GLP-1 chills

I also suffer from the "chill". Been on tirz (no more than 5) since July. It's weird because I also have severe hot flashes because I am a woman of age. Tried to pin in down to a specific time , such as 2 days after shot or whatever but have not been able to.
It sucks.
 
I want someone to do studies on why this happens. The only time this has happened to me is from fasting, after 24 hours of no food, you get cold from your metabolism slowing down to adjust for no calories coming in. I wonder if the chills are tied to calorie consumption, as in we're not eating enough calories due to the meds. If you eat at a moderate calorie deficit while on glp-1's, would that avoid the feeling cold?

Or is it affecting thyroid function through a different mechanism that makes us cold?

I'm super curious, as someone who has run extremely hot all my life, no matter what I've weighed. I mentioned the chills effect to both my menopause doctor and my endocrinologist who Rx'd Zepbound, and neither had a clue, had never heard of it. I want answers!
 
i always had cold hands and feet because of my thyroid issues, but all of me has been freezing since i started on reta. i prefer it though - i love blankets.
 
I have been freezing for 15 months. It does not go away or get any better. I wear layers daily, a space heater at my desk at work and multiple blankets at home even with the heater always on. Luckily I am single so I keep my home the temp I want without complaints lol
 
Back when I did extended fasting (before glp-1) I would continuously be freezing. From my research, when I started Tirz, I stacked with Reta to combat the cold and the fatigue that so many get on Tirz only. I haven't had either.
 
I am cold all the time even in the summer. Post menopausal and I too have lost most of my insulation.
 
As I sit here under two comforters and two fleece blankets, I'm questioning my life choices. Is being skinny worth being freezing even while sweating? I can't decide right now, I'm too busy shivering. I'm debating sleeping on the couch so I can add in a heated blanket without killing my eskimo of a partner.
 
As I sit here under two comforters and two fleece blankets, I'm questioning my life choices. Is being skinny worth being freezing even while sweating? I can't decide right now, I'm too busy shivering. I'm debating sleeping on the couch so I can add in a heated blanket without killing my eskimo of a partner.
For me, it's definitely worth freezing when it's not cold in order to be thin. I looked in the mirror today and realized I don't look fat at all. I weighed myself yesterday and my BMI is 25.8. I wouldn't have thought this possible before. Maybe I'm just nuts but I'm willing to put up with the bad things from weight loss drugs.
 
For me, it's definitely worth freezing when it's not cold in order to be thin. I looked in the mirror today and realized I don't look fat at all. I weighed myself yesterday and my BMI is 25.8. I wouldn't have thought this possible before. Maybe I'm just nuts but I'm willing to put up with the bad things from weight loss drugs.
Congratulations! 😘
 
As I sit here under two comforters and two fleece blankets, I'm questioning my life choices. Is being skinny worth being freezing even while sweating? I can't decide right now, I'm too busy shivering. I'm debating sleeping on the couch so I can add in a heated blanket without killing my eskimo of a partner.
Who’s sweating and cold at the same time?

Not me. I’m just always cold.

Whereas I used to sweat from watching an action movie, or sitting outside when it’s 78°.
 
How long until the freezing feelings become void? According to my calculations, Maybe Possibly Never. 😋

It seems like sitting on my floor, camped out next to my space heater, has become a daily event... est. late Fall 2023... 😆😅

Most mornings also involve my signature phrase, "holy 🤬 IT'S coooold" """why is it so cold""" and also "are you cold, too?!" @ my (longhair) cat. 🐈‍⬛
 
Who’s sweating and cold at the same time?

Not me. I’m just always cold.

Whereas I used to sweat from watching an action movie, or sitting outside when it’s 78°.
Yoyo ❤️ I haven't seen you around in ages!

I do, it's the worst. 🥲 And then you get colder because of the sweat!
 
Who’s sweating and cold at the same time?

Not me. I’m just always cold.

Whereas I used to sweat from watching an action movie, or sitting outside when it’s 78°.
Probably menopausal women having hot flashes, like someone mentioned up thread. That's gotta be a special kind of hell.

For me, I have always hated the feeling of sweating (severe sensory issue) and I've always broken out into a sweat in any mild heat, anything over 70-72. Now, being "cold" just makes me feel like I'm finally experiencing temperature like normal people--I live in Miami and going outside is finally tolerable.

