Go on without me ...

HalfPintOG

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This is going to be long and I apologize, but I just don't really know where to start without starting at the beginning. Maybe grab some popcorn or an energy drink. I am a 71 year-old female. Ran a successful business for over 25 years, exercised religiously, and never weighed over 110# @ 5'2". Six years old I had my first kidney stone. Passed it while driving to the ER screaming all the way. About three months later, got another one. Stayed home for this one as I knew the routine, but Dr decided to do an ultrasound as I had had several kidney infections that year. Ultrasound showed I had quite a few kidney stones, and some of them were fairly good sized with the queen bee being at 9MM. Two large to safely pass. They took me in to blast them, which was going to take approximately 40 minutes to an hour. 2 1/2 hours in my husband said I need to know what's going on. Connected him with the doctor doing my surgery and she said we ran into complications. My kidney was being strangled by veins and arteries that had grown and attach themselves to it. Said it had probably been going on since birth. They were trying to peel back as much as they could. Could not get the big one because my liver was so enlarged. Stopped all coffee and caffeine. Kidney infections continued. New Dr discovered kidney wasn't draining completely, ureter was partially blocked. Had another surgery to place temporary stent. Kept 6 weeks and removed. Infections started again. Put in nephrostomy bag. Had to have replaced every 3 months. Had for over a year. Also developed 14" blood clot in left thigh. In hospital for 2 weeks on IV blood thinners. Said best to amputate. Hubby spent all next day on phone and found a doctor that said to bring me right in to the hospital in another city. Roto-Rooter it out, place a permanent stent a year on Coumadin. Still have my leg. Back to kidney, during a nephrostomy back change i contracted a very bad bacteria called pseudomonas. Back into the hospital for 10 days on 24 hour IV drip. Then home on IV drip for another 10 days, but only an hour a day. I am getting weaker and weaker and I just want to be done. Still have nephrostomy bag and then I get Covid.
There is water built-up around my heart. They do a neuro stress test on me and I have the worst reaction they have ever seen. If you've ever had one of these, you know that it cannot be stopped, it has to run its course. My heart went into a fib, I was sweating profusely and almost seizing. Once it was out of my system, my doctor told me I am just taking you into surgery, if you need a stent, I'm just going to do it. I said please just let me die. I can't do this anymore. Then I was asleep. Heart turned out to be fine. It was just protecting itself from all my body has been going through. I went to who was willing to try to repair my ureter. There was a lot of scar tissue that was blocking it, he said I have one chance and if it doesn't work, we have to remove your kidney because it's doing more damage than GOOD. It worked. He looked at the kidney stone and said that they could not get to it because of the liver so it was time to address that. He said the 9 mm kidney stone was like a bomb waiting to go off. I have stage 4 non-alcoholic fibrosis. I am one step away from cirrhosis. They've taken 18 bottles of blood from me and run every possible test on it. Still can't pinpoint exactly what the problem is, but it is looking like some kind of immuno disease. Great. We all know there's nothing you really can do about that. I have to have a liver ultrasound and biopsy done the end of July. So here I am. 100 pounds overweight, week, severe, I wish there was a word stronger than severe to describe my weakness. I also have PTSD and a fear of open places because my balance is so bad and I get dizzy and start to blackout so I have to use a walker. I try to do chair aerobics and a little bit of gardening, but it wears me out so fast. If I have a good day, I will sleep the next two days. Speaking of sleeping, I have had sleep apnea since I was 21 has nothing to do with weight because I was very thin then. I've been on a Sleep Apnea machine for the last 20 years. Doesn't matter, I wake up feeling like I have not slept for days. No matter what I do, I cannot regain my energy level. Started tizepatide I think about eight months ago and have lost 65 pounds. Still feel exactly the same. Still sleep just as much. I'm up to 15 units now and I'm hungry all the time. Do not want to put on the weight that I've lost. Starte MotsC two weeks ago, 5 mg once a week. No change. I thought maybe I could stack it with some Reta , I've done a lot of reading and learning, but my husband thinks it's too dangerous. All I know is I just can't keep doing this. Conventional medicine has not helped me at all. If it wasn't for my husband being proactive, I would be sitting here today with an nephrostomy bag, full of bacteria and only one leg and 125 pounds over weight at least. I just need to get back up on my feet and I think that peptides could help me get there, but I'm just not really sure what to take. Any help is greatly, greatly appreciated.
 
Last edited:
Go on without me ...
Not sure what's going on, but not surprisingly a number of folks have reported this post expressing their concern for you.

If this is simply your way of leaving the forum to frequent a different platform, we'll miss you and wish you the best. If it's more than that, please know there are people who care and resources available. You can dial 9-8-8 from any phone in the US to talk to someone and access a lot of caring and helpful resources.

❤️
 
I'm so sorry, I have two of my grandkids here and I keep getting interrupted. I did not know that had gone through. I'm not very technical anymore. But I did just send a new post that I hope did go through explaining my situation. Thank you so much for checking up on me about it is so much appreciated that it made me cry.
 
