feel like if it's tirz and it's not doing anything harmful to me (like it's a filler that just stings or ph is a little off) then sting me up bro. Actually that sounds really stupid now that I say it. Don't be like me lol
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Don't be like me - but I had no other supply and I was due so I did another stinging injection last night. That SOB stung like hell for close to an hour and kept me awake but dang I have no appetite this am soooo.... shrug.
 
Peppers said:
For those who experienced prolonged burning, how long did you wait after reconstituting to use it?
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Well, I did another injection with my stinging batch and it has been reconstituted for a week so...
 
I’ve seen reports of stinging from June, July and August orders and from before and after they started vacuum sealing.

I would feel a lot better if we can figure out the source (likely ph or filament… but could be something more serious like sterility)
 
mostlydamp said:
Maybe I'm weird but I feel like if it's tirz and it's not doing anything harmful to me (like it's a filler that just stings or ph is a little off) then sting me up bro. Actually that sounds really stupid now that I say it. Don't be like me lol
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I feel you. Im seriously thinking of getting a syringe filter to address that somewhat chance of not knowing if whatever is causing that stinging or burning is harmful or not. Test results will not show it as they don't check for it and not having information from Amopure when they likely know what caused it (since they corrected it) is only causing more uncertainty. It's easy to give in hoping nothing will happen when one thing RS shouldn't compromise is the safety element and leave it on chance.

My only concern is if I'm going to actually add more contamination through the filtering process because there are multiple steps involved, including transferring into a completely new vial, ensuring it's sterile etc etc. Because that will defeat the entire purpose.
 
yokskojsj said:
I feel you. Im seriously thinking of getting a syringe filter to address that somewhat chance of not knowing if whatever is causing that stinging or burning is harmful or not. Test results will not show it as they don't check for it and not having information from Amopure when they likely know what caused it (since they corrected it) is only causing more uncertainty. It's easy to give in hoping nothing will happen when one thing RS shouldn't compromise is the safety element and leave it on chance.

My only concern is if I'm going to actually add more contamination through the filtering process because there are multiple steps involved, including transferring into a completely new vial, ensuring it's sterile etc etc. Because that will defeat the entire purpose.
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I don’t think they have fixed it since people are still experiencing the stinging/burning after they initially stated they fixed it (it’s why they went to vacuum sealed vials).

Has anyone tried to push the issue with them at all to see if they have an answer as to the why?

There is a big test of T30/T60 that includes sterility testing so hopefully it rules it out..

Next is to figure out the ph of the stinging vials (only seen ph for one non stinging vial that was slightly acidic). And even then if the ph is too high or too low is this actually going to hurt the RS or is it just a minor discomfort when injecting?

There are test to check the fillament used too that might be helpful to do….
 
nekojeeta said:
I don’t think they have fixed it since people are still experiencing the stinging/burning after they initially stated they fixed it (it’s why they went to vacuum sealed vials).

Has anyone tried to push the issue with them at all to see if they have an answer as to the why?

There is a big test of T30/T60 that includes sterility testing so hopefully it rules it out..

Next is to figure out the ph of the stinging vials (only seen ph for one non stinging vial that was slightly acidic). And even then if the ph is too high or too low is this actually going to hurt the RS or is it just a minor discomfort when injecting?

There are test to check the fillament used too that might be helpful to do….
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I honestly don't see how not being sterile would cause stinging, especially on a freshly reconstituted vial where there hasn't been the opportunity for microbial growth. I have a feeling that they might have some residual from the manufacturing process that some people are sensitive too. But that's just my hunch. I have a kit of T30 on the way so I will find out soon enough whether it stings or not.
 
nekojeeta said:
Next is to figure out the ph of the stinging vials (only seen ph for one non stinging vial that was slightly acidic).
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Yeah I keep hoping to see someone has PH tested their stinging vial but so far no dice. It would also be helpful to see the PH of their bac water before constituting as a side by side comparison.

Curious if anyone would be willing to swap a non-stinging vial with a stinging vial and see if it stings for both parties. It may be that some people are more sensitive to whatever is causing it.

I also wonder if anyone has reported stinging from one vial and no stinging from another vial from the same kit.
 
moonpies4misfits said:
Yeah I keep hoping to see someone has PH tested their stinging vial but so far no dice. It would also be helpful to see the PH of their bac water before constituting as a side by side comparison.

Curious if anyone would be willing to swap a non-stinging vial with a stinging vial and see if it stings for both parties. It may be that some people are more sensitive to whatever is causing it.

