GHK Basic. Who has it?

HereKittyKitty said:
Hmmmm... I haven't gotten any aches, fortunately. Thank you for the info about Glycine. I take zinc glycinate several times/week even though I have read mixed info about its necessity. Better safe than sorry.

That's a good while. There is a member on another chat who has been using Cu non-stop for a couple of years. I may cycle Basic every other vial or third or something.
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I have used ghk cu for over a year non stop and I'm still alive. So there's that!
 
IMHO I think our diets are horribly lacking in zinc - there just isn't that much in the food any more - and I think supplementing zinc should be critical for everyone.

I don't know about joint health but the ghk-cu is definitely responsible for my disappearing turkey neck and 'crepe' skin. And "other" skin has become more velvety feeling like when I was younger, HA! Didn't see that coming.
 
AlexSilver said:
IMHO I think our diets are horribly lacking in zinc - there just isn't that much in the food any more - and I think supplementing zinc should be critical for everyone.

I don't know about joint health but the ghk-cu is definitely responsible for my disappearing turkey neck and 'crepe' skin. And "other" skin has become more velvety feeling like when I was younger, HA! Didn't see that coming.
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My heels have been chronically and irreversibly cracked for a long time. They are normal now.

Definitely noticing improvements in skin texture. And where I pin is amazingly smooth and soft like a baby.
 
Researcher6076 said:
I put 750 mcg KPV in with my daily GHK-cu and no sting or ISR at all.
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I have pinned 3 vials, 1 GLOW, 1 GHK-CU, and 1 KLOW and I don't get a sting. Just a painful dull ache later. Jealous of no reaction tho.
I love KPV. So much that I added a 30mg vial of KPV to my 50mg GHK-cu only vial. For every 2mg of copper, that's 1.2mg of KPV. But same result.
KPV does indeed help. And so does BPC. I don't know why the original creator included TB500 in there. Some where I read that the combo BPC/TB500 in the GHK-CU has a half life of about 6 hours. I understood that BPC only has a half-life of 30 minutes. Could the combo change the half-life like that?
And for me, it is after about 5 hours that the dull ache at the injection site starts. Adding lidocaine doesn't change anything. Probably because lidocaine also wears off after about 4 or 5 hours...
But the Glycine was a game changer and mostly killed the dull ache. Shocking. I started taking it to remove the urgency to go at night.
 
HereKittyKitty said:
How long have you been using Cu?
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Haven't taken any in a while. But I took 2mg a day for 4-5 months at one point with no effect on serum levels. Everyone shouldn't do that though because there are genetic factors. Test your serum levels to be sure.
AlexSilver said:
Since Dec. Off and on. Haven't been able to do continuously because of pincushion issues, lol!

If you add Glycine to your supplements, it will totally help with the copper ache. BPC has Glycine in it's profile. That's why it helps. After numerous chemical studies and discovering that one of the aminos in the GHK profile is Glycine, I am definitely going to try a blend.
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Oral supplements will do nothing for copper in subq
 
zpped said:
Oral supplements will do nothing for copper in subq
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But when I forgot to take the glycine one week, the ache came back, and when I started again, the ache went away...

It can't be placebo because I wasn't taking it for that and didn't know it would do that.

I dunno <shrug>
 
Joke's on me.

I've been testing Basic for the first time. Duration: 2.5 weeks. My RS has not responded well. I was so hopeful!

On Cu, cuticles were perfect. They have dramatically devolved in the last couple of weeks.

Need to do something with the Basic and return to the Cu.
 
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HereKittyKitty said:
Joke's on me.

I've been testing Basic for the first time. Duration: 2.5 weeks. My RS has not responded well.

On Cu, cuticles were perfect. They have dramatically devolved in the last couple of weeks.

Need to do something with the Basic and return to the Cu.
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I think you should blend it. AMAZING. For me and a client. Lots of naysayers here but if you search elsewhere, there are a buttload of people doing it blended and loving it.
 
AlexSilver said:
I think you should blend it.
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I agree blending with GHK-Cu might be a good option to still get some use out of it while also getting the Cu back into the schedule. I currently blend 3:1 (Cu:basic).
HereKittyKitty said:
Need to do something with the Basic and return to the Cu.
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Just for some data points, singles sell for $10 each (seemingly whether it’s 50 mg or 100 mg). My own personal risk tolerance doesn’t allow me to sell anything grey to anyone. (I won’t even order for someone else while I’m ordering because I don’t ever want to have been in the position to have accepted money in exchange for peptides.) But everyone own legal risk tolerance is different.
 
Dos-Dox said:
I agree blending with GHK-Cu might be a good option to still get some use out of it while also getting the Cu back into the schedule. I currently blend 3:1 (Cu:basic).

Just for some data points, singles sell for $10 each (seemingly whether it’s 50 mg or 100 mg). My own personal risk tolerance doesn’t allow me to sell anything grey to anyone. (I won’t even order for someone else while I’m ordering because I don’t ever want to have been in the position to have accepted money in exchange for peptides.) But everyone own legal risk tolerance is different.
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Thank you!

3:1....what is your daily dose, if I can ask.

I'm intrigued to mix them. I was thinking 1:1 just because the daily pin is so small, a combined vial would last 3+ months.
 
HereKittyKitty said:
Thank you!

3:1....what is your daily dose, if I can ask.

