Help me decide: Stay on Tirz, Switch to Reta, Stack Tirz & Reta, Stack Cagr & Reta?

[ColdSmoke]

I too am at seven months on Zepbound. At around 11.25 mg dose (55 units from 10mg vial) and have been very successful, I’m down 50lbs. Almost exactly 1.5 lbs a week.

That said, the FOMO around the glucagon agonist is real though. Would I be down 70 instead of 50 on Reta? I will probably hold off on the Reta until I have an actual plateau. The increased heart rate has me a bit tentative.

Now we have Elora and I think if I had to choose a non FDA approved weight loss med, I’d go with Elora based on what I’m hearing about it.

 

[lessthanhalf]

This is hard. I'm currently on 10mg tirz and have been on Tirz for about 7 months with awesome results. Been taking it prescribed but when the costs got too high I decided to go the gray way instead. So I decided to switch to Reta (not started yet). Then reconsidered and decided to stack tirz + reta. Now I read about Cagrilintide and looked in to stacking reta + cagr. Can't think straight anymore from all the alternatives 😭 any help and experiences would be hugely appreciated. Sorry if there's a thread almost like this one.

I think a good answer to this requires knowing the usual stats, like age, start weight, current weight, target, height, lifelong obesity problem or not etc? And side effects from tirz?

My first guess is if you are not that far from your target and do not have a lot of side effects, then the lowest risk approach is just stick with the tirz so long as you think there is a good chance of it getting you to your target at or before 15mg/w. Tirz has the lowest rate of side effects, Elora might even be better but only at low doses. So adding drugs adds to the risks of drug allergies and almost certainly more side effects than you currently have.

If you have a lot of weight left to lose, and think 15mg of tirz will not get you there, then adding in extras now or later makes more sense. In general the idea is to get the most or to target weight loss with the least side effects, and tirz is actually pretty good at that. Reta and especially cagri do have higher rates of adverse effects than tirz.

 

[JohannesSweden77]

You need to start thinking about TG and the GB's.

(I need to stop thinking about TG and the GBs. It’s all I think about!)

Sorry but I totally lost you guys there with the TG and the GB. What is that?

 

[BigDaddyJ]

Yes, I was on tirz like 9 or 10 weeks (was at 5mg), but glucagon fomo and here we are. I think for me it was probably the same reasoning as why a lot of people split dose, I didn't like the end of the week return of not-really-hungry hunger, and reta seemed worth trying. It was also the first thing I ever reconstituted, so I was definitely only going to start with a small amount anyway. And I liked the results, have stuck with it, titrate something up every 4-6 weeks depending on what I want to improve on. "Science" 😂

Fixing to start my first time with Tirz based on my food noise. That’s the one thing I wondered about is the end of the week part. We shall see. The place I’ve decided upon is closed till after their holiday so it will be the end of the month before my order.

 

[JohannesSweden77]

I think a good answer to this requires knowing the usual stats, like age, start weight, current weight, target, height, lifelong obesity problem or not etc? And side effects from tirz?

My first guess is if you are not that far from your target and do not have a lot of side effects, then the lowest risk approach is just stick with the tirz so long as you think there is a good chance of it getting you to your target at or before 15mg/w. Tirz has the lowest rate of side effects, Elora might even be better but only at low doses. So adding drugs adds to the risks of drug allergies and almost certainly more side effects than you currently have.

If you have a lot of weight left to lose, and think 15mg of tirz will not get you there, then adding in extras now or later makes more sense. In general the idea is to get the most or to target weight loss with the least side effects, and tirz is actually pretty good at that. Reta and especially cagri do have higher rates of adverse effects than tirz.

I'm a 48 year old male. I'm 185cm/6feet tall. I haven't been obese my whole life in fact add young i was quite thin. The obesity problems started at about late 20s early 30s. My start weight was 125kg/276lbs. My current weight is 98kg/216lbs after about 7 months on Tirz + healthy diet and a lot of excersise (gym 5 days a week and cardio the other 2). My side effects (the annoying ones) are just the lack of sleep. I fall asleep fine but wake up like 3am and can't go back to sleep. when I started on 10mg I got some diarrhea for 2-3 day sapproximately 3 days after taking it but that side effect is almost gone by now and decreased after every dose until it was just one bowel movement. My goal is about 85kg/187lbs. I have increased the dose approximately after every 4 weeks and I'm currently doing 10mg for the 6th week now.