This is going to be long and I apologize, but I just don't really know where to start without starting at the beginning. Maybe grab some popcorn or an energy drink. I am a 71 year-old female. Ran a successful business for over 25 years, exercised religiously, and never weighed over 110# @ 5'2". Six years old I had my first kidney stone. Passed it while driving to the ER screaming all the way. About three months later, got another one. Stayed home for this one as I knew the routine, but Dr decided to do an ultrasound as I had had several kidney infections that year. Ultrasound showed I had quite a few kidney stones, and some of them were fairly good sized with the queen bee being at 9MM. Two large to safely pass. They took me in to blast them, which was going to take approximately 40 minutes to an hour. 2 1/2 hours in my husband said I need to know what's going on. Connected him with the doctor doing my surgery and she said we ran into complications. My kidney was being strangled by veins and arteries that had grown and attach themselves to it. Said it had probably been going on since birth. They were trying to peel back as much as they could. Could not get the big one because my liver was so enlarged. Stopped all coffee and caffeine. Kidney infections continued. New Dr discovered kidney wasn't draining completely, ureter was partially blocked. Had another surgery to place temporary stent. Kept 6 weeks and removed. Infections started again. Put in nephrostomy bag. Had to have replaced every 3 months. Had for over a year. Also developed 14" blood clot in left thigh. In hospital for 2 weeks on IV blood thinners. Said best to amputate. Hubby spent all next day on phone and found a doctor that said to bring me right in to the hospital in another city. Roto-Rooter it out, place a permanent stent a year on Coumadin. Still have my leg. Back to kidney, during a nephrostomy back change i contracted a very bad bacteria called pseudomonas. Back into the hospital for 10 days on 24 hour IV drip. Then home on IV drip for another 10 days, but only an hour a day. I am getting weaker and weaker and I just want to be done. Still have nephrostomy bag and then I get Covid.
There is water built-up around my heart. They do a neuro stress test on me and I have the worst reaction they have ever seen. If you've ever had one of these, you know that it cannot be stopped, it has to run its course. My heart went into a fib, I was sweating profusely and almost seizing. Once it was out of my system, my doctor told me I am just taking you into surgery, if you need a stent, I'm just going to do it. I said please just let me die. I can't do this anymore. Then I was asleep. Heart turned out to be fine. It was just protecting itself from all my body has been going through. I went to who was willing to try to repair my ureter. There was a lot of scar tissue that was blocking it, he said I have one chance and if it doesn't work, we have to remove your kidney because it's doing more damage than GOOD. It worked. He looked at the kidney stone and said that they could not get to it because of the liver so it was time to address that. He said the 9 mm kidney stone was like a bomb waiting to go off. I have stage 4 non-alcoholic fibrosis. I am one step away from cirrhosis. They've taken 18 bottles of blood from me and run every possible test on it. Still can't pinpoint exactly what the problem is, but it is looking like some kind of immuno disease. Great. We all know there's nothing you really can do about that. I have to have a liver ultrasound and biopsy done the end of July. So here I am. 100 pounds overweight, week, severe, I wish there was a word stronger than severe to describe my weakness. I also have PTSD and a fear of open places because my balance is so bad and I get dizzy and start to blackout so I have to use a walker. I try to do chair aerobics and a little bit of gardening, but it wears me out so fast. If I have a good day, I will sleep the next two days. Speaking of sleeping, I have had sleep apnea since I was 21 has nothing to do with weight because I was very thin then. I've been on a Sleep Apnea machine for the last 20 years. Doesn't matter, I wake up feeling like I have not slept for days. No matter what I do, I cannot regain my energy level. Started tizepatide I think about eight months ago and have lost 65 pounds. Still feel exactly the same. Still sleep just as much. I'm up to 15 units now and I'm hungry all the time. Do not want to put on the weight that I've lost. Starte MotsC two weeks ago, 5 mg once a week. No change. I thought maybe I could stack it with some Reta , I've done a lot of reading and learning, but my husband thinks it's too dangerous. All I know is I just can't keep doing this. Conventional medicine has not helped me at all. If it wasn't for my husband being proactive, I would be sitting here today with an nephrostomy bag, full of bacteria and only one leg and 125 pounds over weight at least. I just need to get back up on my feet and I think that peptides could help me get there, but I'm just not really sure what to take. Any help is greatly, greatly appreciated.
Wow, I'm not an expert at all but I hope a few people here can steer you in the right direction. I'm sorry this has been happening to you!
 
