Have you noticed Tirz tolerance developing over time?

[Superchicken1]

My impression was that many on oral AAS avoid statins, especially as a preventative, because they know oral AAS can be toxic to the liver. And they take other things like reta or supplements to help cholesterol instead. Not to mention that statins are not the best for muscle health.

Nah, they keep statins and other pharmaceuticals on hand. They do use glp/gip meds though for stuff like liver, blood sugar, weight control.

My husband is on it alongside ezetimibe, and his dr was impressed with its profile. He was shocked when he told him the harm reduction steroid forum is where he learned of it. I learned more about health and treatment from them than any dr lol They’re pretty smart.

 

[Superchicken1]

Thanks. I looked it up at Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset, https://www.fda.gov/science-researc...induced-liver-injury-rank-dilirank-20-dataset. You're right. The numbers (5 or 3) indicate the seriousness of the injury that might result.

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To use another source, Livertox [https://www.ncbi.nlm.nih.gov/books/NBK548236/] ranks atorvastatin as an A:

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Livertox [https://www.ncbi.nlm.nih.gov/books/NBK548065/] ranks pitavastatin as a D. View attachment 8592

I have stopped taking the statin and told the cardiologist by an electronic, email-like message that I did so. Assuming the Lipitor turns out to be the cause, as I believe it will be, then I can discuss with the cardiologist whether with my reduced weight and a past history of having statin-induced liver injury, it's medically advisable to still take a statin. If he recommends taking a different statin, I'd likely do so.

There are other options for cholesterol control. My husband uses ezetimibe, clinically has about a 20% reduction in LDL. It’s what he started on before adding the pita, and it worked, but 20% wasn’t enough. Now he’s using the pita 3x a week and he’s good. I knew he wouldn’t push for the ezetimibe on his own and just sourced it from India pharma. There are also pcsk9 inhibitors and bempedoic acid. Sometimes insurance can be obnoxious on coverage for these things, and want you to fail all other statins first. Filling the rx, then “developing a side effect” until you meet the requirements for coverage is a workaround. The other option is to use telehealth for the rx, then an in person dr is more likely to go along with it if it’s a med you’re established on.

Just throwing ideas out.