A huge thank you for taking your time I really appreciate it. Yes the most sensible thing to do is to increase the dose another 2,5mg and then do the same again when/if 12,5 mg isn't enough but I feel that I don't hit the platues as hard anymore like I did on the lower doses. Staying on 12,5mg Tirz as long as it works is the sensible and best way to go I do know that but FOMO is real for sure.

 

[BNLFL]

Sorry but I totally lost you guys there with the TG and the GB. What is that?

Telegram and GB is Group Buys. Worth it money wise plus a couple other things.

 

[JohannesSweden77]

Telegram and GB is Group Buys. Worth it money wise plus a couple other things.

Ah. Yes I am on TG but I haven't figured out what Group Buys means. Please elaborate?

 

[BNLFL]

Easiest way to explain. A vendor in a group promotes a certain product/products buy for a set dollar amount.

 

[HouseCat]

Ah. Yes I am on TG but I haven't figured out what Group Buys means. Please elaborate?

What @BNLFL said; the thing I like most about GBs is that they will often include testing in the price of the product (generally at least mass/purity, but also sometimes things like endotoxin or molecular structure).

 

[JohannesSweden77]

Easiest way to explain. A vendor in a group promotes a certain product/products buy for a set dollar amount.

You buy several products like a package deal?

 

[Lifeworthliving]

My story, lost 80 lbs on Tirz, highest dose 12.5. Lost my insurance coverage, gained back 30 lbs. Found the grey market. Went to Reta, slowly titrated up, and I struggled. Tirz for me, makes all the food noise go away, gives me clarity of mind, focus, I'm just so much happier. I have also been overweight all my life, it was a coping thing. When I first went on Tirz I had a little bit of the dopamine drain, but maybe a month and it was gone.

On Reta the mental side was really really hard, I did not get that food noise suppression. I also felt so meh, unmotivated, I've never felt like that in my life. I've read when you go from Tirz to Reta it is different because the body is already used to some of the GLP/GLP1 but the Reta is hitting differently. Now I'm back to 7.5 of Tirz on Monday, and 2mg of Reta on Saturdays, and I feel so good. No food noise, loosing weight, doing the couch to 5K, motivated. Starting to go heavier on the weight training which I feel the Reta will compliment well.

 

[Lifeworthliving]

You buy several products like a package deal?

Yes, vendors will sell vials in 10 packs, make it much cheaper, there are always different vendors and you have to find one you feel comfortable with. I personally use one that does third party testing through Janoshik and then there is an active group of folks who purchase from them, they also organize an independent testing through Janoshik, so there are two test reports per batch to reference. Now the vendor I use is also more expensive than others for the same amount I just paid $200 ish for Tirz, 10 vials of 30 mg a piece (so 300 mg over 10 vials) in a pre-order. But I feel safer using them (more test data points) and they ship from the US. If I say the name, I'm guessing there would be fans of this vendor and others that would role their eyes, and that is okay (purple label). I also haven't been paying attention, but I'm sure there are just as good other vendor alternatives that have popped up, where there is demand, there will be people selling it.

 

[BNLFL]

You buy several products like a package deal?

No, they just offer a bunch at low prices, well most of them. Sometimes one product, some times more. It's organized, you fill out buy form, and pay right there. Then wait, because the vendor need to pay who's making it. Then you wait, sometimes 3 months. Huge money savings. Example, I bought two kits (10 vials) of R30 Wednesday for $110 each, plus a few small fees. I think the one was $10.

 

[BNLFL]

. But I feel safer using them (more test data points) and they ship from the US. If I say the name, I'm guessing there would be fans of this vendor and others that would role their eyes, and that is okay (purple label). I also haven't been paying attention, but I'm sure there are just as good other vendor alternatives that have popped up, where there is demand, there will be people selling it.

I have 6 I trust, two don't do GB an, but good products and not on TG. The others are all TG, and I've ordered from them. Good organization, and good at keeping the buyers up to date on the GB shipping and stuff.