This is going to be long and I apologize, but I just don't really know where to start without starting at the beginning. Maybe grab some popcorn or an energy drink. I am a 71 year-old female. Ran a successful business for over 25 years, exercised religiously, and never weighed over 110# @ 5'2". Six years old I had my first kidney stone. Passed it while driving to the ER screaming all the way. About three months later, got another one. Stayed home for this one as I knew the routine, but Dr decided to do an ultrasound as I had had several kidney infections that year. Ultrasound showed I had quite a few kidney stones, and some of them were fairly good sized with the queen bee being at 9MM. Two large to safely pass. They took me in to blast them, which was going to take approximately 40 minutes to an hour. 2 1/2 hours in my husband said I need to know what's going on. Connected him with the doctor doing my surgery and she said we ran into complications. My kidney was being strangled by veins and arteries that had grown and attach themselves to it. Said it had probably been going on since birth. They were trying to peel back as much as they could. Could not get the big one because my liver was so enlarged. Stopped all coffee and caffeine. Kidney infections continued. New Dr discovered kidney wasn't draining completely, ureter was partially blocked. Had another surgery to place temporary stent. Kept 6 weeks and removed. Infections started again. Put in nephrostomy bag. Had to have replaced every 3 months. Had for over a year. Also developed 14" blood clot in left thigh. In hospital for 2 weeks on IV blood thinners. Said best to amputate. Hubby spent all next day on phone and found a doctor that said to bring me right in to the hospital in another city. Roto-Rooter it out, place a permanent stent a year on Coumadin. Still have my leg. Back to kidney, during a nephrostomy back change i contracted a very bad bacteria called pseudomonas. Back into the hospital for 10 days on 24 hour IV drip. Then home on IV drip for another 10 days, but only an hour a day. I am getting weaker and weaker and I just want to be done. Still have nephrostomy bag and then I get Covid.
There is water built-up around my heart. They do a neuro stress test on me and I have the worst reaction they have ever seen. If you've ever had one of these, you know that it cannot be stopped, it has to run its course. My heart went into a fib, I was sweating profusely and almost seizing. Once it was out of my system, my doctor told me I am just taking you into surgery, if you need a stent, I'm just going to do it. I said please just let me die. I can't do this anymore. Then I was asleep. Heart turned out to be fine. It was just protecting itself from all my body has been going through. I went to who was willing to try to repair my ureter. There was a lot of scar tissue that was blocking it, he said I have one chance and if it doesn't work, we have to remove your kidney because it's doing more damage than GOOD. It worked. He looked at the kidney stone and said that they could not get to it because of the liver so it was time to address that. He said the 9 mm kidney stone was like a bomb waiting to go off. I have stage 4 non-alcoholic fibrosis. I am one step away from cirrhosis. They've taken 18 bottles of blood from me and run every possible test on it. Still can't pinpoint exactly what the problem is, but it is looking like some kind of immuno disease. Great. We all know there's nothing you really can do about that. I have to have a liver ultrasound and biopsy done the end of July. So here I am. 100 pounds overweight, week, severe, I wish there was a word stronger than severe to describe my weakness. I also have PTSD and a fear of open places because my balance is so bad and I get dizzy and start to blackout so I have to use a walker. I try to do chair aerobics and a little bit of gardening, but it wears me out so fast. If I have a good day, I will sleep the next two days. Speaking of sleeping, I have had sleep apnea since I was 21 has nothing to do with weight because I was very thin then. I've been on a Sleep Apnea machine for the last 20 years. Doesn't matter, I wake up feeling like I have not slept for days. No matter what I do, I cannot regain my energy level. Started tizepatide I think about eight months ago and have lost 65 pounds. Still feel exactly the same. Still sleep just as much. I'm up to 15 units now and I'm hungry all the time. Do not want to put on the weight that I've lost. Starte MotsC two weeks ago, 5 mg once a week. No change. I thought maybe I could stack it with some Reta , I've done a lot of reading and learning, but my husband thinks it's too dangerous. All I know is I just can't keep doing this. Conventional medicine has not helped me at all. If it wasn't for my husband being proactive, I would be sitting here today with an nephrostomy bag, full of bacteria and only one leg and 125 pounds over weight at least. I just need to get back up on my feet and I think that peptides could help me get there, but I'm just not really sure what to take. Any help is greatly, greatly appreciated.
This explains the original post..
It sounds like you have had a tough time!

I hope you get the help you need and it seems like you are tough and you have a good partner to help you.

I do not know what type of experimentation with peptides you are interested in, and I believe that you should likely listen to your Husband on this one, but I am not qualified to comment on any of that.

I will say, you seem like a fighter and that goes a long way to dealing with these things.

Good Luck!!
🙂
 
This explains the original post..
It sounds like you have had a tough time!

I hope you get the help you need and it seems like you are tough and you have a good partner to help you.

I do not know what type of experimentation with peptides you are interested in, and I believe that you should likely listen to your Husband on this one, but I am not qualified to comment on any of that.

I will say, you seem like a fighter and that goes a long way to dealing with these things.

Good Luck!!
🙂
Thank you so much for your kindness
 
Do you have a pool near you? Try the YMCA. They have groups that swim together and do water aquatics for people in the same age group from little kids to seniors. It's normally free too. The ability to move without the constant joint pain may be helpful.

You likely need a new support group too. The mental stress over the events you shared has to be challenging to say the least. Give yourself a break and your husband may also need a mental and/or physical break. You can get it by joining a group of senior swimmers that are beginners or an art class. Having a few laughs while becoming more active will help your mind stay strong. I bet you'll make some friends in the process too. If not swimming, try to just find a way to do something just for fun outside of the home that includes movement.

You are clearly a very strong woman. I don't know if peptides can assist you, but be careful with the possible interactions they may have with other medications if you decide to go into the grey market and self-medicate.

Bless You & Stay Strong!
 
Do you have a pool near you? Try the YMCA. They have groups that swim together and do water aquatics for people in the same age group from little kids to seniors. It's normally free too. The ability to move without the constant joint pain may be helpful.

You likely need a new support group too. The mental stress over the events you shared has to be challenging to say the least. Give yourself a break and your husband may also need a mental and/or physical break. You can get it by joining a group of senior swimmers that are beginners or an art class. Having a few laughs while becoming more active will help your mind stay strong. I bet you'll make some friends in the process too. If not swimming, try to just find a way to do something just for fun outside of the home that includes movement.

You are clearly a very strong woman. I don't know if peptides can assist you, but be careful with the possible interactions they may have with other medications if you decide to go into the grey market and self-medicate.