We need AC year-round here, so I'm just bundled up inside. I prefer it to always being hot and sweaty, which made me incredibly irritable.
 
Probably menopausal women having hot flashes, like someone mentioned up thread. That's gotta be a special kind of hell.

For me, I have always hated the feeling of sweating (severe sensory issue) and I've always broken out into a sweat in any mild heat, anything over 70-72. Now, being "cold" just makes me feel like I'm finally experiencing temperature like normal people--I live in Miami and going outside is finally tolerable.

We need AC year-round here, so I'm just bundled up inside. I prefer it to always being hot and sweaty, which made me incredibly irritable.
🤬 I'm 34, sir! Good day!

😭😬😂

Florida is the worst. It's so humid your skin is tacky no matter how chilly it is. How can you be sure it's even really sweat? 🙃 I can barely stand visiting with my sensory issues, props to you for managing to LIVE THERE!
 
@keangkong the freezing constantly is killing me. It’s mid-30’s and this morning I was wearing 2 pairs of sweatpants and a hoody. Laying under a blanket on the couch. That is the worst part for me. My wife swears I’m going to catch hypothermia. When I get out to my car I just sit there for like 2 minutes unable to drive or move at all.

Edit: I was just informed you can’t “catch” hypothermia. lol. I never once claimed to be smart.
 
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For me, it's definitely worth freezing when it's not cold in order to be thin. I looked in the mirror today and realized I don't look fat at all. I weighed myself yesterday and my BMI is 25.8. I wouldn't have thought this possible before. Maybe I'm just nuts but I'm willing to put up with the bad things from weight loss drugs.
🎊👏
 
@keangkong the freezing constantly is killing me. It’s mid-30’s and this morning I was wearing 2 pairs of sweatpants and a hoody. Laying under a blanket on the couch. That is the worst part for me. My wife swears I’m going to catch hypothermia. When I get out to my car I just sit there for like 2 minutes unable to drive or move at all.

Edit: I was just informed you can’t “catch” hypothermia. lol. I never once claimed to be smart.
You were able to figure out that you’re way too cold.
 
I'm perimenopausal too, but hot flashes haven't gotten me. (yet?) I'm assuming it's being mostly cold and then hot flashes come and go in between. Worst of both worlds.

In my 20's, the times when I had way too many liquor drinks and would get sick throwing up, I would have these random hot flashes that started around my neck and I could feel the heat radiating from my torso, head and face. That's what I imagine hot flashes are like, minus the vomiting.
 
As I sit here under two comforters and two fleece blankets, I'm questioning my life choices. Is being skinny worth being freezing even while sweating? I can't decide right now, I'm too busy shivering. I'm debating sleeping on the couch so I can add in a heated blanket without killing my eskimo of a partner.
My wife and I sleep swedish style with our own sheets and blankets. She keeps the bedroom at a balmy 64 degrees (even in the TX summer heat) and takes the blanket on and off throughout the night. I sleep with flannel PJ plus three blankets. You could get an electric blanket that is double-bed size. Then you can be toasty without impacting your partner.
 
I'm perimenopausal too, but hot flashes haven't gotten me. (yet?) I'm assuming it's being mostly cold and then hot flashes come and go in between. Worst of both worlds.

What I’m saying is that I haven’t had a single hot flash or night sweat since starting Tirz. The hot is gone, in its entirety. I’ve swung to the other side, I’m always, always cold. I barely break a sweat when running indoors on the treadmill.
 
My wife and I sleep swedish style with our own sheets and blankets. She keeps the bedroom at a balmy 64 degrees (even in the TX summer heat) and takes the blanket on and off throughout the night. I sleep with flannel PJ plus three blankets. You could get an electric blanket that is double-bed size. Then you can be toasty without impacting your partner.
That's how we sleep too. We share a giant fleece (10ftx10ft, so there's no blanket hogging) and a comforter that he usually throws on top of the pile that's already on me. A heated blanket would just be too much, he already complains I'm a radiator when I sleep.

Wouldn't be surprised if it's my hormones being all fucked up, I've got a lot of wonky shit going on there. Sema definitely made it worse though.
 
