I think you're confused about what harm reduction means. The purpose of this forum is harm reduction. We all take risks, but encouraging reckless behavior won't be tolerated. That kind of dose escalation can easily put someone in the hospital or worse.
Yeah I totally could be conflating Harm reduction with Harm avoidance(Risk aversion? I need sleep, finals week).
What's wrong with pinning subq in your thigh? That's a pretty standard place on the Mounjaro docs, for testosterone replacement etc.
I don't see why, my thigh has plenty of skin + fat on it. Regardless, subq is only supposed to break through to just under the final layer of the skin. It's why most subq needles are only 5mm. If you're using a 8-12mm needle that you brought mistakenly I can see it maybe hurting. But for even practical reasons (like being better able to visualize where I'm going to pin it), my thighs are way easier than my stomach for me. Lots of people report less side effects as well (I haven't experienced that), but that could just be placebo so who knows.
Thigh is usually not recommended for IM anymore because ventroglute and lateral delt are so much better. But its fine for subQ, especially if you're not very lean.
Much of it isn't responsive to my actual question, but what is seems pretty good, and I'm grateful for it.
Interestingly, my resting heart rate wasn't higher than normal, even when I was most agitated. Still, if I ever experience elevated heart rate, I'll consider atenolol, of which I happen to have some. Thanks!
Betaine for backed up? How much?
Interesting. The geometric mean of the %gCV (or do we use arithmetic?) for all 3 injection sites is like 5x the AUC concentration, so I'm not even sure we can conclude it matters. That's a lot more noise than signal.
Yes, this is the correct conclusion. Is there a difference, probably. But it's not enough to matter for the majority of people.
Quicker weight loss isn't necessarily the best thing for your body. I myself need to lose nearly 200 pounds, so I absolutely understand the appeal of quick results. Triggering more severe side effects isn't worth it though. Especially when some of them can be very serious. Personally I want a slower loss to minimize loose skin as much as I can. There are many other reasons but I think the one that you would likely be most interested in .. rapid weight loss damages your metabolism and I haven't seen a single bit of research on how that can be fixed.
I only pin in my thighs, subq. I was doing belly injections as that was easy and recommend for Mounjaro auto-injectors. I got heavy nausea for 2 days. My doctor gave me an Rx for Zofran, but isn’t in general a fan of treating drug side effects with another drug, it can become an endless cycle. He suggested using the thighs, as it is absorbed slower. The glutes would be the slowest, and would probably fine, but it is not an approved injection site for Mounjaro. And it’s harder to self inject back there. But guess what? That simple change of injection location to the thigh significantly reduced the amount and duration of the nausea. Even tho I rarely get nausea now, I still only do thighs.
Exactly. The study was designed as a non-inferiority trial. If non-inferiority criteria was met, then they would have spent the $$$ needed to run a proper trial with more patients, but since the 3 injection sites were non-inferior, they didn't bother going any further. You could say that there is a signal towards slightly higher peak AUC and worse side effect profile with abdominal injection but we can't draw a definitive conclusion one way or another.
Good point.
You're approaching it with the right mindset. That speed of loss is definitely healthy and more than achievable.
He just started his fox journey.
All I changed was my diet, and I lost 20% in six months on sema. I think it varies wildly by person, because I am absolutely still a couch potato.
I lost 75lbs (255->180) on tirz alone in 10 months. but mine is technically side effect as my objective was to get my blood glucose back down to normal. fasting was 137 with an a1c of 6.3. now it’s 74 and 5.2 as well after the same 10 months. but I was a slow responder and I think i only lost 8 lbs and no glucose change in the first 3 months. yet i got many of the bad side effects: super nausea, massive constipation, crushing fatigue. It was some much I wanted to stop, more than once and was just going to take metformin for the rest of my life, but my doctor kept encouraging me to stick with it. the selling point was he kept referring to the 94% cure rate for pre-diabetes from tirz, “we never see cure rates like that in medicine!” he kept saying. but eventually it kicked in around month 4 to 5 for me.
Taking the time to allow your body to adjust to gradually higher doses would only prolong the process by a few weeks at most .. but if you aren't worried about how much time it takes then you should absolutely take your time upping your doses slowly. Just because the people in the study didn't get to a 25% weight loss by 72 weeks on a lower dose does not mean that they would not EVENTUALLY get there. I am taking semaglutide, the glp1 with the least impressive numbers according to the studies .. but there are plenty of people out there telling their stories of losing much more weight than they were predicted to lose using it. Will I be one of those stories? I don't know. But as long as I continue to lose weight with it I will keep using it.
His Fox journey?
It’s not just “aggressive.” It’s reckless. What part of “it takes 4 weeks to reach full effect” do you not understand? Titrating up faster isn’t aggressive, it’s just plain stupid.
If it’s contemptuous to you, that could be a hint you are not acting in your own best interests. If having knowledge and sharing it is “peacocking,” then why are you here? You could go to Meso and get uneducated poor advice more in line with your thinking.
What good is giving him good advice when he has made it clear he prefers ill advised shortcuts to actual knowledge? Because apparently facts = “peacocking.” Does not sound like he plans to listen to any good advice- he discounted it al with, “they didn’t tell me what I asked for.” No we did not- we told you what you need to do to be safe. But hey- he already poisoned himself with a Reta overdose- let’s throw more drugs into the mix! Then when he titrates up to 20 mg like the other one, the ED will have no idea how to help him. 🙄
Well .. because not only is there a chance that he will listen to a kinder voice gently pointing him in the right direction .. there are going to be other people reading this thread who can benefit not only from his mistakes but our advice on how to deal with them after the fact if they have already done the same thing.
