First grey order question

[NoMoreFatPants]

Just received my first grey kit - Tirz 15mg. There is test results for this batch - the results on the three vials submitted show they contain 18.55mg, 19.19mg and 18.61mg. Safe to assume that all vials potentially are over filled in this batch. If your kit had test results that showed three different amounts in three different vials, do you average out the three and reconstitute from the average or do you usually go with whatever the largest amount is and assume your vials may contain that larger amount? I am not so much concerned about myself... I was taking 15mg weekly of Mounjaro through insurance. I've switched to grey and have been titrating down so that I can move to Reta. I have bumped myself down to 10mg weekly, so if by chance my mgs were higher in these vials, I would not be dosing over what I had already been on previously. I have split the kit with someone who is just starting out and tends to be a little sensitive to tirz and so their pins have started out smaller than the "normal" starting dose of 2.5mg. They aim for 2mg max. I am thinking, just to be safe, we should assume there is 19mg in each vial of this batch.

Probably seems like a stupid question. Just needed to confirm with experienced researchers that my assumptions about the contents of grey vials is correct.

 

[Bflo_Bflo_Bflo_Bfl]

Personally, with them so close, I would average-ish. I’d recon with 1.88 ml (as close as I could get with rather imprecise syringe measurements) for about 1 mg/ml. Or maybe go for .94 ml for around 2 mg/ml, depending on my dose and what was more convenient to measure.

 

[randompersonrandom]

It doesn't sound stupid to me, though I'm not experienced. I'm on a low dose too, and if I'm still on that low dose by the time I get through my compounding, then I'll average out the fills on the tests, pin on a Friday when I don't have weekend plans, and see how I feel. If I'm a little nauseated, then I'll go ope, too high, and go lower next week.

My answer would be different if the stakes were higher, of course.

 

[Calm Logic]

Personally, with them so close, I would average-ish.

Me too.

I’d recon with 1.88 ml (as close as I could get with rather imprecise syringe measurements) for about 1 mg/ml. Or maybe go for .94 ml for around 2 mg/ml, depending on my dose and what was more convenient to measure.

With the help of a reverse calculation website, a general guideline for a manageable injection volume is 20 to 50 units (0.2 to 0.5 mL) for each subq injection. At least 20 units to help with accuracy and eyeing the syringe amount, but no more than 40 or 50 units to keep the injection volume comfortable. But I have injected anywhere from 6 units (when starting out with a new GLP) to as much as 100 units (for a B-12 injection).

 

[BooneDonk]

Me too.



With the help of a reverse calculation website, a general guideline for a manageable injection volume is 20 to 50 units (0.2 to 0.5 mL) for each subq injection. At least 20 units to help with accuracy in eyeing the syringe amount, but no more than 40 or 50 units to keep the injection volume comfortable. But I have injected anywhere from 6 units (when starting out with a new GLP) to as much as 100 units (for a B-12 injection).

I’m with you on the 20-50 units is for nothing other than it seems like something was utilized. Does the math work and meds are injected? Absolutely. Does a drop off a faucet seem like enough? No.

It’s all emotion! 🤣🤣

 

[MsGizmo]

Just received my first grey kit - Tirz 15mg. There is test results for this batch - the results on the three vials submitted show they contain 18.55mg, 19.19mg and 18.61mg. Safe to assume that all vials potentially are over filled in this batch. If your kit had test results that showed three different amounts in three different vials, do you average out the three and reconstitute from the average or do you usually go with whatever the largest amount is and assume your vials may contain that larger amount?

From what I've seen overfilling is the standard. Yes, when there are 3 results I personally would go with a rounded average. Like with your numbers I would just call it 19mg and get on with life. But let's say my goal was a 5mg dose .. I would round it up and call it 20mg just so I would have 4 doses per vial. Sure, I would only be getting 4.75mg .. but whatever. I like easy math.

In your friends case calling the vial 20mg would give them 10 doses ... but their actual dose would be 1.9 mg instead of 2mg. Not really that big of a deal.

 

[nonyabizznez]

Just received my first grey kit - Tirz 15mg. There is test results for this batch - the results on the three vials submitted show they contain 18.55mg, 19.19mg and 18.61mg.

18.78 is the average and the variances here are minimal. To keep it simple I'd go with 19mg.

Personally, with them so close, I would average-ish. I’d recon with 1.88 ml (as close as I could get with rather imprecise syringe measurements) for about 1 mg/ml. Or maybe go for .94 ml for around 2 mg/ml, depending on my dose and what was more convenient to measure.

If you take this advice be mindful there's a decimal point missing:

1.88ml BAC for about 1mg/.10ml (10 units)
.94ml Bac for around 2mg/ .10ml (10 units)

In this example I'm more a fan of the first.

 

[NoMoreFatPants]

Thank you all for the replies. Being over cautious is a good thing, but it can also be annoying. I appreciate your patience in answering.

 

[randompersonrandom]

Thank you all for the replies. Being over cautious is a good thing, but it can also be annoying. I appreciate your patience in answering.

I mean....humans relax and think of things as "not a big deal" as they get familiar with them. So if you start out SUPER cautious, then when you mellow, you'll land in "reasonably careful." Also, we're not pharmacists (mostly) and are learning pharmacy practices at home; of course we all want to do the checks on what is a big deal.

 

[clayd]

Just received my first grey kit - Tirz 15mg. There is test results for this batch - the results on the three vials submitted show they contain 18.55mg, 19.19mg and 18.61mg. Safe to assume that all vials potentially are over filled in this batch. If your kit had test results that showed three different amounts in three different vials, do you average out the three and reconstitute from the average or do you usually go with whatever the largest amount is and assume your vials may contain that larger amount? I am not so much concerned about myself... I was taking 15mg weekly of Mounjaro through insurance. I've switched to grey and have been titrating down so that I can move to Reta. I have bumped myself down to 10mg weekly, so if by chance my mgs were higher in these vials, I would not be dosing over what I had already been on previously. I have split the kit with someone who is just starting out and tends to be a little sensitive to tirz and so their pins have started out smaller than the "normal" starting dose of 2.5mg. They aim for 2mg max. I am thinking, just to be safe, we should assume there is 19mg in each vial of this batch.

Probably seems like a stupid question. Just needed to confirm with experienced researchers that my assumptions about the contents of grey vials is correct.

The correct answer is it's your best judgment. It does seem like a 15-20% overfill is becoming more common.

Personally I ignore the noise and assume 30mg is 30mg, but I admit this is a lazy approach.

My suggestion is to assume the fill is correct, or assume it's overfilled by 20%, your choice. But make one and stick with it.