GLP-1/GlP agonists

John316

GLP-1 Novice
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The following was posted by FLEXNP on bluesky social along with these pics.

“Things that make me go 🧐🧐 Long acting GIP agonist given to humans for 12 weeks resulted in a significant increase in insulin sensitivity (~33%) vs GLP-1 agonist. Combine the two and the effect mirrors GIP alone. Makes one wonder why there aren't more dual GLP 1/GIP agonists in development!”
 

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The following was posted by FLEXNP on bluesky social along with these pics.

“Things that make me go 🧐🧐 Long acting GIP agonist given to humans for 12 weeks resulted in a significant increase in insulin sensitivity (~33%) vs GLP-1 agonist. Combine the two and the effect mirrors GIP alone. Makes one wonder why there aren't more dual GLP 1/GIP agonists in development!”
How may dual GIP and GLP-1 agonists ("twincretins") do you want? We already have tirezpatide. The slides mentioned a few I hadn't heard of. Retatrutide and pemvidutide are also twincretins.
 
is lily making another one? why when they already have tirezaptide and retatrutide?
 
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