Bless You & Stay Strong!
Thank you for your response. Yes, my sister-in-law actually has a pool and I go over there at least once a week. I took up gardening lately because it seemed to relax me and I enjoy it. It's not that I'm in pain or that my joints hurt. It's that my legs and my arms just gets so heavy that I can hardly lift them. And I can't stay awake. It's not constant, some days are worse than others. It seems like I will have a really great day and I go swimming. Do some gardening actually go to a grocery store. The next day I'm wiped out. I also homeschool my two youngest grandchildren, one is neurodivergent and needs lots of extra attention. I am moving around, it's just so hard.
 
Thank you for your response. Yes, my sister-in-law actually has a pool and I go over there at least once a week. I took up gardening lately because it seemed to relax me and I enjoy it. It's not that I'm in pain or that my joints hurt. It's that my legs and my arms just gets so heavy that I can hardly lift them. And I can't stay awake. It's not constant, some days are worse than others. It seems like I will have a really great day and I go swimming. Do some gardening actually go to a grocery store. The next day I'm wiped out. I also homeschool my two youngest grandchildren, one is neurodivergent and needs lots of extra attention. I am moving around, it's just so hard.
AHHHHHHHH OK You just need a "pick me up" You're in the land of that sticky GREEN! Ever tried that Cali Kush? I lived in Cali for 17yrs. You can legally get the version you need right down the street at the store. Get it in a pen or a brownie and you won't stink up your clothes or the house either. Kids won't even know and I'm sure you will feel better.
 
This is a lot for any 3 people to manage let alone all happening to one. A husband like yours is worth his weight in gold.

I know there is a lot of hype in the media and pop culture about peptides and weight loss medications. I hear your frustration with traditional Western medicine. Yours is a complicated medical history. I would not be comfortable to recommend any peptides to you for fear of inadvertently causing you harm. I am not a medical professional. I wouldn't know enough to assure your safety.

Perhaps a Naturopath MD in your area might be better equipped to safely support you.

Godspeed for a path to live your very best life.
 
AHHHHHHHH OK You just need a "pick me up" You're in the land of that sticky GREEN! Ever tried that Cali Kush? I lived in Cali for 17yrs. You can legally get the version you need right down the street at the store. Get it in a pen or a brownie and you won't stink up your clothes or the house either. Kids won't even know and I'm sure you will feel better.
I will look into it. Thank you.!!
 
This is a lot for any 3 people to manage let alone all happening to one. A husband like yours is worth his weight in gold.

I know there is a lot of hype in the media and pop culture about peptides and weight loss medications. I hear your frustration with traditional Western medicine. Yours is a complicated medical history. I would not be comfortable to recommend any peptides to you for fear of inadvertently causing you harm. I am not a medical professional. I wouldn't know enough to assure your safety.

Perhaps a Naturopath MD in your area might be better equipped to safely support you.

Godspeed for a path to live your very best life.
Thank you so much! I guess I was hoping to run into "another me" that could help. I have been to many doctors who don't want to touch me. Trying to be silent and listen to God for my next move. I was hoping peptides would be it.
 
They may be! I'm just not knowledgeable enough to know or help.

20+ yrs ago I had a complicated surgical case. I called a physician I trusted. He advised me to seek care from a teaching hospital near to where I lived. I did. It was the best decision and my case resolved.

Do you live near a teaching hospital?
 
I will look into it. Thank you.!!
A couple of things worth noting in case you feel like your search needs to continue and I want to contribute some specifics, to the degree I am able.

Reta is known to have the potential of raising the heart rate, certainly seems to be a concern

Reta as well as most of the other "stacks" designed for weight loss are in research phase and not yet approved by FDA

Many of the other exercise mimetics—experimental compounds that replicate the cellular or metabolic benefits of physical activity could also be a concern with your co-morbidities.

Any of the "research" type compounds may be an issue for insurance or medical treatment.

THE GOOD NEWS

You may need an adjustment on your tirz or added movement or reduced calorie, sometimes just more protein calories.

Fatigue is common but can be mitigated with more exercise, hydration, protein.

I have lived a normal life with 1 kidney for 5 years, it may not be the worst outcome (I don't know what it would mean for you)

You have been the through the ringer, and I get you are grasping for straws, there may be an area this community can help.

Tell us about your Tirzepatide program dosage, diet, movement, etc.
 
I'm so sorry for so the issues you are dealing with. Sounds like you have a wonderful hubby standing beside you. I hope you find relief from all of that. I myself cannot recommend any peps because all of them effect people differently. I would never want to cause you more issues. Praying for you
 
Thank you for your response. Yes, my sister-in-law actually has a pool and I go over there at least once a week. I took up gardening lately because it seemed to relax me and I enjoy it. It's not that I'm in pain or that my joints hurt. It's that my legs and my arms just gets so heavy that I can hardly lift them. And I can't stay awake. It's not constant, some days are worse than others. It seems like I will have a really great day and I go swimming. Do some gardening actually go to a grocery store. The next day I'm wiped out. I also homeschool my two youngest grandchildren, one is neurodivergent and needs lots of extra attention. I am moving around, it's just so hard.
Please be sure you are staying hydrated! I didn't take it seriously until I found myself practically crawling to the restroom and on the couch with bottles of water and electrolytes around me last year. If you can get some IV fluids in you that might help. There may be a health spa/drip bar near you that can get you back on track.
You have a lot going on which makes it hard to take care of yourself. Add sone salt and sugar and get that water in!! ❤️
 
