Have you noticed Tirz tolerance developing over time?

[AndyPanda]

The research that wine was not healthy was a big buzzkill for me. Now I use my few remaining bottles for cooking.

Even resveratrol supplements lost their magic in the public eye and in some exercise-related research: "Resveratrol supplementation can actually blunt some of the positive adaptations to exercise, such as improvements in cardiovascular fitness or muscle protein synthesis" (Google Gemini).

I make and drink Mead, and it makes me feel invincible! 😂 Some of my scars prove otherwise. I’ve cut back on it dramatically but sometimes I think making it is more fun than actually drinking it. It’s supposed to be high in antioxidants because of the honey but I doubt it outweighs the liver damage.

 

[Calm Logic]

Pitavastatin recently went generic and has far less side effects and liver impact, than all the other statins. It was so expensive oop that some drs aren’t familiar with it as an option yet. I’m not sure where the person saying people who use AAS avoid statins, because I learned of this one from the Meso steroid forum. It’s one they recommend. Sharing in case it’s an option for you.

My impression was that many on oral AAS avoid statins, especially as a preventative, because they know oral AAS can be toxic to the liver. And they take other things like reta or supplements to help cholesterol instead. Not to mention that statins are not the best for muscle health.

 

[Lucas]

Tolerance is often mixed up with a plateau: https://glp1effect.com/p/tolerance-on-glp-1-does-the-medication-lose-its-efficiency-over-time

 

[Airborne Daddy]

My completely unscientific opinion is that it might be tied to how heavy you are. I mean if you are approaching a healthy weight maybe the body just becomes more resistant to losing? Sure, it might SEEM like its a tolerance build up but you are already thinner.

I base this opinion solely on my husband, who has never been overweight let alone obese but he is a diabetic. He and I both took the same amount of sema over a 3 month period, starting dose up to 1mg per week. He didn't lose any weight. He didn't NEED to lose any weight. He has since upped his dose to 2mg because he was still having some blood sugar spikes and I have added reta. He has still not lost any weight and I am down 30 pounds.

I don't know, just a stray thought. In any case I'm only 4 months in and still need to lose over 100 pounds. What the heck do I know?

I agree. I'm 14 months in and go sema, then tirz, then reta and ultimately repeat. Went from 249 to to 225 but that's it. I'm only 5'8.....:told the Bride if nothing else Doc loved my a1c, cholesterol, triglycerides, liver values, glucose, etc.... he said see ya next year instead of we need to run ur labs again in 6-8 weeks.

 

[Batscout]

Wish I could get the 0 desire for alcohol. It costs me 1000 calories every time I drink

I have experienced a profound reduction in my desire to drink alcohol. I met my goal back in February and I am now on maintenance, using only about 10-15 mg a month, in a combination of Reta and Tirz. Even if I used only 5 mg within 10 days, I can still barely choke back a drink.

 

[keangkong]

Again referring to my skinny husband who is taking twice as much sema as me .. he has not had any appetite suppression at all. While I almost need to force myself to eat to get some protein in. I will concede that maybe that is just his personal biology. But I don't know anyone else who is taking ozempic who started out at a healthy weight.

It sounds like it's a good thing that your hubby isn't losing weight.

 

[keangkong]

Pitavastatin recently went generic and has far less side effects and liver impact, than all the other statins. It was so expensive oop that some drs aren’t familiar with it as an option yet. I’m not sure where the person saying people who use AAS avoid statins, because I learned of this one from the Meso steroid forum. It’s one they recommend. Sharing in case it’s an option for you.

Thanks. I looked it up at Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset, https://www.fda.gov/science-researc...induced-liver-injury-rank-dilirank-20-dataset. You're right. The numbers (5 or 3) indicate the seriousness of the injury that might result.





To use another source, Livertox [https://www.ncbi.nlm.nih.gov/books/NBK548236/] ranks atorvastatin as an A:


Livertox [https://www.ncbi.nlm.nih.gov/books/NBK548065/] ranks pitavastatin as a D.

I have stopped taking the statin and told the cardiologist by an electronic, email-like message that I did so. Assuming the Lipitor turns out to be the cause, as I believe it will be, then I can discuss with the cardiologist whether with my reduced weight and a past history of having statin-induced liver injury, it's medically advisable to still take a statin. If he recommends taking a different statin, I'd likely do so.

 

[keangkong]

My impression was that many on oral AAS avoid statins, especially as a preventative, because they know oral AAS can be toxic to the liver. And they take other things like reta or supplements to help cholesterol instead. Not to mention that statins are not the best for muscle health.

Years ago, because I get bad DOMS, my primary care doctor took me off Lipitor for a few months. I still got DOMS worse than most people. We resumed the Lipitor. The solution when lifting weights is easy although a bit frustrating: I can increase weight without suffering bad DOMS but I can only do so slowly.

