Do y’all test every time you order? re: Amopure stinging
- Thread starter Sseker
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Gwenhwyfar227
GLP-1 Enthusiast
This wasn't what I was referring to. I was referring to the large group testing..thanks
Obvious not conclusive but I’m pretty sure I’ve seen users on this forum claim stinging from T10, T15, and T30 but haven’t seen anything solid on T60 or any R.
GustyWinds
New Member
There’s two folks with late August purchase of R10 (my RS being one) in another thread both experiencing same sting.
Reta thread has similar reports on stinging.
Not sure why you are saying we know this is not because of lower sterility, since (as we have discussed to exhaustion in other forums) there really is no good test for sterility / contamination. I think someone else's comment implied a freshly mixed vial should be sterile / uncontaminated, but bac water does not kill existing bacteria, it only slows the growth.
zpped
GLP-1 Specialist
You are correct that there is no great test for sterility as most people think. But the right way to frame it is that it's unlikely a sterility issue because that isn't how they manifest. The mere presence of bacteria doesn't present as burning, that comes from the body's antibody response.
geoguy78
GLP-1 Specialist
This is why I think people are way too focused on sterility, and some are even spreading unfounded claims that Amo has sterility issues. A sterility problem would cause after-the-fact injection site infections, not instant burning. This issue is more likely an irritant leftover from the manufacturing process.
raw_oyster_eater
lemon bottle brewer
How much hay needs to be made of this? You start googling around and find stories of Ozempic, Wegovy, Zepbound and such stinging on injection as well. You gonna get a refund from them too?
I agree that if it was a sterility issue, there would be longer lasting symptoms and no one seems to be reporting that, although I don't agree it wouldn't also cause an immediate response as the body goes to work fighting off invaders.
It would be helpful if Amo would just be clear about what they think the "resolved" issue was, but seems unlikely they're going to do that.
sterility testing is done on agar on min. 2 different mediums, and as someone who did grow 'shrooms I know that any contamination will be 100% visible on agar after 1 week+
but we know it is not sterility issue for sure, because if it is, there will be no stinging during the injection, but there will be injection site reaction later - swelling, redness and itchiness
agree + the most possibly the filler issue
+ ph I saw somewhere someone did already and it was OK
just lets hope the issue is resolved already, I would like to read some reviews about the new batch or the replacement batch
geoguy78
GLP-1 Specialist
I have a Labor Day sale batch of T30 sitting in my freezer right now. I don't need it at the moment so I'm playing a wait and see game for this group test that's happening and if there are any more reports of stinging. Like you said, nobody has complained about an injection site infection, which really should put the sterility concerns to rest
Hi, I'm new and have been asking around specifically about GCMS testing for residual solvents vs HPLC testing for purity, and so far I can't find any examples of test results for residual solvents.
The solvents used in solid-phase peptide synthesis are often really, really, really toxic, even in small amounts, and this would be my biggest concern. Do you know if these groups are testing for harmful contaminants or just testing for the amount of tirz in a vial?
if it was a microbial contaminant you'd likely already have seen the ill effects (infections aren't subtle). I'd be much more concerned about toxic residual solvents from the manufacturing process that weren't effectively filtered out
Do you know if these tests include GCMS testing for residual solvents? I've just confirmed the Jano offers this testing, but I can't find any examples of test results
geoguy78
GLP-1 Specialist
Only tests I've seen have been for peptide purity/quantity and a few for sterility. Nobody has looked for other things that I know of.
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There have been numerous tests done, including for TFA which is the "evil solvent" everybody panics about, along with heavy metals, endotoxins, and countless other concerns and the end result is always the same: nothing to worry about.
Remember that the 2-3 companies synthesizing the raw peptides in China are part of larger legit pharmaceutical manufacturers that have to meet many standards including the purification process post-synthesis. The likelihood of the kind of "problems" people get all up in arms about after reading some random article online or anything any one of the fear-mongering loners posting from their mom's basement "warn" people about is nearly nil. Every few weeks or so someone catches a glimpse of once of these articles/posts and starts asking questions about all the terrible things that might be in their illicit gray-market Chinese drugs. Pro tip: worry more about proper pH, net peptide content, purity, sterility (to a point) and the reputation of the source.
