GLP-1 chills

YoYoFat said:
Back in October, when the temp could still be warm, I appreciated the cold. But now, with the already cold weather, it’s unpleasant. I’m hoping in a few months and into the summer that I’m back to appreciating the chills… if only for my A/C bill. Ha.
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I started tirz in early August. I had no complaints about chills during those first few months, but the temperatures were far higher than they are today.
 
If you're too cold, you could always take DNP!

(do no do this this is an awful idea please this is a bad joke under no circumstances should anyone be taking DNP)
 
keangkong said:
How long does it take for the GLP-1 chills to pass? Or am I stuck with getting cold super easy as long as I keep these drugs. I’ve been on either reta or tirz for 6 months and I still get cold quite easily.
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I have been the "overly" warm-blooded type my entire life. Then, about 3 months ago (about 4 months into my blossoming friendship with Tirz), I suddenly became the one that is 🥶 FREEZING all the damn time. For some reason, my legs are the worst. Literally, icy cold to the touch. I now sleep in fleece-lined leggings and socks which I have never been able to do my entire life. If I don't, I will lay there miserable for hours and just shiver until I get up and put clothes and socks on.

I read that the chills are caused more by a sudden drop in body weight and a significant reduction in caloric intake; more so than the Tirz/GLP-1's causing the chills.
For women (especially those with PCOS like myself), it's also caused by hormonal imbalance ... which is the entire reason my doctor prescribed Mounjaro to me. Other than hormone therapy to treat SOME of the PCOS symptoms, the other "treatment" (so to speak) is a sudden (and significant) reduction of body weight. Sudden weight loss of a significant amount can put the endocrine system in a bit of shock with the hope of it forcing to "reset" so to speak. My "lady doctor" described it as being very similar to how Electrocompulsive Therapy (ECT) to the brain works to treat psychological disorders.
Overall, I guess there is something to it (at least in my case) as I have lost close to 60 pounds since October. I am chilly🥶 ALL THE TIME and I no longer experience a fraction of the PCOS symptoms I had learned to live with my whole life prior to this journey.
 
hexagonal said:
If you're too cold, you could always take DNP!

(do no do this this is an awful idea please this is a bad joke under no circumstances should anyone be taking DNP)
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Me: rushing to Google to look up "DNP" just to appease my curiosity as I dont think I have ever heard of it. 🤣😂

Results ... TERRIFYING!!! I just had to read "isolated from the venom of the Green Mamba snake" 🐍 ... I'M OUT! That's some scary shizz right there!!!!
 
hotdog! said:
I'm perimenopausal too, but hot flashes haven't gotten me. (yet?) I'm assuming it's being mostly cold and then hot flashes come and go in between. Worst of both worlds.

In my 20's, the times when I had way too many liquor drinks and would get sick throwing up, I would have these random hot flashes that started around my neck and I could feel the heat radiating from my torso, head and face. That's what I imagine hot flashes are like, minus the vomiting.
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Yes. Exactly. Without the vomiting. And the sweating without the heat. That is uncomfortable too. Get some estrogen. Women who take it have a 1% above baseline incidence of cancer but a 60% reduction in all causes mortality when it's begun within so many (10?5?) Years of menopause onset.
 
I wasn't even aware of that DNP, but now there are more things abbreviated to DNP that I will not be using, lol.

I was talking about this DNP: https://en.wikipedia.org/wiki/2,4-Dinitrophenol

Some bodybuilders use it when cutting. It basically breaks your mitochondria so instead of doing what they're supposed to, they just start burning a lot of calories making heat.
 
jimbothigpen said:
Thank you for reminding me -- time to grab my pail and go milk the snakes. I often forget, and the snakes get surly.
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I'll let you milk the snakes. I'll pass. I remember watching some TV show many years ago where they explained that there are 3 or 4 people in the US who are officially authorized by the US government to extract venom from snakes. Snake venom is used somehow to make anti-venom. When the snake milkers do so, they have tons of anti-venom on-hand in case they need it. Then I saw one of the authorized guys basically grab a snake a and have it bite down on jar. I would be the wrong gorilla for the job.
 
keangkong said:
I'll let you milk the snakes. I'll pass. I remember watching some TV show many years ago where they explained that there are 3 or 4 people in the US who are officially authorized by the US government to extract venom from snakes. Snake venom is used somehow to make anti-venom. When the snake milkers do so, they have tons of anti-venom on-hand in case they need it. Then I saw one of the authorized guys basically grab a snake a and have it bite down on jar. I would be the wrong gorilla for the job.
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Antivenom is also extremely expensive and expires. Keeping venomous snakes is actually a hobby for some reptile enthusiasts. This leads to problems, as they rarely keep antivenom on hand. Hospitals have to scramble to locate the correct one, and zoo's will refuse to help because then they'd have none for employees if there's an accident.