This is going to be long and I apologize, but I just don't really know where to start without starting at the beginning. Maybe grab some popcorn or an energy drink. I am a 71 year-old female. Ran a successful business for over 25 years, exercised religiously, and never weighed over 110# @ 5'2". Six years old I had my first kidney stone. Passed it while driving to the ER screaming all the way. About three months later, got another one. Stayed home for this one as I knew the routine, but Dr decided to do an ultrasound as I had had several kidney infections that year. Ultrasound showed I had quite a few kidney stones, and some of them were fairly good sized with the queen bee being at 9MM. Two large to safely pass. They took me in to blast them, which was going to take approximately 40 minutes to an hour. 2 1/2 hours in my husband said I need to know what's going on. Connected him with the doctor doing my surgery and she said we ran into complications. My kidney was being strangled by veins and arteries that had grown and attach themselves to it. Said it had probably been going on since birth. They were trying to peel back as much as they could. Could not get the big one because my liver was so enlarged. Stopped all coffee and caffeine. Kidney infections continued. New Dr discovered kidney wasn't draining completely, ureter was partially blocked. Had another surgery to place temporary stent. Kept 6 weeks and removed. Infections started again. Put in nephrostomy bag. Had to have replaced every 3 months. Had for over a year. Also developed 14" blood clot in left thigh. In hospital for 2 weeks on IV blood thinners. Said best to amputate. Hubby spent all next day on phone and found a doctor that said to bring me right in to the hospital in another city. Roto-Rooter it out, place a permanent stent a year on Coumadin. Still have my leg. Back to kidney, during a nephrostomy back change i contracted a very bad bacteria called pseudomonas. Back into the hospital for 10 days on 24 hour IV drip. Then home on IV drip for another 10 days, but only an hour a day. I am getting weaker and weaker and I just want to be done. Still have nephrostomy bag and then I get Covid.
There is water built-up around my heart. They do a neuro stress test on me and I have the worst reaction they have ever seen. If you've ever had one of these, you know that it cannot be stopped, it has to run its course. My heart went into a fib, I was sweating profusely and almost seizing. Once it was out of my system, my doctor told me I am just taking you into surgery, if you need a stent, I'm just going to do it. I said please just let me die. I can't do this anymore. Then I was asleep. Heart turned out to be fine. It was just protecting itself from all my body has been going through. I went to who was willing to try to repair my ureter. There was a lot of scar tissue that was blocking it, he said I have one chance and if it doesn't work, we have to remove your kidney because it's doing more damage than GOOD. It worked. He looked at the kidney stone and said that they could not get to it because of the liver so it was time to address that. He said the 9 mm kidney stone was like a bomb waiting to go off. I have stage 4 non-alcoholic fibrosis. I am one step away from cirrhosis. They've taken 18 bottles of blood from me and run every possible test on it. Still can't pinpoint exactly what the problem is, but it is looking like some kind of immuno disease. Great. We all know there's nothing you really can do about that. I have to have a liver ultrasound and biopsy done the end of July. So here I am. 100 pounds overweight, week, severe, I wish there was a word stronger than severe to describe my weakness. I also have PTSD and a fear of open places because my balance is so bad and I get dizzy and start to blackout so I have to use a walker. I try to do chair aerobics and a little bit of gardening, but it wears me out so fast. If I have a good day, I will sleep the next two days. Speaking of sleeping, I have had sleep apnea since I was 21 has nothing to do with weight because I was very thin then. I've been on a Sleep Apnea machine for the last 20 years. Doesn't matter, I wake up feeling like I have not slept for days. No matter what I do, I cannot regain my energy level. Started tizepatide I think about eight months ago and have lost 65 pounds. Still feel exactly the same. Still sleep just as much. I'm up to 15 units now and I'm hungry all the time. Do not want to put on the weight that I've lost. Starte MotsC two weeks ago, 5 mg once a week. No change. I thought maybe I could stack it with some Reta , I've done a lot of reading and learning, but my husband thinks it's too dangerous. All I know is I just can't keep doing this. Conventional medicine has not helped me at all. If it wasn't for my husband being proactive, I would be sitting here today with an nephrostomy bag, full of bacteria and only one leg and 125 pounds over weight at least. I just need to get back up on my feet and I think that peptides could help me get there, but I'm just not really sure what to take. Any help is greatly, greatly appreciated.
IDK if this is permitted here but...I let Grok analyze your post and even though it isn't a doctor I asked for just a set of guidelines to explore given your symptoms, this is the result:

