Glutathione - are the tablets on amazon the same as the CN vials?

[john_askins]

I ask because the vendor I'm purchasing from is $66 for 10x1500mg vials. But for $20 on amazon, there are 60x500mg pills. Could you, in theory, open the pills, put them in a vial, add BAC and use it?

 

[AndyPanda]

I ask because the vendor I'm purchasing from is $66 for 10x1500mg vials. But for $20 on amazon, there are 60x500mg pills. Could you, in theory, open the pills, put them in a vial, add BAC and use it?

No. They will have fillers that you shouldn’t be injecting and who knows what they have been exposed to.

 

[john_askins]

No. They will have fillers that you shouldn’t be injecting and who knows what they have been exposed to.

I sort of figured. And i'm assuming orally it doesn't work nearly as well since it has to be digested?

 

[Waclive]

I ask because the vendor I'm purchasing from is $66 for 10x1500mg vials. But for $20 on amazon, there are 60x500mg pills. Could you, in theory, open the pills, put them in a vial, add BAC and use it?

Absolutely not. It doesn't really work that way. I wish it did though, it would make things easier.

 

[cheaperseeker]

You can make liposomal glutathione by blending it with sunflower seed powder and distilled water. It makes it more effective when taken orally because it encapsulates the glutathione in fat molecules, protecting it from digestive breakdown.

 

[Airborne Daddy]

No. They will have fillers that you shouldn’t be injecting and who knows what they have been exposed to.

I ran 12 weeks of injectable. Now I'm running tb500 but in the spring I'll try the liposomal pill glutathione that's reportedly up to 90% absorption. I'd be happy with 50% cuz everyone has a liposomal for another 30 bucks but never any testing to back it up. Swear it's all bs.

 

[CNCCurrency]

Easier to just inject it and not worrying about it working or not. Could be just me?

 

[Calm Logic]

Easier to just inject it and not worrying about it working or not. Could be just me?

Oral NAC (or GlyNAC) along with oral liposomal glutathione may be superior to subq glutathione over the long term. Will post studies later.

I am injecting Korean glutathione now though with oral vitamin C, and have been taking oral NAC too sometimes.

 

[CNCCurrency]

Oral NAC
[td]Bioavailability[/td][td]Very low (less than 10%), due to first-pass metabolism in the liver.

 

[Calm Logic]

Oral NAC
[td]Bioavailability[/td][td]Very low (less than 10%), due to first-pass metabolism in the liver.

The first pass is actually how oral NAC works so well for the liver, essentially forcing the liver to produce glutathione, including for the rest of the body. NAC is the gold standard treatment for Tylenol overdose.

 

[CNCCurrency]

The first pass is actually how oral NAC works so well for the liver, essentially forcing the liver to produce glutathione, including for the rest of the body. NAC is the gold standard treatment for Tylenol overdose.

I see

 

[lessthanhalf]

I just want to second the post about GLYNAC. Everything I read indicated that glutathione molecules ( basically glutamine plus glycine plus Nac ) don't get through cell membranes that easily, so it is possible to increase cellular glutathione with injected glutathione, but taking precursors orally that do enter cells more easily is much more effective at raising cellular glutathione and especially if you are talking about getting it past the blood brain barrier into neurones.
There is much more solid evidence that N Acetyl Cysteine NAC raises intracellular glutathione levels as well as it in combination with Glycine. And even some actual human trial evidence that Nac or GlyNac suplementation have positive effects in humans. Doses are fairly high at about 7 grams of each per day .

 

[Calm Logic]

Both in theory and reality, 7 grams per day of oral NAC is way too high and would raise hematocrit too much. That's why the standard dose on supplement bottles is only 600 or 1200 mg per day and why I stopped using oral NAC at high does, after getting bloodwork back.

In general, glutathione is best for the short term and oral NAC is best for the long term. (In other words, glutathione is more like HGH for being more direct, and NAC is more sustainable like sermorelin.)

 

[Waclive]

I've been taking NAC everyday at 600mg for years now 😅

 

[cheaperseeker]

I've been taking NAC everyday at 600mg for years now 😅

What benefits have you noticed?

 

[Waclive]

What benefits have you noticed?

I don't ever get sick. My lungs don't burn when rucking at higher elevations. My family has a history of cardio events, so taking it for those benefits as well.

Something else that interest me is the research into the neurodegenerative diseases. It's also why I'm an advocate for nicotine via a safe consumption method.

 

[cheaperseeker]

I don't ever get sick. My lungs don't burn when rucking at higher elevations. My family has a history of cardio events, so taking it for those benefits as well.

Something else that interest me is the research into the neurodegenerative diseases. It's also why I'm an advocate for nicotine via a safe consumption method.

My lungs get sore easily ever since I had COVID, so I'd definitely benefit from support there.

 

[Waclive]

My lungs get sore easily ever since I had COVID, so I'd definitely benefit from support there.

It might be worth looking into the oral NAC and quercetin. It's two things on the list that I take everyday.

 

[Calm Logic]

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function - PMC

Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Maintenance of optimal tissues GSH levels may be an important strategy for prevention of oxidative stress-related diseases. We investigated ...

pmc.ncbi.nlm.nih.gov

(2017)

These preliminary findings support the effectiveness of daily liposomal GSH [glutathione] administration at elevating stores of GSH and impacting immune function and levels of oxidative stress...

