Drugs for reta side effects

It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.
I think you're confused about what harm reduction means. The purpose of this forum is harm reduction. We all take risks, but encouraging reckless behavior won't be tolerated. That kind of dose escalation can easily put someone in the hospital or worse.
 
I think you're confused about what harm reduction means. The purpose of this forum is harm reduction. We all take risks, but encouraging reckless behavior won't be tolerated. That kind of dose escalation can easily put someone in the hospital or worse.
Yeah I totally could be conflating Harm reduction with Harm avoidance(Risk aversion? I need sleep, finals week).

I've been that kid running 400mgs of DNP because the info sources I had access to were not good, a large percent of people in this space become a lot more careful after they touch the stove once or twice and thats just how they learned. When you know better, you do better.

Hopefully he gleans some info and gets himself educated. I've never really thought about the consequences of OD'ing on GLPs, because that would require some TENACIOUS stupidity, but the deeper I get into this world I do find that bar creeping lower and lower.
 
It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.
What's wrong with pinning subq in your thigh? That's a pretty standard place on the Mounjaro docs, for testosterone replacement etc.
 

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What's wrong with pinning subq in your thigh? That's a pretty standard place on the Mounjaro docs, for testosterone replacement etc.

I could totally be of the mark, Ive only pinned sema as far as GLP's go - I guess some people dont experience as much PIP as others, but Ive learned to avoid areas that involve a lot of movement. most Subq injections can be done in the stomach as easily as anywhere else.

Its also probably not as big of a risk with Subq as IM, but Ive seen a lot of medical warnings about needles and thighs - potential for nerve damage and whatnot. both of my last two doctors instructed the same to me.
 
I could totally be of the mark, Ive only pinned sema as far as GLP's go - I guess some people dont experience as much PIP as others, but Ive learned to avoid areas that involve a lot of movement. most Subq injections can be done in the stomach as easily as anywhere else.

Its also probably not as big of a risk with Subq as IM, but Ive seen a lot of medical warnings about needles and thighs - potential for nerve damage and whatnot. both of my last two doctors instructed the same to me.
I don't see why, my thigh has plenty of skin + fat on it. Regardless, subq is only supposed to break through to just under the final layer of the skin. It's why most subq needles are only 5mm. If you're using a 8-12mm needle that you brought mistakenly I can see it maybe hurting. But for even practical reasons (like being better able to visualize where I'm going to pin it), my thighs are way easier than my stomach for me. Lots of people report less side effects as well (I haven't experienced that), but that could just be placebo so who knows.
 
I could totally be of the mark, Ive only pinned sema as far as GLP's go - I guess some people dont experience as much PIP as others, but Ive learned to avoid areas that involve a lot of movement. most Subq injections can be done in the stomach as easily as anywhere else.

Its also probably not as big of a risk with Subq as IM, but Ive seen a lot of medical warnings about needles and thighs - potential for nerve damage and whatnot. both of my last two doctors instructed the same to me.
Thigh is usually not recommended for IM anymore because ventroglute and lateral delt are so much better. But its fine for subQ, especially if you're not very lean.
 
It's not the most popular opinion(especially here), but RESULTS are the goal, harm reduction is and always will be priority 2.

No matter what anyone here or anywhere says, If you're injecting experimental peptides, not even considering they come from the chinese gray market of all fkn places, you're willing to at least risk a LITTLE harm if it will get you the RESULTS you want.

This guy seems like the average newcomer in SSA's Discord(You guys should take a peek in there when bored, some of those idiots are HILARIOUS) who is lacking general understandings of Half-lifes(lives? nah),and probably reta itself. For the love of god hes pinning subq into his THIGH. he probably just needs to fuck himself up a little bit(in a clean and safe ish and reparable way) and he'll learn his lesson and start reading. He's already taken the first step by coming here and opening himself up to verbal abusein exchange for (if hes lucky) some good advice.
Much of it isn't responsive to my actual question, but what is seems pretty good, and I'm grateful for it.

I don't appreciate the contemptuous, peacocking digressions, kind of like Linux USENET in the late '90s ("RTFM!!1"; "n00b!!"). I rarely post on forums, and I'd hoped the culture had matured. Apparently not.

As far as I've read, subq injection into the anterolateral thigh is fine, especially with a fatty thigh, as I have. Nothing I can find in published protocols for GLP-1 drugs mandates a specific injection site. Papers report that some patients prefer the thigh, with no shade cast on this site. From what sources I can find, thigh might yield slightly less/slower availability than abdomen, but the difference is regarded as insignificant.

If there are sources I've missed that indicate otherwise, I'd be curious to learn about them and change my injection site accordingly.
 
I take just a 1/4 dose of a cardio selective beta blocker and it seems to help. Same thing if stacking with T3 or T4. Its hard to sleep when your pulse rate is though the roof!

If you like natural, a few Hawthorn Berry capsules can be surprisingly effective as well.
Interestingly, my resting heart rate wasn't higher than normal, even when I was most agitated. Still, if I ever experience elevated heart rate, I'll consider atenolol, of which I happen to have some. Thanks!
 
Interestingly, my resting heart rate wasn't higher than normal, even when I was most agitated. Still, if I ever experience elevated heart rate, I'll consider atenolol, of which I happen to have some. Thanks!

Yes sir, same one I choose also. 12.5mg is all it takes for me to take the edge off, and I just take it situationally, maybe once or twice a week as needed.
 
Much of it isn't responsive to my actual question, but what is seems pretty good, and I'm grateful for it.