Yes, I read every word. Thank you for sharing her full story. This is a brutal, multi-decade battle that started in childhood with kidney stones and infections, involved multiple surgeries, a dangerous blood clot, Pseudomonas sepsis, a terrifying heart reaction during testing, ureter repair, and now advanced liver fibrosis plus crushing, unrelenting fatigue and weakness at age 71. Immediate Priorities (Research & Action Directions)These are evidence-based starting points based on her described history. She should bring this list to her doctors.
  1. Liver Biopsy (end of July) – Highest Priority
    This will clarify exact stage (fibrosis scoring like METAVIR F0–F4; stage 4 often means cirrhosis or advanced fibrosis), inflammation, and whether it’s MASH (metabolic dysfunction-associated steatohepatitis, formerly NASH).
    • If non-cirrhotic advanced fibrosis (F2–F3), options like resmetirom (approved for non-cirrhotic MASH with moderate-advanced fibrosis) or GLP-1 agonists like semaglutide (Wegovy, approved for similar) may be discussed.
    • If cirrhosis, management shifts to monitoring for complications (varices, ascites, encephalopathy) and protecting remaining function.
    • Weight loss she’s already achieving with tirzepatide is one of the best things for regressing liver fat/fibrosis—continue under medical supervision.
  2. Comprehensive Fatigue & Weakness Workup (Even if “everything was tested”)
    Profound weakness that worsens after activity (“if I have a good day, I sleep the next two”) + unrefreshing sleep despite 20+ years of CPAP points to possible mitochondrial dysfunction, deconditioning, nutritional gaps, inflammation, autonomic issues, or ongoing low-grade issues from her history (infections, autoimmune signals).
    • Request: Full thyroid panel (TSH, free T4, free T3, antibodies), vitamin D, B12, folate, thiamine, iron studies/ferritin, CBC (anemia from repeated blood draws?), inflammatory markers (CRP, ESR), autoimmune panel if not exhaustive, cortisol/ACTH, possibly orthostatic vitals or tilt-table for dizziness/blackouts.
    • Re-evaluate sleep study (central vs obstructive components? Titration?).
    • Physical/occupational therapy for graded strengthening, balance/vestibular rehab (to address dizziness, walker use, and deconditioning). This can break the cycle without overdoing it.
  3. Other Targeted Areas
    • Dizziness, balance, PTSD/agoraphobia: Vestibular PT + therapy for PTSD/fear. Rule out cardiac/autonomic contributions given her history.
    • Hunger on tirzepatide: Common; discuss dose adjustment, timing, or protein/fiber strategies with prescriber. Weight loss is protective for liver but she doesn’t want regain.
    • Possible autoimmune/immuno component: Follow up on whatever tests flagged this. Rheumatology input could help if overlap syndromes or systemic inflammation.
 
This is the second half of Grok's post:

On Peptides (Her Specific Question)She’s already on tirzepatide (good progress on weight) and started MOTS-c 5 mg weekly. Considering stacking Retatrutide (Reta).
  • MOTS-c: Mitochondrial-derived peptide that activates AMPK (energy/metabolic regulator), often called an “exercise mimetic” in research. Preclinical data supports benefits for insulin sensitivity, fat metabolism, and mitochondrial function. Human data is very limited—one small Phase 1 on an analog (CB4211) in NAFLD patients showed good short-term safety and some liver enzyme improvement; native MOTS-c has almost no interventional human trials yet. Her 5 mg weekly dose is in the range people discuss anecdotally for energy/mito support. Theoretical fit for her fatigue, but no strong evidence it will dramatically restore energy in advanced liver disease or her full history. Monitor liver/kidney labs closely. Sourcing quality is essential.
  • Retatrutide (triple agonist: GLP-1 + GIP + glucagon): As of June/July 2026, not FDA-approved—still in Phase 3 trials; NDA expected late 2026, possible approval 2027–2028 at earliest. It shows impressive weight loss and liver fat reduction in studies (including a Phase 2a in MASLD where high doses resolved steatosis in >85% of participants), with no major hepatotoxicity signals in those patients. However, that trial excluded advanced fibrosis/cirrhosis, so safety in her situation (stage 4, near cirrhosis) is unknown. There are reports of liver injury linked to illegal/gray-market versions (contamination suspected). Stacking with tirzepatide is experimental and adds risks (GI side effects, unknown interactions). Her husband’s caution is reasonable—strongly advise against gray-market sources or self-stacking right now. Legitimate access is only via clinical trials.
Bottom line on peptides: MOTS-c is lower-risk to continue exploring under doctor supervision with monitoring. Retatrutide is higher-risk/lower-evidence for her current health status. Other mitochondrial-targeted options (e.g., SS-31/elamipretide in research settings) exist but are even less accessible. Peptides are not a magic fix for decades of complex organ damage + possible autoimmune drivers.Broader Research Directions She/Doctors Can Explore
  • Mitochondrial dysfunction in chronic illness, fatigue, and liver disease (search PubMed or clinicaltrials.gov for “mitochondrial peptides” or “MOTS-c”).
  • Advanced MASLD/MASH management guidelines (2026 updates emphasize noninvasive fibrosis staging like FIB-4 + elastography/ELF, then targeted therapies).
  • Functional/integrative approaches: Nutrient optimization, gut health (post-antibiotics/infections), environmental factors, though evidence varies.
  • Clinical trials: Search clinicaltrials.gov for MASLD + fibrosis, mitochondrial support, or fatigue in older adults.
Her story shows conventional medicine can stabilize crises but often struggles with the “why am I still so exhausted and weak?” part when multiple systems are involved. The liver biopsy is a key next data point. Many people in similar “mystery + organ damage + fatigue” situations eventually get clearer answers and incremental improvements through targeted specialists + addressing reversible factors (weight, nutrition, deconditioning, sleep optimization, possible mito support).If she shares the biopsy results, specific lab findings, or more details on the “immuno disease” tests, I can help narrow research leads further. In the meantime, encourage her to rest when needed, celebrate the 65 lb loss as a real win for her liver, and lean on that supportive husband. She doesn’t have to figure this out alone—good doctors who listen to complex cases exist.Hang in there. This level of persistence deserves real answers. Let me know how else I can help research specific angles.
 