I also wonder if anyone has reported stinging from one vial and no stinging from another vial from the same kit.
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Yeah - my guess is it’s either ph or the filler that is causing issues.
 
I had an exchange of emails with Amo about this the other day and long story short he can't or wont say what exactly the problem is. He acknowledges it and has reshipped product for anyone experiencing the issue that contacts him. He claims it's ~3-4% and that it happens to every vendor...? But I would say that "he fixed it" is not an accurate description at this point.

Obviously not an ideal response but there you have it. It doesn't put me off doing future business with them.

Now people have speculated what issue could be. It's almost definitely not a sanitary issue. The best theory I've seen is TFA which is an acid used in the manufacturing process that might not have been completely removed. I have not seen a ph test on any confirmed stinging vials.
 
zpped said:
I had an exchange of emails with Amo about this the other day and long story short he can't or wont say what exactly the problem is. He acknowledges it and has reshipped product for anyone experiencing the issue that contacts him. He claims it's ~3-4% and that it happens to every vendor...? But I would say that "he fixed it" is not an accurate description at this point.

Obviously not an ideal response but there you have it. It doesn't put me off doing future business with them.

Now people have speculated what issue could be. It's almost definitely not a sanitary issue. The best theory I've seen is TFA which is an acid used in the manufacturing process that might not have been completely removed. I have not seen a ph test on any confirmed stinging vials.
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That’s similar to the response I got… not that reassuring given I don’t see any other major supplier having reports of stinging/burning.
 
nekojeeta said:
That’s similar to the response I got… not that reassuring given I don’t see any other major supplier having reports of stinging/burning.
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I have, but Amo also does something different in their manufacturing process by not including mannitol. Who knows if that has an effect.
 
zpped said:
I have, but Amo also does something different in their manufacturing process by not including mannitol. Who knows if that has an effect.
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Amopure is one of the few suppliers without a discord or telegram channel or named salesperson as well which makes it a little harder to get answers like this answered.

I would be interested in doing a test to identify the fillament they are using since it’s not mannitol
 
nekojeeta said:
Amopure is one of the few suppliers without a discord or telegram channel or named salesperson as well which makes it a little harder to get answers like this answered.

I would be interested in doing a test to identify the fillament they are using since it’s not mannitol
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Looks like my T30 is arriving today. I still have 4 weeks of compounded tirz so it will be a while before I pin it. Right now I'm debating sending a vial in for testing. There's currently a big group test happening that plans to release the results publicly so I don't know.... The test will cost almost as much as the kit and won't tell me anything about everything else in the vial (fillers, contaminants, etc..) so we will see....
 
geoguy78 said:
Looks like my T30 is arriving today. I still have 4 weeks of compounded tirz so it will be a while before I pin it. Right now I'm debating sending a vial in for testing. There's currently a big group test happening that plans to release the results publicly so I don't know.... The test will cost almost as much as the kit and won't tell me anything about everything else in the vial (fillers, contaminants, etc..) so we will see....
Click to expand...

Yeah, given the size and how recent that test is likely diminishing returns (of course there is nothing like testing your own batch)

This large test will include sterility which is good…

There are tests that can be done to figure out the primary filler used, but that’s not part of this test, but I think that’s likely the next one to do
 
geoguy78 said:
Looks like my T30 is arriving today. I still have 4 weeks of compounded tirz so it will be a while before I pin it. Right now I'm debating sending a vial in for testing. There's currently a big group test happening that plans to release the results publicly so I don't know.... The test will cost almost as much as the kit and won't tell me anything about everything else in the vial (fillers, contaminants, etc..) so we will see....
Click to expand...
The results have been trickling in on Peppys btw...so far good results as far as the fill amounts and percentage.
 
Gwenhwyfar227 said:
The results have been trickling in on Peppys btw...so far good results as far as the fill amounts and percentage.
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We know the stinging is not because of lower purity or lower sterility so not sure how much help are those tests in identifying the root cause. Unless someone from Amopure provides a definite answer, we are just guessing here.
 
yokskojsj said:
We know the stinging is not because of lower purity or lower sterility so not sure how much help are those tests in identifying the root cause. Unless someone from Amopure provides a definite answer, we are just guessing here.
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All the recent tests have been proper fill level and high purity. Unfortunately, like you are saying, the standard testing won't point us towards the culprit. I seriously doubt the sterility testing being done right now will show anything either. I'll bet there's a residual from manufacture that is causing it. That being said, my batch of T30 came today, just six days after I ordered. I will find out in a few weeks whether it stings or not
 
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