 

[ZippityDooDah]

Wish I could get the 0 desire for alcohol. It costs me 1000 calories every time I drink

Before tirz, for 20-something years I was the evening cocktail guy 3-4 nights a week after work, and that stopped very shortly after my first couple of doses without really even thinking about it; I just realized one day that a few weeks had gone by since I had a drink.

The big wake-up came when during our regular Friday night hangouts, one of the neighbors in the cul de sac brought out a bottle of Weller Full Proof he received as gift from a parent (he's the athletic director at the local catholic school) and two shots destroyed me - I literally lost a day. I was no lightweight, and hadn't had alcohol do that to me since my teens.

 

[keangkong]

Tolerance is often mixed up with a plateau: https://glp1effect.com/p/tolerance-on-glp-1-does-the-medication-lose-its-efficiency-over-time

I 100% agree. A person who weighs 500 pounds and loses 200 pounds on a GLP-1 drug but has trouble losing anything more probably hasn't experienced tolerance to the drug. Rather, that drug may be only helped so much by the drug. The drug works although not quite as well as the user hopes.

 

[keangkong]

Before tirz, for 20-something years I was the evening cocktail guy 3-4 nights a week after work, and that stopped very shortly after my first couple of doses without really even thinking about it; I just realized one day that a few weeks had gone by since I had a drink.

The big wake-up came when during our regular Friday night hangouts, one of the neighbors in the cul de sac brought out a bottle of Weller Full Proof he received as gift from a parent (he's the athletic director at the local catholic school) and two shots destroyed me - I literally lost a day. I was no lightweight, and hadn't had alcohol do that to me since my teens.

I'm sure you could build up your tolerance again. However, since you haven't been drinking much, I suspect you have not wanted to do so.

 

[ZippityDooDah]

I'm sure you could build up your tolerance again. However, since you haven't been drinking much, I suspect you have not wanted to do so.

That's the thing, I literally have zero desire for alcohol. I assumed that would change as I adapted to the side-effects of tirz and now reta, but it hasn't.

 

[keangkong]

That's the thing, I literally have zero desire for alcohol. I assumed that would change as I adapted to the side-effects of tirz and now reta, but it hasn't.

Does it bother you that you don't desire alcohol?

 

[MsGizmo]

That's good info!

Is he taking it just to control blood sugar or is he after some other effect?

Just for his diabetes. He isn't allowed to use insulin because he is a truck driver .. something about the possibility of his blood sugar dropping too low and that doesn't happen with ozempic.

 

[keangkong]

Pitavastatin recently went generic and has far less side effects and liver impact, than all the other statins. It was so expensive oop that some drs aren’t familiar with it as an option yet. I’m not sure where the person saying people who use AAS avoid statins, because I learned of this one from the Meso steroid forum. It’s one they recommend. Sharing in case it’s an option for you.

Thank you. I'll discuss this with my cardiologist. I don't use AAS.

 

[keangkong]

Just for his diabetes. He isn't allowed to use insulin because he is a truck driver .. something about the possibility of his blood sugar dropping too low and that doesn't happen with ozempic.

That makes sense: I don't want a truck driver on the road who can't pay attention because his sugar has fallen too much.

 

[ZippityDooDah]

Does it bother you that you don't desire alcohol?

Nope, I find it fascinating how GLPs can impact so many different parts of the body and mind.

 

[MsGizmo]

I have stopped taking the statin and told the cardiologist by an electronic, email-like message that I did so. Assuming the Lipitor turns out to be the cause, as I believe it will be, then I can discuss with the cardiologist whether with my reduced weight and a past history of having statin-induced liver injury, it's medically advisable to still take a statin. If he recommends taking a different statin, I'd likely do so.

Just a side note. My husband was not a diabetic before he was put on lipitor. He had his first heart attack 2 weeks after they gave him a prescription of 40mg. At that point they gave him crestor and upped his dose to 80mg of lipitor. (maximum dose) They kept him on that for about a year while jerking him around with other meds to try and counteract what lipitor was doing before I was able to convince him to stop it taking it. In that year had 2 more heart attacks a stroke and developed diabetes. Also of note when they did 2 cardiac caths on 2 different occasions he had no blockages and no plaque build up either. Ever since he stopped taking lipitor his health improved dramatically but the diabetes is permanent likely caused by undiagnosed pancreatitis. (the pancreatitis is officially just my opinion, but the diabetes had to come from something)

Also of note I AM NOT A DOCTOR. Do not start or stop a medicine based on one dude's case history told to you by his wife at one o'clock in the morning.

 

[keangkong]

Just a side note. My husband was not a diabetic before he was put on lipitor. He had his first heart attack 2 weeks after they gave him a prescription of 40mg. At that point they gave him crestor and upped his dose to 80mg of lipitor. (maximum dose) They kept him on that for about a year while jerking him around with other meds to try and counteract what lipitor was doing before I was able to convince him to stop it taking it. In that year had 2 more heart attacks a stroke and developed diabetes. Also of note when they did 2 cardiac caths on 2 different occasions he had no blockages and no plaque build up either. Ever since he stopped taking lipitor his health improved dramatically but the diabetes is permanent likely caused by undiagnosed pancreatitis. (the pancreatitis is officially just my opinion, but the diabetes had to come from something)

Also of note I AM NOT A DOCTOR. Do not start or stop a medicine based on one dude's case history told to you by his wife at one o'clock in the morning.