IDK if this is permitted here but...I let Grok analyze your post and even though it isn't a doctor I asked for just a set of guidelines to explore given your symptoms, this is the result:

Yes, I read every word. Thank you for sharing her full story. This is a brutal, multi-decade battle that started in childhood with kidney stones and infections, involved multiple surgeries, a dangerous blood clot, Pseudomonas sepsis, a terrifying heart reaction during testing, ureter repair, and now advanced liver fibrosis plus crushing, unrelenting fatigue and weakness at age 71. Immediate Priorities (Research & Action Directions)These are evidence-based starting points based on her described history. She should bring this list to her doctors.
  1. Liver Biopsy (end of July) – Highest Priority
    This will clarify exact stage (fibrosis scoring like METAVIR F0–F4; stage 4 often means cirrhosis or advanced fibrosis), inflammation, and whether it’s MASH (metabolic dysfunction-associated steatohepatitis, formerly NASH).
    • If non-cirrhotic advanced fibrosis (F2–F3), options like resmetirom (approved for non-cirrhotic MASH with moderate-advanced fibrosis) or GLP-1 agonists like semaglutide (Wegovy, approved for similar) may be discussed.
    • If cirrhosis, management shifts to monitoring for complications (varices, ascites, encephalopathy) and protecting remaining function.
    • Weight loss she’s already achieving with tirzepatide is one of the best things for regressing liver fat/fibrosis—continue under medical supervision.
  2. Comprehensive Fatigue & Weakness Workup (Even if “everything was tested”)
    Profound weakness that worsens after activity (“if I have a good day, I sleep the next two”) + unrefreshing sleep despite 20+ years of CPAP points to possible mitochondrial dysfunction, deconditioning, nutritional gaps, inflammation, autonomic issues, or ongoing low-grade issues from her history (infections, autoimmune signals).
    • Request: Full thyroid panel (TSH, free T4, free T3, antibodies), vitamin D, B12, folate, thiamine, iron studies/ferritin, CBC (anemia from repeated blood draws?), inflammatory markers (CRP, ESR), autoimmune panel if not exhaustive, cortisol/ACTH, possibly orthostatic vitals or tilt-table for dizziness/blackouts.
    • Re-evaluate sleep study (central vs obstructive components? Titration?).
    • Physical/occupational therapy for graded strengthening, balance/vestibular rehab (to address dizziness, walker use, and deconditioning). This can break the cycle without overdoing it.
  3. Other Targeted Areas
    • Dizziness, balance, PTSD/agoraphobia: Vestibular PT + therapy for PTSD/fear. Rule out cardiac/autonomic contributions given her history.
    • Hunger on tirzepatide: Common; discuss dose adjustment, timing, or protein/fiber strategies with prescriber. Weight loss is protective for liver but she doesn’t want regain.
    • Possible autoimmune/immuno component: Follow up on whatever tests flagged this. Rheumatology input could help if overlap syndromes or systemic inflammation.
Thank you so much for this. I recognize a lot of the tests recommended and some have been done, some not. The problem that my doctor is having a diagnosis is that nothing points directly to one thing. For example, she really thought that it would be some form of hepatitis, but one test will show positive and another test that will confirm it will show negative. I have also spoken with my sleep apnea doctor to order a new sleep study and I am the same as I have always been, SEVERE. I forgot to mention that he did give me a prescription for Provigil, which is used in narcolepsy. Started with 200mg, helped for awhile until my body adjusted. Increased to 300mg is helping somewhat. He won't increase again. I feel like I just keep masking symptoms without finding the core problem. Have the rheumatology test and it was clear. It has to be some kind of auto immune disease that I'm carrying in my body. Again, I cannot thank you enough for doing some research on this. You guys have been so great. I do also want to say that I have an incredible support team. My husband, my oldest daughter who lives with me, and 13 grandchildren that help keep the kitchen clean and washing the dogs etc.
This is the second half of Grok's post:

