Hello, I have question about Retatrutide and it's long term effect

Kalinser

Kalinser

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I stopped using it for 2 weeks, how long does it usually take for saturation to go down?
Is there any chance, that after small break, lower dose could do the job?
Currently on 6mg every 5 days, lost 25kg.
 
Not really enough information to answer properly. Age, start weight, goal weight, height, how long you were on reta? Why you stopped? Adverse effects before you stopped?

After 2 weeks blood drug levels of retatrutide would be bit less than 1/4 peak levels , or about half what they would be just before the next weekly dose. The half life is 6 days rather than a week, but close enough, so in a week levels will drop 50% or maybe more like 55%. GLPplotter is excellent for looking at this to help understand what is going on with doses and effects and side effects versus timing of doses.

Stopping for 2 weeks is probably not long enough to lose tolerance to gastrointestinal side effects, so you could probably restart at 6mg , or 4mg if you want to be careful or had some side effects at 6mg before you stopped it.

I do not believe there is any evidence at all that tolerance develops to the hunger suppressing or weight loss effects of GLP's, so stopping for a few weeks will not reset receptors and all that crap. There is evidence that in the first few months tolerance does develop to delayed gastric emptying and to gastrointestinal side effects, as often nausea and vomiting are worst at the 2-4 month stage and then often very slowly improve.

Restarting at a lower dose only makes sense if you are at your goal weight? If that is the case then there is no harm in trying say 4mg and see what happens, if you start putting on weight or are hungry all the time then you probably need to go back to a higher dose.

I think the science on long term weight maintenance on GLP drugs says that you need to stay on the dose you used to lose the weight to keep the weight off, but there are plenty of people on this forum maintaining at lower doses.
 
lessthanhalf said:
Not really enough information to answer properly. Age, start weight, goal weight, height, how long you were on reta? Why you stopped? Adverse effects before you stopped?

After 2 weeks blood drug levels of retatrutide would be bit less than 1/4 peak levels , or about half what they would be just before the next weekly dose. The half life is 6 days rather than a week, but close enough, so in a week levels will drop 50% or maybe more like 55%. GLPplotter is excellent for looking at this to help understand what is going on with doses and effects and side effects versus timing of doses.

Stopping for 2 weeks is probably not long enough to lose tolerance to gastrointestinal side effects, so you could probably restart at 6mg , or 4mg if you want to be careful or had some side effects at 6mg before you stopped it.

I do not believe there is any evidence at all that tolerance develops to the hunger suppressing or weight loss effects of GLP's, so stopping for a few weeks will not reset receptors and all that crap. There is evidence that in the first few months tolerance does develop to delayed gastric emptying and to gastrointestinal side effects, as often nausea and vomiting are worst at the 2-4 month stage and then often very slowly improve.

Restarting at a lower dose only makes sense if you are at your goal weight? If that is the case then there is no harm in trying say 4mg and see what happens, if you start putting on weight or are hungry all the time then you probably need to go back to a higher dose.

I think the science on long term weight maintenance on GLP drugs says that you need to stay on the dose you used to lose the weight to keep the weight off, but there are plenty of people on this forum maintaining at lower doses.
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20
140kg, I m currently at 115kg.
186cm height
Since 11/11/2025
I stopped because I went on vacation and couldn't bring it with me.
No adverse effects, worst side effect I've ever had was mild diarhea.

Okey thanks, I will restard at 6mg.

not really, MY goal weight is 90kg.

Thanks for the answers friend!
 
Sounds very reasonable.
The only thing I might add is. Despite everyone on this forum always emphasising using the lowest possible dose for as long as possible, I do not think this is really the correct approach if you are trying to lose 50kg, unless you are a super responder it is pretty likely you will need to get to standard maximum doses of 12mg/week or about 9mg/5days to get to 90kg, and hopefully that will get you there.

I am not saying you need to increase doses if you are losing weight at a reasonable weight , are not too hungry, or have side effects, but reta does have some added bonus effects from the glucagon agonism that get you to burn an extra 1-200 kcal/day for free and this effect is stronger at higher doses, and given you will probably need to get to 12mg eventually it makes sense to slowly push the dose up towards that over months.
 