GSH increases were accompanied by reductions in oxidative stress biomarkers including decreases of 35% in plasma 8-isoprostane and 20% in oxidized:reduced GSH ratios

Sublingual gluta (only 150 mg) as superior to oral NAC (only 200 mg):

https://www.sciencedirect.com/science/article/pii/S2213231715000841 (2015)

Oral GSH is known for its poor bioavailability in humans.

• We compared a new sublingual GSH with NAC and oral GSH on oxidative stress markers.

• On a 3-weeks period, sublingual GSH improved the GSH/GSSG ratio.

• Sublingual GSH significantly increased plasmatic vitamin E levels in subjects.

• The sublingual form of GSH showed superior effects over NAC and oral GSH.

One sublingual tablet contains 150 mg of reduced GSH. The dosage was one tablet 3 times per day (in the morning, the midday and the evening), to let melt under the tongue. It represents a daily intake of 450 mg of GSH.

The NAC drug used for this study was marketed under the brand name Fluimucil® (Laboratoires Zambon, France). A sachet contains 200 mg of NAC. The dosage was one sachet per day.

More info:

https://pmc.ncbi.nlm.nih.gov/articles/PMC10075255/ (2023)

The main routes of administration of glutathione are oral, intramuscular, and intravenous. Intravenous GSH has a short half-life but has shown to be effective in several diseases. For example, the GSH intravenous administration in patients with Parkinson’s disease determined significant improvements, which lasted for 2–4 months after the administration (26). Also oral administration, although with conflicting results, resulted in increased serum GSH levels with reduced oxidative stress and beneficial effects in several diseases (27, 28).

Richie et al. recently found that oral GSH at either 250 or 1,000 mg/day was associated to significant increase in the body storage of GSH in non-smoking adults, in a dose-dependent manner (27). They also noticed a decrease in the markers of oxidative stress at 6 months, as shown by the improvement in the GSSG/GSH ratio.

Furthermore, recent studies suggested that GSH oral administration in liposomal or sublingual forms may have a better bioavailability, with a favorable impact on systemic GSH levels (29, 30). For example, a novel GSH formulation bypassing the gastrointestinal digestion through an oral absorption, gave positive results in raising GSH blood concentration in vitro and in vivo (31). Moreover, this molecule showed a promising hepatoprotective function in a murine model of acute liver injury (32).

 

[Jellybelly54]

Another benefit for Glutathione is how it interacts with the hormone pathways. Glutathione acts as a crucial protector and detoxifier within the body, creating a healthier internal environment where hormone pathways can function optimally, rather than directly producing or regulating hormones. Specifically it can help eliminate some of the toxic estrogen forms thereby reducing symptoms of excess estrogen. It could potentially help a lot with PCOS symptoms. You don’t want 4-OH-E1. That’s the toxic form of estrogen. The less 4OHE1 the better. Glutathione is a key step in this detox pathway. Here’s a pic of the pathway:

 

[Airborne Daddy]

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function - PMC

Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Maintenance of optimal tissues GSH levels may be an important strategy for prevention of oxidative stress-related diseases. We investigated ...

pmc.ncbi.nlm.nih.gov

(2017)



Sublingual gluta (only 150 mg) as superior to oral NAC (only 200 mg):



More info:

Sublingual glut for the win.... no more pinning 1.5cc of Sulphur burning like a Brute Enforcer Emeritus sting for 20 seconds...

 

[Calm Logic]

Sublingual glut for the win.... no more pinning 1.5cc of Sulphur burning like a Brute Enforcer Emeritus sting for 20 seconds...

Subq is not bad for me with the Korean diluted to about 200 mg/ml (6 mL added to 1200 mg vial). The Korean tests at about 1300 mg, but I don't factor that in for anything, since less than 10 percent difference. The Korean vials let you add a ton of BAC if you wanted, haha.

 

[AndyPanda]

Sublingual glut for the win.... no more pinning 1.5cc of Sulphur burning like a Brute Enforcer Emeritus sting for 20 seconds...

I do intravenous and feel it instantly with zero pain. I think it’s the Ascorbic Acid that gives the energy boost, but I love it. Feels super clean and I know I’m getting maximum absorption.

 

[Calm Logic]

I do intravenous and feel it instantly with zero pain. I think it’s the Ascorbic Acid that gives the energy boost, but I love it. Feels super clean and I know I’m getting maximum absorption.

Of course, very few are qualified for that. Even if you were board certified, doing that on your own is never a good idea: "If you are alone and lose consciousness or go into respiratory distress, there is no one to pull the line, stop the flow, or call 911." (Gemini) So I assume you already have someone there with youl.

Someone yesterday I mentioned just had some anaphylactic reaction to MOTS-C by IM. For what it's worth, Gemini says gluta IV is far more likely cause such a reaction compared to gluta subq or IM:

When comparing Glutathione Intramuscular (IM) versus Subcutaneous (Subq) for the risk of a severe allergic reaction, IM is slightly "riskier" than Subq, but both are vastly safer than IV.

Same issue when comparing gluta IV to MOTS-C (by IV/IM/subq).