First Reta Phase III Results

Here is the link: Eli Lilly (Dec. 11, 2025). Lilly's triple agonist, retatrutide, delivered weight loss of up to an average of 71.2 lbs along with substantial relief from osteoarthritis pain in first successful Phase 3 trial. PR Newswire, https://www.prnewswire.com/news-rel...first-successful-phase-3-trial-302638804.html.

We'll have to wait until they present their results at a medical conference or through a scholarly article before we learn additional details.

Although I'll jump on the bandwagon and praise retatrutide as being the next huge weight loss drug to enter the market, I suspect that large numbers of new weight loss drugs get approved in the next five years.
 
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miss-sanne said:
It's even better than weight loss surgery, thanks for this.
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There will be less need for weight loss surgery. Some folks will likely still require retatrutide to lose weight before the surgery and will have to resume taking reta at some point after the surgery.

It's good that weight loss surgery will be less necessary. I have read about and watched televisions about folks who have undergone weight loss surgery. Despite there being some side effects from GLP-1 and GLP-1+ medications, their side effects are usually nowhere close to being as severe as those from weight loss surgery.
 
Thanks for posting the results. Here is an article commenting on the results: First Retatrutide phase 3 data, a Triumph of Science! https://the-incretins.beehiiv.com/p/first-retatrutide-phase-3-data-a-triumph-of-science. The author points out some good and bad things that I hadn't noticed. For instance, many people had to drop out of the study because they lost too much weight! And the author points out some fairly significant side effects.
 
Thank you! What shocks me is that 1.3% on Placebo lost greater than 25%!!! (4.8% of placebo takers quit due to adverse events i.e.side effects!)
🤣
What was the timeline of the study? I'm not seeing it..
Found it on website; 68 wks.
 
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Funny, I just came off a sub reddit where people were talking about this. Well, started off with this and then turned into an argument about "roid heads". I swear sometimes reddit is an ADHD support group.
 
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keangkong said:
It's good that weight loss surgery will be less necessary. I have read about and watched televisions about folks who have undergone weight loss surgery. Despite there being some side effects from GLP-1 and GLP-1+ medications, their side effects are usually nowhere close to being as severe as those from weight loss surgery.
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These medications (and those in the pipeline) are definitely making surgery less and less necessary. I had gastric bypass in 2003 and the side-effects weren't too bad. The main side effect was losing 225 pounds 🤣😂🤣.

Hopefully, bariatric surgeons are using these medications as an adjunctive to surgery in the super-morbidly obese. For regularly obese people, I would never recommend gastric surgery. If these medications were available in 2003, I would have never had surgery.
 
keangkong said:
Thanks for posting the results. Here is an article commenting on the results: First Retatrutide phase 3 data, a Triumph of Science! https://the-incretins.beehiiv.com/p/first-retatrutide-phase-3-data-a-triumph-of-science. The author points out some good and bad things that I hadn't noticed. For instance, many people had to drop out of the study because they lost too much weight! And the author points out some fairly significant side effects.
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I have the dysesthesia side effect but the benefits outweigh that tremendously.
 
Grogu said:
These medications (and those in the pipeline) are definitely making surgery less and less necessary. I had gastric bypass in 2003 and the side-effects weren't too bad. The main side effect was losing 225 pounds 🤣😂🤣.

Hopefully, bariatric surgeons are using these medications as an adjunctive to surgery in the super-morbidly obese. For regularly obese people, I would never recommend gastric surgery. If these medications were available in 2003, I would have never had surgery.
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Add to that, a large majority of people put the weight back on and some, more than what was lost. At least with reta, if used correctly, people will get a chance to work on their diet as opposed to being forced to eat less through a bypass or sleeve.
 
Chucky said:
Add to that, a large majority of people put the weight back on and some, more than what was lost. At least with reta, if used correctly, people will get a chance to work on their diet as opposed to being forced to eat less through a bypass or sleeve.
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Thankfully, I “only” gained back about 100lbs from my lowest and didn’t gain back all 225 or more, but some people do gain it all back.

Tirzepatide has been life altering for me and can’t wait to try reta.
 
keangkong said:
It sounds like your bariatric surgery result was reasonably good. You didn't have bad side effects and you lost a large amount of weight, although you likely still wanted to lose a great deal more.
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I actually lost ~55% of my starting weight after surgery and was very near goal (maybe 10 lbs). So, I did way better than most people do with surgery. But I was relatively young back then and I’m really good a losing weight, just not good at keeping it off 😂.

Thank you for sharing the links to the press release and also website that reviewed the findings. I love clinical research and can’t wait to see additional reta studies. Just looking at the phase II in the NEJM, interesting stuff. Thanks again!
 
Since the subject of gastric bypass came up, I thought it might be worth mentioning this:
GLP-1RA and gastric bypass surgery surprisingly work in the exact opposite way to trigger weight loss!