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I dont know about lowest poazible dose, but I'm definitely one of those lowest effective does people. If its working, why would you increase? Especially with Reta which is much harder on your system than Tirz is, it doesn't make sense to chase a small bump in calorie burn. Faster isn't better, its just faster. I would always recommend that someone stays on as low a dose as possible that let's you lose 1-1.5 lbs (2-3kg) a week without having miserable food cravings.

EDIT: Did my lbs to kg wrong. .5 to .75kg
 
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I think losing weight too fast is a bad idea, it can definitely cause problems, and increasing the dose while weight is being lost at a reasonable rate and you are not hungry is not needed.

But if you are trying to lose 50kg, you are almost 100% certain to end up needing maximum doses of 12mg, so it makes sense to slowly push doses up towards that, but obviously not if you are already rapidly losing weight or feel ill and tired or have side effects.

I have seen sooo many people on this forum complaining about being stalled on 5 or 10 mg of tirz , or 5 or 8 mg of reta and trying to lose a lot of weight. The drugs are designed to be used at the doses in the studies, lower doses may well be a good idea if only trying to lose 10 or 15% body weight, but not such a great idea if trying to lose 40% body weight.
 
lessthanhalf said:
Sounds very reasonable.
The only thing I might add is. Despite everyone on this forum always emphasising using the lowest possible dose for as long as possible, I do not think this is really the correct approach if you are trying to lose 50kg, unless you are a super responder it is pretty likely you will need to get to standard maximum doses of 12mg/week or about 9mg/5days to get to 90kg, and hopefully that will get you there.

I am not saying you need to increase doses if you are losing weight at a reasonable weight , are not too hungry, or have side effects, but reta does have some added bonus effects from the glucagon agonism that get you to burn an extra 1-200 kcal/day for free and this effect is stronger at higher doses, and given you will probably need to get to 12mg eventually it makes sense to slowly push the dose up towards that over months.
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I don't worry too much about it mate, I have 9 vials of 50mg left, so I m gonna be running 8mg soon every 5 days.
5byfive said:
I dont know about lowest poazible dose, but I'm definitely one of those lowest effective does people. If its working, why would you increase? Especially with Reta which is much harder on your system than Tirz is, it doesn't make sense to chase a small bump in calorie burn. Faster isn't better, its just faster. I would always recommend that someone stays on as low a dose as possible that let's you lose 1-1.5 lbs (2-3kg) a week without having miserable food cravings.
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2-3kg a week is agressive loss, not possible without having perfect plan or literally starving.
I slowly went up to my dose of 6mg, while trying to stay at lower does for as long as possible, since reta is not cheap for my 3rd world ahh.
lessthanhalf said:
I think losing weight too fast is a bad idea, it can definitely cause problems, and increasing the dose while weight is being lost at a reasonable rate and you are not hungry is not needed.

But if you are trying to lose 50kg, you are almost 100% certain to end up needing maximum doses of 12mg, so it makes sense to slowly push doses up towards that, but obviously not if you are already rapidly losing weight or feel ill and tired or have side effects.

I have seen sooo many people on this forum complaining about being stalled on 5 or 10 mg of tirz , or 5 or 8 mg of reta and trying to lose a lot of weight. The drugs are designed to be used at the doses in the studies, lower doses may well be a good idea if only trying to lose 10 or 15% body weight, but not such a great idea if trying to lose 40% body weight.
Click to expand...
thanks for your insight men, I m planning to get to 90kg, whatever it takes, after that I will maintain it with gym and at least 5 days a clean eating days in a week while staying at 3-6mg dose, going as low as possible, that will keep my apetite in check, so I do not accidentally carve whole christmas pig on random tuesday night jajajaj
 
General statements about losing a given weight per week are asinine. Week over week percentage change is much better at illustrating the variability of weight and differences in metabolic rates. A 5’120lb person and a 6’4” 375lb person likely shouldn’t both target the same pound figure. Weight loss speed can be overly fast or overly slow, depending on goals.