Anyone that is concerned about testing for anything dangerous is certainly free to commission all the tests they would like to assuage their fears, or they may want to consider if sticking to the name-brand pens might be a better option.
From what I've seen, Jano usually will try to talk customers out of this easy (for him) money because his many years of experience in this field have demonstrated that these concerns are unwarranted and he hates so see people waste money and focus on more useful tests. It's kind of like asking to test the air inside your car for cyanide because it's used in the processes to make many plastics etc.
CBettie
New Member
I can testify to this. Brand Oz pen had stinging & bruising occasionally over 9mo using. So did c. Pharmacy version sema. And C. Pharmacy tirz.
Some more than others, but also not thru the entire vial. 🤷♀️ never thought much of it until reading this thread honestly, to know it shouldn't sting at all.
Chizikitide-1977
GLP-1 Enthusiast
Has this ever been verified? It can be really hard sometimes to sort through educated best guesses based on logic and the very limited info available and actual verified facts in the grey market peptide world. This statement about the source of grey market raws is one thing I've seen come up multiple times, and seems like a very reasonable possibility, but like so many thing in the grey market peptide world, it would likely be impossible to verify, so i had always thought this fell into the first category. But if you have something that does verify this, it would be great to share.
For what it's worth, I do see value in making and sharing these types of educated guesses and have done both myself on this and other forums, but usually try to explain when I'm speculating or when something is verifiable.
Only amount and purity are tested, there are many posted examples of COAs in this forum
as for residual etc. you can ask specific vendor if they have test for the raw, but so far we are all alive! 😉 if you want a custom testing for specific residuals etc. you better ask some lab directly as they can also provide you with a price list
anyway I don't think there is any difference between CN vendors, domestics or compounding pharmacies - its all coming from the same raws I guess, as there are not many actual peptide manufacturers
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the peptide manufacture process is nothing like cooking meth in your basement, so yeah, logically there are not many actual raws manufacturers
delululemonade
New Member
Ok I finally tried some of the T15 I ordered on 8/21 and happy to report no stinging. Also my first ever gray market injection woo! It was fun.
Loulabelle
New Member
My replacement batch of t10 is also stinging a bit….
Posted this elsewhere but including my update:
My AmoPure order for T15 and R5 from 9/3 arrived yesterday 9/21.
Today I used fresh Hospira bac water to reconstitute. It was definitely vacuum sealed and dissolved quickly with no cloudiness. And I’m pleased to report there was *No Stinging!* At least no more than any old needle poke.
I didn’t filter or pH test but I’m excited to see how it goes. I have a bit of compounded Tirz to use up before I try the T15 but I’ll report back if there’s anything of note.
My AmoPure order for T15 and R5 from 9/3 arrived yesterday 9/21.
Today I used fresh Hospira bac water to reconstitute. It was definitely vacuum sealed and dissolved quickly with no cloudiness. And I’m pleased to report there was *No Stinging!* At least no more than any old needle poke.
I didn’t filter or pH test but I’m excited to see how it goes. I have a bit of compounded Tirz to use up before I try the T15 but I’ll report back if there’s anything of note.
I received Semaglutide from Amopure 2 weeks ago without Mannitol. It hurts as much as GHK-Cu to inject. It is awful. I also find that an identical quantity to that from Sigma is far less effective. But overall the stinging is really, really bad.
Sucks - there is a test being run on Amo’s sema so hopefully we can confirm purity
Unless they're testing for specific binders or fillers, a purity test probably won't be revealing.
zpped
GLP-1 Specialist
Which weight vials did you get? Also you can contact Amo and they will replace them.
It did only the first pinning of T60. I am thinking that the next one that I mix I will let sit a few days before use. I’m wondering if it just needed time to dissolve fully.
How far in advance of pinning did you mix and when did you order? Curious if mine is from the same batch.