Thanks. There is some evidence that taking Lipitor increases the chances one will get diabetes. I do wonder whether it would be wise for me to take a statin now that I have lost weight. However, right now I have ceased taking Lipitor based solely upon concern for my liver.

 

[MsGizmo]

Thanks. There is some evidence that taking Lipitor increases the chances one will get diabetes. I do wonder whether it would be wise for me to take a statin now that I have lost weight. However, right now I have ceased taking Lipitor based solely upon concern for my liver.

I just wish I would have been pushier about him stopping it sooner or at the vey least reduce the dose. I mean in 2 weeks time he went from no drug at all to the maximum dose. Just sitting here thinking about what that drug did to him makes me so angry.

 

[Calm Logic]

I'm 14 months in and go sema, then tirz, then reta and ultimately repeat.

Seems very zen.

 

[keangkong]

I just wish I would have been pushier about him stopping it sooner or at the vey least reduce the dose. I mean in 2 weeks time he went from no drug at all to the maximum dose. Just sitting here thinking about what that drug did to him makes me so angry.

Your frustration is understandable. Still taking statins is standard medical advice. There are risks in following standard medical advice, along with risks in ignoring standard medical advice. How does he feel now?

 

[keangkong]

I looked through some studies on this and it seems the topic hasn’t been researched well.

I’m curious about your personal experience, especially as a long-term users. Do you feel tirzepatide loses effectiveness over time?

I earlier provided an answer basically stating that folks do not generally develop GLP-1 tolerance over time. I basically meant what I wrote but I believe that someone with medical knowledge who spoke precisely would have answered differently. We do develop tolerance to GLP-1 drugs. That's why we start GLP-1 drugs on a dose that will eventually be insufficient for most people. If we started on a higher dose or the highest dose, there is a good chance we'd have terrible side effects. Our bodies adapt. Still the tolerance we develop doesn't keep the GLP-1 drugs from continuing to work. We know that for tirzepatide, for instance, that even after three years people continue to stay at about the same weight as they had earlier plateaued.

 

[Batscout]

Does it bother you that you don't desire alcohol?

I have wondered how people feel about this myself. If you have zero desire for something, why do you miss having a desire for it? There must be a feeling of missing the social relaxation and feeling of participation and inclusiveness.

 

[MsGizmo]

Your frustration is understandable. Still taking statins is standard medical advice. There are risks in following standard medical advice, along with risks in ignoring standard medical advice. How does he feel now?

All his medical issues happened while taking Lipitor. 3 heart attacks and a stroke in one year while taking that poison and he felt like garbage. That was 2003/2004. 21 years without a statin and his only problem is diabetes. He did the smart thing and weaned himself off of it slowly and didn't go cold turkey. He is currently 62.

 

[desinr-gal]

Wish I could get the 0 desire for alcohol. It costs me 1000 calories every time I drink

try subbing with a mocktail like HIYO. It has ashwaganda and mushroom extracts. almost instant chill out, like a drink, but no rush or buzz. Then with more, you get more relaxed and sleepy.
Also only 30 calories. other mocks are very sugary

 

[Airborne Daddy]

try subbing with a mocktail like HIYO. It has ashwaganda and mushroom extracts. almost instant chill out, like a drink, but no rush or buzz. Then with more, you get more relaxed and sleepy.
Also only 30 calories. other mocks are very sugary

Thank you and bless you.

 

[desinr-gal]

Thank you and bless you.

my favorite flavor is blackberry lemon, it's not too sweet.

 

[latviantower]

Believe my daughter gave me that a few years ago, didn't seem to help much. Maybe cuz I stopped after a few weeks. Thanks brother.

Naltrexone was a game changer for me. After decades of heavy drinking, I went inpatient for 28 days. They put me on 100 mg Naltrexone daily (normal dose is 50 mg for most folks?), which I took for 12 months. Never had any craving for booze. And I think it helped with food too (this was before I started tirz). Now closing in on 3 years sober and definitely no cravings - tirz might be helping there too!

 

[Airborne Daddy]

Naltrexone was a game changer for me. After decades of heavy drinking, I went inpatient for 28 days. They put me on 100 mg Naltrexone daily (normal dose is 50 mg for most folks?), which I took for 12 months. Never had any craving for booze. And I think it helped with food too (this was before I started tirz). Now closing in on 3 years sober and definitely no cravings - tirz might be helping there too!

Appreciate it. I prolly took min dose for 8 or 9 days and said ehh.... may get with doc or my indian bruh.