Personally, I want to lose it relatively as fast as I practically can, comfortably, while maintaining lean mass. So far that works out to 1-1.1% lost per week which averages out to 2.6lb/week. As my weight decreases, so does my weight loss target in terms of pounds. On a rolling 7 day period I’ve lost as much as 6lb and gained as much as 4lb… like with caloric budgets longer averages matter more than shorter sampling periods.



Reta’s effectiveness over Tirz is GCGR. I don’t know how to measure that, but it’s not appetite suppression. I’ve escalated my dose mainly based on side effects, although I didn’t have any of note until I got above trail levels and they were short lived and mild. GCGR is only good for 100-300cal/day it seems, but the catabolic protection seems to also be real. Appetite control hasn’t been an issue or reason I’ve moved up my dose.

I elevated my dose to improve my odds of reducing my weight by a third without hitting a plateau or having to stack. On the high side I hope I get to my target and have to reduce my dose to maintain, or to say another way I hope my equilibrium point at this dose is below my target.

1777471487281.webp

This doesn’t include the 3 weeks I was on Tirz.
1777471682340.webp

5byfive said:
1-1.5 lbs (2-3kg)
Click to expand...
2-3kg is 4.4-6.6lb
 
If side effects haven't been an issue I would go right back to your usual dosage. There is a lot of good advice here for you. You have the right attitude, determination, and an achievable goal.
 
woundcarping said:
General statements about losing a given weight per week are asinine. Week over week percentage change is much better at illustrating the variability of weight and differences in metabolic rates. A 5’120lb person and a 6’4” 375lb person likely shouldn’t both target the same pound figure. Weight loss speed can be overly fast or overly slow, depending on goals.

Personally, I want to lose it relatively as fast as I practically can, comfortably, while maintaining lean mass. So far that works out to 1-1.1% lost per week which averages out to 2.6lb/week. As my weight decreases, so does my weight loss target in terms of pounds. On a rolling 7 day period I’ve lost as much as 6lb and gained as much as 4lb… like with caloric budgets longer averages matter more than shorter sampling periods.



Reta’s effectiveness over Tirz is GCGR. I don’t know how to measure that, but it’s not appetite suppression. I’ve escalated my dose mainly based on side effects, although I didn’t have any of note until I got above trail levels and they were short lived and mild. GCGR is only good for 100-300cal/day it seems, but the catabolic protection seems to also be real. Appetite control hasn’t been an issue or reason I’ve moved up my dose.

I elevated my dose to improve my odds of reducing my weight by a third without hitting a plateau or having to stack. On the high side I hope I get to my target and have to reduce my dose to maintain, or to say another way I hope my equilibrium point at this dose is below my target.

View attachment 21557

This doesn’t include the 3 weeks I was on Tirz.
View attachment 21558


2-3kg is 4.4-6.6lb
Click to expand...
really interesting honestly, I think reta is much better then tirz
anhydrous said:
If side effects haven't been an issue I would go right back to your usual dosage. There is a lot of good advice here for you. You have the right attitude, determination, and an achievable goal.
Click to expand...
thanks men, I appreciate the kind words!
 
woundcarping said:
Personally, I want to lose it relatively as fast as I practically can, comfortably, while maintaining lean mass. So far that works out to 1-1.1% lost per week which averages out to 2.6lb/week. As my weight decreases, so does my weight loss target in terms of pounds. On a rolling 7 day period I’ve lost as much as 6lb and gained as much as 4lb… like with caloric budgets longer averages matter
Click to expand...
I usually use 500-700 calorie deficit and 1-1.5 lbs a week for most people as a shortcut, for heavier people percent body weight is the way to go. I also agree with measuring based on a rolling 7-day average; day-to-day doesn't tell you much. And any time you transition to/from a surplus to a deficit, you will generally see a bigger swing due to water weight.

I would argue that losing faster is going to result in more muscle loss in general. If you have never seriously lifted before and you train hard enough with the right diet you can mitigate this and even recomp while losing at the higher end (your 1-1.1%) but I would still not recommend it for most. Studies show that most people do not lift with enough intensity to gain or even preserve muscle in this kind of deficit.
 
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