With gastric bypass, there's certainly a strong nudge towards changing habits (via a smaller stomach, band, etc.), but the larger effect is believed to be accomplished by severing the vagus nerve from your stomach (which happens as part of the surgery). With that nerve severed, your stomach is no longer able to directly signal to your brain that you just ate via the GLP-1 pathway. Bariatric surgeons believe that prior to surgery your brain had kind of went haywire in trying to manage satiety based on GLP-1 (and related) signaling so by severing that connection, they're shutting down that "faulty" signal and it sounds like a reasonable story to me.

With GLP-1RA, instead of dropping the signal to zero, you're now maxing it out.
 
keangkong said:
For instance, many people had to drop out of the study because they lost too much weight!
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I am fairly certain this was more of a psychological and sociological effect rather than medical one. I.e. I believe this was the result of patients and their families being shocked to see someone who was obese their whole life suddenly slim down, and so they panicked as a result even though the patients could have continued taking the drug with some weight left to lose.
 

A link For those that want to delve into the open access published journal study.

“Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials”

Hadn’t read much about basket trial study design before so that was interesting. Lots of very interesting bits in here.
 
Regarding side effects, the jump in dysesthesia going from 9mg to 12mg is dramatic: 8.8% and 20.9%respectively.
The others (vomiting, nausea, ect...) don't seem too different than sema and triz.

The weight loss results are amazing, plus it helps with osteoarthritis? Exciting times. Now I need to put in another order to add to my horde like a peptide dragon.
 
bogardbilla said:
I am fairly certain this was more of a psychological and sociological effect rather than medical one. I.e. I believe this was the result of patients and their families being shocked to see someone who was obese their whole life suddenly slim down, and so they panicked as a result even though the patients could have continued taking the drug with some weight left to lose.
Click to expand...
I believe I am seeing something similar with my mother-in-law. She's morbidly obese and has been most of her adult life. Her doctor recommended tirz, but she won't take it. She complains about all her comorbidities, like sleep apnea, joint pain, difficulty walking, and diabetes, but doesn't seem to want to admit that weight loss would help all that. I've tried to talk her into it, but weight is a sensitive subject, so I have to tread lightly. It's frustrating. I want her to be healthy, but she won't even try.
 
Thistley said:

A link For those that want to delve into the open access published journal study.

“Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials”

Hadn’t read much about basket trial study design before so that was interesting. Lots of very interesting bits in here.
Click to expand...

Thanks for posting this. Just started reading and it really is fascinating and the concept of basket trial methodology. I was wondering how the researchers were going to disintangle the heterogeneity issue. When I read the title of the article, I was like "duh", if someone loses weight of course their going to experience less OA knee pain. Same for OSA in the tirzepatide clincial studies. If I'm understanding correctly, they used independent "baskets" of those being treated for weight management, OSA, and OA. And somehow are able to "isolate" the effects of reta on OA and OSA. Really clever and going to have to read it when I can really focus. Thanks again!
 
I just received my first Reta kit - I've been on the fence about switching from Tirz to Reta since my Tirz isn't really Tirzing for me anymore (9 weeks at 12.5mg and I keep gaining and losing the same 7 pounds and the sides are getting brutal).

This helped solidify that decision and I'll be interested to get underway with Reta soon.
 
cheaperseeker said:
I believe I am seeing something similar with my mother-in-law. She's morbidly obese and has been most of her adult life. Her doctor recommended tirz, but she won't take it. She complains about all her comorbidities, like sleep apnea, joint pain, difficulty walking, and diabetes, but doesn't seem to want to admit that weight loss would help all that. I've tried to talk her into it, but weight is a sensitive subject, so I have to tread lightly. It's frustrating. I want her to be healthy, but she won't even try.
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What about the pron pill so she doesn't have to do injections? 🤔
 
keangkong said:
There will be less need for weight loss surgery. Some folks will likely still require retatrutide to lose weight before the surgery and will have to resume taking reta at some point after the surgery.

It's good that weight loss surgery will be less necessary. I have read about and watched televisions about folks who have undergone weight loss surgery. Despite there being some side effects from GLP-1 and GLP-1+ medications, their side effects are usually nowhere close to being as severe as those from weight loss surgery.
Click to expand...
Sure thing, I have a lot of paitents who had weight loss surgery, mostly gastric bypass, loads of pain and side effects etc. It's not reversible. I do also have a lot who are happy.
GB it's amazing for curing diabetes and reversing metabolic dysfunction, but I would prefer reta or similar.
 
These studies and reports were what I had been waiting on. I’m in maintenance having reached goal on Tirz, and I have a freezer full to last me until retirement, so I don’t plan on purchasing any Reta.

But if I were starting out now, or still had a lot of weight to lose, I’d definitely be a Retastan.
 
bogardbilla said:
I am fairly certain this was more of a psychological and sociological effect rather than medical one. I.e. I believe this was the result of patients and their families being shocked to see someone who was obese their whole life suddenly slim down, and so they panicked as a result even though the patients could have continued taking the drug with some weight left to lose.
Click to expand...

Perhaps However, they were medically supervised and got to hear the advice from medical professionals. It looks like we'll have to wait for the study results to be published before we'll know.
 
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