On Peptides (Her Specific Question)She’s already on tirzepatide (good progress on weight) and started MOTS-c 5 mg weekly. Considering stacking Retatrutide (Reta).
  • MOTS-c: Mitochondrial-derived peptide that activates AMPK (energy/metabolic regulator), often called an “exercise mimetic” in research. Preclinical data supports benefits for insulin sensitivity, fat metabolism, and mitochondrial function. Human data is very limited—one small Phase 1 on an analog (CB4211) in NAFLD patients showed good short-term safety and some liver enzyme improvement; native MOTS-c has almost no interventional human trials yet. Her 5 mg weekly dose is in the range people discuss anecdotally for energy/mito support. Theoretical fit for her fatigue, but no strong evidence it will dramatically restore energy in advanced liver disease or her full history. Monitor liver/kidney labs closely. Sourcing quality is essential.
  • Retatrutide (triple agonist: GLP-1 + GIP + glucagon): As of June/July 2026, not FDA-approved—still in Phase 3 trials; NDA expected late 2026, possible approval 2027–2028 at earliest. It shows impressive weight loss and liver fat reduction in studies (including a Phase 2a in MASLD where high doses resolved steatosis in >85% of participants), with no major hepatotoxicity signals in those patients. However, that trial excluded advanced fibrosis/cirrhosis, so safety in her situation (stage 4, near cirrhosis) is unknown. There are reports of liver injury linked to illegal/gray-market versions (contamination suspected). Stacking with tirzepatide is experimental and adds risks (GI side effects, unknown interactions). Her husband’s caution is reasonable—strongly advise against gray-market sources or self-stacking right now. Legitimate access is only via clinical trials.
Bottom line on peptides: MOTS-c is lower-risk to continue exploring under doctor supervision with monitoring. Retatrutide is higher-risk/lower-evidence for her current health status. Other mitochondrial-targeted options (e.g., SS-31/elamipretide in research settings) exist but are even less accessible. Peptides are not a magic fix for decades of complex organ damage + possible autoimmune drivers.Broader Research Directions She/Doctors Can Explore
  • Mitochondrial dysfunction in chronic illness, fatigue, and liver disease (search PubMed or clinicaltrials.gov for “mitochondrial peptides” or “MOTS-c”).
  • Advanced MASLD/MASH management guidelines (2026 updates emphasize noninvasive fibrosis staging like FIB-4 + elastography/ELF, then targeted therapies).
  • Functional/integrative approaches: Nutrient optimization, gut health (post-antibiotics/infections), environmental factors, though evidence varies.
  • Clinical trials: Search clinicaltrials.gov for MASLD + fibrosis, mitochondrial support, or fatigue in older adults.
Her story shows conventional medicine can stabilize crises but often struggles with the “why am I still so exhausted and weak?” part when multiple systems are involved. The liver biopsy is a key next data point. Many people in similar “mystery + organ damage + fatigue” situations eventually get clearer answers and incremental improvements through targeted specialists + addressing reversible factors (weight, nutrition, deconditioning, sleep optimization, possible mito support).If she shares the biopsy results, specific lab findings, or more details on the “immuno disease” tests, I can help narrow research leads further. In the meantime, encourage her to rest when needed, celebrate the 65 lb loss as a real win for her liver, and lean on that supportive husband. She doesn’t have to figure this out alone—good doctors who listen to complex cases exist.Hang in there. This level of persistence deserves real answers. Let me know how else I can help research specific angles.
 
Thank you so much for this. I recognize a lot of the tests recommended and some have been done, some not. The problem that my doctor is having a diagnosis is that nothing points directly to one thing. For example, she really thought that it would be some form of hepatitis, but one test will show positive and another test that will confirm it will show negative. I have also spoken with my sleep apnea doctor to order a new sleep study and I am the same as I have always been, SEVERE. I forgot to mention that he did give me a prescription for Provigil, which is used in narcolepsy. Started with 200mg, helped for awhile until my body adjusted. Increased to 300mg is helping somewhat. He won't increase again. I feel like I just keep masking symptoms without finding the core problem. Have the rheumatology test and it was clear. It has to be some kind of auto immune disease that I'm carrying in my body. Again, I cannot thank you enough for doing some research on this. You guys have been so great. I do also want to say that I have an incredible support team. My husband, my oldest daughter who lives with me, and 13 grandchildren that help keep the kitchen clean and washing the dogs etc.
I do think it has something to do with mitochondria, that's why I thought I would start with MotsC. Seemed like a fairly reasonable jump. I was also considering NAD+ but read some things that put my radar up. My short-term memory is not great so I can't remember at the moment but something turned me off about it. I guess I'll just keep taking the MotsC and Provigil for now. I do also take levothyroxine for thyroid and folic acid prescribed by my primary. I also ordered some liquid saffron extract, L-THEANINE Liquid and a liquid multivitamin. I figured none of those would hurt but could help. Otherwise, I'll wait till July.
 
I do also take levothyroxine for thyroid
Is there an autoimmune reason for this? Thyroid hormone levels can be a reason for fatigue, of course. Not everybody who is within reference range is where their individual healthy range is (which is much smaller than the whole reference range). Some people (like me) do better with taking a little bit of T3 as well.
Do you see any timely context of your fatigue with the thyroid story?

I'm up to 15 units now
By units you mean mg (of tirzepatide)?
 
Is there an autoimmune reason for this? Thyroid hormone levels can be a reason for fatigue, of course. Not everybody who is within reference range is where their individual healthy range is (which is much smaller than the whole reference range). Some people (like me) do better with taking a little bit of T3 as well.
Do you see any timely context of your fatigue with the thyroid story?


By units you mean mg (of tirzepatide)?
I honestly dont know. I have taken it for many years and it's just the last 6 years that my fatigue started and continues to worsen.
Yes I was referring to the Tirzepatide, sorry
I don't know what T3 is
 
This is a lot for any 3 people to manage let alone all happening to one. A husband like yours is worth his weight in gold.

I know there is a lot of hype in the media and pop culture about peptides and weight loss medications. I hear your frustration with traditional Western medicine. Yours is a complicated medical history. I would not be comfortable to recommend any peptides to you for fear of inadvertently causing you harm. I am not a medical professional. I wouldn't know enough to assure your safety.

Perhaps a Naturopath MD in your area might be better equipped to safely support you.

Godspeed for a path to live your very best life.
This is probably the best answer I've seen for you. So sorry for all of your afflictions. Wishing you the best. ❤️
 

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