What I’m saying is that I haven’t had a single hot flash or night sweat since starting Tirz. The hot is gone, in its entirety. I’ve swung to the other side, I’m always, always cold. I barely break a sweat when running indoors on the treadmill.
Oh no, then I'm not that far gone into the freeze effect. I still get hot and if I were to run, I would definitely sweat. Ick.
 
Oh no, then I'm not that far gone into the freeze effect. I still get hot and if I were to run, I would definitely sweat. Ick.
Back in October, when the temp could still be warm, I appreciated the cold. But now, with the already cold weather, it’s unpleasant. I’m hoping in a few months and into the summer that I’m back to appreciating the chills… if only for my A/C bill. Ha.
 
Back in October, when the temp could still be warm, I appreciated the cold. But now, with the already cold weather, it’s unpleasant. I’m hoping in a few months and into the summer that I’m back to appreciating the chills… if only for my A/C bill. Ha.
I started tirz in early August. I had no complaints about chills during those first few months, but the temperatures were far higher than they are today.
 
If you're too cold, you could always take DNP!

(do no do this this is an awful idea please this is a bad joke under no circumstances should anyone be taking DNP)
 
How long does it take for the GLP-1 chills to pass? Or am I stuck with getting cold super easy as long as I keep these drugs. I’ve been on either reta or tirz for 6 months and I still get cold quite easily.
I have been the "overly" warm-blooded type my entire life. Then, about 3 months ago (about 4 months into my blossoming friendship with Tirz), I suddenly became the one that is 🥶 FREEZING all the damn time. For some reason, my legs are the worst. Literally, icy cold to the touch. I now sleep in fleece-lined leggings and socks which I have never been able to do my entire life. If I don't, I will lay there miserable for hours and just shiver until I get up and put clothes and socks on.

I read that the chills are caused more by a sudden drop in body weight and a significant reduction in caloric intake; more so than the Tirz/GLP-1's causing the chills.
For women (especially those with PCOS like myself), it's also caused by hormonal imbalance ... which is the entire reason my doctor prescribed Mounjaro to me. Other than hormone therapy to treat SOME of the PCOS symptoms, the other "treatment" (so to speak) is a sudden (and significant) reduction of body weight. Sudden weight loss of a significant amount can put the endocrine system in a bit of shock with the hope of it forcing to "reset" so to speak. My "lady doctor" described it as being very similar to how Electrocompulsive Therapy (ECT) to the brain works to treat psychological disorders.
Overall, I guess there is something to it (at least in my case) as I have lost close to 60 pounds since October. I am chilly🥶 ALL THE TIME and I no longer experience a fraction of the PCOS symptoms I had learned to live with my whole life prior to this journey.
 
If you're too cold, you could always take DNP!

(do no do this this is an awful idea please this is a bad joke under no circumstances should anyone be taking DNP)
Me: rushing to Google to look up "DNP" just to appease my curiosity as I dont think I have ever heard of it. 🤣😂

Results ... TERRIFYING!!! I just had to read "isolated from the venom of the Green Mamba snake" 🐍 ... I'M OUT! That's some scary shizz right there!!!!
 
Eastern green mamba?

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Or Western green mamba?

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I don't plan on taking DNP (dendroaspis natriuretic peptide), however, I did, I'd probably avoid the snake and just buy the supplement.
 
I'm perimenopausal too, but hot flashes haven't gotten me. (yet?) I'm assuming it's being mostly cold and then hot flashes come and go in between. Worst of both worlds.

In my 20's, the times when I had way too many liquor drinks and would get sick throwing up, I would have these random hot flashes that started around my neck and I could feel the heat radiating from my torso, head and face. That's what I imagine hot flashes are like, minus the vomiting.
Yes. Exactly. Without the vomiting. And the sweating without the heat. That is uncomfortable too. Get some estrogen. Women who take it have a 1% above baseline incidence of cancer but a 60% reduction in all causes mortality when it's begun within so many (10?5?) Years of menopause onset.
 
I wasn't even aware of that DNP, but now there are more things abbreviated to DNP that I will not be using, lol.

I was talking about this DNP: https://en.wikipedia.org/wiki/2,4-Dinitrophenol

Some bodybuilders use it when cutting. It basically breaks your mitochondria so instead of doing what they're supposed to, they just start burning a lot of calories making heat.
 