One example. Fourteen of his snakes were euthanized as they were considered a public health risk and no zoos would take them for a variety of reasons. He had a YouTube channel. If you ever want to watch someone recklessly risk their life for internet likes, it's worth checking out.
 
hotdog! said:
I would have these random hot flashes that started around my neck and I could feel the heat radiating from my torso, head and face. That's what I imagine hot flashes are like, minus the vomiting.
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That is exactly what they are like. The heat sort of radiates from my torso and works up to my neck and face. Within 1 minute, I have sweat rolling down my forehead and the discomfort is very real. Then the great part is they pass in five minutes and then you have the chills because of the sweat. Not fun at all and sleeping is hell because that is when they strike the most.
Before tirz I was in a medical study at Northwestern for severe flashes testing out using a Stellate Ganglion Block. Unfortunately I knew right away that I was in the control group because after the procedure I felt nothing different. Damn saline injection!
 
keangkong said:
I'll let you milk the snakes. I'll pass. I remember watching some TV show many years ago where they explained that there are 3 or 4 people in the US who are officially authorized by the US government to extract venom from snakes. Snake venom is used somehow to make anti-venom. When the snake milkers do so, they have tons of anti-venom on-hand in case they need it. Then I saw one of the authorized guys basically grab a snake a and have it bite down on jar. I would be the wrong gorilla for the job.
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They milk the snake, dilute the venom, and then inject it into (usually) horses and harvest the antibodies. Lots of people end up having allergic reactions to the antibodies, so it's kind of rough in general.

They're starting to use AI/ML to design bespoke antivenoms that won't require animal antibodies or milking snakes, and have had pretty good success so far, so snake milking might soon be a dead profession.
 
Lo
hexagonal said:
They milk the snake, dilute the venom, and then inject it into (usually) horses and harvest the antibodies. Lots of people end up having allergic reactions to the antibodies, so it's kind of rough in general.

They're starting to use AI/ML to design bespoke antivenoms that won't require animal antibodies or milking snakes, and have had pretty good success so far, so snake milking might soon be a dead profession.
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Thanks for the information.
 
chmuse said:
Antivenom is also extremely expensive and expires. Keeping venomous snakes is actually a hobby for some reptile enthusiasts. This leads to problems, as they rarely keep antivenom on hand. Hospitals have to scramble to locate the correct one, and zoo's will refuse to help because then they'd have none for employees if there's an accident.

One example. Fourteen of his snakes were euthanized as they were considered a public health risk and no zoos would take them for a variety of reasons. He had a YouTube channel. If you ever want to watch someone recklessly risk their life for internet likes, it's worth checking out.
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I'm not willing to check out that youTube channel. I'll get scared simply by watching it and get frustrated that folks can be that dumb.
 
Garbo said:
Okay, so consensus seems to be a big NO on the Green Mamba .... but we all still love the Gila Monster, right?
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I avoid all mambas. I still love the gila monster. We wouldn't have the more effective weight loss medications without gila monsters. Vox, How a lizard’s venom inspired the promising weight loss drug Wegovy - Semaglutide is the start of a new chapter in obesity treatments (July 2021); The Gila monster gave the weight-loss revolution its bite. Every time you give yourself an injection, just imagine a gila monster kissing you.

1739290901502.png 1739290949364.png
 
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keangkong said:
I'm not willing to check out that youTube channel. I'll get scared simply by watching it and get frustrated that folks can be that dumb.
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That's how all of us reptile people felt watching it, tbh. Most of us wouldn't watch his videos directly so we wouldn't give him revenue.
 
chmuse said:
Antivenom is also extremely expensive and expires. Keeping venomous snakes is actually a hobby for some reptile enthusiasts. This leads to problems, as they rarely keep antivenom on hand. Hospitals have to scramble to locate the correct one, and zoo's will refuse to help because then they'd have none for employees if there's an accident.

One example. Fourteen of his snakes were euthanized as they were considered a public health risk and no zoos would take them for a variety of reasons. He had a YouTube channel. If you ever want to watch someone recklessly risk their life for internet likes, it's worth checking out.
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Gurl... I'm hearing Sarah McLachlan singing in the background of some of your posts. 😥
 
nonyabizznez said:
Gurl... I'm hearing Sarah McLachlan singing in the background of some of your posts. 😥
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I don't understand the reference. 🙃

In my defense, I'm not the one who brought up snakes.
 
chmuse said:
I don't understand the reference. 🙃

In my defense, I'm not the one who brought up snakes.
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I don't understand this: 🙃 (asked Alexa and she says emoji means "quirky or silly but still happy") so I'll explain:

The ASPCA used the Sarah McLachlan song "Angels" (as "in the arms of" ) in a commercial with suffering animals from the day I was born until I was old enough for an AARP card... It was sad.
 
nonyabizznez said:
I don't understand this: 🙃 (asked Alexa and she says emoji means "quirky or silly but still happy") so I'll explain:

The ASPCA used the song "Angels" (as "in the arms of" ) in a commercial with suffering animals from the day I was born until I was old enough for an AARP card... It was sad.
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I get it now 😂😂😂

I did animal rescue for years- so it fits.
 
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jimbothigpen said:
So besides my 9 to 5 job here at the Green Mamba Dairy Farm, I have a little side hustle roasting coffee. Roaster's out in the unheated garage, but today wasn't terribly cold. Still, with that roaster in front of me and my propane heater blasting right up my backside, I came back in after 3 hours of work convinced I was about to lose my toes to frostbite.
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I don't like what I've been reading about the chills. I was hoping that they'd pass over time. According to most users, we don't get used to them.
 
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