I had this same concern when I started and even found this info stated on a legit respectable medical website - Cochrane. However, I read somewhere that this only applies to certain peptides. While I don't know which those might be, it doesn't seem to apply to glp1's. I've not personally experimented enough to be able to say for sure 1 way or another. But I asked this of multiple people in the beginning and the consensus was that the dripping down the side of the vial and gently swirling is not necessary. I'm probably more skeptical than most, and often rely on what my grandpa told me - Believe nothing you hear or read, and only half of what you see. I have read a lot of contradicting info over the last 3 months. That Jano Q&A dispelled several things that I'd heard numerous times. But even someone with 20 years experience can be wrong, so this remains unsolved in my mind.
I attempted to drip in the first vial I recon'd but was not aware of negative pressure, so the bac water was in and it foamed before I could blink.
Next vial I injected a bit of air first and held the plunger at the tube so I could drip.
I will say that I've noticed less food noise control from research sema vs brand name ozempic. Could that be due to damaged peptides from that blasting the water in? I have no clue.
Since we can do whatever we want, I now strive to release pressure and drip. That first vial lasted me 3 months of titration, so I'm just now starting my second vial, which I dripped down the side, so I'm at the very beginning of testing the difference.
That said, I will add that the bac water blasted into my first vial still had significant results as my appetite is less than half what it was, food noise is significantly reduced, and I've lost 15# without changing what I eat - I just eat less and less frequently. And I don't exercise due to severe chronic pain - 8 herniated discs and 11 bone spurs. So it's working just fine!
So I can say that blasting the water in does not destroy the peptides. Might it slightly harm them resulting in slightly less efficacy... Maybe, a little tiny bit, but not enough to worry about.
I will strive to drip, because my OCD dictates that I do that, but also will not throw out a vial that was blasted with bac.
