Do you guys dose based on the vial or the COA?

[woundcarping]

I'm not entirely sure how micro-accurate dosing even needs to be even considering EL's protocol of 2.5, 5, 7.5, etc. given that we ALL accept this as the industry standard for (and here's the catch) ALL users who will range DRAMATICALLY in age, gender, height, weight, etc. - but there's a one-size-fits-all dosing schedule?

Really?

Makes me think that fractions of milligrams on a weekly basis really probably don't matter at all.

Close counts.

Bingo, add in dosing errors at 30mg/ml and the variability grows another way.

I'd say the biggest thing would be what mg vial they're using. If it's a lower 10mg vial, that's probably right at 10 or maybe even 11-12. That's not that big of a deal. But let's say they have a 30 or 60mg vial, that can have much higher overfill, and if they're just starting out, they may have more side effects. Of course everyone is different and everyone will do what they want, I just think it's a good idea for beginners to dose off a COA, then decide after a month or so if they want to keep doing it.

Percentage is percentage.

10mg containing 12mg is exactly the same as a 60mg containing 72mg, or a 120mg containing 144mg.

A 10mg containing 13mg is “worse” than a 60mg containing 70mg.

 

[d0se1]

I check COA's but go by what is stated on the vial. No two vitals are the same. Not even big pharma can't do it. Everything is plus or minus 10%. No one has ever taken the exact amount they think they have.

 

[CandyCap]

Great information! I have been going by COA, but think I will be switching to vial dosage.

 

[littledragon25]

I dose based by the COA of my own testing.

 

[YoYoFat]

I initially dose by the vial and then adjust by feelz.

We talk a lot about fill variability in the gray world. Does anyone have any degree of confidence that compounding doesn’t present the same degree of variability? Or BP with their name brand stuff? I can’t imagine they would be concerned so long as they stay +/-10%.

Per USP and cGMP, brand name manufacturers aim keep to less than 5% variability for most drugs, 3% or less for others. They aim for 1-2% for meds that affect blood glucose or blood pressure.

 

[YoYoFat]

Great information! I have been going by COA, but think I will be switching to vial dosage.

Bad idea.

 

[YoYoFat]

I'm not entirely sure how micro-accurate dosing even needs to be even considering EL's protocol of 2.5, 5, 7.5, etc. given that we ALL accept this as the industry standard for (and here's the catch) ALL users who will range DRAMATICALLY in age, gender, height, weight, etc. - but there's a one-size-fits-all dosing schedule?

Really?

EL’s dosing schedule has nothing to do with grey.

I would have significant sides if I was off by as little as 1.5mg. I know, because I’ve experienced it.

 

[Zydeceltico]

EL’s dosing schedule has nothing to do with grey.

I would have significant sides if I was off by as little as 1.5mg. I know, because I’ve experienced it.

I understand. I should put in my signature "YMMdefV from mine as I appear to have a very robust metabolism."

I have a friend who is stacking T and S alongside me and he also has to watch dosage that I am not affected by at all.

We all do possess diverse and unique combinations of metabolic character apparently.

 

[Rootus346]

I use the average of the mass from the COA, the independent test, and any more independent tests. Usually a dozen vials or so. But I don’t stress about it, either.

 

[trips]

I'm not entirely sure how micro-accurate dosing even needs to be even considering EL's protocol of 2.5, 5, 7.5, etc. given that we ALL accept this as the industry standard for (and here's the catch) ALL users who will range DRAMATICALLY in age, gender, height, weight, etc. - but there's a one-size-fits-all dosing schedule?

Really?

Makes me think that fractions of milligrams on a weekly basis really probably don't matter at all.

Close counts.

i'd argue its fairly important to have accurate dosing as you titrate up and find the does that works for you, particularly when you finish one batch and start using a new one.

 

[Rp121]

The COA for my R20 states 29.16mg which is nearly a 46% increase. Really not sure what to go by in this case as 46% seems a lot to me. But I'm a newbie to this so might be I am over-reacting. I'm planning on starting with wither 0.5 or 1.0 dose. Any advice folks?

 

[Dos-Dox]

The COA for my R20 states 29.16mg which is nearly a 46% increase. Really not sure what to go by in this case as 46% seems a lot to me. But I'm a newbie to this so might be I am over-reacting. I'm planning on starting with wither 0.5 or 1.0 dose. Any advice folks?

I’d use the COA value. Better to underdose than overdose, especially when you’re first starting out. I’d start with 0.5 mg and hold that for a few weeks. (I personally started at 0.25 just to assess tolerability and then went to 0.5 mg for weeks.) Some want to titrate up to the clinical trial starting point of 2 mg as quickly as possible or start there immediately, but my philosophy is to be patient and work up slowly so you let your body adjust and don’t get hit with all the sides. Good luck!

 

[Rp121]

I’d use the COA value. Better to underdose than overdose, especially when you’re first starting out. I’d start with 0.5 mg and hold that for a few weeks. (I personally started at 0.25 just to assess tolerability and then went to 0.5 mg for weeks.) Some want to titrate up to the clinical trial starting point of 2 mg as quickly as possible or start there immediately, but my philosophy is to be patient and work up slowly so you let your body adjust and don’t get hit with all the sides. Good luck!

Thanks Dos-Dox. Your advice mirrors that from another on a separate forum I'd posed the question. I'm in no rush to titrate either. Slow and steady for me too. I'm nervous but really excited. I hope this works. I've been overweight/obese all my life despite trying a lot in terms of gyms, diets etc. Thanks again for your tips. 👍

 

[wildcat0367]

FWIW, I am only a few months in to this, coming from branded Mounjaro. So far, I have dosed based on the coa. If I were to feel as if it was underdosed or something, I would probably revert to the vial mg. I am still @ 5mg Tirz currently and buying T30. IME so far, the gray market stuff has "felt" stronger than the Lily stuff.

If it is over or under 10% of label I will adjust dosage otherwise I just dose according to label contents.

 

[Tron Carter]

COA usually. Especially if there was any group testing and they look to be pretty consistent.

 

[Twowheelr2]

Im used to taking 5mg, triz from the white market. I purchased some 30mg vials, but the COA says 33.68mg. Should I use it with the assumption its 30mg or 33.68mg?

I haven’t seen any measured volume or weight from any source to be exact. Pharmacy, compound pharmacy or internet venders. Even vials from the same batch have different values. If you’re concerned, go low.