I don't appreciate the contemptuous, peacocking digressions, kind of like Linux USENET in the late '90s ("RTFM!!1"; "n00b!!"). I rarely post on forums, and I'd hoped the culture had matured. Apparently not.

As far as I've read, subq injection into the anterolateral thigh is fine, especially with a fatty thigh, as I have. Nothing I can find in published protocols for GLP-1 drugs mandates a specific injection site. Papers report that some patients prefer the thigh, with no shade cast on this site. From what sources I can find, thigh might yield slightly less/slower availability than abdomen, but the difference is regarded as insignificant.

If there are sources I've missed that indicate otherwise, I'd be curious to learn about them and change my injection site accordingly.

What you are reading is correct. Eli Lilly looked into this with tirzepatide recently. Link to clinical trial: https://clinicaltrials.gov/study/NCT04050670?tab=results#limitations-and-caveats

Summary:
  • abdomen gets you a bit more tirzepatide (112000 h * ng/mL) versus arm (111000 h * ng/mL) or thigh (106000 h * nh/mL), but it's not a big difference; Outcome Measure 1
  • abdomen gets you a noticeably higher peak concentration of tirzepatide (603 ng/mL) than upper arm (556 ng/mL), which is in turn higher than thigh (520 ng/mL); Outcome Measure 2
  • abdomen also gets you noticeably more side effects (68.5%) than upper arm (57.41%) or thigh (43.40%), particularly for nausea (21 events vs. 12 vs. 12) and vomiting (10 events vs. 10 vs. 4); Adverse Events
Since they used the same people on all arms of the study, the effect of variation between people (i.e. some people are more sensitive to tirzepatide than others) should be minimized.
 
What you are reading is correct. Eli Lilly looked into this with tirzepatide recently. Link to clinical trial: https://clinicaltrials.gov/study/NCT04050670?tab=results#limitations-and-caveats

Summary:
  • abdomen gets you a bit more tirzepatide (112000 h * ng/mL) versus arm (111000 h * ng/mL) or thigh (106000 h * nh/mL), but it's not a big difference; Outcome Measure 1
  • abdomen gets you a noticeably higher peak concentration of tirzepatide (603 ng/mL) than upper arm (556 ng/mL), which is in turn higher than thigh (520 ng/mL); Outcome Measure 2
  • abdomen also gets you noticeably more side effects (68.5%) than upper arm (57.41%) or thigh (43.40%), particularly for nausea (21 events vs. 12 vs. 12) and vomiting (10 events vs. 10 vs. 4); Adverse Events
Since they used the same people on all arms of the study, the effect of variation between people (i.e. some people are more sensitive to tirzepatide than others) should be minimized.
Interesting. The geometric mean of the %gCV (or do we use arithmetic?) for all 3 injection sites is like 5x the AUC concentration, so I'm not even sure we can conclude it matters. That's a lot more noise than signal.
It looks like the tests conclude that neither arm nor thigh is inferior, but they don't assess if the observed difference in AUC concentration, C_max, or side effect rate is significant.

My guess is that the differences are not statistically significant (except for maybe nausea/vomitting), and we should presume that changing the injection site doesn't matter.

No?
 
Interesting. The geometric mean of the %gCV (or do we use arithmetic?) for all 3 injection sites is like 5x the AUC concentration, so I'm not even sure we can conclude it matters. That's a lot more noise than signal.
It looks like the tests conclude that neither arm nor thigh is inferior, but they don't assess if the observed difference in AUC concentration, C_max, or side effect rate is significant.

My guess is that the differences are not statistically significant (except for maybe nausea/vomitting), and we should presume that changing the injection site doesn't matter.

No?
Yes, this is the correct conclusion. Is there a difference, probably. But it's not enough to matter for the majority of people.
 
I figured the quicker weight loss was worth it.
Quicker weight loss isn't necessarily the best thing for your body. I myself need to lose nearly 200 pounds, so I absolutely understand the appeal of quick results. Triggering more severe side effects isn't worth it though. Especially when some of them can be very serious. Personally I want a slower loss to minimize loose skin as much as I can. There are many other reasons but I think the one that you would likely be most interested in .. rapid weight loss damages your metabolism and I haven't seen a single bit of research on how that can be fixed.
 
I don't see why, my thigh has plenty of skin + fat on it. Regardless, subq is only supposed to break through to just under the final layer of the skin. It's why most subq needles are only 5mm. If you're using a 8-12mm needle that you brought mistakenly I can see it maybe hurting. But for even practical reasons (like being better able to visualize where I'm going to pin it), my thighs are way easier than my stomach for me. Lots of people report less side effects as well (I haven't experienced that), but that could just be placebo so who knows.
I only pin in my thighs, subq. I was doing belly injections as that was easy and recommend for Mounjaro auto-injectors. I got heavy nausea for 2 days. My doctor gave me an Rx for Zofran, but isn’t in general a fan of treating drug side effects with another drug, it can become an endless cycle. He suggested using the thighs, as it is absorbed slower. The glutes would be the slowest, and would probably fine, but it is not an approved injection site for Mounjaro. And it’s harder to self inject back there. But guess what? That simple change of injection location to the thigh significantly reduced the amount and duration of the nausea. Even tho I rarely get nausea now, I still only do thighs.
 
Yes, this is the correct conclusion. Is there a difference, probably. But it's not enough to matter for the majority of people.
But, but, overthinking every little thing!

Thoughts Overthinking GIF
 
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