Thank you for reminding me -- time to grab my pail and go milk the snakes. I often forget, and the snakes get surly.
I'll let you milk the snakes. I'll pass. I remember watching some TV show many years ago where they explained that there are 3 or 4 people in the US who are officially authorized by the US government to extract venom from snakes. Snake venom is used somehow to make anti-venom. When the snake milkers do so, they have tons of anti-venom on-hand in case they need it. Then I saw one of the authorized guys basically grab a snake a and have it bite down on jar. I would be the wrong gorilla for the job.
 
I'll let you milk the snakes. I'll pass. I remember watching some TV show many years ago where they explained that there are 3 or 4 people in the US who are officially authorized by the US government to extract venom from snakes. Snake venom is used somehow to make anti-venom. When the snake milkers do so, they have tons of anti-venom on-hand in case they need it. Then I saw one of the authorized guys basically grab a snake a and have it bite down on jar. I would be the wrong gorilla for the job.
Antivenom is also extremely expensive and expires. Keeping venomous snakes is actually a hobby for some reptile enthusiasts. This leads to problems, as they rarely keep antivenom on hand. Hospitals have to scramble to locate the correct one, and zoo's will refuse to help because then they'd have none for employees if there's an accident.

One example. Fourteen of his snakes were euthanized as they were considered a public health risk and no zoos would take them for a variety of reasons. He had a YouTube channel. If you ever want to watch someone recklessly risk their life for internet likes, it's worth checking out.
 
I would have these random hot flashes that started around my neck and I could feel the heat radiating from my torso, head and face. That's what I imagine hot flashes are like, minus the vomiting.
That is exactly what they are like. The heat sort of radiates from my torso and works up to my neck and face. Within 1 minute, I have sweat rolling down my forehead and the discomfort is very real. Then the great part is they pass in five minutes and then you have the chills because of the sweat. Not fun at all and sleeping is hell because that is when they strike the most.
Before tirz I was in a medical study at Northwestern for severe flashes testing out using a Stellate Ganglion Block. Unfortunately I knew right away that I was in the control group because after the procedure I felt nothing different. Damn saline injection!
 
I'll let you milk the snakes. I'll pass. I remember watching some TV show many years ago where they explained that there are 3 or 4 people in the US who are officially authorized by the US government to extract venom from snakes. Snake venom is used somehow to make anti-venom. When the snake milkers do so, they have tons of anti-venom on-hand in case they need it. Then I saw one of the authorized guys basically grab a snake a and have it bite down on jar. I would be the wrong gorilla for the job.
They milk the snake, dilute the venom, and then inject it into (usually) horses and harvest the antibodies. Lots of people end up having allergic reactions to the antibodies, so it's kind of rough in general.

They're starting to use AI/ML to design bespoke antivenoms that won't require animal antibodies or milking snakes, and have had pretty good success so far, so snake milking might soon be a dead profession.
 
Lo
They milk the snake, dilute the venom, and then inject it into (usually) horses and harvest the antibodies. Lots of people end up having allergic reactions to the antibodies, so it's kind of rough in general.

They're starting to use AI/ML to design bespoke antivenoms that won't require animal antibodies or milking snakes, and have had pretty good success so far, so snake milking might soon be a dead profession.
Thanks for the information.
 
Antivenom is also extremely expensive and expires. Keeping venomous snakes is actually a hobby for some reptile enthusiasts. This leads to problems, as they rarely keep antivenom on hand. Hospitals have to scramble to locate the correct one, and zoo's will refuse to help because then they'd have none for employees if there's an accident.

One example. Fourteen of his snakes were euthanized as they were considered a public health risk and no zoos would take them for a variety of reasons. He had a YouTube channel. If you ever want to watch someone recklessly risk their life for internet likes, it's worth checking out.
I'm not willing to check out that youTube channel. I'll get scared simply by watching it and get frustrated that folks can be that dumb.
 
Okay, so consensus seems to be a big NO on the Green Mamba .... but we all still love the Gila Monster, right?
I avoid all mambas. I still love the gila monster. We wouldn't have the more effective weight loss medications without gila monsters. Vox, How a lizard’s venom inspired the promising weight loss drug Wegovy - Semaglutide is the start of a new chapter in obesity treatments (July 2021); The Gila monster gave the weight-loss revolution its bite. Every time you give yourself an injection, just imagine a gila monster kissing you.

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