I'm intrigued to mix them. I was thinking 1:1 just because the daily pin is so small, a combined vial would last 3+ months.
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Yep! Here’s a link to a thread in Peppy’s I read awhile back. I have seen where some people had good experiences with 5:1, but I did 3:1 mainly because I have a 100 mg GHK-basic vial (so I wanted to use a little more rather than have extra sitting around for a long time) and 3:1 made my recon math nice and easy. With this blend, I’m dosing with 1.5 mg GHK-Cu, 0.5 mg GHK-basic, and 0.5 mg BPC-157. I’m taking a break from my second true pep love (KPV) for a cycle.
 
Dos-Dox said:
Yep! Here’s a link to a thread in Peppy’s I read awhile back. I have seen where some people had good experiences with 5:1, but I did 3:1 mainly because I have a 100 mg GHK-basic vial (so I wanted to use a little more rather than have extra sitting around for a long time) and 3:1 made my recon math nice and easy. With this blend, I’m dosing with 1.5 mg GHK-Cu, 0.5 mg GHK-basic, and 0.5 mg BPC-157. I’m taking a break from my second true pep love (KPV) for a cycle.
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Yeah, yeah, me too, I might be slightly addicted to KPV. Gosh, but it's a wonder. I haven't had any KPV for 2 weeks because I didn't want to open another 30mg vial I while was doing other experiments but I miss it. I think I'll go ahead and do it. I could pin at lunch.
 
AlexSilver said:
I have pinned 3 vials, 1 GLOW, 1 GHK-CU, and 1 KLOW and I don't get a sting. Just a painful dull ache later. Jealous of no reaction tho.
I love KPV. So much that I added a 30mg vial of KPV to my 50mg GHK-cu only vial. For every 2mg of copper, that's 1.2mg of KPV. But same result.
KPV does indeed help. And so does BPC. I don't know why the original creator included TB500 in there. Some where I read that the combo BPC/TB500 in the GHK-CU has a half life of about 6 hours. I understood that BPC only has a half-life of 30 minutes. Could the combo change the half-life like that?
And for me, it is after about 5 hours that the dull ache at the injection site starts. Adding lidocaine doesn't change anything. Probably because lidocaine also wears off after about 4 or 5 hours...
But the Glycine was a game changer and mostly killed the dull ache. Shocking. I started taking it to remove the urgency to go at night.
Click to expand...
What benefits do you see from kpv and bpc?

I mean if one is healthy do they need kpv or bpc at all?
 
Calm Logic said:
No. GHK basic is white (copper free) lyophilized powder to be reconned for injection. It doesn't sting like the GHK-Cu for injection.

The raw GHK-Cu powder is sold in tubes usually and has copper, is relatively loose, and is for topical use, like by mixing into a moisturizer.
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I got ghk.cu and ahk cu. Both are in vials and looks dark blue. How do I find out whether its safe to pin?
 
Rickcaps said:
What benefits do you see from kpv and bpc?

I mean if one is healthy do they need kpv or bpc at all?
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KPV was originally desighned for gut health. It is also a major anti-inflammatory and it turns off several signals that cause inflammation. It also has assorted side effects like it will wipe out a candida infection. Over time it will also heal a few skin problems, for example excema.

Not enough experience with BPC.

I can't tell you if you need anything. You have to decide that for yourself.
 
I've been on klow, hardly know what all is getting effected. Maybe a break will enlighten me with the benefits.
 
Rickcaps said:
What benefits do you see from kpv and bpc?
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I love KPV for diminishing all the aches and pains. My hips and shoulders don’t hurt or pop when I’m taking it. And it’s great for just general inflammation. I haven’t really ever noticed any mind-blowing effects from BPC, but I bought a lot on one of my first grey purchases, so I’m adding it in when I’m taking a break from KPV.

Both are supposed to be good for gut healing and musculoskeletal issues.
 
Back to GHK-basic...

  1. Signaling Molecule for Tissue Repair: GHK Basic acts as an endogenous signal released during tissue injury, triggering processes like fibroblast migration and gene expression changes related to repair and regeneration. It is found in human plasma, saliva, and urine, with levels declining from ~200 ng/mL at age 20 to ~80 ng/mL at age 60.
  2. Potent Antioxidant Activity: GHK Basic is a powerful scavenger of reactive oxygen species (ROS) and cytotoxic byproducts of lipid peroxidation (e.g., acrolein and 4-hydroxy-2-nonenal). At 10µM, it can reduce ROS levels by nearly 50% in cells. Its ability to quench hydroxyl radicals is stronger than that of glutathione (GSH), a major cellular antioxidant.
  3. Anti-Inflammatory Effects: In cellular models, GHK Basic reduces the expression of key pro-inflammatory cytokines like TNF-α and IL-6. It modulates inflammatory pathways, including NF-κB and p38 MAPK signaling, which are central regulators of the body's inflammatory response.
  4. Copper Homeostasis and Gene Regulation: While GHK Basic itself is copper-free, its primary biological function is intrinsically linked to copper. Its histidine residue has a high affinity for copper (II) ions, allowing it to act as a natural copper carrier. It modulates the expression of over 4,000 human genes, influencing pathways involved in tissue remodeling, oxidative stress response, and inflammation. Its gene-regulating effects are often studied in comparison to its copper-bound form.
 
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